{"id":"https://openalex.org/W3164288609","doi":"https://doi.org/10.1186/s12859-020-03882-y","title":"In silico drug repositioning using deep learning and comprehensive similarity measures","display_name":"In silico drug repositioning using deep learning and comprehensive similarity measures","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3164288609","doi":"https://doi.org/10.1186/s12859-020-03882-y","mag":"3164288609","pmid":"https://pubmed.ncbi.nlm.nih.gov/34074242"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03882-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03882-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03882-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03882-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102010573","display_name":"Hai-Cheng Yi","orcid":"https://orcid.org/0000-0001-8339-396X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Cheng Yi","raw_affiliation_strings":["The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","University of Chinese Academy of Sciences, Beijing, 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019805735","display_name":"Zhu\u2010Hong You","orcid":"https://orcid.org/0000-0003-1266-2696"},"institutions":[{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhu-Hong You","raw_affiliation_strings":["The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China. zhuhongyou@ms.xjb.ac.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China. zhuhongyou@ms.xjb.ac.cn","institution_ids":["https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436059","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0003-0184-307X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045680312","display_name":"Xiaorui Su","orcid":"https://orcid.org/0000-0001-5468-6085"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Rui Su","raw_affiliation_strings":["The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","University of Chinese Academy of Sciences, Beijing, 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100602869","display_name":"Xi Zhou","orcid":"https://orcid.org/0000-0002-3846-5079"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Zhou","raw_affiliation_strings":["The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]},{"author_position":"last","author":{"id":null,"display_name":"Tong-Hai Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong-Hai Jiang","raw_affiliation_strings":["The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019805735"],"corresponding_institution_ids":["https://openalex.org/I4210106108"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.8462,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.86985982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"22","issue":"S3","first_page":"293","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9431999921798706,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9431999921798706,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8443043828010559},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.8004271984100342},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5764546394348145},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5254841446876526},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5148367285728455},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5010066032409668},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4495767056941986},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4236096143722534},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37878960371017456},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3589639961719513},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2585661709308624},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.1720958948135376},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10119268298149109},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.0899403989315033}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8443043828010559},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.8004271984100342},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5764546394348145},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5254841446876526},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5148367285728455},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5010066032409668},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4495767056941986},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4236096143722534},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37878960371017456},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3589639961719513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2585661709308624},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1720958948135376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10119268298149109},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0899403989315033},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-03882-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03882-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03882-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34074242","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34074242","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a5ae63f7628d466399b44667a1a35676","is_oa":true,"landing_page_url":"https://doaj.org/article/a5ae63f7628d466399b44667a1a35676","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss S3, Pp 1-15 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8170943","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8170943","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03882-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03882-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03882-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7599999904632568,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G5294168992","display_name":null,"funder_award_id":"61873212","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5579736629","display_name":null,"funder_award_id":"61722212","funder_id":"https://openalex.org/F4320333688","funder_display_name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China"},{"id":"https://openalex.org/G74711194","display_name":"\u57fa\u56e0\u7ec4\u975e\u7f16\u7801\u533a\u53d8\u5f02\u4e0e\u8f6c\u5f55\u56e0\u5b50\u8c03\u63a7\u5173\u7cfb\u7684\u8ba1\u7b97\u5206\u6790\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61732012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8031058355","display_name":null,"funder_award_id":"61861146002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G82793888","display_name":null,"funder_award_id":"61722212","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320333688","display_name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3164288609.pdf","grobid_xml":"https://content.openalex.org/works/W3164288609.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1522301498","https://openalex.org/W1541232310","https://openalex.org/W1791453308","https://openalex.org/W1924770834","https://openalex.org/W1975147762","https://openalex.org/W1978370150","https://openalex.org/W1984084871","https://openalex.org/W1994658365","https://openalex.org/W1998898494","https://openalex.org/W2009313526","https://openalex.org/W2031954078","https://openalex.org/W2038122249","https://openalex.org/W2062941476","https://openalex.org/W2064675550","https://openalex.org/W2082565035","https://openalex.org/W2094791588","https://openalex.org/W2096541451","https://openalex.org/W2100929382","https://openalex.org/W2106029302","https://openalex.org/W2111213181","https://openalex.org/W2113072832","https://openalex.org/W2116261113","https://openalex.org/W2119412782","https://openalex.org/W2121604817","https://openalex.org/W2136848157","https://openalex.org/W2137052779","https://openalex.org/W2143251418","https://openalex.org/W2148797284","https://openalex.org/W2155157373","https://openalex.org/W2160264790","https://openalex.org/W2171437346","https://openalex.org/W2346950316","https://openalex.org/W2607802139","https://openalex.org/W2609468276","https://openalex.org/W2729788619","https://openalex.org/W2762358889","https://openalex.org/W2782735072","https://openalex.org/W2786578820","https://openalex.org/W2790385355","https://openalex.org/W2793344725","https://openalex.org/W2795829718","https://openalex.org/W2896262061","https://openalex.org/W2943935116","https://openalex.org/W2946099214","https://openalex.org/W2963417420","https://openalex.org/W2964199361","https://openalex.org/W2986990569","https://openalex.org/W2994158303","https://openalex.org/W2996489182","https://openalex.org/W3006242222","https://openalex.org/W3006417694","https://openalex.org/W3010821291","https://openalex.org/W3011122062","https://openalex.org/W3012898475","https://openalex.org/W3034617560","https://openalex.org/W3042289107","https://openalex.org/W3140207494","https://openalex.org/W4248234957"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2003194288","https://openalex.org/W391093122","https://openalex.org/W4226161264","https://openalex.org/W3156186218"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drug":[1],"repositioning,":[2],"meanings":[3],"finding":[4],"new":[5,16,162,184,189],"uses":[6],"for":[7,32,95,160,182,186,191],"existing":[8],"drugs,":[9],"which":[10],"can":[11,194],"accelerate":[12,195],"the":[13,86,103,139,155,175],"processing":[14],"of":[15,114,138,165],"drugs":[17,40,50,96,166,187],"research":[18,201],"and":[19,41,51,79,193,198,202],"development.":[20],"Various":[21],"computational":[22],"methods":[23],"have":[24],"been":[25],"presented":[26],"to":[27,70,91,110,130,152],"predict":[28,71,131],"novel":[29],"drug-disease":[30,73,133],"associations":[31,48],"drug":[33,196,200],"repositioning":[34,197],"based":[35,97,116],"on":[36,98,117,144],"similarity":[37,77,87],"measures":[38,78],"among":[39],"diseases.":[42],"However,":[43],"there":[44],"are":[45],"some":[46],"known":[47,118],"between":[49],"diseases":[52,115],"that":[53],"previous":[54],"studies":[55,159],"not":[56],"utilized.":[57],"METHODS:":[58],"In":[59],"this":[60],"work,":[61],"we":[62],"develop":[63],"a":[64,122,179],"deep":[65,123],"gated":[66,124],"recurrent":[67,125],"units":[68,126],"model":[69,127,141,177],"potential":[72,132,163],"interactions":[74,105],"using":[75],"comprehensive":[76],"Gaussian":[80,104],"interaction":[81],"profile":[82,106],"kernel.":[83],"More":[84],"specifically,":[85],"measure":[88],"is":[89,108,128,142,178],"used":[90],"exploit":[92],"discriminative":[93],"feature":[94,113],"their":[99],"chemical":[100],"fingerprints.":[101],"Meanwhile,":[102],"kernel":[107],"employed":[109],"obtain":[111],"efficient":[112],"disease-disease":[119],"associations.":[120],"Then,":[121],"developed":[129],"interactions.":[134],"RESULTS:":[135],"The":[136,171],"performance":[137],"proposed":[140,176],"evaluated":[143],"two":[145],"benchmark":[146],"datasets":[147],"under":[148],"tenfold":[149],"cross-validation.":[150],"And":[151],"further":[153],"verify":[154],"predictive":[156],"ability,":[157],"case":[158],"predicting":[161,183],"indications":[164,185],"were":[167],"carried":[168],"out.":[169],"CONCLUSION:":[170],"experimental":[172],"results":[173],"proved":[174],"useful":[180],"tool":[181],"or":[188],"treatments":[190],"diseases,":[192],"related":[199],"discovery.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}