{"id":"https://openalex.org/W2971188062","doi":"https://doi.org/10.1186/s12859-019-3041-9","title":"Analyzing the regulation of miRNAs on protein-protein interaction network in Hodgkin lymphoma","display_name":"Analyzing the regulation of miRNAs on protein-protein interaction network in Hodgkin lymphoma","publication_year":2019,"publication_date":"2019-09-02","ids":{"openalex":"https://openalex.org/W2971188062","doi":"https://doi.org/10.1186/s12859-019-3041-9","mag":"2971188062","pmid":"https://pubmed.ncbi.nlm.nih.gov/31477006"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-3041-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3041-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3041-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3041-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070886126","display_name":"Huimin Lei","orcid":null},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Lei","raw_affiliation_strings":["School of Biomedical Engineering, Tianjin Medical University, Tianjin, China","School of Continuation Education, Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"School of Continuation Education, Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013931083","display_name":"Wenxu Liu","orcid":"https://orcid.org/0000-0002-1647-9162"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenxu Liu","raw_affiliation_strings":["School of Biomedical Engineering, Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039725645","display_name":"Jiarui Si","orcid":null},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiarui Si","raw_affiliation_strings":["School of Basic Medicine, Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100648233","display_name":"Ju Wang","orcid":"https://orcid.org/0000-0002-6514-0923"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ju Wang","raw_affiliation_strings":["School of Biomedical Engineering, Tianjin Medical University, Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":null,"display_name":"Tao Zhang","orcid":"https://orcid.org/0000-0003-3414-7820"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tao Zhang","raw_affiliation_strings":["School of Biomedical Engineering, Tianjin Medical University, Tianjin, China. zhangtao@tijmu.edu.cn","School of Biomedical Engineering, Tianjin Medical University, Tianjin, China"],"raw_orcid":"https://orcid.org/0000-0003-3414-7820","affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Tianjin Medical University, Tianjin, China. zhangtao@tijmu.edu.cn","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"School of Biomedical Engineering, Tianjin Medical University, Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5740404"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.171,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53042562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"20","issue":"1","first_page":"449","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.396699994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.396699994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.10450000315904617,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6767073273658752},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6600598096847534},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5232564210891724},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5143066644668579},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4854736626148224},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4572971761226654},{"id":"https://openalex.org/keywords/lymphoma","display_name":"Lymphoma","score":0.4552934467792511},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.42247602343559265},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36726605892181396},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24672240018844604},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.231876403093338},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.20080292224884033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1505214273929596},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.14366596937179565},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.07020291686058044}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6767073273658752},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6600598096847534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5232564210891724},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5143066644668579},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4854736626148224},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4572971761226654},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4552934467792511},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.42247602343559265},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36726605892181396},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24672240018844604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.231876403093338},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20080292224884033},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1505214273929596},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14366596937179565},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07020291686058044}],"mesh":[{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-019-3041-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3041-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3041-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31477006","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31477006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:723844f4fee2444eb022c1a2211e4167","is_oa":true,"landing_page_url":"https://doaj.org/article/723844f4fee2444eb022c1a2211e4167","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss 1, Pp 1-13 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6720096","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6720096","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-3041-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3041-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3041-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6100000143051147,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G4971374813","display_name":null,"funder_award_id":"2017M621092","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G5731123307","display_name":null,"funder_award_id":"2013M530878","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2971188062.pdf","grobid_xml":"https://content.openalex.org/works/W2971188062.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W955243042","https://openalex.org/W1538151223","https://openalex.org/W1598357174","https://openalex.org/W1648301895","https://openalex.org/W1713341164","https://openalex.org/W1974254202","https://openalex.org/W1978077008","https://openalex.org/W1988163167","https://openalex.org/W1988587254","https://openalex.org/W1994801733","https://openalex.org/W1994900589","https://openalex.org/W2002561873","https://openalex.org/W2008620264","https://openalex.org/W2014510325","https://openalex.org/W2023833090","https://openalex.org/W2024544530","https://openalex.org/W2042244373","https://openalex.org/W2042742026","https://openalex.org/W2051960497","https://openalex.org/W2058539819","https://openalex.org/W2062533676","https://openalex.org/W2062548737","https://openalex.org/W2066712944","https://openalex.org/W2069295843","https://openalex.org/W2072034250","https://openalex.org/W2072602645","https://openalex.org/W2081931663","https://openalex.org/W2090247362","https://openalex.org/W2092310019","https://openalex.org/W2095867585","https://openalex.org/W2101181377","https://openalex.org/W2105493915","https://openalex.org/W2106750766","https://openalex.org/W2108296098","https://openalex.org/W2110541531","https://openalex.org/W2116075981","https://openalex.org/W2120228756","https://openalex.org/W2122863289","https://openalex.org/W2132582966","https://openalex.org/W2137734450","https://openalex.org/W2142674442","https://openalex.org/W2145361279","https://openalex.org/W2150066952","https://openalex.org/W2155589321","https://openalex.org/W2156737316","https://openalex.org/W2157869647","https://openalex.org/W2165253681","https://openalex.org/W2258129851","https://openalex.org/W2332076714","https://openalex.org/W2411950200","https://openalex.org/W2501330374","https://openalex.org/W2587471612","https://openalex.org/W2620486423","https://openalex.org/W2767546566","https://openalex.org/W2770983033","https://openalex.org/W2915536738","https://openalex.org/W3146565636"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W4386628104","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W2509687359","https://openalex.org/W4206945140","https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W2156421048"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hodgkin":[1],"Lymphoma":[2],"(HL)":[3],"is":[4,57,290],"a":[5,83,106,112,204],"type":[6],"of":[7,23,39,114,121,164,181,187,198,212,262,287,295,309,326,347],"aggressive":[8],"malignancy":[9],"in":[10,16,301],"lymphoma":[11],"that":[12,229,284],"has":[13],"high":[14],"incidence":[15],"young":[17],"adults":[18],"and":[19,27,37,66,100,130,151,177,195,224,256,267],"elderly":[20],"patients.":[21],"Identification":[22],"reliable":[24],"diagnostic":[25,325],"markers":[26],"efficient":[28],"therapeutic":[29],"targets":[30,104],"are":[31,233],"especially":[32],"important":[33],"for":[34,324],"the":[35,51,55,73,93,98,119,128,132,161,165,171,193,210,219,230,246,260,285,291,298,302,307,321],"diagnosis":[36],"treatment":[38],"HL.":[40,136,279,327,348],"Although":[41],"many":[42],"HL-related":[43,166,222,231],"molecules":[44],"have":[45,315,332],"been":[46,333],"identified,":[47],"our":[48],"understanding":[49],"on":[50,118,174,214,297,311],"molecular":[52,74,94,133],"mechanisms":[53,75,95,134],"underlying":[54,76,135,345],"disease":[56,99],"still":[58],"far":[59],"from":[60,105],"complete":[61],"due":[62],"to":[63,91,97,126,216,236,242,306,335],"its":[64],"complex":[65],"heterogeneous":[67],"characteristics.":[68],"In":[69,86,280],"such":[70],"situation,":[71],"exploring":[72],"HL":[77],"via":[78],"systems":[79],"biology":[80],"approaches":[81],"provides":[82,341],"promising":[84],"option.":[85],"this":[87],"study,":[88],"we":[89,124,138,159,169,202,282,314],"try":[90],"elucidate":[92,131],"related":[96,143],"identify":[101,127],"potential":[102,322],"pharmaceutical":[103],"network-based":[107],"perspective.":[108],"RESULTS:":[109],"We":[110,227],"constructed":[111,203],"series":[113],"network":[115,150,176,207,248,264,300],"models.":[116],"Based":[117],"analysis":[120],"these":[122,156,269],"networks,":[123,145,158],"attempted":[125],"biomarkers":[129,323],"Initially,":[137],"built":[139],"three":[140,157,179],"different":[141],"but":[142],"protein":[144,188,206,288,299,312,330],"i.e.,":[146,185],"background":[147],"network,":[148,313],"HL-basic":[149],"HL-specific":[152,175,247,263,303],"network.":[153,304],"By":[154],"analyzing":[155],"investigated":[160],"connection":[162],"characteristic":[163],"proteins.":[167,200,244],"Subsequently,":[168],"explored":[170],"miRNA":[172,310],"regulation":[173,183,197,211,308],"analyzed":[178],"kinds":[180],"simple":[182],"patterns,":[184],"co-regulation":[186,286],"pairs,":[189],"as":[190,192,259,320],"well":[191],"direct":[194],"indirect":[196],"triple":[199],"Finally,":[201,328],"simplified":[205],"combined":[208],"with":[209,238,278,338],"miRNAs":[213,296,319],"proteins":[215,223,232,258],"better":[217],"understand":[218],"relation":[220],"between":[221],"miRNAs.":[225],"CONCLUSIONS:":[226],"find":[228,283],"more":[234],"likely":[235],"connect":[237,268],"each":[239],"other":[240,243],"compared":[241],"Moreover,":[245],"can":[249],"be":[250,275],"further":[251],"divided":[252],"into":[253,344],"five":[254],"sub-networks":[255],"49":[257],"backbone":[261],"make":[265],"up":[266],"5":[270,317],"sub-networks.":[271],"Thus,":[272],"they":[273],"may":[274],"closely":[276,336],"associated":[277,337],"addition,":[281],"pairs":[289],"main":[292],"regulatory":[293],"pattern":[294],"According":[305],"identified":[316,334],"core":[318],"several":[329],"pathways":[331],"HL,":[339],"which":[340],"deep":[342],"insights":[343],"mechanism":[346]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}