{"id":"https://openalex.org/W3120798591","doi":"https://doi.org/10.1186/s12859-020-03929-0","title":"Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach","display_name":"Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach","publication_year":2021,"publication_date":"2021-01-12","ids":{"openalex":"https://openalex.org/W3120798591","doi":"https://doi.org/10.1186/s12859-020-03929-0","mag":"3120798591","pmid":"https://pubmed.ncbi.nlm.nih.gov/33435872"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03929-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03929-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03929-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03929-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072618907","display_name":"Mike Fang","orcid":"https://orcid.org/0000-0002-8318-1016"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210153792","display_name":"University School","ror":"https://ror.org/05ap66461","country_code":"US","type":"education","lineage":["https://openalex.org/I4210153792"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Fang","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Suite 1-314, Cleveland, OH, 44106-7295, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Suite 1-314, Cleveland, OH, 44106-7295, USA","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I4210153792","https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004846233","display_name":"Brian Richardson","orcid":"https://orcid.org/0000-0002-7332-9152"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210153792","display_name":"University School","ror":"https://ror.org/05ap66461","country_code":"US","type":"education","lineage":["https://openalex.org/I4210153792"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Richardson","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Suite 1-314, Cleveland, OH, 44106-7295, USA","Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Suite 1-314, Cleveland, OH, 44106-7295, USA","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I4210153792","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043554351","display_name":"Cheryl Cameron","orcid":"https://orcid.org/0000-0002-0574-3781"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl M. Cameron","raw_affiliation_strings":["Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA","Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006017973","display_name":"Jean\u2010Eudes Dazard","orcid":"https://orcid.org/0000-0003-4720-3684"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jean-Eudes Dazard","raw_affiliation_strings":["Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, USA. jxd101@case.edu","Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA. jxd101@case.edu","Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, USA. jxd101@case.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA. jxd101@case.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066809761","display_name":"Mark J. Cameron","orcid":"https://orcid.org/0000-0003-4768-4094"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Cameron","raw_affiliation_strings":["Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Suite 1-314, Cleveland, OH, 44106-7295, USA. mark.cameron@case.edu","Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA. mark.cameron@case.edu","Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":"https://orcid.org/0000-0003-4768-4094","affiliations":[{"raw_affiliation_string":"Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Suite 1-314, Cleveland, OH, 44106-7295, USA. mark.cameron@case.edu","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA. mark.cameron@case.edu","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Systems Biology and Bioinformatics Program, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5006017973"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.9772,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.73695344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"1","first_page":"22","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7296000123023987,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7296000123023987,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.1354999989271164,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6800615787506104},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6708681583404541},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6287041902542114},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5392218232154846},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.530913233757019},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.41888678073883057},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33956387639045715},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3129616975784302},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2898227572441101},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2825919985771179}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6800615787506104},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6708681583404541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6287041902542114},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5392218232154846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.530913233757019},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.41888678073883057},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33956387639045715},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3129616975784302},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2898227572441101},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2825919985771179}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-03929-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03929-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03929-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33435872","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33435872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:42800fa051264c41a3470bdcf2477a85","is_oa":true,"landing_page_url":"https://doaj.org/article/42800fa051264c41a3470bdcf2477a85","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7805197","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7805197","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03929-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03929-0","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03929-0","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[{"id":"https://openalex.org/G8735862058","display_name":null,"funder_award_id":"P30AI036219","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8990350945","display_name":null,"funder_award_id":"T32HL007567","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G909854940","display_name":null,"funder_award_id":"P50AR070590","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310281","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3120798591.pdf","grobid_xml":"https://content.openalex.org/works/W3120798591.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1989909503","https://openalex.org/W2030531674","https://openalex.org/W2068533231","https://openalex.org/W2099582158","https://openalex.org/W2110065044","https://openalex.org/W2112946624","https://openalex.org/W2121604817","https://openalex.org/W2123332780","https://openalex.org/W2130410032","https://openalex.org/W2133465414","https://openalex.org/W2138512826","https://openalex.org/W2142339805","https://openalex.org/W2146512944","https://openalex.org/W2155157373","https://openalex.org/W2158217645","https://openalex.org/W2159707944","https://openalex.org/W2188691228","https://openalex.org/W2234480502","https://openalex.org/W2336355791","https://openalex.org/W2489003193","https://openalex.org/W2518752834","https://openalex.org/W2528904141","https://openalex.org/W2612467560","https://openalex.org/W2612649098","https://openalex.org/W2773309042","https://openalex.org/W2806662900","https://openalex.org/W2808357284","https://openalex.org/W2891024163","https://openalex.org/W2896002881","https://openalex.org/W2896947777","https://openalex.org/W2900044275","https://openalex.org/W2915213334","https://openalex.org/W2952794296"],"related_works":["https://openalex.org/W2073305407","https://openalex.org/W2052655934","https://openalex.org/W104645380","https://openalex.org/W2027213253","https://openalex.org/W2017047508","https://openalex.org/W2165201120","https://openalex.org/W2023641020","https://openalex.org/W2188530857","https://openalex.org/W2133040682","https://openalex.org/W1971081588"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,70],"this":[2],"study,":[3],"we":[4,74],"demonstrate":[5],"that":[6,30,76,132],"our":[7,41],"modified":[8],"Gene":[9],"Set":[10],"Enrichment":[11],"Analysis":[12],"(GSEA)":[13],"method,":[14],"drug":[15,23,71,84,156],"perturbation":[16,51,64],"GSEA":[17],"(dpGSEA),":[18],"can":[19],"detect":[20,81],"phenotypically":[21,82],"relevant":[22,83],"targets":[24,85],"through":[25],"a":[26],"unique":[27],"transcriptomic":[28],"enrichment":[29],"emphasizes":[31],"biological":[32],"directionality":[33,141],"of":[34,52,92,142],"drug-derived":[35],"gene":[36,137,143],"sets.":[37],"RESULTS:":[38],"We":[39,145],"detail":[40],"dpGSEA":[42,77,120,128,147],"method":[43],"and":[44,62,99,117],"show":[45],"its":[46],"effectiveness":[47],"in":[48,54,65,86,104],"detecting":[49],"specific":[50],"drugs":[53],"independent":[55],"public":[56],"datasets":[57],"by":[58],"confirming":[59],"fluvastatin,":[60],"paclitaxel,":[61],"rosiglitazone":[63],"gastroenteropancreatic":[66],"neuroendocrine":[67],"tumor":[68],"cells.":[69],"discovery":[72],"experiments,":[73],"found":[75],"was":[78],"able":[79],"to":[80,101,152],"previously":[87],"published":[88],"differentially":[89],"expressed":[90],"genes":[91],"CD4+T":[93],"regulatory":[94],"cells":[95],"from":[96],"immune":[97],"responders":[98],"non-responders":[100],"antiviral":[102],"therapy":[103],"HIV-infected":[105],"individuals,":[106],"such":[107],"as":[108,148],"those":[109],"involved":[110],"with":[111],"virion":[112],"replication,":[113],"cell":[114],"cycle":[115],"dysfunction,":[116],"mitochondrial":[118],"dysfunction.":[119],"is":[121,129],"publicly":[122],"available":[123],"at":[124],"https://github.com/sxf296/drug_targeting":[125],".":[126],"CONCLUSIONS:":[127],"an":[130,149],"approach":[131],"uniquely":[133],"enriches":[134],"on":[135],"drug-defined":[136],"sets":[138],"while":[139],"considering":[140],"modulation.":[144],"recommend":[146],"exploratory":[150],"tool":[151],"screen":[153],"for":[154],"possible":[155],"targeting":[157],"molecules.":[158]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}