{"id":"https://openalex.org/W3113072416","doi":"https://doi.org/10.1186/s12859-020-03776-z","title":"Generation of digital patients for the simulation of tuberculosis with UISS-TB","display_name":"Generation of digital patients for the simulation of tuberculosis with UISS-TB","publication_year":2020,"publication_date":"2020-12-01","ids":{"openalex":"https://openalex.org/W3113072416","doi":"https://doi.org/10.1186/s12859-020-03776-z","mag":"3113072416","pmid":"https://pubmed.ncbi.nlm.nih.gov/33308156"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03776-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03776-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03776-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03776-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063808404","display_name":"Miguel A. Ju\u00e1rez","orcid":"https://orcid.org/0000-0002-5128-0976"},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Miguel A. Ju\u00e1rez","raw_affiliation_strings":["School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK. m.juarez@sheffield.ac.uk","School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK"],"raw_orcid":"https://orcid.org/0000-0002-5128-0976","affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK. m.juarez@sheffield.ac.uk","institution_ids":["https://openalex.org/I91136226"]},{"raw_affiliation_string":"School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003874484","display_name":"Marzio Pennisi","orcid":"https://orcid.org/0000-0003-0231-7653"},"institutions":[{"id":"https://openalex.org/I123338534","display_name":"Universit\u00e0 degli Studi del Piemonte Orientale \u201cAmedeo Avogadro\u201d","ror":"https://ror.org/04387x656","country_code":"IT","type":"education","lineage":["https://openalex.org/I123338534"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marzio Pennisi","raw_affiliation_strings":["Computer Science Institute, DiSIT, University of Eastern Piedmont, Alessandria, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science Institute, DiSIT, University of Eastern Piedmont, Alessandria, Italy","institution_ids":["https://openalex.org/I123338534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004880055","display_name":"Giulia Russo","orcid":"https://orcid.org/0000-0001-6616-7856"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulia Russo","raw_affiliation_strings":["Department of Drug Sciences, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043450998","display_name":"Dimitrios Kiagias","orcid":null},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dimitrios Kiagias","raw_affiliation_strings":["School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, University of Sheffield, Sheffield, S3 7RH, UK","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032192084","display_name":"Cristina Curreli","orcid":"https://orcid.org/0000-0002-9904-3849"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Curreli","raw_affiliation_strings":["Department of Industrial Engineering, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086585880","display_name":"Marco Viceconti","orcid":"https://orcid.org/0000-0002-2293-1530"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marco Viceconti","raw_affiliation_strings":["Department of Industrial Engineering, University of Bologna, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Engineering, University of Bologna, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044340074","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0003-1668-3320"},"institutions":[{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["Department of Drug Sciences, University of Catania, Catania, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Sciences, University of Catania, Catania, Italy","institution_ids":["https://openalex.org/I39063666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063808404"],"corresponding_institution_ids":["https://openalex.org/I91136226"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.3147,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.71891281,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"21","issue":"S17","first_page":"449","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.5925999879837036,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.5925999879837036,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.1527000069618225,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.05040000006556511,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.5988186001777649},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5767105221748352},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5732389092445374},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5096876621246338},{"id":"https://openalex.org/keywords/sampling","display_name":"Sampling (signal processing)","score":0.4566539525985718},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"Tuberculosis","score":0.4459307789802551},{"id":"https://openalex.org/keywords/virtual-patient","display_name":"Virtual patient","score":0.42643776535987854},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.32926303148269653},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.31102925539016724},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3103591203689575},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1901225745677948},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.13028937578201294}],"concepts":[{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5988186001777649},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5767105221748352},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5732389092445374},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5096876621246338},{"id":"https://openalex.org/C140779682","wikidata":"https://www.wikidata.org/wiki/Q210868","display_name":"Sampling (signal processing)","level":3,"score":0.4566539525985718},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.4459307789802551},{"id":"https://openalex.org/C2778533338","wikidata":"https://www.wikidata.org/wiki/Q7935148","display_name":"Virtual patient","level":2,"score":0.42643776535987854},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.32926303148269653},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31102925539016724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3103591203689575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1901225745677948},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13028937578201294},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.0},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C106131492","wikidata":"https://www.wikidata.org/wiki/Q3072260","display_name":"Filter (signal processing)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-020-03776-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03776-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03776-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33308156","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33308156","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:eprints.whiterose.ac.uk:169581","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:65f96e504825408a90024490ad64a437","is_oa":true,"landing_page_url":"https://doaj.org/article/65f96e504825408a90024490ad64a437","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss S17, Pp 1-8 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7733699","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7733699","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03776-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03776-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03776-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7356765593","display_name":null,"funder_award_id":"777123","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3113072416.pdf","grobid_xml":"https://content.openalex.org/works/W3113072416.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1771999207","https://openalex.org/W1973720948","https://openalex.org/W1991716304","https://openalex.org/W2041075980","https://openalex.org/W2043514557","https://openalex.org/W2102439908","https://openalex.org/W2110518406","https://openalex.org/W2118037724","https://openalex.org/W2139745270","https://openalex.org/W2147763277","https://openalex.org/W2158327192","https://openalex.org/W2346839593","https://openalex.org/W2365316759","https://openalex.org/W2779931721","https://openalex.org/W2911407484","https://openalex.org/W2943357979","https://openalex.org/W2994705677","https://openalex.org/W2996373685","https://openalex.org/W3005110582","https://openalex.org/W3113072416"],"related_works":["https://openalex.org/W2806061655","https://openalex.org/W1955737261","https://openalex.org/W2775573077","https://openalex.org/W2765354416","https://openalex.org/W2110949356","https://openalex.org/W2796117997","https://openalex.org/W3032245684","https://openalex.org/W3122854054","https://openalex.org/W2788431082","https://openalex.org/W2394826894"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"STriTuVaD":[2],"project,":[3],"funded":[4],"by":[5],"Horizon":[6],"2020,":[7],"aims":[8],"to":[9,77,134,150,160,194],"test":[10],"through":[11,100,114],"a":[12,34,75,110,118,147,162],"Phase":[13],"IIb":[14],"clinical":[15,60,178],"trial":[16,193],"one":[17],"of":[18,28,64,81,93,103,117,120,141,164],"the":[19,65,82,101,104,115,131,136,139,142,153,172,176,187,190,192],"most":[20,66],"advanced":[21],"therapeutic":[22],"vaccines":[23],"against":[24],"tuberculosis.":[25],"As":[26],"part":[27],"this":[29],"initiative,":[30],"we":[31],"have":[32],"developed":[33],"strategy":[35,89],"for":[36,69,90,175,185],"generating":[37,91],"in":[38,51,54,109,158],"silico":[39],"patients":[40,72,166],"consistent":[41],"with":[42,53,167],"target":[43,83,177],"population":[44,156],"characteristics,":[45,170],"which":[46,180],"can":[47,182],"then":[48,181],"be":[49,183],"used":[50,184],"combination":[52],"vivo":[55],"data":[56],"on":[57],"an":[58,87],"augmented":[59],"trial.":[61],"RESULTS:":[62],"One":[63],"challenging":[67],"tasks":[68],"using":[70],"virtual":[71,165],"is":[73],"developing":[74],"methodology":[76],"reproduce":[78,135],"biological":[79,125],"diversity":[80],"population,":[84],"ie,":[85],"providing":[86],"appropriate":[88],"libraries":[92],"digital":[94,132],"patients.":[95],"This":[96],"has":[97],"been":[98],"achieved":[99],"creation":[102],"initial":[105],"immune":[106],"system":[107],"repertoire":[108],"stochastic":[111],"way,":[112],"and":[113,126,138,199],"identification":[116],"vector":[119],"features":[121,155],"that":[122,129],"combines":[123],"both":[124],"pathophysiological":[127],"parameters":[128],"personalise":[130],"patient":[133],"physiology":[137],"pathophysiology":[140],"subject.":[143],"CONCLUSIONS:":[144],"We":[145],"propose":[146],"sequential":[148],"approach":[149],"sampling":[151],"from":[152,189],"joint":[154],"distribution":[157],"order":[159],"create":[161],"cohort":[163],"some":[168],"specific":[169],"resembling":[171],"recruitment":[173],"process":[174],"trial,":[179],"augmenting":[186],"information":[188],"physical":[191],"help":[195],"reduce":[196],"its":[197],"size":[198],"duration.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
