{"id":"https://openalex.org/W3044920383","doi":"https://doi.org/10.1186/s12859-020-03664-6","title":"Predicting DNA binding protein-drug interactions based on network similarity","display_name":"Predicting DNA binding protein-drug interactions based on network similarity","publication_year":2020,"publication_date":"2020-07-20","ids":{"openalex":"https://openalex.org/W3044920383","doi":"https://doi.org/10.1186/s12859-020-03664-6","mag":"3044920383","pmid":"https://pubmed.ncbi.nlm.nih.gov/32689927"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03664-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03664-6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03664-6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03664-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054667546","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-9616-1145"},"institutions":[{"id":"https://openalex.org/I4210165883","display_name":"Xinxiang University","ror":"https://ror.org/05qvskn85","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210165883"]},{"id":"https://openalex.org/I75955062","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28","country_code":"CN","type":"education","lineage":["https://openalex.org/I75955062"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Big Data Engineering Laboratory for Teaching Resources & assessment of Education Quality, Henan Province, Xinxiang, China. weiwang@htu.edu.cn","Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, 453007, China. weiwang@htu.edu.cn","Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China","Big Data Engineering Laboratory for Teaching Resources & assessment of Education Quality, Henan Province, Xinxiang, China"],"raw_orcid":"https://orcid.org/0000-0002-9616-1145","affiliations":[{"raw_affiliation_string":"Big Data Engineering Laboratory for Teaching Resources & assessment of Education Quality, Henan Province, Xinxiang, China. weiwang@htu.edu.cn","institution_ids":["https://openalex.org/I4210165883"]},{"raw_affiliation_string":"Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, 453007, China. weiwang@htu.edu.cn","institution_ids":["https://openalex.org/I75955062"]},{"raw_affiliation_string":"Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China","institution_ids":["https://openalex.org/I75955062"]},{"raw_affiliation_string":"Big Data Engineering Laboratory for Teaching Resources & assessment of Education Quality, Henan Province, Xinxiang, China","institution_ids":["https://openalex.org/I4210165883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083461674","display_name":"Hehe Lv","orcid":null},"institutions":[{"id":"https://openalex.org/I75955062","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28","country_code":"CN","type":"education","lineage":["https://openalex.org/I75955062"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hehe Lv","raw_affiliation_strings":["Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, 453007, China","Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, 453007, China","institution_ids":["https://openalex.org/I75955062"]},{"raw_affiliation_string":"Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China","institution_ids":["https://openalex.org/I75955062"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113629381","display_name":"Yuan Zhao","orcid":"https://orcid.org/0000-0002-2922-6578"},"institutions":[{"id":"https://openalex.org/I75955062","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28","country_code":"CN","type":"education","lineage":["https://openalex.org/I75955062"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Zhao","raw_affiliation_strings":["Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, 453007, China","Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, 453007, China","institution_ids":["https://openalex.org/I75955062"]},{"raw_affiliation_string":"Department of Computer Science and Technology, College of Computer and Information Engineering, Henan Normal University, Xinxiang, China","institution_ids":["https://openalex.org/I75955062"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054667546"],"corresponding_institution_ids":["https://openalex.org/I4210165883","https://openalex.org/I75955062"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.583,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.73594214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"1","first_page":"322","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.6623578667640686},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6085840463638306},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5561556816101074},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.54836505651474},{"id":"https://openalex.org/keywords/trimer","display_name":"Trimer","score":0.4975450336933136},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.4920172393321991},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.45961281657218933},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.45437073707580566},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.4332640767097473},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4313245117664337},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.42398059368133545},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3934396505355835},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31456029415130615},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.29253607988357544},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2626602351665497},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20743587613105774},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.17890840768814087},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17332151532173157},{"id":"https://openalex.org/keywords/dimer","display_name":"Dimer","score":0.1510114073753357},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1351754367351532}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6623578667640686},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6085840463638306},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5561556816101074},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.54836505651474},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.4975450336933136},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.4920172393321991},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.45961281657218933},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.45437073707580566},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4332640767097473},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4313245117664337},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.42398059368133545},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3934396505355835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31456029415130615},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29253607988357544},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2626602351665497},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20743587613105774},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17890840768814087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17332151532173157},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.1510114073753357},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1351754367351532},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-03664-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03664-6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03664-6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32689927","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32689927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:2039749d484d49e7bdd12406f4e893f9","is_oa":true,"landing_page_url":"https://doaj.org/article/2039749d484d49e7bdd12406f4e893f9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-13 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7372772","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7372772","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03664-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03664-6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03664-6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6100000143051147}],"awards":[{"id":"https://openalex.org/G1277352542","display_name":null,"funder_award_id":"qd15132","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G128463709","display_name":null,"funder_award_id":"172102210338","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G1379776269","display_name":null,"funder_award_id":"172102210338","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G1755856950","display_name":null,"funder_award_id":"172102210338","funder_id":"https://openalex.org/F4320327051","funder_display_name":"Science and Technology Department of Henan Province"},{"id":"https://openalex.org/G176435917","display_name":null,"funder_award_id":"162300410177","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G2143804069","display_name":null,"funder_award_id":"17B520002","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G243422269","display_name":null,"funder_award_id":"16A520016","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G2672943081","display_name":null,"funder_award_id":"201702115008","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G3021698286","display_name":null,"funder_award_id":"qd15130","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G3319777373","display_name":null,"funder_award_id":"182300410368","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G3419998376","display_name":null,"funder_award_id":"182300410306","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G3444376333","display_name":null,"funder_award_id":"182300410368","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G3692155136","display_name":null,"funder_award_id":"qd15130","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G3712351554","display_name":null,"funder_award_id":"201702115008","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G3919970536","display_name":null,"funder_award_id":"2018YFB1701400","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3976845336","display_name":null,"funder_award_id":"17B520002","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G4206875280","display_name":null,"funder_award_id":"qd15130","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G4255330616","display_name":null,"funder_award_id":"182102210208","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G4363906057","display_name":null,"funder_award_id":"qd15129","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G4599894840","display_name":null,"funder_award_id":"182300410306","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G5222079993","display_name":null,"funder_award_id":"182102210208","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G5469367667","display_name":null,"funder_award_id":"qd15132","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G5626049319","display_name":null,"funder_award_id":"172102210338","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G590209913","display_name":null,"funder_award_id":"16A520016","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G5917827055","display_name":null,"funder_award_id":"16A520016","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G5961821985","display_name":null,"funder_award_id":"qd15132","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G6479094260","display_name":null,"funder_award_id":"201702115008","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G6541767213","display_name":null,"funder_award_id":"182300410368","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G6654273942","display_name":null,"funder_award_id":"182300410306","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G668868353","display_name":null,"funder_award_id":"182102210208","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G6732203679","display_name":null,"funder_award_id":"182300410130","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G7762200695","display_name":null,"funder_award_id":"qd15129","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G8313756683","display_name":null,"funder_award_id":"qd15129","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"},{"id":"https://openalex.org/G8322654098","display_name":null,"funder_award_id":"182300410130","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G8689003394","display_name":null,"funder_award_id":"17B520002","funder_id":"https://openalex.org/F4320311345","funder_display_name":"Henan Normal University"},{"id":"https://openalex.org/G8830237757","display_name":null,"funder_award_id":"182300410130","funder_id":"https://openalex.org/F4320323845","funder_display_name":"Natural Science Foundation of Henan Province"}],"funders":[{"id":"https://openalex.org/F4320311345","display_name":"Henan Normal University","ror":"https://ror.org/00s13br28"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320323845","display_name":"Natural Science Foundation of Henan Province","ror":null},{"id":"https://openalex.org/F4320327051","display_name":"Science and Technology Department of Henan Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3044920383.pdf","grobid_xml":"https://content.openalex.org/works/W3044920383.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1680392829","https://openalex.org/W1738373647","https://openalex.org/W1884544501","https://openalex.org/W1977831461","https://openalex.org/W1979914800","https://openalex.org/W1984084871","https://openalex.org/W1986240377","https://openalex.org/W2007444087","https://openalex.org/W2009470087","https://openalex.org/W2016381774","https://openalex.org/W2018408116","https://openalex.org/W2019062641","https://openalex.org/W2037263319","https://openalex.org/W2037933327","https://openalex.org/W2061293154","https://openalex.org/W2113951828","https://openalex.org/W2114779636","https://openalex.org/W2119203914","https://openalex.org/W2125655246","https://openalex.org/W2137507165","https://openalex.org/W2146382443","https://openalex.org/W2148426707","https://openalex.org/W2150452800","https://openalex.org/W2164078810","https://openalex.org/W2256119113","https://openalex.org/W2257065207","https://openalex.org/W2304455477","https://openalex.org/W2470414691","https://openalex.org/W2539072086","https://openalex.org/W2567713598","https://openalex.org/W2587935821","https://openalex.org/W2588022099","https://openalex.org/W2592742128","https://openalex.org/W2605952223","https://openalex.org/W2607497028","https://openalex.org/W2782538094","https://openalex.org/W2804549231","https://openalex.org/W2891838559","https://openalex.org/W2964299987","https://openalex.org/W4232932184"],"related_works":["https://openalex.org/W2509838516","https://openalex.org/W1971106435","https://openalex.org/W2623587811","https://openalex.org/W2008235780","https://openalex.org/W2148679377","https://openalex.org/W2133776184","https://openalex.org/W2177411254","https://openalex.org/W1598853836","https://openalex.org/W2106029302","https://openalex.org/W2055792849"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,52,172,193,239,247],"study":[2],"of":[3,16,174,249,265],"DNA":[4],"binding":[5,68,77,93,162,248,252,257],"protein":[6,242],"(DBP)-drug":[7],"interactions":[8,210],"can":[9,35,221],"open":[10],"a":[11,43,82],"breakthrough":[12],"for":[13,27,48,115],"the":[14,58,89,92,96,102,108,112,117,128,131,143,161,170,175,180,188,202,250,263],"treatment":[15],"genetic":[17],"diseases":[18],"and":[19,31,160,190,211,241],"cancers.":[20],"Currently,":[21],"network-based":[22],"methods":[23,124],"are":[24,54,70,98,125,244],"widely":[25],"used":[26],"protein-drug":[28],"interaction":[29,113,224],"prediction,":[30],"many":[32],"hidden":[33],"relationships":[34],"be":[36],"found":[37,217],"through":[38],"network":[39,109,145,149,195],"analysis.":[40],"We":[41],"proposed":[42],"DCA":[44,118],"(drug-cluster":[45],"association)":[46],"model":[47,197],"predicting":[49],"DBP-drug":[50,144,194,212,236,266],"interactions.":[51,213,267],"clusters":[53],"some":[55],"similarities":[56],"in":[57,91,127,142],"drug-binding":[59],"site":[60,78,253],"trimmers":[61],"with":[62,226,234],"their":[63],"physicochemical":[64,103],"properties.":[65,104],"First,":[66],"DBPs-drug":[67],"sites":[69,159],"extracted":[71],"from":[72],"scPDB":[73],"database.":[74],"Second,":[75],"each":[76],"is":[79,85,136,164,198,231],"represented":[80],"as":[81],"trimer":[83],"which":[84,205,230,259],"obtained":[86],"by":[87,110,200],"sliding":[88],"window":[90],"sites.":[94],"Third,":[95],"trimers":[97],"clustered":[99],"based":[100],"on":[101],"Fourth,":[105],"we":[106,216],"build":[107],"generating":[111],"matrix":[114],"representing":[116],"network.":[119,129],"Fifth,":[120],"three":[121],"link":[122,176],"prediction":[123,177,185,196],"detected":[126],"Finally,":[130],"common":[132],"neighbor":[133],"(CN)":[134],"method":[135,182,204],"selected":[137],"to":[138,154,156,167,261],"predict":[139],"drug-cluster":[140],"associations":[141],"model.":[146],"RESULT:":[147],"This":[148],"shows":[150],"that":[151,179,218],"drugs":[152],"tend":[153],"bind":[155],"positively":[157],"charged":[158],"process":[163],"more":[165,207],"likely":[166],"occur":[168],"inside":[169],"DBPs.":[171],"results":[173],"indicate":[178],"CN":[181,203],"has":[183],"better":[184],"performance":[186],"than":[187],"PA":[189],"JA":[191],"methods.":[192],"generated":[199],"using":[201],"predicted":[206],"accurately":[208],"drug-trimer":[209],"Such":[214],"as,":[215],"Erythromycin":[219],"(ERY)":[220],"establish":[222],"an":[223],"relationship":[225],"HTH-type":[227],"transcriptional":[228],"repressor,":[229],"fitted":[232],"well":[233],"silico":[235],"prediction.":[237],"CONCLUSION:":[238],"drug":[240],"bindings":[243],"local":[245,256],"events.":[246],"drug-DBPs":[251],"represents":[254],"this":[255],"event,":[258],"helps":[260],"understand":[262],"mechanism":[264]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
