{"id":"https://openalex.org/W2996493131","doi":"https://doi.org/10.1186/s12859-020-03897-5","title":"Toward computational modelling on immune system function","display_name":"Toward computational modelling on immune system function","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W2996493131","doi":"https://doi.org/10.1186/s12859-020-03897-5","mag":"2996493131","pmid":"https://pubmed.ncbi.nlm.nih.gov/33308137"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03897-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03897-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03897-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03897-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044340074","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0003-1668-3320"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125, Catania, Italy. francesco.pappalardo@unict.it","Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125, Catania, Italy. francesco.pappalardo@unict.it","institution_ids":["https://openalex.org/I39063666"]},{"raw_affiliation_string":"Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004880055","display_name":"Giulia Russo","orcid":"https://orcid.org/0000-0001-6616-7856"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Russo","raw_affiliation_strings":["Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug and Health Sciences, University of Catania, V.le A. Doria 6, 95125, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051034667","display_name":"Pedro A. Reche","orcid":"https://orcid.org/0000-0003-3966-5838"},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pedro A. Reche","raw_affiliation_strings":["Departamento de Immunolog\u00eda (Microbiolog\u00eda I), Universidad Complutense de Madrid, Facultad de Medicina, Plaza Ram\u00f3n y Cajal, 28040, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Immunolog\u00eda (Microbiolog\u00eda I), Universidad Complutense de Madrid, Facultad de Medicina, Plaza Ram\u00f3n y Cajal, 28040, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.5915,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67706472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"21","issue":"S17","first_page":"546","last_page":"546"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9728000164031982,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomedicine","display_name":"Biomedicine","score":0.8035359978675842},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6387714743614197},{"id":"https://openalex.org/keywords/presentation","display_name":"Presentation (obstetrics)","score":0.58579021692276},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5696471333503723},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.47503215074539185},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.47311684489250183},{"id":"https://openalex.org/keywords/artificial-immune-system","display_name":"Artificial immune system","score":0.46768027544021606},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.405293345451355},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37400397658348083},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36813968420028687},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.275165855884552},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20174163579940796}],"concepts":[{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.8035359978675842},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6387714743614197},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.58579021692276},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5696471333503723},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.47503215074539185},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.47311684489250183},{"id":"https://openalex.org/C93768804","wikidata":"https://www.wikidata.org/wiki/Q2518735","display_name":"Artificial immune system","level":2,"score":0.46768027544021606},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.405293345451355},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37400397658348083},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36813968420028687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.275165855884552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20174163579940796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003226","descriptor_name":"Congresses as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003226","descriptor_name":"Congresses as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003226","descriptor_name":"Congresses as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003226","descriptor_name":"Congresses as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-03897-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03897-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03897-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33308137","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33308137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a1f5c5ff73f84ae68fdb2970f37a8ebf","is_oa":true,"landing_page_url":"https://doaj.org/article/a1f5c5ff73f84ae68fdb2970f37a8ebf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss S17, Pp 1-5 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7733695","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7733695","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03897-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03897-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03897-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322690","display_name":"Universit\u00e0 di Catania","ror":"https://ror.org/03a64bh57"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2996493131.pdf","grobid_xml":"https://content.openalex.org/works/W2996493131.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2994705677","https://openalex.org/W2994890869","https://openalex.org/W2995168129","https://openalex.org/W2995326322","https://openalex.org/W2995858307","https://openalex.org/W2996092916","https://openalex.org/W2996284486","https://openalex.org/W2996373685","https://openalex.org/W3110699319","https://openalex.org/W3111610496","https://openalex.org/W3111667594","https://openalex.org/W3112135657","https://openalex.org/W3112174179","https://openalex.org/W3112837331","https://openalex.org/W3112990679","https://openalex.org/W3113072416","https://openalex.org/W3113138910"],"related_works":["https://openalex.org/W2017899917","https://openalex.org/W2080571363","https://openalex.org/W2481322495","https://openalex.org/W2912862995","https://openalex.org/W2898682754","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2889841093","https://openalex.org/W2151082141","https://openalex.org/W2365236913"],"abstract_inverted_index":{"The":[0,39,79],"3rd":[1],"edition":[2],"of":[3,49,86,93,105,109],"the":[4,8,23,64,91],"computational":[5],"methods":[6],"for":[7,73],"immune":[9],"system":[10],"function":[11],"workshop":[12,40],"has":[13,41],"been":[14,55,69],"held":[15],"in":[16,20,57,75],"San":[17],"Diego,":[18],"CA,":[19],"conjunction":[21],"with":[22,46],"IEEE":[24],"International":[25],"Conference":[26],"on":[27],"Bioinformatics":[28],"and":[29,71,107],"Biomedicine":[30],"(BIBM":[31],"2019)":[32],"from":[33,83,101],"November":[34],"18":[35,50],"to":[36,90,97,112,116],"21,":[37],"2019.":[38],"continued":[42],"its":[43],"growing":[44],"tendency,":[45],"a":[47,58],"total":[48],"accepted":[51],"papers":[52,67],"that":[53],"have":[54,68],"presented":[56],"full":[59],"day":[60],"workshop.":[61],"Among":[62],"these,":[63],"best":[65],"10":[66],"selected":[70],"extended":[72],"presentation":[74],"this":[76],"special":[77],"issue.":[78],"covered":[80],"topics":[81],"range":[82],"computer-aided":[84],"identification":[85],"T":[87],"cell":[88],"epitopes":[89],"prediction":[92],"heart":[94],"rate":[95],"variability":[96],"prevent":[98],"brain":[99],"injuries,":[100],"In":[102],"Silico":[103],"modeling":[104],"Tuberculosis":[106],"generation":[108],"digital":[110],"patients":[111],"machine":[113],"learning":[114],"applied":[115],"predict":[117],"type-2":[118],"diabetes":[119],"risk.":[120]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}