{"id":"https://openalex.org/W3039636321","doi":"https://doi.org/10.1186/s12859-020-03633-z","title":"PDXGEM: patient-derived tumor xenograft-based gene expression model for predicting clinical response to anticancer therapy in cancer patients","display_name":"PDXGEM: patient-derived tumor xenograft-based gene expression model for predicting clinical response to anticancer therapy in cancer patients","publication_year":2020,"publication_date":"2020-07-06","ids":{"openalex":"https://openalex.org/W3039636321","doi":"https://doi.org/10.1186/s12859-020-03633-z","mag":"3039636321","pmid":"https://pubmed.ncbi.nlm.nih.gov/32631229"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-020-03633-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03633-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03633-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03633-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101832672","display_name":"Youngchul Kim","orcid":"https://orcid.org/0000-0002-2307-0330"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Youngchul Kim","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, 33612-9416, USA. Youngchul.kim@moffitt.org","Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, 33612-9416, USA"],"raw_orcid":"https://orcid.org/0000-0002-2307-0330","affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, 33612-9416, USA. Youngchul.kim@moffitt.org","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, 33612-9416, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650944","display_name":"Daewon Kim","orcid":"https://orcid.org/0000-0002-3487-5943"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daewon Kim","raw_affiliation_strings":["Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, 33612-9416, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, 33612-9416, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084794080","display_name":"Biwei Cao","orcid":"https://orcid.org/0009-0000-4255-8369"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biwei Cao","raw_affiliation_strings":["Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, 33612-9416, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, 33612-9416, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035247776","display_name":"Rodrigo Carvajal","orcid":"https://orcid.org/0000-0002-7607-8272"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodrigo Carvajal","raw_affiliation_strings":["Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, 33612-9416, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics Shared Resource, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida, 33612-9416, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100333890","display_name":"Minjung Kim","orcid":"https://orcid.org/0000-0002-5682-6640"},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minjung Kim","raw_affiliation_strings":["Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL, 33620, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL, 33620, USA","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101832672"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.9694,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.73445431,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"288","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.21080000698566437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.21080000698566437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.18729999661445618,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.08129999786615372,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6917526125907898},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6905657649040222},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.5432213544845581},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"Pancreatic cancer","score":0.5412160754203796},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5124173760414124},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.5043784379959106},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.4907301664352417},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4778825342655182},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.47396132349967957},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4696582853794098},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.44564780592918396},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3849582076072693},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.38022440671920776},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2555546164512634},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18376120924949646},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.17476648092269897}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6917526125907898},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6905657649040222},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5432213544845581},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5412160754203796},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5124173760414124},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5043784379959106},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4907301664352417},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4778825342655182},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.47396132349967957},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4696582853794098},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.44564780592918396},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3849582076072693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38022440671920776},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2555546164512634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18376120924949646},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17476648092269897}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-020-03633-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03633-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03633-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32631229","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32631229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:9818177548f04f2ea35bb79916f97b5c","is_oa":true,"landing_page_url":"https://doaj.org/article/9818177548f04f2ea35bb79916f97b5c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-21 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7336455","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7336455","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-020-03633-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-020-03633-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-020-03633-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G362094","display_name":null,"funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320311073","funder_display_name":"Moffitt Cancer Center"},{"id":"https://openalex.org/G4551976579","display_name":null,"funder_award_id":"CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G634390504","display_name":null,"funder_award_id":"P30 CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8135003176","display_name":null,"funder_award_id":"CA076292","funder_id":"https://openalex.org/F4320311073","funder_display_name":"Moffitt Cancer Center"}],"funders":[{"id":"https://openalex.org/F4320311073","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3039636321.pdf","grobid_xml":"https://content.openalex.org/works/W3039636321.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W25117316","https://openalex.org/W176315691","https://openalex.org/W1092526207","https://openalex.org/W1417555467","https://openalex.org/W1535020710","https://openalex.org/W1607267312","https://openalex.org/W1965302838","https://openalex.org/W1980094335","https://openalex.org/W1995169322","https://openalex.org/W2008095940","https://openalex.org/W2012277838","https://openalex.org/W2033997064","https://openalex.org/W2036291018","https://openalex.org/W2040998864","https://openalex.org/W2043398720","https://openalex.org/W2051483759","https://openalex.org/W2069399470","https://openalex.org/W2074270635","https://openalex.org/W2095264870","https://openalex.org/W2098462873","https://openalex.org/W2098775844","https://openalex.org/W2101163066","https://openalex.org/W2104074461","https://openalex.org/W2108068107","https://openalex.org/W2118527670","https://openalex.org/W2118952409","https://openalex.org/W2119025581","https://openalex.org/W2121113526","https://openalex.org/W2130333852","https://openalex.org/W2132144873","https://openalex.org/W2141609698","https://openalex.org/W2147692258","https://openalex.org/W2147908679","https://openalex.org/W2148811436","https://openalex.org/W2154790710","https://openalex.org/W2154941270","https://openalex.org/W2158501247","https://openalex.org/W2159342260","https://openalex.org/W2159491167","https://openalex.org/W2162713066","https://openalex.org/W2168213749","https://openalex.org/W2169105660","https://openalex.org/W2313339984","https://openalex.org/W2345356016","https://openalex.org/W2466033276","https://openalex.org/W2490023472","https://openalex.org/W2518696212","https://openalex.org/W2557938525","https://openalex.org/W2574695762","https://openalex.org/W2683486796","https://openalex.org/W2774934814","https://openalex.org/W2883070899"],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W4399651953","https://openalex.org/W4386960999","https://openalex.org/W2899657781","https://openalex.org/W4322484660","https://openalex.org/W3193951088","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4403376686","https://openalex.org/W4298001029"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cancer":[1],"is":[2,260],"a":[3,27,46,64,81,87,134,142,147,247],"highly":[4,32],"heterogeneous":[5],"disease":[6],"with":[7,154],"varying":[8],"responses":[9,97],"to":[10,19,30,38,85,170,183],"anti-cancer":[11,22,40],"drugs.":[12],"Although":[13],"several":[14,171],"attempts":[15],"have":[16],"been":[17],"made":[18],"predict":[20],"the":[21,39,59,76,150,159,168,231],"therapeutic":[23],"responses,":[24],"there":[25],"remains":[26],"great":[28],"need":[29],"develop":[31,80],"accurate":[33,197],"prediction":[34,137],"models":[35,56],"of":[36,149,199,234,242],"response":[37,136,203],"drugs":[41],"for":[42,93,201,253],"clinical":[43,225],"applications":[44],"toward":[45],"personalized":[47],"medicine.":[48],"Patient":[49],"derived":[50],"xenografts":[51],"(PDXs)":[52],"are":[53,67,181],"preclinical":[54],"cancer":[55,94,163,215,251,254],"in":[57,129,141,209,245],"which":[58],"tissue":[60],"or":[61,72,191,204],"cells":[62],"from":[63,106,219],"patient's":[65],"tumor":[66,126],"implanted":[68],"into":[69],"an":[70,117],"immunodeficient":[71],"humanized":[73],"mouse.":[74],"In":[75],"present":[77],"study,":[78],"we":[79],"bioinformatics":[82],"analysis":[83,119],"pipeline":[84],"build":[86],"predictive":[88,250],"gene":[89,100,121],"expression":[90,101,122],"model":[91,138],"(GEM)":[92],"patients'":[95],"drug":[96,103,135,151,239],"based":[98],"on":[99,213],"and":[102,124,161,223,238],"activity":[104,240],"data":[105,241],"PDX":[107,130,243],"models.":[108,131],"RESULTS:":[109],"Drug":[110],"sensitivity":[111],"biomarkers":[112,153,252],"were":[113,207],"identified":[114],"by":[115,145],"performing":[116],"association":[118],"between":[120,158],"levels":[123],"post-treatment":[125],"volume":[127],"changes":[128],"We":[132,166],"built":[133],"(called":[139],"PDXGEM)":[140],"random-forest":[143],"algorithm":[144],"using":[146,235],"subset":[148],"sensitvity":[152],"concordant":[155],"co-expression":[156],"patterns":[157],"PDXs":[160],"pretreatment":[162],"patient":[164,216],"tumors.":[165],"applied":[167],"PDXGEM":[169,200,257],"cytotoxic":[172],"chemotherapies":[173],"as":[174,176],"well":[175],"targeted":[177],"therapy":[178],"agents":[179],"that":[180],"used":[182],"treat":[184],"breast":[185],"cancer,":[186,188,190],"pancreatic":[187],"colorectal":[189],"non-small":[192],"cell":[193],"lung":[194],"cancer.":[195],"Significantly":[196],"predictions":[198],"pathological":[202],"survival":[205],"outcomes":[206],"observed":[208],"extensive":[210],"independent":[211],"validations":[212],"multiple":[214],"datasets":[217],"obtained":[218],"retrospective":[220],"observational":[221],"studies":[222],"prospective":[224],"trials.":[226],"CONCLUSION:":[227],"Our":[228],"results":[229],"demonstrated":[230],"strong":[232],"potential":[233],"molecular":[236],"profiles":[237],"tumors":[244],"developing":[246],"clinically":[248],"translatable":[249],"patients.":[255],"The":[256],"web":[258],"application":[259],"publicly":[261],"available":[262],"at":[263],"http://pdxgem.moffitt.org":[264],".":[265]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2}],"updated_date":"2026-08-01T09:00:35.917206","created_date":"2025-10-10T00:00:00"}