{"id":"https://openalex.org/W3162362563","doi":"https://doi.org/10.1186/s12859-020-03873-z","title":"Identifying cell types from single-cell data based on similarities and dissimilarities between cells","display_name":"Identifying cell types from single-cell data based on similarities and dissimilarities between cells","publication_year":2021,"publication_date":"2021-05-01","ids":{"openalex":"https://openalex.org/W3162362563","doi":"https://doi.org/10.1186/s12859-020-03873-z","mag":"3162362563","pmid":"https://pubmed.ncbi.nlm.nih.gov/34006217"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03873-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03873-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03873-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03873-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011390157","display_name":"Yuanyuan Li","orcid":"https://orcid.org/0000-0003-2981-8976"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I91125648","display_name":"Wuhan Institute of Technology","ror":"https://ror.org/04jcykh16","country_code":"CN","type":"education","lineage":["https://openalex.org/I91125648"]}],"countries":["CA","CN"],"is_corresponding":true,"raw_author_name":"Yuanyuan Li","raw_affiliation_strings":["Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada. yuanyuanli_wit@hotmail.com","School of Mathematics and Physics, Wuhan Institute of Technology, No.206, Guanggu 1st road, Wuhan, 430205, Hubei, China. yuanyuanli_wit@hotmail.com","School of Mathematics and Physics, Wuhan Institute of Technology, No.206, Guanggu 1st road, Wuhan, 430205, Hubei, China"],"raw_orcid":"https://orcid.org/0000-0003-2981-8976","affiliations":[{"raw_affiliation_string":"Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada. yuanyuanli_wit@hotmail.com","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"School of Mathematics and Physics, Wuhan Institute of Technology, No.206, Guanggu 1st road, Wuhan, 430205, Hubei, China. yuanyuanli_wit@hotmail.com","institution_ids":["https://openalex.org/I91125648"]},{"raw_affiliation_string":"School of Mathematics and Physics, Wuhan Institute of Technology, No.206, Guanggu 1st road, Wuhan, 430205, Hubei, China","institution_ids":["https://openalex.org/I91125648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064240230","display_name":"Ping Luo","orcid":"https://orcid.org/0000-0002-0039-747X"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ping Luo","raw_affiliation_strings":["Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113517453","display_name":"Yi Lu","orcid":"https://orcid.org/0000-0001-6960-461X"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yi Lu","raw_affiliation_strings":["Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091157395","display_name":"Fang\u2010Xiang Wu","orcid":"https://orcid.org/0000-0002-4593-9332"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4210118524","display_name":"Universit\u00e9 Bourgogne Franche-Comt\u00e9","ror":"https://ror.org/02dn7x778","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210118524"]}],"countries":["CA","FR"],"is_corresponding":false,"raw_author_name":"Fang-Xiang Wu","raw_affiliation_strings":["Department of Computer Science, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada","Department of Mechanical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada","Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721","https://openalex.org/I4210118524"]},{"raw_affiliation_string":"Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada","institution_ids":["https://openalex.org/I32625721"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011390157"],"corresponding_institution_ids":["https://openalex.org/I32625721","https://openalex.org/I91125648"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.7402,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.67768109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"22","issue":"S3","first_page":"255","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.8474341630935669},{"id":"https://openalex.org/keywords/spectral-clustering","display_name":"Spectral clustering","score":0.6702835559844971},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.5045000314712524},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4915946424007416},{"id":"https://openalex.org/keywords/categorical-variable","display_name":"Categorical variable","score":0.49003350734710693},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4799244999885559},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.4653756320476532},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4480743706226349},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4344113767147064},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.42428481578826904},{"id":"https://openalex.org/keywords/clustering-high-dimensional-data","display_name":"Clustering high-dimensional data","score":0.4240576922893524},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4108458459377289},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38466495275497437},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3717159926891327},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2502872049808502},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.2065812647342682},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13497349619865417},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.12605202198028564}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.8474341630935669},{"id":"https://openalex.org/C105611402","wikidata":"https://www.wikidata.org/wiki/Q2976589","display_name":"Spectral clustering","level":3,"score":0.6702835559844971},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.5045000314712524},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4915946424007416},{"id":"https://openalex.org/C5274069","wikidata":"https://www.wikidata.org/wiki/Q2285707","display_name":"Categorical variable","level":2,"score":0.49003350734710693},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4799244999885559},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.4653756320476532},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4480743706226349},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4344113767147064},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.42428481578826904},{"id":"https://openalex.org/C184509293","wikidata":"https://www.wikidata.org/wiki/Q5136711","display_name":"Clustering high-dimensional data","level":3,"score":0.4240576922893524},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4108458459377289},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38466495275497437},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3717159926891327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2502872049808502},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2065812647342682},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13497349619865417},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.12605202198028564},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-03873-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03873-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03873-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34006217","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34006217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:9f3cc77e833d472fa005e629a606053d","is_oa":true,"landing_page_url":"https://doaj.org/article/9f3cc77e833d472fa005e629a606053d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 22, Iss S3, Pp 1-18 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8132444","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8132444","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03873-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03873-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03873-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1798451720","display_name":null,"funder_award_id":"61571052","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G1853601733","display_name":null,"funder_award_id":"61571052","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G2049576116","display_name":null,"funder_award_id":"12001408","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2135331430","display_name":null,"funder_award_id":"K201746","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3518167352","display_name":null,"funder_award_id":"12001408","funder_id":"https://openalex.org/F4320325438","funder_display_name":"Wuhan Institute of Technology"},{"id":"https://openalex.org/G8364498477","display_name":null,"funder_award_id":"K201746","funder_id":"https://openalex.org/F4320325438","funder_display_name":"Wuhan Institute of Technology"},{"id":"https://openalex.org/G8656286507","display_name":null,"funder_award_id":"61571052","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320325438","display_name":"Wuhan Institute of Technology","ror":"https://ror.org/04jcykh16"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3162362563.pdf","grobid_xml":"https://content.openalex.org/works/W3162362563.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1977556410","https://openalex.org/W1990523483","https://openalex.org/W1996146483","https://openalex.org/W1998871699","https://openalex.org/W2010653277","https://openalex.org/W2023781725","https://openalex.org/W2033072655","https://openalex.org/W2051658465","https://openalex.org/W2089468765","https://openalex.org/W2109890799","https://openalex.org/W2111435630","https://openalex.org/W2111882541","https://openalex.org/W2132914434","https://openalex.org/W2160443244","https://openalex.org/W2279323413","https://openalex.org/W2338756998","https://openalex.org/W2510746232","https://openalex.org/W2522945402","https://openalex.org/W2598326928","https://openalex.org/W2610509384","https://openalex.org/W2741564801","https://openalex.org/W2767431383","https://openalex.org/W2789949350","https://openalex.org/W2796325895","https://openalex.org/W2804460316","https://openalex.org/W2907783748","https://openalex.org/W2911725280","https://openalex.org/W2918882492","https://openalex.org/W2953251392","https://openalex.org/W4285719527","https://openalex.org/W6644682428"],"related_works":["https://openalex.org/W3162910294","https://openalex.org/W2196560602","https://openalex.org/W1974303229","https://openalex.org/W2962997812","https://openalex.org/W783379390","https://openalex.org/W1692134900","https://openalex.org/W1989705029","https://openalex.org/W2126442420","https://openalex.org/W4295246512","https://openalex.org/W2187596245"],"abstract_inverted_index":{"BACKGROUND:":[0],"With":[1],"the":[2,5,27,36,45,65,83,91,97,108,113,118,136,159,182,188,201,204,213,217,233,271],"development":[3],"of":[4,7,21,29,42,47,52,67,85,99,110,112,120,150,203],"technology":[6],"single-cell":[8,166,245],"sequence,":[9],"revealing":[10],"homogeneity":[11],"and":[12,44,95,174,211,261,264],"heterogeneity":[13],"between":[14,39,93,176],"cells":[15,43,62,94,141,151],"has":[16],"become":[17],"a":[18],"new":[19],"area":[20],"computational":[22],"systems":[23],"biology":[24],"research.":[25],"However,":[26],"clustering":[28,69,78,102,115,162,165,228,236,268,274],"cell":[30,86,240],"types":[31,41,149,241],"becomes":[32],"more":[33],"complex":[34],"with":[35,195,232],"mutual":[37],"penetration":[38],"different":[40,148],"instability":[46],"gene":[48,144,154],"expression.":[49],"One":[50],"way":[51],"overcoming":[53],"this":[54],"problem":[55],"is":[56,169,230],"to":[57,124,207,221],"group":[58],"similar,":[59],"related":[60],"single":[61],"together":[63],"by":[64,135,191],"means":[66],"various":[68],"analysis":[70],"methods.":[71],"Although":[72],"some":[73],"methods":[74,127],"such":[75],"as":[76],"spectral":[77,161,227,235,267,273],"can":[79,257],"do":[80],"well":[81],"in":[82,216,238,276],"identification":[84,119],"types,":[87],"they":[88],"only":[89],"consider":[90],"similarities":[92,173],"ignore":[96],"influence":[98],"dissimilarities":[100,175],"on":[101,171,242],"results.":[103],"This":[104],"methodology":[105],"may":[106],"limit":[107],"performance":[109],"most":[111],"conventional":[114,234],"algorithms":[116],"for":[117,128,164],"clusters,":[121],"it":[122],"needs":[123],"develop":[125],"special":[126],"high-dimensional":[129],"sparse":[130],"categorical":[131],"data.":[132],"RESULTS:":[133],"Inspired":[134],"phenomenon":[137],"that":[138,168,253,265],"same":[139],"type":[140],"have":[142],"similar":[143],"expression":[145,155],"patterns,":[146,156],"but":[147],"evoke":[152],"dissimilar":[153],"we":[157,251],"improve":[158,259],"existing":[160],"method":[163,179,229,237,269,275],"data":[167],"based":[170],"both":[172],"cells.":[177,278],"The":[178,224],"first":[180],"measures":[181],"similarity/dissimilarity":[183],"among":[184],"cells,":[185],"then":[186],"constructs":[187],"incidence":[189,205],"matrix":[190,194,206],"fusing":[192],"similarity":[193],"dissimilarity":[196,256],"matrix,":[197],"and,":[198],"finally,":[199],"uses":[200],"eigenvalues":[202],"perform":[208],"dimensionality":[209],"reduction":[210],"employs":[212],"K-means":[214],"algorithm":[215],"low":[218],"dimensional":[219],"space":[220],"achieve":[222,262],"clustering.":[223],"proposed":[225],"improved":[226,266],"compared":[231],"recognizing":[239],"several":[243],"real":[244],"RNA-seq":[246],"datasets.":[247],"CONCLUSIONS:":[248],"In":[249],"summary,":[250],"show":[252],"adding":[254],"intercellular":[255],"effectively":[258],"accuracy":[260],"robustness":[263],"outperforms":[270],"traditional":[272],"grouping":[277]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}