{"id":"https://openalex.org/W3120693614","doi":"https://doi.org/10.1186/s12859-020-03947-y","title":"Predicting chemosensitivity using drug perturbed gene dynamics","display_name":"Predicting chemosensitivity using drug perturbed gene dynamics","publication_year":2021,"publication_date":"2021-01-07","ids":{"openalex":"https://openalex.org/W3120693614","doi":"https://doi.org/10.1186/s12859-020-03947-y","mag":"3120693614","pmid":"https://pubmed.ncbi.nlm.nih.gov/33413081"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03947-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03947-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03947-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03947-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090290234","display_name":"Joshua Mannheimer","orcid":"https://orcid.org/0009-0006-0527-1805"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua D. Mannheimer","raw_affiliation_strings":["Flint Animal Cancer Center, Colorado State University, Fort Collins, CO, USA","School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Flint Animal Cancer Center, Colorado State University, Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027796280","display_name":"Ashok Prasad","orcid":"https://orcid.org/0000-0002-0832-8153"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashok Prasad","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, USA","School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072152051","display_name":"Daniel L. Gustafson","orcid":"https://orcid.org/0000-0002-3063-1669"},"institutions":[{"id":"https://openalex.org/I4210134151","display_name":"University of Colorado Cancer Center","ror":"https://ror.org/04cqn7d42","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134151"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]},{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L. Gustafson","raw_affiliation_strings":["Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA. daniel.gustafson@colostate.edu","Flint Animal Cancer Center, Colorado State University, Fort Collins, CO, USA. daniel.gustafson@colostate.edu","School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA. daniel.gustafson@colostate.edu","University of Colorado, Cancer Center Developmental Therapeutics Program, University of Colorado, Aurora, CO, USA. daniel.gustafson@colostate.edu","School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA"],"raw_orcid":"https://orcid.org/0000-0002-3063-1669","affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA. daniel.gustafson@colostate.edu","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Flint Animal Cancer Center, Colorado State University, Fort Collins, CO, USA. daniel.gustafson@colostate.edu","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA. daniel.gustafson@colostate.edu","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"University of Colorado, Cancer Center Developmental Therapeutics Program, University of Colorado, Aurora, CO, USA. daniel.gustafson@colostate.edu","institution_ids":["https://openalex.org/I921990950","https://openalex.org/I51713134","https://openalex.org/I4210134151"]},{"raw_affiliation_string":"School of Biomedical Engineering, Colorado State University, Fort Collins, CO, USA","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090290234"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.1629,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.47272284,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"22","issue":"1","first_page":"15","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.3862000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.3862000107765198,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.3765000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.06120000034570694,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.6456498503684998},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5938370227813721},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5411542654037476},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5309953689575195},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.5128243565559387},{"id":"https://openalex.org/keywords/workbench","display_name":"Workbench","score":0.47133469581604004},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.448722779750824},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4304730296134949},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4273967146873474},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.413699209690094},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.40529289841651917},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.335265189409256},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.2242068648338318},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1902233064174652},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.16321346163749695}],"concepts":[{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6456498503684998},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5938370227813721},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5411542654037476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5309953689575195},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5128243565559387},{"id":"https://openalex.org/C2779145975","wikidata":"https://www.wikidata.org/wiki/Q347690","display_name":"Workbench","level":3,"score":0.47133469581604004},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.448722779750824},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4304730296134949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4273967146873474},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.413699209690094},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40529289841651917},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.335265189409256},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2242068648338318},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1902233064174652},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.16321346163749695},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-020-03947-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03947-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03947-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33413081","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33413081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:54890129fb254292ba7c8445d19cea28","is_oa":true,"landing_page_url":"https://doaj.org/article/54890129fb254292ba7c8445d19cea28","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-18 (2021)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:6700756","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7789515","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7789515","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7789515","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03947-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03947-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03947-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6299999952316284,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3120693614.pdf","grobid_xml":"https://content.openalex.org/works/W3120693614.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1438237719","https://openalex.org/W1495061682","https://openalex.org/W1509557815","https://openalex.org/W1962994287","https://openalex.org/W1963836361","https://openalex.org/W1977838702","https://openalex.org/W1981788436","https://openalex.org/W1984345669","https://openalex.org/W1985046246","https://openalex.org/W1994295468","https://openalex.org/W1995434120","https://openalex.org/W1995560258","https://openalex.org/W2013558607","https://openalex.org/W2018843280","https://openalex.org/W2022572692","https://openalex.org/W2028068087","https://openalex.org/W2032421282","https://openalex.org/W2033591223","https://openalex.org/W2033919910","https://openalex.org/W2042619042","https://openalex.org/W2043398720","https://openalex.org/W2060427373","https://openalex.org/W2070786367","https://openalex.org/W2072059383","https://openalex.org/W2087046369","https://openalex.org/W2090097708","https://openalex.org/W2091226837","https://openalex.org/W2091814024","https://openalex.org/W2099939399","https://openalex.org/W2100347702","https://openalex.org/W2101234009","https://openalex.org/W2104989233","https://openalex.org/W2108068107","https://openalex.org/W2108933868","https://openalex.org/W2113878188","https://openalex.org/W2121604817","https://openalex.org/W2122101258","https://openalex.org/W2123287557","https://openalex.org/W2123312554","https://openalex.org/W2125789330","https://openalex.org/W2132022337","https://openalex.org/W2139585684","https://openalex.org/W2141831880","https://openalex.org/W2146384083","https://openalex.org/W2146512944","https://openalex.org/W2152184637","https://openalex.org/W2169302611","https://openalex.org/W2179429273","https://openalex.org/W2195605072","https://openalex.org/W2230843763","https://openalex.org/W2253854431","https://openalex.org/W2343453515","https://openalex.org/W2386915284","https://openalex.org/W2481111253","https://openalex.org/W2530014580","https://openalex.org/W2612467560","https://openalex.org/W2770594202","https://openalex.org/W2794644212","https://openalex.org/W2802321540","https://openalex.org/W2898097650","https://openalex.org/W2912993305","https://openalex.org/W2947148284","https://openalex.org/W2950148487","https://openalex.org/W2973039076","https://openalex.org/W6661314986","https://openalex.org/W6675354045","https://openalex.org/W6676990869"],"related_works":["https://openalex.org/W2069695727","https://openalex.org/W1996185163","https://openalex.org/W2084813257","https://openalex.org/W2045929470","https://openalex.org/W2081127504","https://openalex.org/W2122223946","https://openalex.org/W4233500668","https://openalex.org/W1974145978","https://openalex.org/W1977867163","https://openalex.org/W2393426762"],"abstract_inverted_index":{"BACKGROUND:":[0],"One":[1],"of":[2,6,12,23,42,83,92,104,124,129,177,183,202,266,280],"the":[3,10,18,76,81,102,112,122,130,148,186,193,214,247],"current":[4],"directions":[5],"precision":[7],"medicine":[8],"is":[9,225],"use":[11],"computational":[13,136,320],"methods":[14,321],"to":[15,60,74,100,138,179,192,239,263,287,322],"aid":[16,79],"in":[17,32,64,65,80,135,140,171,234,302,303,317],"diagnosis,":[19],"prognosis,":[20],"and":[21,44,52,78,259],"treatment":[22],"disease":[24,326],"based":[25],"on":[26,40,147,252],"data":[27],"driven":[28],"approaches.":[29],"For":[30],"instance,":[31],"oncology,":[33],"there":[34],"has":[35],"been":[36,72,96],"a":[37,90,180],"particular":[38,56],"focus":[39],"development":[41,82],"algorithms":[43],"biomarkers":[45,110],"that":[46,164,168,246,274],"can":[47,260],"be":[48,261,285,315],"used":[49,73,262,316],"for":[50,98,144,207],"pre-clinical":[51],"clinical":[53,87],"applications.":[54],"In":[55,117],"large-scale":[57],"omics-based":[58],"models":[59,85,137,162,190,272],"predict":[61,139,288],"drug":[62,105,125,142,184,281,289,297,325],"sensitivity":[63,143],"vitro":[66,141,304],"cancer":[67,267],"cell":[68,150,305],"line":[69,151],"panels":[70],"have":[71,95],"explore":[75,101,121],"utility":[77],"these":[84,253],"as":[86,109],"tools.":[88],"Additionally,":[89],"number":[91],"web-based":[93],"interfaces":[94],"constructed":[97],"researchers":[99],"potential":[103],"perturbed":[106,126,275,298],"gene":[107,127,165,172,209,215,220,229,235,241,248,276,293,299],"expression":[108,166,173,194,210,221,236,300],"including":[111],"NCI":[113,131],"Transcriptional":[114,132],"Pharmacodynamic":[115],"Workbench.":[116],"this":[118],"paper":[119],"we":[120,244],"influence":[123],"dynamics":[128],"Pharmacodynamics":[133],"Workbench":[134],"15":[145],"drugs":[146],"NCI60":[149],"panel.":[152],"RESULTS:":[153],"This":[154],"work":[155],"presents":[156],"three":[157],"main":[158],"findings.":[159],"First,":[160],"our":[161],"show":[163,245,255],"profiles":[167,195,222],"capture":[169],"changes":[170,233],"after":[174],"24":[175],"h":[176],"exposure":[178],"high":[181],"concentration":[182],"generates":[185],"most":[187],"accurate":[188],"predictive":[189,279,310],"compared":[191],"under":[196],"different":[197,208,256],"dosing":[198],"conditions.":[199],"Second,":[200],"signatures":[201,216,230,254,277],"100":[203],"genes":[204],"are":[205,217,237,278],"developed":[206,231,251],"profiles;":[211],"furthermore,":[212],"when":[213,228],"applied":[218,238,286],"across":[219],"model":[223],"performance":[224],"substantially":[226],"decreased":[227],"using":[232,291],"non-drugged":[240],"expression.":[242,294],"Lastly,":[243],"interaction":[249],"networks":[250],"network":[257],"topologies":[258],"inform":[264],"selection":[265],"relevant":[268],"genes.":[269],"CONCLUSION:":[270],"Our":[271],"suggest":[273],"response,":[282],"but":[283],"cannot":[284],"response":[290],"unperturbed":[292],"Furthermore,":[295],"additional":[296],"measurements":[301],"lines":[306],"could":[307],"generate":[308],"more":[309,313],"models;":[311],"but,":[312],"importantly":[314],"conjunction":[318],"with":[319],"discover":[323],"important":[324],"relationships.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
