{"id":"https://openalex.org/W3004221309","doi":"https://doi.org/10.1186/s12859-019-3314-3","title":"Bayesian differential analysis of gene regulatory networks exploiting genetic perturbations","display_name":"Bayesian differential analysis of gene regulatory networks exploiting genetic perturbations","publication_year":2020,"publication_date":"2020-01-09","ids":{"openalex":"https://openalex.org/W3004221309","doi":"https://doi.org/10.1186/s12859-019-3314-3","mag":"3004221309","pmid":"https://pubmed.ncbi.nlm.nih.gov/31918656"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-3314-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3314-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3314-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3314-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101766443","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-1249-9326"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210134929","display_name":"Jilin Province Science and Technology Department","ror":"https://ror.org/049x38272","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210134929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["College of Computer Science and Technology, Jilin University, Changchun, 130012, China","Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, 130012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I4210134929","https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103088617","display_name":"Dayou Liu","orcid":"https://orcid.org/0000-0002-2746-6527"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210134929","display_name":"Jilin Province Science and Technology Department","ror":"https://ror.org/049x38272","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210134929"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dayou Liu","raw_affiliation_strings":["College of Computer Science and Technology, Jilin University, Changchun, 130012, China. liudy@jlu.edu.cn","Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, 130012, China. liudy@jlu.edu.cn","College of Computer Science and Technology, Jilin University, Changchun, 130012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun, 130012, China. liudy@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, 130012, China. liudy@jlu.edu.cn","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I4210134929","https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398883","display_name":"Tengfei Li","orcid":"https://orcid.org/0000-0002-7696-5779"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210134929","display_name":"Jilin Province Science and Technology Department","ror":"https://ror.org/049x38272","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210134929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tengfei Li","raw_affiliation_strings":["College of Computer Science and Technology, Jilin University, Changchun, 130012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I4210134929","https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101647838","display_name":"Yungang Zhu","orcid":"https://orcid.org/0000-0002-8305-4092"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210134929","display_name":"Jilin Province Science and Technology Department","ror":"https://ror.org/049x38272","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210134929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yungang Zhu","raw_affiliation_strings":["College of Computer Science and Technology, Jilin University, Changchun, 130012, China","Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, 130012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I4210134929","https://openalex.org/I194450716"]},{"raw_affiliation_string":"Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103088617"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210134929"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0834,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.42667182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"21","issue":"1","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9736999869346619,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9736999869346619,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6197540163993835},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6176957488059998},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6128376722335815},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.4956902265548706},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4876059591770172},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4647848606109619},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4647345542907715},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.46374329924583435},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35947108268737793},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.21956375241279602},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1917220950126648}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6197540163993835},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6176957488059998},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6128376722335815},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.4956902265548706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4876059591770172},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4647848606109619},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4647345542907715},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.46374329924583435},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35947108268737793},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21956375241279602},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1917220950126648}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-019-3314-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3314-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3314-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31918656","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31918656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:bfd82e19053242c8a0dfea8cd467cca5","is_oa":false,"landing_page_url":"https://doaj.org/article/bfd82e19053242c8a0dfea8cd467cca5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 21, Iss 1, Pp 1-13 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/26802655","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Bayesian_differential_analysis_of_gene_regulatory_networks_exploiting_genetic_perturbations/26802655","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6953167","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6953167","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-3314-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3314-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3314-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3004221309.pdf","grobid_xml":"https://content.openalex.org/works/W3004221309.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1481287147","https://openalex.org/W1672581350","https://openalex.org/W1901309112","https://openalex.org/W1903347830","https://openalex.org/W1965055200","https://openalex.org/W1970094674","https://openalex.org/W1972764318","https://openalex.org/W1973025982","https://openalex.org/W1976365540","https://openalex.org/W1981409633","https://openalex.org/W1981991166","https://openalex.org/W1982652137","https://openalex.org/W2000264668","https://openalex.org/W2013718670","https://openalex.org/W2016580965","https://openalex.org/W2017726167","https://openalex.org/W2018220225","https://openalex.org/W2020925091","https://openalex.org/W2039346468","https://openalex.org/W2040359462","https://openalex.org/W2045656233","https://openalex.org/W2050029156","https://openalex.org/W2055234679","https://openalex.org/W2069313265","https://openalex.org/W2069986908","https://openalex.org/W2074682976","https://openalex.org/W2076372398","https://openalex.org/W2080369972","https://openalex.org/W2085766216","https://openalex.org/W2090176019","https://openalex.org/W2100697281","https://openalex.org/W2107180520","https://openalex.org/W2108069662","https://openalex.org/W2116634113","https://openalex.org/W2122708083","https://openalex.org/W2122825543","https://openalex.org/W2129651180","https://openalex.org/W2132555912","https://openalex.org/W2134744955","https://openalex.org/W2135046866","https://openalex.org/W2136342418","https://openalex.org/W2136988691","https://openalex.org/W2140514146","https://openalex.org/W2143831002","https://openalex.org/W2147848557","https://openalex.org/W2148460690","https://openalex.org/W2164078761","https://openalex.org/W2165009258","https://openalex.org/W2166794017","https://openalex.org/W2168399023","https://openalex.org/W2170704198","https://openalex.org/W2179675792","https://openalex.org/W2236556634","https://openalex.org/W2303875941","https://openalex.org/W2323642760","https://openalex.org/W2416717089","https://openalex.org/W2426535589","https://openalex.org/W2592661264","https://openalex.org/W2793440490","https://openalex.org/W2801381492","https://openalex.org/W2808879120","https://openalex.org/W2896475953","https://openalex.org/W2900429498","https://openalex.org/W2950225911","https://openalex.org/W2950612652","https://openalex.org/W2954914243","https://openalex.org/W2963107416","https://openalex.org/W2963368478","https://openalex.org/W2964302184","https://openalex.org/W4232383088"],"related_works":["https://openalex.org/W2972991241","https://openalex.org/W2415545834","https://openalex.org/W2069695727","https://openalex.org/W1802639773","https://openalex.org/W2118505788","https://openalex.org/W4254166511","https://openalex.org/W2381390841","https://openalex.org/W2150084125","https://openalex.org/W1542823905","https://openalex.org/W2349909726"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gene":[1],"regulatory":[2],"networks":[3],"(GRNs)":[4],"can":[5],"be":[6,28],"inferred":[7,126],"from":[8,30,111,124],"both":[9,173],"gene":[10,20,25,52,148],"expression":[11],"data":[12,21,182,222],"and":[13,54,120,150,169,193,207,227,235],"genetic":[14,96],"perturbations.":[15],"Under":[16],"different":[17,29,36,44,76],"conditions,":[18],"the":[19,23,102,112,122,125,131,144,153,164,199,231,241],"of":[22,47,72,143,147,201,224],"same":[24],"set":[26,223],"may":[27],"each":[31],"other,":[32],"which":[33,90],"results":[34,196,243],"in":[35,244,255],"GRNs.":[37],"Detecting":[38],"structural":[39,86],"difference":[40,123],"between":[41],"GRNs":[42,73,83,119,168],"under":[43,74],"conditions":[45],"is":[46,80,203,208,216,252],"great":[48],"significance":[49],"for":[50,82],"understanding":[51],"functions":[53],"biological":[55],"mechanisms.":[56],"RESULTS:":[57],"In":[58],"this":[59],"paper,":[60],"we":[61,106,128],"propose":[62],"a":[63,158,220],"Bayesian":[64,160],"Fused":[65],"algorithm":[66,79,215],"to":[67,94,100,134,183,186,205,219],"jointly":[68],"infer":[69,117],"differential":[70,170,236],"structures":[71],"two":[75,132,145,187],"conditions.":[77],"The":[78,195,213],"developed":[81],"modeled":[84],"with":[85,240],"equation":[87],"models":[88,99],"(SEMs),":[89],"makes":[91],"it":[92,108],"possible":[93],"incorporate":[95],"perturbations":[97],"into":[98],"improve":[101],"inference":[103,190],"accuracy,":[104],"so":[105],"name":[107],"BFDSEM.":[109],"Different":[110],"naive":[113],"approaches":[114],"that":[115,139,166,198],"separately":[116],"pair-wise":[118],"identify":[121],"GRNs,":[127],"first":[129],"re-parameterize":[130],"SEMs":[133],"form":[135],"an":[136],"integrated":[137],"model":[138,155],"takes":[140],"full":[141],"advantage":[142],"groups":[146],"data,":[149],"then":[151],"solve":[152],"re-parameterized":[154],"by":[156],"developing":[157],"novel":[159],"fused":[161],"prior":[162],"following":[163],"criterion":[165],"separate":[167],"GRN":[171,234,237],"are":[172,178,238],"sparse.":[174],"CONCLUSIONS:":[175],"Computer":[176],"simulations":[177],"run":[179],"on":[180],"synthetic":[181],"compare":[184],"BFDSEM":[185,202,214,251],"state-of-the-art":[188],"joint":[189],"algorithms:":[191],"FSSEM":[192],"ReDNet.":[194,212],"demonstrate":[197],"performance":[200],"comparable":[204],"FSSEM,":[206],"generally":[209],"better":[210],"than":[211],"also":[217],"applied":[218],"real":[221],"lung":[225],"cancer":[226],"adjacent":[228],"normal":[229,233],"tissues,":[230],"yielded":[232],"consistent":[239],"reported":[242],"previous":[245],"literatures.":[246],"An":[247],"open-source":[248],"program":[249],"implementing":[250],"freely":[253],"available":[254],"Additional":[256],"file":[257],"1.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}
