{"id":"https://openalex.org/W3006194839","doi":"https://doi.org/10.1186/s12859-020-3399-8","title":"iSeqQC: a tool for expression-based quality control in RNA sequencing","display_name":"iSeqQC: a tool for expression-based quality control in RNA sequencing","publication_year":2020,"publication_date":"2020-02-13","ids":{"openalex":"https://openalex.org/W3006194839","doi":"https://doi.org/10.1186/s12859-020-3399-8","mag":"3006194839","pmid":"https://pubmed.ncbi.nlm.nih.gov/32054449"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-3399-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3399-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3399-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3399-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102025019","display_name":"Gaurav Kumar","orcid":"https://orcid.org/0000-0003-2298-2212"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gaurav Kumar","raw_affiliation_strings":["Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA. Gaurav.kumar@jefferson.edu","Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA. Gaurav.kumar@jefferson.edu","institution_ids":["https://openalex.org/I4210106595"]},{"raw_affiliation_string":"Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA","institution_ids":["https://openalex.org/I4210106595","https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006339979","display_name":"Adam Ertel","orcid":"https://orcid.org/0000-0001-7455-1559"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Ertel","raw_affiliation_strings":["Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA","institution_ids":["https://openalex.org/I4210106595","https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040988098","display_name":"George Feldman","orcid":"https://orcid.org/0000-0002-8879-310X"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Feldman","raw_affiliation_strings":["Department of Orthopedic Research, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Research, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001318474","display_name":"Joan Kupper","orcid":null},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Kupper","raw_affiliation_strings":["Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA","institution_ids":["https://openalex.org/I4210106595","https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062228025","display_name":"Paolo Fortina","orcid":"https://orcid.org/0000-0002-5898-2081"},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paolo Fortina","raw_affiliation_strings":["Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Genomics and Bioinformatics Laboratory, Sidney Kimmel Cancer Center, Department of Cancer Biology, BLSB 1009, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA-19107, USA","institution_ids":["https://openalex.org/I4210106595","https://openalex.org/I149251103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102025019"],"corresponding_institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":2050,"currency":"EUR","value_usd":2210},"fwci":1.7507,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.84687037,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"56","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.5964999794960022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.5964999794960022,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6565537452697754},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6186206936836243},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4768320620059967},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.4462616443634033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.42212122678756714},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3783099353313446},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.32742172479629517},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18528622388839722}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6565537452697754},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6186206936836243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4768320620059967},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4462616443634033},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42212122678756714},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3783099353313446},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32742172479629517},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18528622388839722}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011786","descriptor_name":"Quality Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-020-3399-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3399-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3399-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32054449","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32054449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:224e77a8713640abb35ef3231a474838","is_oa":true,"landing_page_url":"https://doaj.org/article/224e77a8713640abb35ef3231a474838","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-10 (2020)","raw_type":"article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1407445","is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/1407445","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7020508","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7020508","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-3399-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-3399-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-3399-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1891857452","display_name":null,"funder_award_id":"P30 CA056036","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G286283496","display_name":null,"funder_award_id":"P30 CA056036-23","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5016707533","display_name":null,"funder_award_id":"P30 CA056036","funder_id":"https://openalex.org/F4320310581","funder_display_name":"Thomas Jefferson University"},{"id":"https://openalex.org/G7066338595","display_name":null,"funder_award_id":"CA056036","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7128595184","display_name":null,"funder_award_id":"P30 CA056036","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310581","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3006194839.pdf","grobid_xml":"https://content.openalex.org/works/W3006194839.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1968458420","https://openalex.org/W1999574084","https://openalex.org/W2020966397","https://openalex.org/W2072602203","https://openalex.org/W2107208863","https://openalex.org/W2120076861","https://openalex.org/W2121180999","https://openalex.org/W2127274965","https://openalex.org/W2134526812","https://openalex.org/W2137586531","https://openalex.org/W2138207763","https://openalex.org/W2160443244","https://openalex.org/W2168342464","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2259938310","https://openalex.org/W2323326409","https://openalex.org/W2429031812","https://openalex.org/W2592811885","https://openalex.org/W2901783195","https://openalex.org/W4212903522"],"related_works":["https://openalex.org/W2147993839","https://openalex.org/W1840103016","https://openalex.org/W54859794","https://openalex.org/W106077234","https://openalex.org/W2041374557","https://openalex.org/W2081929287","https://openalex.org/W2132561013","https://openalex.org/W2144348650","https://openalex.org/W1994852842","https://openalex.org/W4246178523"],"abstract_inverted_index":{"BACKGROUND:":[0],"Quality":[1],"Control":[2],"in":[3],"any":[4],"high-throughput":[5],"sequencing":[6,32],"technology":[7],"is":[8,116],"a":[9,70,117],"critical":[10],"step,":[11],"which":[12],"if":[13],"overlooked":[14],"can":[15,93,107],"compromise":[16],"an":[17,51],"experiment":[18],"and":[19,84],"the":[20],"resulting":[21],"conclusions.":[22],"A":[23,103],"number":[24],"of":[25],"methods":[26],"exist":[27,39],"to":[28,40,44,61,67,87],"identify":[29],"biases":[30,42],"during":[31],"or":[33,65,100],"alignment,":[34],"yet":[35],"not":[36],"many":[37],"tools":[38],"interpret":[41],"due":[43,60,66],"outliers.":[45,91],"RESULTS:":[46],"Hence,":[47],"we":[48],"developed":[49],"iSeqQC,":[50],"expression-based":[52,120],"QC":[53,121],"tool":[54,122],"that":[55,123],"detects":[56,124],"outliers":[57,125],"either":[58],"produced":[59],"variable":[62],"laboratory":[63],"conditions":[64],"dissimilarity":[68],"within":[69],"phenotypic":[71],"group.":[72],"iSeqQC":[73,115],"implements":[74],"various":[75,128],"statistical":[76,129],"approaches":[77],"including":[78],"unsupervised":[79],"clustering,":[80],"agglomerative":[81],"hierarchical":[82],"clustering":[83],"correlation":[85],"coefficients":[86],"provide":[88],"insight":[89],"into":[90],"It":[92],"be":[94,109],"utilized":[95],"through":[96],"command-line":[97],"(Github:":[98],"https://github.com/gkumar09/iSeqQC)":[99],"web-interface":[101],"(http://cancerwebpa.jefferson.edu/iSeqQC).":[102],"local":[104],"shiny":[105],"installation":[106],"also":[108],"obtained":[110],"from":[111],"github":[112],"(https://github.com/gkumar09/iSeqQC).":[113],"CONCLUSION:":[114],"fast,":[118],"light-weight,":[119],"by":[126],"implementing":[127],"approaches.":[130]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}