{"id":"https://openalex.org/W3015490972","doi":"https://doi.org/10.1186/s12859-020-3474-1","title":"ppiGReMLIN: a graph mining based detection of conserved structural arrangements in protein-protein interfaces","display_name":"ppiGReMLIN: a graph mining based detection of conserved structural arrangements in protein-protein interfaces","publication_year":2020,"publication_date":"2020-04-15","ids":{"openalex":"https://openalex.org/W3015490972","doi":"https://doi.org/10.1186/s12859-020-3474-1","mag":"3015490972","pmid":"https://pubmed.ncbi.nlm.nih.gov/32293241"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-3474-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3474-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3474-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3474-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007242258","display_name":"Felippe C. Queiroz","orcid":null},"institutions":[{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Felippe C. Queiroz","raw_affiliation_strings":["Department of Computer Science, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil. felippe.queiroz@ufv.br","Department of Computer Science, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil. felippe.queiroz@ufv.br","institution_ids":["https://openalex.org/I146165071"]},{"raw_affiliation_string":"Department of Computer Science, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil","institution_ids":["https://openalex.org/I146165071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110676375","display_name":"Adriana Maria Patarroyo Vargas","orcid":null},"institutions":[{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana M. P. Vargas","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil","institution_ids":["https://openalex.org/I146165071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110910371","display_name":"M. G. A. Oliveira","orcid":null},"institutions":[{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria G. A. Oliveira","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil","Instituto de Biotecnologia aplicada a Agropecuaria, BIOAGRO-UFV, Av Peter Henry Rolfs, Vi\u00e7osa MG, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil","institution_ids":["https://openalex.org/I146165071"]},{"raw_affiliation_string":"Instituto de Biotecnologia aplicada a Agropecuaria, BIOAGRO-UFV, Av Peter Henry Rolfs, Vi\u00e7osa MG, Brazil","institution_ids":["https://openalex.org/I146165071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080975003","display_name":"Giovanni Comarela","orcid":"https://orcid.org/0000-0001-7612-9650"},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giovanni V. Comarela","raw_affiliation_strings":["Department of Computer Science, Universidade Federal do Esp\u00edrito Santo, Av Fernando Ferrari, Vit\u00f3ria, ES, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Universidade Federal do Esp\u00edrito Santo, Av Fernando Ferrari, Vit\u00f3ria, ES, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021817826","display_name":"Sabrina de Azevedo Silveira","orcid":"https://orcid.org/0000-0002-4723-2349"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I146165071","display_name":"Universidade Federal de Vi\u00e7osa","ror":"https://ror.org/0409dgb37","country_code":"BR","type":"education","lineage":["https://openalex.org/I146165071"]}],"countries":["BR","GB"],"is_corresponding":false,"raw_author_name":"Sabrina A. Silveira","raw_affiliation_strings":["Department of Computer Science, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil","European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, CB10 1SD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Universidade Federal de Vi\u00e7osa, Av Peter Henry Rolfs, Vi\u00e7osa, MG, Brazil","institution_ids":["https://openalex.org/I146165071"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, CB10 1SD, UK","institution_ids":["https://openalex.org/I1303153112"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007242258"],"corresponding_institution_ids":["https://openalex.org/I146165071"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.4473,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.57642628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"1","first_page":"143","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.49939998984336853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.49939998984336853,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.1597999930381775,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0989999994635582,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4925726056098938},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4898321330547333},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.46799299120903015},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4559938609600067},{"id":"https://openalex.org/keywords/protein-microarray","display_name":"Protein microarray","score":0.44329631328582764},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3498430848121643},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33475106954574585},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33032751083374023},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27224522829055786},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.23372071981430054},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.22676894068717957},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.07727950811386108}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4925726056098938},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4898321330547333},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.46799299120903015},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4559938609600067},{"id":"https://openalex.org/C195814341","wikidata":"https://www.wikidata.org/wiki/Q494918","display_name":"Protein microarray","level":5,"score":0.44329631328582764},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3498430848121643},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33475106954574585},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33032751083374023},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27224522829055786},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23372071981430054},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.22676894068717957},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07727950811386108}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-3474-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3474-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3474-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32293241","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32293241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:fdedb48396474d2aac8af7982dbeaac1","is_oa":true,"landing_page_url":"https://doaj.org/article/fdedb48396474d2aac8af7982dbeaac1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-25 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7158050","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7158050","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-3474-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3474-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3474-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1382761819","display_name":null,"funder_award_id":"23038.004007/2014-82","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G4246447654","display_name":null,"funder_award_id":"23038","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G6074959722","display_name":null,"funder_award_id":"051/2013","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3015490972.pdf","grobid_xml":"https://content.openalex.org/works/W3015490972.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W255556494","https://openalex.org/W1522198160","https://openalex.org/W1552266425","https://openalex.org/W1565377632","https://openalex.org/W1567268701","https://openalex.org/W1576533924","https://openalex.org/W1599801350","https://openalex.org/W1860382351","https://openalex.org/W1969350101","https://openalex.org/W1970560001","https://openalex.org/W1973756092","https://openalex.org/W1983478747","https://openalex.org/W1985644065","https://openalex.org/W1987126302","https://openalex.org/W1993591356","https://openalex.org/W2004091546","https://openalex.org/W2010685876","https://openalex.org/W2014688483","https://openalex.org/W2037913468","https://openalex.org/W2038555943","https://openalex.org/W2052968292","https://openalex.org/W2053856417","https://openalex.org/W2067305633","https://openalex.org/W2067596330","https://openalex.org/W2074964005","https://openalex.org/W2087118491","https://openalex.org/W2087381350","https://openalex.org/W2089883223","https://openalex.org/W2096768134","https://openalex.org/W2098693556","https://openalex.org/W2098972539","https://openalex.org/W2101234009","https://openalex.org/W2106191978","https://openalex.org/W2114801649","https://openalex.org/W2117692326","https://openalex.org/W2125471137","https://openalex.org/W2130479394","https://openalex.org/W2132914434","https://openalex.org/W2135762988","https://openalex.org/W2138345179","https://openalex.org/W2138865250","https://openalex.org/W2140883620","https://openalex.org/W2143411881","https://openalex.org/W2147405597","https://openalex.org/W2148768886","https://openalex.org/W2149053037","https://openalex.org/W2150420891","https://openalex.org/W2155960310","https://openalex.org/W2163046259","https://openalex.org/W2165874743","https://openalex.org/W2170726034","https://openalex.org/W2174725453","https://openalex.org/W2199634952","https://openalex.org/W2223119478","https://openalex.org/W2329592726","https://openalex.org/W2399229449","https://openalex.org/W2482589566","https://openalex.org/W2537623931","https://openalex.org/W2558534012","https://openalex.org/W2562004831","https://openalex.org/W2620589125","https://openalex.org/W2741990630","https://openalex.org/W2756360571","https://openalex.org/W2765843462","https://openalex.org/W2768151985","https://openalex.org/W2794683306","https://openalex.org/W2809000676","https://openalex.org/W2810267605","https://openalex.org/W2913996609","https://openalex.org/W2915536738","https://openalex.org/W2949301282","https://openalex.org/W3145004415","https://openalex.org/W4239055561","https://openalex.org/W4240231372","https://openalex.org/W4300601563","https://openalex.org/W6807695228"],"related_works":["https://openalex.org/W292433598","https://openalex.org/W138917419","https://openalex.org/W150910722","https://openalex.org/W4250142241","https://openalex.org/W2384737449","https://openalex.org/W2076275400","https://openalex.org/W2008350047","https://openalex.org/W2074064799","https://openalex.org/W2007390442","https://openalex.org/W1605800951"],"abstract_inverted_index":{"BACKGROUND:":[0],"Protein-protein":[1],"interactions":[2,13,123,149,178],"(PPIs)":[3],"are":[4,119,269],"fundamental":[5],"in":[6,60,77,124,138,212,251,270,276],"many":[7],"biological":[8,32],"processes":[9],"and":[10,26,37,42,130,157,226],"understanding":[11],"these":[12],"is":[14],"key":[15,120],"for":[16,121,164,214],"a":[17,52,61],"myriad":[18],"of":[19,28,63,90,99,127,155,189,192,206,219,228,242,249,253],"applications":[20],"including":[21],"drug":[22,29],"development,":[23],"peptide":[24],"design":[25],"identification":[27],"targets.":[30],"The":[31],"data":[33],"deluge":[34],"demands":[35],"efficient":[36],"scalable":[38],"methods":[39],"to":[40,56,79,101,114,136,185,203,224,234],"characterize":[41],"understand":[43],"protein-protein":[44,64,108,122,243],"interfaces.":[45,94],"In":[46],"this":[47],"paper,":[48],"we":[49,110],"present":[50],"ppiGReMLIN,":[51],"graph":[53],"based":[54,85],"strategy":[55,72],"infer":[57],"interaction":[58,273],"patterns":[59,117,260,274],"set":[62],"complexes.":[65],"Our":[66],"method":[67,169,268],"combines":[68],"an":[69,139],"unsupervised":[70],"learning":[71],"with":[73,245,272],"frequent":[74],"subgraph":[75],"mining":[76],"order":[78],"detect":[80],"conserved":[81,105,142,148,172,181,237],"structural":[82,143],"arrangements":[83,144,173],"(patterns)":[84],"on":[86,92,107,239,263],"the":[87,97,151,165,180,186,207,240,259,277],"physicochemical":[88],"properties":[89],"atoms":[91],"protein":[93,264],"To":[95],"assess":[96],"ability":[98],"ppiGReMLIN":[100,133,200,231],"point":[102],"out":[103,171],"relevant":[104,209],"substructures":[106],"interfaces,":[109],"compared":[111],"our":[112,168,215,267],"results":[113],"experimentally":[115],"determined":[116],"that":[118,145,174,258],"2":[125],"datasets":[126,252],"complexes,":[128,244],"Serine-protease":[129,161],"BCL-2.":[131],"RESULTS:":[132],"was":[134,201,232],"able":[135,202,233],"detect,":[137],"automatic":[140],"fashion,":[141],"represent":[146],"highly":[147,236],"at":[150,220],"specificity":[152,188],"binding":[153,187],"pocket":[154],"trypsin":[156],"trypsin-like":[158],"proteins":[159,195],"from":[160],"dataset.":[162],"Also,":[163],"BCL-2":[166,194],"dataset,":[167],"pointed":[170],"include":[175],"critical":[176],"residue":[177],"within":[179],"motif":[182],"LXXXXD,":[183],"pivotal":[184],"BH3":[190],"domains":[191],"pro-apoptotic":[193],"towards":[196],"apoptotic":[197],"suppressors.":[198],"Quantitatively,":[199],"find":[204,235],"all":[205],"most":[208],"residues":[210],"described":[211,275],"literature":[213],"datasets,":[216],"showing":[217],"precision":[218],"least":[221],"69%":[222],"up":[223],"100%":[225],"recall":[227],"100%.":[229],"CONCLUSIONS:":[230],"structures":[238],"interfaces":[241,265],"minimum":[246],"support":[247],"value":[248],"60%,":[250],"similar":[254],"proteins.":[255],"We":[256],"showed":[257],"automatically":[261],"detected":[262],"by":[266],"agreement":[271],"literature.":[278]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}