{"id":"https://openalex.org/W2993199494","doi":"https://doi.org/10.1186/s12859-019-3290-7","title":"An improved random forest-based computational model for predicting novel miRNA-disease associations","display_name":"An improved random forest-based computational model for predicting novel miRNA-disease associations","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2993199494","doi":"https://doi.org/10.1186/s12859-019-3290-7","mag":"2993199494","pmid":"https://pubmed.ncbi.nlm.nih.gov/31795954"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-3290-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3290-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3290-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3290-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006789705","display_name":"Dengju Yao","orcid":"https://orcid.org/0000-0002-4974-3054"},"institutions":[{"id":"https://openalex.org/I100188998","display_name":"Harbin University of Science and Technology","ror":"https://ror.org/04e6y1282","country_code":"CN","type":"education","lineage":["https://openalex.org/I100188998"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dengju Yao","raw_affiliation_strings":["School of Software and Microelectronics, Harbin University of Science and Technology, Harbin, 150080, China. ydkvictory@hrbust.edu.cn","School of Software and Microelectronics, Harbin University of Science and Technology, Harbin, 150080, China"],"raw_orcid":"https://orcid.org/0000-0002-4974-3054","affiliations":[{"raw_affiliation_string":"School of Software and Microelectronics, Harbin University of Science and Technology, Harbin, 150080, China. ydkvictory@hrbust.edu.cn","institution_ids":["https://openalex.org/I100188998"]},{"raw_affiliation_string":"School of Software and Microelectronics, Harbin University of Science and Technology, Harbin, 150080, China","institution_ids":["https://openalex.org/I100188998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109549118","display_name":"Xiaojuan Zhan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210161462","display_name":"Heilongjiang Institute of Technology","ror":"https://ror.org/05x0m9n95","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210161462"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojuan Zhan","raw_affiliation_strings":["College of Computer Science and Technology, Heilongjiang Institute of Technology, Harbin, 150050, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Heilongjiang Institute of Technology, Harbin, 150050, China","institution_ids":["https://openalex.org/I4210161462"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112553040","display_name":"Chee-Keong Kwoh","orcid":null},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Chee-Keong Kwoh","raw_affiliation_strings":["School of Computer Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Nanyang Technological University, Singapore, 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006789705"],"corresponding_institution_ids":["https://openalex.org/I100188998"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.7814,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.9144613,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"624","last_page":"624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9666000008583069,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9666000008583069,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.7607924938201904},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.7189265489578247},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.573456346988678},{"id":"https://openalex.org/keywords/semantic-similarity","display_name":"Semantic similarity","score":0.5533063411712646},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5189409255981445},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.4969682991504669},{"id":"https://openalex.org/keywords/cross-validation","display_name":"Cross-validation","score":0.48167407512664795},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4775453507900238},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4677000045776367},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.459097683429718},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4451201260089874},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3709715008735657},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.367353618144989},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3465026617050171},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26954221725463867},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2485046088695526},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21126630902290344},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1840164065361023},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1403414011001587},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10164368152618408},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09464097023010254}],"concepts":[{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.7607924938201904},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.7189265489578247},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.573456346988678},{"id":"https://openalex.org/C130318100","wikidata":"https://www.wikidata.org/wiki/Q2268914","display_name":"Semantic similarity","level":2,"score":0.5533063411712646},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5189409255981445},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.4969682991504669},{"id":"https://openalex.org/C27181475","wikidata":"https://www.wikidata.org/wiki/Q541014","display_name":"Cross-validation","level":2,"score":0.48167407512664795},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4775453507900238},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4677000045776367},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.459097683429718},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4451201260089874},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3709715008735657},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.367353618144989},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3465026617050171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26954221725463867},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2485046088695526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21126630902290344},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1840164065361023},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1403414011001587},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10164368152618408},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09464097023010254},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-019-3290-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3290-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3290-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31795954","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31795954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:2ca551a1f9144d939285710864573631","is_oa":true,"landing_page_url":"https://doaj.org/article/2ca551a1f9144d939285710864573631","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss 1, Pp 1-14 (2019)","raw_type":"article"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/142190","is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/142190","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6889672","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6889672","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-3290-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3290-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3290-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.7599999904632568,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G7857513147","display_name":null,"funder_award_id":"2017RAQXJ027","funder_id":"https://openalex.org/F4320326687","funder_display_name":"Harbin Science and Technology Bureau"}],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320326687","display_name":"Harbin Science and Technology Bureau","ror":"https://ror.org/03qdcb993"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2993199494.pdf","grobid_xml":"https://content.openalex.org/works/W2993199494.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W90362830","https://openalex.org/W144423133","https://openalex.org/W1436642346","https://openalex.org/W1744683414","https://openalex.org/W1967087625","https://openalex.org/W1988925753","https://openalex.org/W2014578524","https://openalex.org/W2022732522","https://openalex.org/W2027744584","https://openalex.org/W2042757100","https://openalex.org/W2075860675","https://openalex.org/W2086809547","https://openalex.org/W2090335107","https://openalex.org/W2096003689","https://openalex.org/W2106029302","https://openalex.org/W2110234420","https://openalex.org/W2117019857","https://openalex.org/W2126619650","https://openalex.org/W2129158737","https://openalex.org/W2132694427","https://openalex.org/W2138664009","https://openalex.org/W2141222510","https://openalex.org/W2142937131","https://openalex.org/W2158135353","https://openalex.org/W2162674813","https://openalex.org/W2293262018","https://openalex.org/W2410390867","https://openalex.org/W2416873003","https://openalex.org/W2463737032","https://openalex.org/W2511620854","https://openalex.org/W2550129889","https://openalex.org/W2607159126","https://openalex.org/W2765950793","https://openalex.org/W2780584018","https://openalex.org/W2780777007","https://openalex.org/W2799307902","https://openalex.org/W2802314916","https://openalex.org/W2809363952","https://openalex.org/W2887745561","https://openalex.org/W2888358121","https://openalex.org/W2895927009","https://openalex.org/W2902435726","https://openalex.org/W2911964244","https://openalex.org/W2929491112","https://openalex.org/W2942820662","https://openalex.org/W2947781475","https://openalex.org/W2950834624","https://openalex.org/W2953610552","https://openalex.org/W2960158858","https://openalex.org/W2962928958","https://openalex.org/W2977393556","https://openalex.org/W2990147123","https://openalex.org/W3012496267","https://openalex.org/W3099000562","https://openalex.org/W3146565636","https://openalex.org/W4246271082","https://openalex.org/W6754405563"],"related_works":["https://openalex.org/W4386259002","https://openalex.org/W1546989560","https://openalex.org/W4388745254","https://openalex.org/W2980082554","https://openalex.org/W2767419625","https://openalex.org/W2389704471","https://openalex.org/W1517228774","https://openalex.org/W2117019857","https://openalex.org/W2000473249","https://openalex.org/W2791534013"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"large":[2],"body":[3],"of":[4,12,22,40,45,49,52,77,99,105,121,129,136,142,193,210,233,282,330],"evidence":[5],"shows":[6],"that":[7,272,308],"miRNA":[8,23],"regulates":[9],"the":[10,20,38,41,50,75,96,102,111,123,133,139,153,159,168,184,189,207,227,283,294,298,327,337],"expression":[11],"its":[13],"target":[14],"genes":[15],"at":[16],"post-transcriptional":[17],"level":[18],"and":[19,43,54,69,101,114,126,138,167,242,248,268,278,304,317,321],"dysregulation":[21],"is":[24,35,310],"related":[25],"to":[26,37,146,197,202,205,225],"many":[27],"complex":[28,333],"human":[29,334],"diseases.":[30,46],"Accurately":[31],"discovering":[32],"disease-related":[33],"miRNAs":[34,106,143,287,331],"conductive":[36],"exploring":[39],"pathogenesis":[42],"treatment":[44],"However,":[47],"because":[48],"limitation":[51],"time-consuming":[53],"expensive":[55],"experimental":[56,295,324],"methods,":[57],"predicting":[58,258],"miRNA-disease":[59,92,149,154,171,212,229,259,313],"associations":[60,93],"by":[61,74,109,289,293],"computational":[62,83],"models":[63,256],"has":[64],"become":[65],"a":[66,215],"more":[67,199],"economical":[68],"effective":[70],"mean.":[71],"RESULTS:":[72],"Inspired":[73],"work":[76],"predecessors,":[78],"we":[79],"proposed":[80],"an":[81,311],"improved":[82],"model":[84,218],"based":[85,187],"on":[86,188,221,264,326],"random":[87],"forest":[88],"(RF)":[89],"for":[90,257,323],"identifying":[91],"(IRFMDA).":[94],"First,":[95],"integrated":[97,103,134,140],"similarity":[98,104,113,120,125,128,135,141],"diseases":[100,137,335],"were":[107,144,163,179,251,291],"calculated":[108],"combining":[110],"semantic":[112],"Gaussian":[115],"interaction":[116],"profile":[117],"kernel":[118],"(GIPK)":[119],"diseases,":[122],"functional":[124],"GIPK":[127],"miRNAs,":[130],"respectively.":[131],"Then,":[132],"combined":[145],"represent":[147,203],"each":[148],"relationship":[150,155,172],"pair.":[151],"Next,":[152,183],"pairs":[156,173],"contained":[157],"in":[158,176,297,332,336],"HMDD":[160,177],"(v2.0)":[161,178,300],"database":[162],"considered":[164,180],"positive":[165],"samples,":[166],"randomly":[169],"constructed":[170],"not":[174],"included":[175],"negative":[181],"samples.":[182],"feature":[185],"selection":[186],"variable":[190],"importance":[191],"score":[192,226],"RF":[194,216],"was":[195,219],"performed":[196],"choose":[198],"useful":[200],"features":[201],"samples":[204],"optimize":[206],"model's":[208],"ability":[209],"inferring":[211],"associations.":[213,230,260],"Finally,":[214],"regression":[217],"trained":[220],"reduced":[222],"sample":[223],"space":[224],"unknown":[228],"The":[231],"AUCs":[232],"IRFMDA":[234,290,309],"under":[235],"local":[236],"leave-one-out":[237],"cross-validation":[238,244],"(LOOCV),":[239],"global":[240],"LOOCV":[241],"5-fold":[243],"achieved":[245],"0.8728,":[246],"0.9398":[247],"0.9363,":[249],"which":[250],"better":[252],"than":[253],"several":[254],"excellent":[255,312],"Moreover,":[261],"case":[262,305],"studies":[263,306,325],"oesophageal":[265],"cancer,":[266],"lymphoma":[267],"lung":[269],"cancer":[270],"showed":[271],"94":[273],"(oesophageal":[274],"cancer),":[275],"98":[276],"(lymphoma)":[277],"100":[279,285],"(lung":[280],"cancer)":[281],"top":[284],"disease-associated":[286],"predicted":[288],"supported":[292],"data":[296],"dbDEMC":[299],"database.":[301],"CONCLUSIONS:":[302],"Cross-validation":[303],"demonstrated":[307],"association":[314],"prediction":[315],"model,":[316],"can":[318],"provide":[319],"guidance":[320],"help":[322],"regulatory":[328],"mechanism":[329],"future.":[338]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}