{"id":"https://openalex.org/W2972737141","doi":"https://doi.org/10.1186/s12859-019-3037-5","title":"Towards pixel-to-pixel deep nucleus detection in microscopy images","display_name":"Towards pixel-to-pixel deep nucleus detection in microscopy images","publication_year":2019,"publication_date":"2019-09-14","ids":{"openalex":"https://openalex.org/W2972737141","doi":"https://doi.org/10.1186/s12859-019-3037-5","mag":"2972737141","pmid":"https://pubmed.ncbi.nlm.nih.gov/31521104"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-3037-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3037-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3037-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3037-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076917512","display_name":"Fuyong Xing","orcid":"https://orcid.org/0000-0003-0982-8675"},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz Medical Campus","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fuyong Xing","raw_affiliation_strings":["Department of Biostatistics and Informatics, and the Data Science to Patient Value initiative, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, Colorado, 80045, United States. fuyong.xing@ucdenver.edu","Department of Biostatistics and Informatics, and the Data Science to Patient Value initiative, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, Colorado, 80045, United States"],"raw_orcid":"https://orcid.org/0000-0003-0982-8675","affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Informatics, and the Data Science to Patient Value initiative, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, Colorado, 80045, United States. fuyong.xing@ucdenver.edu","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Department of Biostatistics and Informatics, and the Data Science to Patient Value initiative, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, Colorado, 80045, United States","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108557537","display_name":"Yuanpu Xie","orcid":null},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanpu Xie","raw_affiliation_strings":["J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, Florida, 32611, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, Florida, 32611, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069008709","display_name":"Xiaoshuang Shi","orcid":"https://orcid.org/0000-0003-4934-0850"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoshuang Shi","raw_affiliation_strings":["J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, Florida, 32611, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, Florida, 32611, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045480484","display_name":"Pingjun Chen","orcid":"https://orcid.org/0000-0003-0528-1713"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pingjun Chen","raw_affiliation_strings":["J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, Florida, 32611, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, Florida, 32611, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101566830","display_name":"Zizhao Zhang","orcid":"https://orcid.org/0000-0002-6754-5123"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zizhao Zhang","raw_affiliation_strings":["Department of Computer and Information Science and Engineering, University of Florida, 432 Newell Drive, Gainesville, Florida, 32611, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science and Engineering, University of Florida, 432 Newell Drive, Gainesville, Florida, 32611, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101725247","display_name":"Lin Yang","orcid":"https://orcid.org/0000-0002-7615-209X"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Yang","raw_affiliation_strings":["Department of Computer and Information Science and Engineering, University of Florida, 432 Newell Drive, Gainesville, Florida, 32611, United States","J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, Florida, 32611, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer and Information Science and Engineering, University of Florida, 432 Newell Drive, Gainesville, Florida, 32611, United States","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Drive, Gainesville, Florida, 32611, United States","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5076917512"],"corresponding_institution_ids":["https://openalex.org/I51713134"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.3526,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.95534496,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"472","last_page":"472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.4307999908924103,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.4307999908924103,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.41760000586509705,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.7774807214736938},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7760133743286133},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.7592391967773438},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7255914807319641},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"Digital pathology","score":0.6579961180686951},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.57682204246521},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.5754684805870056},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5088882446289062},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.4468494653701782},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4205828607082367},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15596610307693481},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08406069874763489}],"concepts":[{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.7774807214736938},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7760133743286133},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.7592391967773438},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7255914807319641},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.6579961180686951},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.57682204246521},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.5754684805870056},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5088882446289062},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.4468494653701782},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4205828607082367},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15596610307693481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08406069874763489}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-019-3037-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3037-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3037-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31521104","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31521104","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a5b9c51379f740aeb1b2ffd06d10d9ca","is_oa":true,"landing_page_url":"https://doaj.org/article/a5b9c51379f740aeb1b2ffd06d10d9ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss 1, Pp 1-16 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6744696","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6744696","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-3037-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-3037-5","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3037-5","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7149443843","display_name":null,"funder_award_id":"R21CA237493","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2972737141.pdf","grobid_xml":"https://content.openalex.org/works/W2972737141.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W22040386","https://openalex.org/W1591008324","https://openalex.org/W1608218651","https://openalex.org/W1836465849","https://openalex.org/W1849277567","https://openalex.org/W1901129140","https://openalex.org/W1903029394","https://openalex.org/W1946635378","https://openalex.org/W2051765910","https://openalex.org/W2062118960","https://openalex.org/W2064512348","https://openalex.org/W2095705004","https://openalex.org/W2102605133","https://openalex.org/W2103243046","https://openalex.org/W2105739910","https://openalex.org/W2112796928","https://openalex.org/W2117539524","https://openalex.org/W2118255421","https://openalex.org/W2130306094","https://openalex.org/W2151608510","https://openalex.org/W2155541015","https://openalex.org/W2156472837","https://openalex.org/W2176412452","https://openalex.org/W2194775991","https://openalex.org/W2222512263","https://openalex.org/W2248620004","https://openalex.org/W2253429366","https://openalex.org/W2280351290","https://openalex.org/W2293083603","https://openalex.org/W2294643827","https://openalex.org/W2304648132","https://openalex.org/W2312404985","https://openalex.org/W2339885376","https://openalex.org/W2344654247","https://openalex.org/W2344912502","https://openalex.org/W2345010043","https://openalex.org/W2346062110","https://openalex.org/W2347064614","https://openalex.org/W2395611524","https://openalex.org/W2398921440","https://openalex.org/W2399832387","https://openalex.org/W2403358744","https://openalex.org/W2406638278","https://openalex.org/W2462651598","https://openalex.org/W2525036370","https://openalex.org/W2525606708","https://openalex.org/W2526712471","https://openalex.org/W2533800772","https://openalex.org/W2559756885","https://openalex.org/W2560920277","https://openalex.org/W2561675875","https://openalex.org/W2581082771","https://openalex.org/W2592905743","https://openalex.org/W2592929672","https://openalex.org/W2593492371","https://openalex.org/W2619094550","https://openalex.org/W2620591646","https://openalex.org/W2738582428","https://openalex.org/W2752098086","https://openalex.org/W2759818938","https://openalex.org/W2768673271","https://openalex.org/W2769502140","https://openalex.org/W2811126861","https://openalex.org/W2886175403","https://openalex.org/W2896018297","https://openalex.org/W2919115771","https://openalex.org/W2945807221","https://openalex.org/W2962835968","https://openalex.org/W2963803174","https://openalex.org/W2963840026"],"related_works":["https://openalex.org/W1975767702","https://openalex.org/W4293226380","https://openalex.org/W4226493464","https://openalex.org/W4312417841","https://openalex.org/W3193565141","https://openalex.org/W3133861977","https://openalex.org/W2951211570","https://openalex.org/W3167935049","https://openalex.org/W3103566983","https://openalex.org/W3029198973"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nucleus":[1],"is":[2],"a":[3,29,108,119,154,211,225,236,259,270,299],"fundamental":[4],"task":[5],"in":[6,36,48,269,311,326],"microscopy":[7,49,65,82,112,134,274,327],"image":[8,34,66,113,135],"analysis":[9,317],"and":[10,60,75,125,133,145,187,203,229,242,287,297,318],"supports":[11],"many":[12],"other":[13,64],"quantitative":[14],"studies":[15,72],"such":[16],"as":[17,28],"object":[18],"counting,":[19],"segmentation,":[20],"tracking,":[21],"etc.":[22],"Deep":[23],"neural":[24,39,78],"networks":[25,40,79],"are":[26,55,86],"emerging":[27],"powerful":[30],"tool":[31],"for":[32,57,104,153,171,266],"biomedical":[33],"computing;":[35],"particular,":[37],"convolutional":[38,121,294],"have":[41,307],"been":[42,309],"widely":[43],"applied":[44],"to":[45,63,92,182,208,252,277,323],"nucleus/cell":[46],"detection":[47,106,268,325],"images.":[50,328],"However,":[51],"almost":[52],"all":[53],"models":[54,102,191,265],"tailored":[56],"specific":[58,155],"datasets":[59],"their":[61],"applicability":[62,99],"data":[67,231,247],"remains":[68],"unknown.":[69],"Some":[70],"existing":[71],"casually":[73],"learn":[74],"evaluate":[76,127,289],"deep":[77,101,190,264],"on":[80,129,210,263],"multiple":[81,148],"datasets,":[83,136],"but":[84,281],"there":[85],"still":[87],"several":[88,279],"critical,":[89],"open":[90],"questions":[91],"be":[93,168,178,209,321],"addressed.":[94],"RESULTS:":[95],"We":[96,150,219,257,285],"analyze":[97],"the":[98,162,175,183],"of":[100,111,139,165,227,239,273,304],"specifically":[103],"nucleus":[105,172,240,267,324],"across":[107],"wide":[109,271],"variety":[110,272],"data.":[114,218],"More":[115],"specifically,":[116],"we":[117],"present":[118,286],"fully":[120,293],"network-based":[122],"regression":[123,295],"model":[124,206,250,315],"extensively":[126,288],"it":[128,243],"large-scale":[130],"digital":[131],"pathology":[132],"which":[137,305],"consist":[138],"23":[140],"organs":[141,166,197],"(or":[142],"cancer":[143],"diseases)":[144],"come":[146],"from":[147,161,195],"institutions.":[149],"demonstrate":[151],"that":[152,222],"target":[156,217,228],"dataset,":[157],"training":[158,223,251],"with":[159,193,213,216,224],"images":[160,176,194],"same":[163,184],"types":[164],"might":[167,198,244,306],"usually":[169],"necessary":[170],"detection.":[173],"Although":[174],"can":[177],"visually":[179],"similar":[180],"due":[181],"staining":[185],"technique":[186],"imaging":[188],"protocol,":[189],"learned":[192],"different":[196],"not":[199,233,308],"deliver":[200],"desirable":[201],"results":[202],"would":[204,320],"require":[205,245],"fine-tuning":[207],"par":[212],"those":[214],"trained":[215],"also":[220],"observe":[221],"mixture":[226],"other/non-target":[230],"does":[232],"always":[234],"mean":[235],"higher":[237],"accuracy":[238],"detection,":[241],"proper":[246],"manipulation":[248],"during":[249],"achieve":[253],"good":[254],"performance.":[255],"CONCLUSIONS:":[256],"conduct":[258],"systematic":[260],"case":[261],"study":[262],"images,":[275],"aiming":[276],"address":[278],"important":[280],"previously":[282],"understudied":[283],"questions.":[284],"an":[290],"end-to-end,":[291],"pixel-to-pixel":[292],"network":[296],"report":[298],"few":[300],"significant":[301],"findings,":[302],"some":[303],"reported":[310],"previous":[312],"studies.":[313],"The":[314],"performance":[316],"observations":[319],"helpful":[322]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}