{"id":"https://openalex.org/W3027646407","doi":"https://doi.org/10.1186/s12859-020-3466-1","title":"Automated image analysis system for studying cardiotoxicity in human pluripotent stem cell-Derived cardiomyocytes","display_name":"Automated image analysis system for studying cardiotoxicity in human pluripotent stem cell-Derived cardiomyocytes","publication_year":2020,"publication_date":"2020-05-14","ids":{"openalex":"https://openalex.org/W3027646407","doi":"https://doi.org/10.1186/s12859-020-3466-1","mag":"3027646407","pmid":"https://pubmed.ncbi.nlm.nih.gov/32408861"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-3466-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3466-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-020-3466-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-020-3466-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100393055","display_name":"Lu Cao","orcid":"https://orcid.org/0000-0002-1847-068X"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lu Cao","raw_affiliation_strings":["Imaging and Bioinformatics group, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, Leiden, 2333 CA, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging and Bioinformatics group, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, Leiden, 2333 CA, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034743017","display_name":"Andries D. van der Meer","orcid":"https://orcid.org/0000-0002-8761-4077"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Andries D. van der Meer","raw_affiliation_strings":["Dept of Applied Stem Cell Technologies, MIRA Institute, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Applied Stem Cell Technologies, MIRA Institute, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022631255","display_name":"Fons J. Verbeek","orcid":"https://orcid.org/0000-0003-2445-8158"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Fons J. Verbeek","raw_affiliation_strings":["Imaging and Bioinformatics group, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, Leiden, 2333 CA, The Netherlands. f.j.verbeek@liacs.leidenuniv.nl","Imaging and Bioinformatics group, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, Leiden, 2333 CA, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging and Bioinformatics group, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, Leiden, 2333 CA, The Netherlands. f.j.verbeek@liacs.leidenuniv.nl","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Imaging and Bioinformatics group, Leiden Institute of Advanced Computer Science (LIACS), Leiden University, Niels Bohrweg 1, Leiden, 2333 CA, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001894450","display_name":"Robert Passier","orcid":"https://orcid.org/0000-0003-4312-9296"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Robert Passier","raw_affiliation_strings":["Dept of Anatomy and Embryology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands. robert.passier@utwente.nl","Dept of Applied Stem Cell Technologies, MIRA Institute, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands. robert.passier@utwente.nl","Dept of Applied Stem Cell Technologies, MIRA Institute, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Anatomy and Embryology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands. robert.passier@utwente.nl","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Dept of Applied Stem Cell Technologies, MIRA Institute, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands. robert.passier@utwente.nl","institution_ids":["https://openalex.org/I94624287"]},{"raw_affiliation_string":"Dept of Applied Stem Cell Technologies, MIRA Institute, University of Twente, Drienerlolaan 5, Enschede, 7522 NB, The Netherlands","institution_ids":["https://openalex.org/I94624287"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001894450","https://openalex.org/A5022631255"],"corresponding_institution_ids":["https://openalex.org/I121797337","https://openalex.org/I2800006345","https://openalex.org/I94624287"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.7621,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.7415904,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"187","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.2705000042915344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.2705000042915344,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.20980000495910645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.09730000048875809,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"Cardiotoxicity","score":0.7220194935798645},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell","display_name":"Induced pluripotent stem cell","score":0.5835310816764832},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.5616748332977295},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.514672577381134},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.48083290457725525},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4757689833641052},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.4715797007083893},{"id":"https://openalex.org/keywords/high-content-screening","display_name":"High-content screening","score":0.4248465299606323},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3639530539512634},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.3636118173599243},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.35735881328582764},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.33220547437667847},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.27041155099868774},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.25361865758895874},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.23560819029808044},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.172483891248703},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1470220386981964},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12709948420524597},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.12426456809043884}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.7220194935798645},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5835310816764832},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5616748332977295},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.514672577381134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48083290457725525},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4757689833641052},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.4715797007083893},{"id":"https://openalex.org/C157044486","wikidata":"https://www.wikidata.org/wiki/Q5754482","display_name":"High-content screening","level":3,"score":0.4248465299606323},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3639530539512634},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3636118173599243},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35735881328582764},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33220547437667847},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27041155099868774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25361865758895874},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.23560819029808044},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.172483891248703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1470220386981964},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12709948420524597},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.12426456809043884},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066126","descriptor_name":"Cardiotoxicity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12859-020-3466-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3466-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-020-3466-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32408861","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32408861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:ris.utwente.nl:openaire_cris_publications/b7e227e8-2efb-4f6f-bf17-2339a043f3cb","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/b7e227e8-2efb-4f6f-bf17-2339a043f3cb","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cao, L, Der Meer, A D V, Verbeek, F J & Passier, R 2020, 'Automated image analysis system for studying cardiotoxicity in human pluripotent stem cell-Derived cardiomyocytes', BMC bioinformatics, vol. 21, no. 1, 187. https://doi.org/10.1186/s12859-020-3466-1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8ff6dd0ccbc9453ebb43ce6543ef29f0","is_oa":true,"landing_page_url":"https://doaj.org/article/8ff6dd0ccbc9453ebb43ce6543ef29f0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-12 (2020)","raw_type":"article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/138390","is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/138390","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"21","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pubmedcentral.nih.gov:7222481","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7222481","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2906082","is_oa":true,"landing_page_url":"https://hdl.handle.net/1887/138390","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-3466-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3466-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-020-3466-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8399999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2284323781","display_name":null,"funder_award_id":"ERA-CVD 2016T092","funder_id":"https://openalex.org/F4320330882","funder_display_name":"European Research Area Network on Cardiovascular Diseases"},{"id":"https://openalex.org/G3731143509","display_name":null,"funder_award_id":"MKMD-40-42600-98-036","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G8656201866","display_name":null,"funder_award_id":"40-42600-98-036","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"},{"id":"https://openalex.org/G8682009210","display_name":null,"funder_award_id":"2016T092","funder_id":"https://openalex.org/F4320330882","funder_display_name":"European Research Area Network on Cardiovascular Diseases"}],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320330882","display_name":"European Research Area Network on Cardiovascular Diseases","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3027646407.pdf","grobid_xml":"https://content.openalex.org/works/W3027646407.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W46659105","https://openalex.org/W86066916","https://openalex.org/W290369406","https://openalex.org/W1589895371","https://openalex.org/W1591540433","https://openalex.org/W1651609297","https://openalex.org/W1901129140","https://openalex.org/W1943807104","https://openalex.org/W1952355053","https://openalex.org/W1959250237","https://openalex.org/W1967770515","https://openalex.org/W1970526294","https://openalex.org/W1992147426","https://openalex.org/W1993978935","https://openalex.org/W2002708055","https://openalex.org/W2008446011","https://openalex.org/W2008485310","https://openalex.org/W2031056828","https://openalex.org/W2038518913","https://openalex.org/W2053669527","https://openalex.org/W2070202276","https://openalex.org/W2074477987","https://openalex.org/W2084540645","https://openalex.org/W2084834807","https://openalex.org/W2085941547","https://openalex.org/W2092753756","https://openalex.org/W2105955220","https://openalex.org/W2115242586","https://openalex.org/W2133059825","https://openalex.org/W2138977668","https://openalex.org/W2141118238","https://openalex.org/W2151620138","https://openalex.org/W2166481425","https://openalex.org/W2187452955","https://openalex.org/W2286471756","https://openalex.org/W2338021849","https://openalex.org/W2345928058","https://openalex.org/W2415670168","https://openalex.org/W2480510582","https://openalex.org/W2512779800","https://openalex.org/W2529327553","https://openalex.org/W2558238441","https://openalex.org/W2616198196","https://openalex.org/W2911823761","https://openalex.org/W2963150697","https://openalex.org/W3091360126","https://openalex.org/W4255375128","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2107556826","https://openalex.org/W3034751833","https://openalex.org/W2021094532","https://openalex.org/W2884937845","https://openalex.org/W2071853918","https://openalex.org/W1865162173","https://openalex.org/W2274888953","https://openalex.org/W2297024106","https://openalex.org/W4313700805","https://openalex.org/W2148354777"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cardiotoxicity,":[1],"characterized":[2],"by":[3,81,149],"severe":[4],"cardiac":[5,157],"dysfunction,":[6],"is":[7],"a":[8,117],"major":[9],"problem":[10],"in":[11,40,101],"patients":[12],"treated":[13,132],"with":[14,133,197],"different":[15],"classes":[16],"of":[17,21,76,104,116,125,136,156,176],"anticancer":[18,137],"drugs.":[19],"Development":[20],"predictable":[22],"human-based":[23],"models":[24,42],"and":[25,43,68,95,98,160,173,178],"assays":[26],"for":[27,32,65,123],"drug":[28,77],"screening":[29,75],"are":[30,46,131],"crucial":[31],"preventing":[33],"potential":[34,64],"drug-induced":[35,69],"adverse":[36],"effects.":[37],"Current":[38],"animal":[39],"vivo":[41],"cell":[44,92],"lines":[45],"not":[47],"always":[48],"adequate":[49],"to":[50,90,167],"represent":[51],"human":[52,55],"biology.":[53],"Alternatively,":[54],"induced":[56],"pluripotent":[57],"stem":[58],"cell-derived":[59],"cardiomyocytes":[60,195],"(hiPSC-CMs)":[61],"show":[62,184],"great":[63],"disease":[66],"modelling":[67],"toxicity":[70,78],"screenings.":[71],"Fully":[72],"automated":[73,119,188],"high-throughput":[74,143],"on":[79,113,146],"hiPSC-CMs":[80,129],"fluorescence":[82],"image":[83,120,189],"analysis":[84,121,190],"is,":[85],"however,":[86],"very":[87],"challenging,":[88],"due":[89],"clustered":[91],"growth":[93],"patterns":[94],"strong":[96],"intracellular":[97],"intercellular":[99],"variation":[100],"the":[102,114],"expression":[103],"fluorescent":[105],"markers.":[106],"RESULTS:":[107],"In":[108],"this":[109],"paper,":[110],"we":[111],"report":[112],"development":[115],"fully":[118,187],"system":[122,144,191],"quantification":[124],"cardiotoxic":[126],"phenotypes":[127],"from":[128],"that":[130,185],"various":[134],"concentrations":[135],"drugs":[138],"doxorubicin":[139],"or":[140],"crizotinib.":[141],"This":[142],"relies":[145],"single-cell":[147],"segmentation":[148],"nuclear":[150,162],"signal":[151,163],"extraction,":[152],"fuzzy":[153],"C-mean":[154],"clustering":[155],"\u03b1-actinin":[158,199],"signal,":[159],"finally":[161],"propagation.":[164],"When":[165],"compared":[166],"manual":[168],"segmentation,":[169],"it":[170],"generates":[171],"precision":[172],"recall":[174],"scores":[175],"0.81":[177],"0.93,":[179],"respectively.":[180],"CONCLUSIONS:":[181],"Our":[182],"results":[183],"our":[186],"can":[192],"reliably":[193],"segment":[194],"even":[196],"heterogeneous":[198],"signals.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}