{"id":"https://openalex.org/W2990610837","doi":"https://doi.org/10.1186/s12859-019-3078-9","title":"A disease-related gene mining method based on weakly supervised learning model","display_name":"A disease-related gene mining method based on weakly supervised learning model","publication_year":2019,"publication_date":"2019-12-01","ids":{"openalex":"https://openalex.org/W2990610837","doi":"https://doi.org/10.1186/s12859-019-3078-9","mag":"2990610837"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-3078-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3078-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3078-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3078-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100399265","display_name":"Han Zhang","orcid":"https://orcid.org/0000-0001-8498-3451"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Han Zhang","raw_affiliation_strings":["College of Artificial Intelligence, Nankai University, Tongyan Road, Tianjin, 300350, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"College of Artificial Intelligence, Nankai University, Tongyan Road, Tianjin, 300350, People\u2019s Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066566727","display_name":"Xueting Huo","orcid":null},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueting Huo","raw_affiliation_strings":["College of Computer Science, Nankai University, Tongyan Road, Tianjin, 300350, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science, Nankai University, Tongyan Road, Tianjin, 300350, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106941638","display_name":"Xia Guo","orcid":"https://orcid.org/0000-0003-4889-2696"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Guo","raw_affiliation_strings":["College of Artificial Intelligence, Nankai University, Tongyan Road, Tianjin, 300350, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"College of Artificial Intelligence, Nankai University, Tongyan Road, Tianjin, 300350, People\u2019s Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008059019","display_name":"Xin Su","orcid":"https://orcid.org/0000-0001-5901-8932"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Su","raw_affiliation_strings":["College of Artificial Intelligence, Nankai University, Tongyan Road, Tianjin, 300350, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"College of Artificial Intelligence, Nankai University, Tongyan Road, Tianjin, 300350, People\u2019s Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082071336","display_name":"Xiongwen Quan","orcid":"https://orcid.org/0000-0003-4138-4365"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiongwen Quan","raw_affiliation_strings":["College of Artificial Intelligence, Nankai University, Tongyan Road, Tianjin, 300350, People\u2019s Republic of China"],"affiliations":[{"raw_affiliation_string":"College of Artificial Intelligence, Nankai University, Tongyan Road, Tianjin, 300350, People\u2019s Republic of China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102005712","display_name":"Chen Jin","orcid":"https://orcid.org/0000-0002-4918-8804"},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Jin","raw_affiliation_strings":["College of Computer Science, Nankai University, Tongyan Road, Tianjin, 300350, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science, Nankai University, Tongyan Road, Tianjin, 300350, China","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100399265"],"corresponding_institution_ids":["https://openalex.org/I205237279"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.2577,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.57442264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"20","issue":"S16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6670705676078796},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5925047397613525},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48594653606414795},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4375174343585968},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42086875438690186},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3685557246208191},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36099618673324585},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35385873913764954},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3429664373397827},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3257494568824768},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2763044238090515},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20983976125717163},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16622605919837952}],"concepts":[{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6670705676078796},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5925047397613525},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48594653606414795},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4375174343585968},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42086875438690186},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3685557246208191},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36099618673324585},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35385873913764954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3429664373397827},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3257494568824768},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2763044238090515},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20983976125717163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16622605919837952},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s12859-019-3078-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3078-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3078-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:21bdf38c35494691be22f286bc4ad6fb","is_oa":true,"landing_page_url":"https://doaj.org/article/21bdf38c35494691be22f286bc4ad6fb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss S16, Pp 1-11 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6886251","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6886251","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-3078-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3078-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3078-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3556308910","display_name":null,"funder_award_id":"61973174","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6016289018","display_name":null,"funder_award_id":"31728013","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8863666567","display_name":null,"funder_award_id":"and No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2990610837.pdf","grobid_xml":"https://content.openalex.org/works/W2990610837.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1506078357","https://openalex.org/W1907754837","https://openalex.org/W1969198379","https://openalex.org/W1976526581","https://openalex.org/W2034328688","https://openalex.org/W2041124103","https://openalex.org/W2047317044","https://openalex.org/W2061603842","https://openalex.org/W2072970553","https://openalex.org/W2074414424","https://openalex.org/W2090538957","https://openalex.org/W2107683509","https://openalex.org/W2125283600","https://openalex.org/W2141624157","https://openalex.org/W2141826465","https://openalex.org/W2143426320","https://openalex.org/W2143840439","https://openalex.org/W2148139839","https://openalex.org/W2165250079","https://openalex.org/W2172215633","https://openalex.org/W2274495055","https://openalex.org/W2344681634","https://openalex.org/W2743340671","https://openalex.org/W2768348081","https://openalex.org/W3021353408","https://openalex.org/W4249279051","https://openalex.org/W4253551305"],"related_works":["https://openalex.org/W2415545834","https://openalex.org/W2069695727","https://openalex.org/W2961085424","https://openalex.org/W1802639773","https://openalex.org/W2118505788","https://openalex.org/W4254166511","https://openalex.org/W2150084125","https://openalex.org/W1542823905","https://openalex.org/W1490878237","https://openalex.org/W2990314835"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Predicting":[2],"disease-related":[3,55,61,132,191,205,223],"genes":[4,28,52,86,133,178],"is":[5,77,112,121],"helpful":[6],"for":[7,26],"understanding":[8],"the":[9,13,17,31,44,67,83,91,97,99,109,126,135,148,158,162,170,176,185,189,204,211,219,222],"disease":[10,18,32,45,110,165],"pathology":[11],"and":[12,47,101,123,188],"molecular":[14],"mechanisms":[15],"during":[16],"progression.":[19],"However,":[20],"traditional":[21],"methods":[22],"are":[23,36,53,87],"not":[24],"suitable":[25],"screening":[27],"related":[29],"to":[30,169],"development,":[33],"because":[34],"there":[35],"some":[37],"samples":[38],"with":[39,227],"weak":[40,102],"label":[41,103],"information":[42,104,193],"in":[43,72,134,184],"dataset":[46,168],"a":[48,60],"small":[49],"number":[50],"of":[51,108,161,221],"known":[54,190],"genes.":[56],"Results":[57],"We":[58],"designed":[59],"gene":[62,119,139,166,192,206,224],"mining":[63,207],"method":[64,76,208],"based":[65,89,146,209],"on":[66,90,147,210],"weakly":[68,92,212],"supervised":[69,93,213],"learning":[70,94,214],"model":[71,215],"this":[73],"paper.":[74],"The":[75,115,152,173,199],"separated":[78],"into":[79],"two":[80,177],"steps.":[81],"Firstly,":[82],"differentially":[84,117,137],"expressed":[85,118,138],"screened":[88],"model.":[95],"In":[96],"model,":[98],"strong":[100],"at":[105],"different":[106],"stages":[107],"progression":[111],"fully":[113],"utilized.":[114],"obtained":[116,136],"set":[120,140],"stable":[122],"complete":[124],"after":[125],"algorithm":[127],"converges.":[128],"Then,":[129],"we":[130],"screen":[131],"using":[141],"transductive":[142],"support":[143],"vector":[144],"machine":[145],"difference":[149,153,171,186],"kernel":[150,154],"function.":[151],"function":[155],"can":[156,179,194,216],"map":[157],"input":[159],"space":[160,187],"original":[163],"Huntington\u2019s":[164],"expression":[167],"space.":[172],"relation":[174],"between":[175],"be":[180,195],"evaluated":[181],"more":[182],"accurately":[183],"used":[196],"effectively.":[197],"Conclusions":[198],"experimental":[200],"results":[201],"show":[202],"that":[203],"effectively":[217],"improve":[218],"precision":[220],"prediction":[225],"compared":[226],"other":[228],"excellent":[229],"methods.":[230]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}