{"id":"https://openalex.org/W3007819083","doi":"https://doi.org/10.1186/s12859-020-3409-x","title":"Graph regularized L2,1-nonnegative matrix factorization for miRNA-disease association prediction","display_name":"Graph regularized L2,1-nonnegative matrix factorization for miRNA-disease association prediction","publication_year":2020,"publication_date":"2020-02-18","ids":{"openalex":"https://openalex.org/W3007819083","doi":"https://doi.org/10.1186/s12859-020-3409-x","mag":"3007819083","pmid":"https://pubmed.ncbi.nlm.nih.gov/32070280"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-3409-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3409-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3409-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3409-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068590943","display_name":"Zhen Gao","orcid":"https://orcid.org/0000-0001-7427-6032"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Gao","raw_affiliation_strings":["School of Software, Qufu Normal University, Qufu, 273165, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Qufu Normal University, Qufu, 273165, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741273","display_name":"Yutian Wang","orcid":"https://orcid.org/0000-0002-8033-8727"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Tian Wang","raw_affiliation_strings":["School of Software, Qufu Normal University, Qufu, 273165, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Qufu Normal University, Qufu, 273165, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101531254","display_name":"Qing-Wen Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing-Wen Wu","raw_affiliation_strings":["School of Software, Qufu Normal University, Qufu, 273165, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Qufu Normal University, Qufu, 273165, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003156605","display_name":"Jiancheng Ni","orcid":"https://orcid.org/0000-0001-5667-9807"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jian-Cheng Ni","raw_affiliation_strings":["School of Software, Qufu Normal University, Qufu, 273165, China. nijch@163.com","School of Software, Qufu Normal University, Qufu, 273165, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Qufu Normal University, Qufu, 273165, China. nijch@163.com","institution_ids":["https://openalex.org/I202126657"]},{"raw_affiliation_string":"School of Software, Qufu Normal University, Qufu, 273165, China","institution_ids":["https://openalex.org/I202126657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064185915","display_name":"Chun-Hou Zheng","orcid":"https://orcid.org/0000-0002-2695-1926"},"institutions":[{"id":"https://openalex.org/I202126657","display_name":"Qufu Normal University","ror":"https://ror.org/03ceheh96","country_code":"CN","type":"education","lineage":["https://openalex.org/I202126657"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chun-Hou Zheng","raw_affiliation_strings":["School of Software, Qufu Normal University, Qufu, 273165, China. zhengch99@126.com","School of Software, Qufu Normal University, Qufu, 273165, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software, Qufu Normal University, Qufu, 273165, China. zhengch99@126.com","institution_ids":["https://openalex.org/I202126657"]},{"raw_affiliation_string":"School of Software, Qufu Normal University, Qufu, 273165, China","institution_ids":["https://openalex.org/I202126657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003156605","https://openalex.org/A5064185915"],"corresponding_institution_ids":["https://openalex.org/I202126657"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":1.9118,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.86428736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"61","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-negative-matrix-factorization","display_name":"Non-negative matrix factorization","score":0.8466349840164185},{"id":"https://openalex.org/keywords/laplacian-matrix","display_name":"Laplacian matrix","score":0.5712953209877014},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5380980372428894},{"id":"https://openalex.org/keywords/preprocessor","display_name":"Preprocessor","score":0.5374271273612976},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49860382080078125},{"id":"https://openalex.org/keywords/cross-validation","display_name":"Cross-validation","score":0.49607762694358826},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4754212200641632},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.47346892952919006},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4523344039916992},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.43598994612693787},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40052977204322815},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.38015294075012207},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3778325319290161},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3446305990219116},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22467663884162903},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.18872606754302979},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.16361767053604126},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13941994309425354},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0871700644493103},{"id":"https://openalex.org/keywords/eigenvalues-and-eigenvectors","display_name":"Eigenvalues and eigenvectors","score":0.08541414141654968}],"concepts":[{"id":"https://openalex.org/C152671427","wikidata":"https://www.wikidata.org/wiki/Q10843505","display_name":"Non-negative matrix factorization","level":4,"score":0.8466349840164185},{"id":"https://openalex.org/C115178988","wikidata":"https://www.wikidata.org/wiki/Q772067","display_name":"Laplacian matrix","level":3,"score":0.5712953209877014},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5380980372428894},{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.5374271273612976},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49860382080078125},{"id":"https://openalex.org/C27181475","wikidata":"https://www.wikidata.org/wiki/Q541014","display_name":"Cross-validation","level":2,"score":0.49607762694358826},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4754212200641632},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.47346892952919006},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4523344039916992},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.43598994612693787},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40052977204322815},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.38015294075012207},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3778325319290161},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3446305990219116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22467663884162903},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.18872606754302979},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.16361767053604126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13941994309425354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0871700644493103},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.08541414141654968},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-3409-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3409-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3409-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32070280","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32070280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:bf9d454bf77c491e85ec9b801f471714","is_oa":false,"landing_page_url":"https://doaj.org/article/bf9d454bf77c491e85ec9b801f471714","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-13 (2020)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5980989","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7029547","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-3409-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3409-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3409-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.5400000214576721,"display_name":"Partnerships for the goals"}],"awards":[{"id":"https://openalex.org/G1474191173","display_name":null,"funder_award_id":"61861146002 and 61732012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2060260478","display_name":null,"funder_award_id":"Nos. U19A2064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G247010507","display_name":null,"funder_award_id":"61873001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5006237592","display_name":null,"funder_award_id":"U19A2064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5160078536","display_name":null,"funder_award_id":"U19A2064, 61873001, 61872220","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5573161910","display_name":null,"funder_award_id":"61672037","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5609717784","display_name":"\u57fa\u4e8e\u4f4e\u79e9\u548c\u56fe\u6b63\u5219\u7ea6\u675f\u7684\u77e9\u9635\u5206\u89e3\u65b9\u6cd5\u7814\u7a76\u53ca\u5728\u764c\u75c7\u591a\u7ec4\u5b66\u6570\u636e\u4e2d\u7684\u5e94\u7528","funder_award_id":"61872220","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6322265744","display_name":null,"funder_award_id":"U19A2064, 61873001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8004256094","display_name":null,"funder_award_id":"Nos. U19A2064, 61873001, 61872220, 61672037, 61861146002 and 61732012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8031058355","display_name":null,"funder_award_id":"61861146002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3007819083.pdf","grobid_xml":"https://content.openalex.org/works/W3007819083.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W14098964","https://openalex.org/W144423133","https://openalex.org/W206759535","https://openalex.org/W1436642346","https://openalex.org/W1577392641","https://openalex.org/W1668595991","https://openalex.org/W1902027874","https://openalex.org/W1967087625","https://openalex.org/W1990933893","https://openalex.org/W2002995168","https://openalex.org/W2014946489","https://openalex.org/W2017426710","https://openalex.org/W2022732522","https://openalex.org/W2026051181","https://openalex.org/W2047967134","https://openalex.org/W2083045667","https://openalex.org/W2101293029","https://openalex.org/W2105884433","https://openalex.org/W2108119513","https://openalex.org/W2110234420","https://openalex.org/W2118814218","https://openalex.org/W2124756133","https://openalex.org/W2126619650","https://openalex.org/W2129158737","https://openalex.org/W2132694427","https://openalex.org/W2138664009","https://openalex.org/W2141222510","https://openalex.org/W2141655062","https://openalex.org/W2142937131","https://openalex.org/W2144719328","https://openalex.org/W2145361279","https://openalex.org/W2145955247","https://openalex.org/W2147339185","https://openalex.org/W2151519667","https://openalex.org/W2158135353","https://openalex.org/W2162674813","https://openalex.org/W2174734928","https://openalex.org/W2213532196","https://openalex.org/W2258129851","https://openalex.org/W2259538443","https://openalex.org/W2313125707","https://openalex.org/W2343107734","https://openalex.org/W2410390867","https://openalex.org/W2494395359","https://openalex.org/W2511620854","https://openalex.org/W2548889510","https://openalex.org/W2567465856","https://openalex.org/W2574217686","https://openalex.org/W2584926544","https://openalex.org/W2597632520","https://openalex.org/W2598821379","https://openalex.org/W2601934706","https://openalex.org/W2607159126","https://openalex.org/W2750900465","https://openalex.org/W2752943586","https://openalex.org/W2753269195","https://openalex.org/W2765950793","https://openalex.org/W2780777007","https://openalex.org/W2781702232","https://openalex.org/W2795540478","https://openalex.org/W2798045697","https://openalex.org/W2799307902","https://openalex.org/W2807490780","https://openalex.org/W2809363952","https://openalex.org/W2888216133","https://openalex.org/W2888358121","https://openalex.org/W2890728516","https://openalex.org/W2895927009","https://openalex.org/W2903959374","https://openalex.org/W2912204568","https://openalex.org/W2912279798","https://openalex.org/W2942820662","https://openalex.org/W2962928958","https://openalex.org/W3146565636","https://openalex.org/W4241442281"],"related_works":["https://openalex.org/W2127243424","https://openalex.org/W2037504162","https://openalex.org/W2792706544","https://openalex.org/W1568451138","https://openalex.org/W2539013788","https://openalex.org/W2156699640","https://openalex.org/W2045265907","https://openalex.org/W2972997031","https://openalex.org/W2075222291","https://openalex.org/W2146544734"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,145],"aberrant":[3],"expression":[4],"of":[5,15,19,85,122,155],"microRNAs":[6,73,141],"is":[7,187],"closely":[8],"connected":[9],"to":[10,118,137],"the":[11,120,123,129],"occurrence":[12],"and":[13,33,76,103,142,157,166],"development":[14],"a":[16,44,108],"great":[17],"deal":[18],"human":[20,24,66],"diseases.":[21,143],"To":[22],"study":[23],"diseases,":[25],"numerous":[26],"effective":[27],"computational":[28,45],"models":[29],"that":[30,173],"are":[31],"valuable":[32],"meaningful":[34],"have":[35],"been":[36],"presented":[37],"by":[38],"researchers.":[39],"Results":[40],"Here,":[41],"we":[42,92,106],"present":[43],"framework":[46,134],"based":[47],"on":[48],"graph":[49],"Laplacian":[50],"regularized":[51],"L":[52],"2,":[53,60,149,175],"1":[54,61,150,176],"-nonnegative":[55],"matrix":[56,126],"factorization":[57],"(":[58],"GRL":[59,130,174],"-NMF)":[62,151],"for":[63,100],"inferring":[64],"possible":[65],"disease-connected":[67,72],"miRNAs.":[68],"First,":[69],"manually":[70],"validated":[71],"were":[74,89],"integrated,":[75],"microRNA":[77],"functional":[78],"similarity":[79],"information":[80],"along":[81],"with":[82],"two":[83],"kinds":[84],"disease":[86],"semantic":[87],"similarities":[88,99],"calculated.":[90],"Next,":[91],"measured":[93],"Gaussian":[94],"interaction":[95],"profile":[96],"(GIP)":[97],"kernel":[98],"both":[101],"diseases":[102],"microRNAs.":[104],"Then,":[105],"adopted":[107],"preprocessing":[109],"step,":[110],"namely,":[111],"weighted":[112],"K":[113],"nearest":[114],"known":[115,189],"neighbours":[116],"(WKNKN),":[117],"decrease":[119],"sparsity":[121],"miRNA-disease":[124],"association":[125],"network.":[127],"Finally,":[128],"2":[131],",1":[132],"-NMF":[133,177],"was":[135],"used":[136],"predict":[138],"links":[139],"between":[140],"Conclusions":[144],"new":[146],"method":[147],"(GRL":[148],"achieved":[152],"AUC":[153],"values":[154],"0.9280":[156],"0.9276":[158],"in":[159],"global":[160],"leave-one-out":[161],"cross":[162,168],"validation":[163,169],"(global":[164],"LOOCV)":[165],"five-fold":[167],"(5-CV),":[170],"respectively,":[171],"showing":[172],"can":[178],"powerfully":[179],"discover":[180],"potential":[181],"disease-related":[182],"miRNAs,":[183],"even":[184],"if":[185],"there":[186],"no":[188],"associated":[190],"disease.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}