{"id":"https://openalex.org/W3092365280","doi":"https://doi.org/10.1186/s12859-020-03787-w","title":"REW-ISA: unveiling local functional blocks in epi-transcriptome profiling data via an RNA expression-weighted iterative signature algorithm","display_name":"REW-ISA: unveiling local functional blocks in epi-transcriptome profiling data via an RNA expression-weighted iterative signature algorithm","publication_year":2020,"publication_date":"2020-10-09","ids":{"openalex":"https://openalex.org/W3092365280","doi":"https://doi.org/10.1186/s12859-020-03787-w","mag":"3092365280","pmid":"https://pubmed.ncbi.nlm.nih.gov/33036550"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03787-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03787-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-020-03787-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-020-03787-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100351875","display_name":"Lin Zhang","orcid":"https://orcid.org/0000-0002-7404-5231"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China","School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, 221116, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China","institution_ids":["https://openalex.org/I25757504"]},{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, 221116, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102962088","display_name":"Shutao Chen","orcid":"https://orcid.org/0000-0001-6188-2631"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shutao Chen","raw_affiliation_strings":["Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China","School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, 221116, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China","institution_ids":["https://openalex.org/I25757504"]},{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, 221116, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101574872","display_name":"Jingyi Zhu","orcid":"https://orcid.org/0000-0003-4299-2899"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Zhu","raw_affiliation_strings":["Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China","School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, 221116, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China","institution_ids":["https://openalex.org/I25757504"]},{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, 221116, China","institution_ids":["https://openalex.org/I25757504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062986831","display_name":"Jia Meng","orcid":"https://orcid.org/0000-0003-3455-205X"},"institutions":[{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Meng","raw_affiliation_strings":["Department of Biological Sciences, AI University Research Center, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, AI University Research Center, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, China","institution_ids":["https://openalex.org/I69356397"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hui Liu","orcid":"https://orcid.org/0000-0002-7404-5231"},"institutions":[{"id":"https://openalex.org/I25757504","display_name":"China University of Mining and Technology","ror":"https://ror.org/01xt2dr21","country_code":"CN","type":"education","lineage":["https://openalex.org/I25757504"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Liu","raw_affiliation_strings":["Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China. hui.liu@cumt.edu.cn","School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, 221116, China. hui.liu@cumt.edu.cn","Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China"],"raw_orcid":"https://orcid.org/0000-0002-7404-5231","affiliations":[{"raw_affiliation_string":"Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China. hui.liu@cumt.edu.cn","institution_ids":["https://openalex.org/I25757504"]},{"raw_affiliation_string":"School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, 221116, China. hui.liu@cumt.edu.cn","institution_ids":["https://openalex.org/I25757504"]},{"raw_affiliation_string":"Engineering Research Center of Intelligent Control for Underground Space, Ministry of Education, China University of Mining and Technology, Xuzhou, 221116, China","institution_ids":["https://openalex.org/I25757504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I25757504"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.3728,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.5618407,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"21","issue":"1","first_page":"447","last_page":"447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-methylation","display_name":"RNA methylation","score":0.7399044632911682},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.6638253927230835},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6285425424575806},{"id":"https://openalex.org/keywords/n6-methyladenosine","display_name":"N6-Methyladenosine","score":0.602990448474884},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5636584758758545},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4641045331954956},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4574929177761078},{"id":"https://openalex.org/keywords/methyltransferase","display_name":"Methyltransferase","score":0.4543948471546173},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.43743014335632324},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.43043142557144165},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.36236149072647095},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2972782850265503},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21827515959739685},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2003042995929718},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1602792739868164}],"concepts":[{"id":"https://openalex.org/C2909856833","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"RNA methylation","level":5,"score":0.7399044632911682},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6638253927230835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6285425424575806},{"id":"https://openalex.org/C2775963939","wikidata":"https://www.wikidata.org/wiki/Q6951996","display_name":"N6-Methyladenosine","level":5,"score":0.602990448474884},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5636584758758545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4641045331954956},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4574929177761078},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.4543948471546173},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.43743014335632324},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.43043142557144165},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.36236149072647095},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2972782850265503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21827515959739685},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2003042995929718},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1602792739868164}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-03787-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03787-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-020-03787-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33036550","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33036550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:8c757011db4f4438a2a8d8b11d53c20a","is_oa":true,"landing_page_url":"https://doaj.org/article/8c757011db4f4438a2a8d8b11d53c20a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-22 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7547494","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7547494","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03787-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03787-w","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-020-03787-w","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.4300000071525574}],"awards":[{"id":"https://openalex.org/G1143551653","display_name":null,"funder_award_id":"61971422","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5450572105","display_name":null,"funder_award_id":"31871337","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G981807214","display_name":null,"funder_award_id":"2015XKQY21","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3092365280.pdf","grobid_xml":"https://content.openalex.org/works/W3092365280.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W776567260","https://openalex.org/W1650797637","https://openalex.org/W1933156045","https://openalex.org/W1941339056","https://openalex.org/W1947267113","https://openalex.org/W1991807334","https://openalex.org/W2002458471","https://openalex.org/W2007429249","https://openalex.org/W2008887283","https://openalex.org/W2009002761","https://openalex.org/W2011131953","https://openalex.org/W2015696149","https://openalex.org/W2022770379","https://openalex.org/W2035618305","https://openalex.org/W2043398720","https://openalex.org/W2050791777","https://openalex.org/W2062821957","https://openalex.org/W2064787891","https://openalex.org/W2065847836","https://openalex.org/W2071930821","https://openalex.org/W2078964320","https://openalex.org/W2080278541","https://openalex.org/W2091235283","https://openalex.org/W2094191210","https://openalex.org/W2095916340","https://openalex.org/W2102872651","https://openalex.org/W2105883975","https://openalex.org/W2140729960","https://openalex.org/W2143451174","https://openalex.org/W2158128075","https://openalex.org/W2161488150","https://openalex.org/W2162522101","https://openalex.org/W2165547003","https://openalex.org/W2175514210","https://openalex.org/W2180404227","https://openalex.org/W2269054226","https://openalex.org/W2508638967","https://openalex.org/W2509465044","https://openalex.org/W2558981096","https://openalex.org/W2563912688","https://openalex.org/W2577490495","https://openalex.org/W2597375791","https://openalex.org/W2616848081","https://openalex.org/W2632544498","https://openalex.org/W2751668414","https://openalex.org/W2754499625","https://openalex.org/W2760498857","https://openalex.org/W2767731367","https://openalex.org/W2769630486","https://openalex.org/W2790756470","https://openalex.org/W2791349417","https://openalex.org/W2791790309","https://openalex.org/W2793785833","https://openalex.org/W2806565274","https://openalex.org/W2808202500","https://openalex.org/W2873882418","https://openalex.org/W2899339826","https://openalex.org/W2911349862","https://openalex.org/W2912369228","https://openalex.org/W2915268839","https://openalex.org/W2921763102","https://openalex.org/W2942683196","https://openalex.org/W2946834045","https://openalex.org/W2989120639","https://openalex.org/W2999012956","https://openalex.org/W3105982350"],"related_works":["https://openalex.org/W46965905","https://openalex.org/W2089104969","https://openalex.org/W2003083382","https://openalex.org/W3147900171","https://openalex.org/W3172822044","https://openalex.org/W2505116771","https://openalex.org/W2475490100","https://openalex.org/W4384916690","https://openalex.org/W1483906698","https://openalex.org/W2399689771"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Recent":[2],"studies":[3],"have":[4],"shown":[5],"that":[6,207,236,242],"N":[7],"6":[8,11,45,173,191,218,263],"-methyladenosine":[9],"(m":[10],"A)":[12],"plays":[13],"a":[14,78],"critical":[15],"role":[16],"in":[17,171,210,261],"numbers":[18],"of":[19,30,39,43,66,94,135,143,154,163,182,245],"biological":[20],"processes":[21],"and":[22,54,63,82,85,92,165,202,226],"complex":[23,52],"human":[24],"diseases.":[25],"However,":[26],"the":[27,40,60,89,127,169,216],"regulatory":[28,55],"mechanisms":[29],"most":[31],"methylation":[32,71,175,184,243],"sites":[33,120,142,185,208,248,267],"remain":[34],"uncharted.":[35],"Thus,":[36],"in-depth":[37],"study":[38],"epi-transcriptomic":[41],"patterns":[42,72,259],"m":[44,172,217,262],"A":[46,174,219,264],"may":[47,249],"provide":[48],"insights":[49],"into":[50],"its":[51],"functional":[53,112,258],"mechanisms.":[56],"Results":[57],"Due":[58],"to":[59,108,140,167,215],"high":[61],"economic":[62],"time":[64],"cost":[65],"wet":[67],"experimental":[68,188],"methods,":[69,97],"revealing":[70],"through":[73],"computational":[74],"models":[75],"has":[76],"become":[77],"more":[79,84,86],"preferable":[80],"way,":[81],"drawn":[83],"attention.":[87],"Considering":[88],"theoretical":[90],"basics":[91],"applications":[93],"conventional":[95],"clustering":[96],"an":[98],"RNA":[99,132],"Expression":[100],"Weighted":[101],"Iterative":[102],"Signature":[103],"Algorithm":[104],"(REW-ISA)":[105],"is":[106],"proposed":[107],"find":[109,168],"potential":[110,256],"local":[111,257],"blocks":[113],"(LFBs)":[114],"based":[115],"on":[116,179],"MeRIP-Seq":[117,180],"data,":[118],"where":[119,266],"are":[121,212,239,268],"hyper-methylated":[122],"or":[123],"hypo-methylated":[124],"simultaneously":[125],"across":[126],"specific":[128,247,271],"conditions.":[129,272],"REW-ISA":[130,254],"adopts":[131],"expression":[133,145],"levels":[134],"each":[136,232],"site":[137],"as":[138,222],"weights":[139],"make":[141],"lower":[144],"level":[146],"less":[147],"significant.":[148],"It":[149],"starts":[150],"from":[151],"random":[152],"sets":[153],"sites,":[155],"then":[156],"follows":[157],"iterative":[158],"search":[159],"strategies":[160],"by":[161],"thresholds":[162],"rows":[164],"columns":[166],"LFBs":[170,211,238],"profile.":[176],"Its":[177],"application":[178],"data":[181],"69,446":[183],"under":[186,270],"32":[187],"conditions":[189],"unveiled":[190],"LFBs,":[192],"which":[193],"achieve":[194],"higher":[195],"enrichment":[196],"scores":[197],"than":[198],"ISA.":[199],"Pathway":[200],"analysis":[201],"enzyme":[203],"specificity":[204],"test":[205],"showed":[206,235],"remained":[209],"highly":[213],"relevant":[214],"methyltransferase,":[220],"such":[221],"METTL3,":[223],"METTL14,":[224],"WTAP":[225],"KIAA1429.":[227],"Further":[228],"detailed":[229],"analyses":[230],"for":[231],"LFB":[233],"even":[234],"some":[237,246],"condition-specific,":[240],"indicating":[241],"profiles":[244],"be":[250],"condition":[251],"relevant.":[252],"Conclusions":[253],"finds":[255],"presented":[260],"profiles,":[265],"co-methylated":[269]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}