{"id":"https://openalex.org/W3106710884","doi":"https://doi.org/10.1186/s12859-020-03824-8","title":"Identification of novel alternative splicing biomarkers for breast cancer with LC/MS/MS and RNA-Seq","display_name":"Identification of novel alternative splicing biomarkers for breast cancer with LC/MS/MS and RNA-Seq","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W3106710884","doi":"https://doi.org/10.1186/s12859-020-03824-8","mag":"3106710884","pmid":"https://pubmed.ncbi.nlm.nih.gov/33272210"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03824-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03824-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03824-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03824-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100403574","display_name":"Fan Zhang","orcid":"https://orcid.org/0000-0003-3502-1808"},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]},{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]},{"id":"https://openalex.org/I4210088533","display_name":"Vermont Oxford Network","ror":"https://ror.org/003gt3k37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210088533"]},{"id":"https://openalex.org/I4210156829","display_name":"Research Network (United States)","ror":"https://ror.org/04tgjxk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210156829"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["Institute for Translational Research and Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA. fan.zhang@uvm.edu","Vermont Biomedical Research Network and Department of Biology, University of Vermont, Burlington, VT, 05405, USA. fan.zhang@uvm.edu","Vermont Biomedical Research Network and Department of Biology, University of Vermont, Burlington, VT, 05405, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Translational Research and Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA. fan.zhang@uvm.edu","institution_ids":["https://openalex.org/I123534392","https://openalex.org/I165139151"]},{"raw_affiliation_string":"Vermont Biomedical Research Network and Department of Biology, University of Vermont, Burlington, VT, 05405, USA. fan.zhang@uvm.edu","institution_ids":["https://openalex.org/I111236770","https://openalex.org/I4210088533"]},{"raw_affiliation_string":"Vermont Biomedical Research Network and Department of Biology, University of Vermont, Burlington, VT, 05405, USA","institution_ids":["https://openalex.org/I4210088533","https://openalex.org/I4210156829","https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032416125","display_name":"Chris K. Deng","orcid":null},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris K. Deng","raw_affiliation_strings":["School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Champaign, IL, 61801, USA","School of Molecular and Cellular Biology, University of Illinois at Urbana\u2013Champaign, Champaign, IL, 61801, USA"],"affiliations":[{"raw_affiliation_string":"School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Champaign, IL, 61801, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"School of Molecular and Cellular Biology, University of Illinois at Urbana\u2013Champaign, Champaign, IL, 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048663075","display_name":"Mu Wang","orcid":"https://orcid.org/0000-0002-3823-1272"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mu Wang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, IU School of Medicine, Indianapolis, IN, 46202, USA","Indiana Center for Systems Biology and Personalized Medicine, Indianapolis, IN, 46202, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, IU School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Indiana Center for Systems Biology and Personalized Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050393620","display_name":"Bin Deng","orcid":"https://orcid.org/0000-0003-0137-885X"},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]},{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]},{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]},{"id":"https://openalex.org/I4210088533","display_name":"Vermont Oxford Network","ror":"https://ror.org/003gt3k37","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210088533"]},{"id":"https://openalex.org/I4210156829","display_name":"Research Network (United States)","ror":"https://ror.org/04tgjxk96","country_code":"US","type":"company","lineage":["https://openalex.org/I4210156829"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Deng","raw_affiliation_strings":["Institute for Translational Research and Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA","Vermont Biomedical Research Network and Department of Biology, University of Vermont, Burlington, VT, 05405, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Translational Research and Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA","institution_ids":["https://openalex.org/I123534392","https://openalex.org/I165139151"]},{"raw_affiliation_string":"Vermont Biomedical Research Network and Department of Biology, University of Vermont, Burlington, VT, 05405, USA","institution_ids":["https://openalex.org/I4210088533","https://openalex.org/I4210156829","https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036089299","display_name":"Robert C. Barber","orcid":"https://orcid.org/0000-0001-6857-0286"},"institutions":[{"id":"https://openalex.org/I123534392","display_name":"University of North Texas","ror":"https://ror.org/00v97ad02","country_code":"US","type":"education","lineage":["https://openalex.org/I123534392"]},{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Barber","raw_affiliation_strings":["Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA","institution_ids":["https://openalex.org/I123534392","https://openalex.org/I165139151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100726056","display_name":"Gang Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Huang","raw_affiliation_strings":["Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, People's Republic of China. huangg@sumhs.edu.cn","Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, People's Republic of China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, People's Republic of China. huangg@sumhs.edu.cn","institution_ids":["https://openalex.org/I4210135985"]},{"raw_affiliation_string":"Shanghai Key Laboratory for Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, People's Republic of China","institution_ids":["https://openalex.org/I4210135985"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100403574"],"corresponding_institution_ids":["https://openalex.org/I111236770","https://openalex.org/I123534392","https://openalex.org/I165139151","https://openalex.org/I4210088533","https://openalex.org/I4210156829"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.8358,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.72144552,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"21","issue":"S9","first_page":"541","last_page":"541"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.7674421072006226},{"id":"https://openalex.org/keywords/protein-isoform","display_name":"Protein isoform","score":0.700857400894165},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.6458753943443298},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6264132261276245},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.6185237169265747},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.579293966293335},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5101993083953857},{"id":"https://openalex.org/keywords/exon-skipping","display_name":"Exon skipping","score":0.49223700165748596},{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.4281710684299469},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4266735911369324},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.42569732666015625},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.41823437809944153},{"id":"https://openalex.org/keywords/intron","display_name":"Intron","score":0.41747811436653137},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.40738290548324585},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3432462811470032},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3386123776435852},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3036140501499176},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.293701171875},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2474285364151001},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.17036277055740356},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.16489744186401367}],"concepts":[{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.7674421072006226},{"id":"https://openalex.org/C135979968","wikidata":"https://www.wikidata.org/wiki/Q609809","display_name":"Protein isoform","level":5,"score":0.700857400894165},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6458753943443298},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6264132261276245},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.6185237169265747},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.579293966293335},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5101993083953857},{"id":"https://openalex.org/C2778776201","wikidata":"https://www.wikidata.org/wiki/Q3474283","display_name":"Exon skipping","level":5,"score":0.49223700165748596},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4281710684299469},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4266735911369324},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.42569732666015625},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.41823437809944153},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.41747811436653137},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.40738290548324585},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3432462811470032},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3386123776435852},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3036140501499176},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.293701171875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2474285364151001},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17036277055740356},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16489744186401367}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-020-03824-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03824-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03824-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33272210","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33272210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:47bc5aed6c7240feb9e75fdbb71880b4","is_oa":true,"landing_page_url":"https://doaj.org/article/47bc5aed6c7240feb9e75fdbb71880b4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss S9, Pp 1-17 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7713335","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7713335","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/28691","is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/28691","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03824-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03824-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03824-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1019147284","display_name":null,"funder_award_id":"GM103466","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1031856235","display_name":null,"funder_award_id":"P20GM10344","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1081364595","display_name":null,"funder_award_id":"Oncology","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1223641584","display_name":null,"funder_award_id":"GM114737","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1271641485","display_name":null,"funder_award_id":"U54MD00760","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1769834158","display_name":null,"funder_award_id":"U54MD0076","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1939176559","display_name":null,"funder_award_id":"P30GM114737","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2068627947","display_name":null,"funder_award_id":"2U54MD007601","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2154072646","display_name":null,"funder_award_id":"GM103466","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3425802160","display_name":null,"funder_award_id":"P20GM103449","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3715734135","display_name":null,"funder_award_id":"P30GM11473","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4771767919","display_name":null,"funder_award_id":"P20GM103449","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4981486250","display_name":null,"funder_award_id":"5P30GM114737","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5379879261","display_name":null,"funder_award_id":"U54 MD007584","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5508519451","display_name":null,"funder_award_id":"GM103449","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6764985097","display_name":null,"funder_award_id":"P30GM114737","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6874095071","display_name":null,"funder_award_id":"54MD007601","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7545056053","display_name":null,"funder_award_id":"P20GM103466","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8322275249","display_name":null,"funder_award_id":"P20GM103466","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8652091348","display_name":null,"funder_award_id":"MD007601","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G992900636","display_name":null,"funder_award_id":"U54MD007601","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3106710884.pdf","grobid_xml":"https://content.openalex.org/works/W3106710884.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1547787294","https://openalex.org/W1964895626","https://openalex.org/W1973268693","https://openalex.org/W1977032270","https://openalex.org/W1981509058","https://openalex.org/W1983737095","https://openalex.org/W1990097247","https://openalex.org/W2001786365","https://openalex.org/W2016097940","https://openalex.org/W2042228684","https://openalex.org/W2047275456","https://openalex.org/W2051477788","https://openalex.org/W2056710301","https://openalex.org/W2068565992","https://openalex.org/W2093131463","https://openalex.org/W2097065948","https://openalex.org/W2100305481","https://openalex.org/W2105993477","https://openalex.org/W2108234281","https://openalex.org/W2112226798","https://openalex.org/W2118416745","https://openalex.org/W2118993019","https://openalex.org/W2124122363","https://openalex.org/W2124985265","https://openalex.org/W2128016314","https://openalex.org/W2133000300","https://openalex.org/W2136178650","https://openalex.org/W2141308479","https://openalex.org/W2141987495","https://openalex.org/W2146389983","https://openalex.org/W2147292635","https://openalex.org/W2149517369","https://openalex.org/W2150089978","https://openalex.org/W2156052197","https://openalex.org/W2159372054","https://openalex.org/W2165700891","https://openalex.org/W2166842799","https://openalex.org/W2411204349","https://openalex.org/W2919588324","https://openalex.org/W2944205042","https://openalex.org/W4210767115","https://openalex.org/W4233550359","https://openalex.org/W6806875027"],"related_works":["https://openalex.org/W2069394339","https://openalex.org/W4321787255","https://openalex.org/W2122169220","https://openalex.org/W4386886742","https://openalex.org/W3031070702","https://openalex.org/W155685562","https://openalex.org/W2026483631","https://openalex.org/W2040026749","https://openalex.org/W2795245767","https://openalex.org/W2045245107"],"abstract_inverted_index":{"This":[0],"paper":[1],"presents":[2],"a":[3,22],"bioinformatics":[4],"workflow":[5],"for":[6,30],"using":[7],"RNA-seq":[8],"data":[9],"to":[10,24],"discover":[11],"novel":[12],"alternative":[13,26,31,55],"splicing":[14,27,32,56],"biomarkers":[15,58],"from":[16],"the":[17,37],"breast":[18],"cancer":[19],"proteome.":[20],"As":[21],"complement":[23],"synthetic":[25],"database":[28],"technique":[29],"identification,":[33],"this":[34],"method":[35],"combines":[36],"advantages":[38],"of":[39,61],"two":[40],"platforms:":[41],"mass":[42],"spectrometry":[43],"and":[44,48],"next":[45],"generation":[46],"sequencing":[47],"can":[49],"help":[50],"identify":[51],"potentially":[52],"highly":[53],"sample-specific":[54],"isoform":[57],"at":[59],"early-stage":[60],"cancer.":[62]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
