{"id":"https://openalex.org/W2967862655","doi":"https://doi.org/10.1186/s12859-019-2992-1","title":"Multiple-kernel learning for genomic data mining and prediction","display_name":"Multiple-kernel learning for genomic data mining and prediction","publication_year":2019,"publication_date":"2019-08-15","ids":{"openalex":"https://openalex.org/W2967862655","doi":"https://doi.org/10.1186/s12859-019-2992-1","mag":"2967862655","pmid":"https://pubmed.ncbi.nlm.nih.gov/31416413"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2992-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2992-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2992-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2992-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102743438","display_name":"Christopher M. Wilson","orcid":"https://orcid.org/0000-0002-2549-2908"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher M. Wilson","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics at Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics at Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001438573","display_name":"Kaiqiao Li","orcid":"https://orcid.org/0000-0001-8069-5639"},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaiqiao Li","raw_affiliation_strings":["Department of Applied Mathematics and Statistics at Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Statistics at Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078872209","display_name":"Xiaoqing Yu","orcid":"https://orcid.org/0000-0003-4585-9372"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqing Yu","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics at Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics at Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055070977","display_name":"Pei Fen Kuan","orcid":"https://orcid.org/0000-0001-7861-916X"},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pei-Fen Kuan","raw_affiliation_strings":["Department of Applied Mathematics and Statistics at Stony Brook University, Stony Brook, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Statistics at Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100451938","display_name":"Xuefeng Wang","orcid":"https://orcid.org/0000-0001-5775-408X"},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuefeng Wang","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics at Moffitt Cancer Center, Tampa, FL, USA. xuefeng.wang@moffitt.org","Department of Biostatistics and Bioinformatics at Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":"https://orcid.org/0000-0001-5775-408X","affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics at Moffitt Cancer Center, Tampa, FL, USA. xuefeng.wang@moffitt.org","institution_ids":["https://openalex.org/I3019308854"]},{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics at Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5102743438"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.4788,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.90095522,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"426","last_page":"426"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.5360000133514404,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.5360000133514404,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.05609999969601631,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-kernel-learning","display_name":"Multiple kernel learning","score":0.8365142941474915},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6996587514877319},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.5218542814254761},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.5140112638473511},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4392753839492798},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4225681722164154},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39540570974349976},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3763468861579895},{"id":"https://openalex.org/keywords/kernel-method","display_name":"Kernel method","score":0.3172626495361328},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21175679564476013},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.1788230836391449},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.17477557063102722},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09570559859275818}],"concepts":[{"id":"https://openalex.org/C2776879701","wikidata":"https://www.wikidata.org/wiki/Q25048660","display_name":"Multiple kernel learning","level":4,"score":0.8365142941474915},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6996587514877319},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.5218542814254761},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.5140112638473511},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4392753839492798},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4225681722164154},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39540570974349976},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3763468861579895},{"id":"https://openalex.org/C122280245","wikidata":"https://www.wikidata.org/wiki/Q620622","display_name":"Kernel method","level":3,"score":0.3172626495361328},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21175679564476013},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.1788230836391449},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17477557063102722},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09570559859275818},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-019-2992-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2992-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2992-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31416413","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31416413","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:34f2d3acce89480fa1aaa76c0bab2e70","is_oa":true,"landing_page_url":"https://doaj.org/article/34f2d3acce89480fa1aaa76c0bab2e70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss 1, Pp 1-7 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5650930","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6694479","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2992-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2992-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2992-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3293960023","display_name":null,"funder_award_id":"14-189-19","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320311073","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2967862655.pdf","grobid_xml":"https://content.openalex.org/works/W2967862655.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1505191356","https://openalex.org/W1915109052","https://openalex.org/W1976611453","https://openalex.org/W1978034558","https://openalex.org/W1981276685","https://openalex.org/W1984838032","https://openalex.org/W2054893217","https://openalex.org/W2058507142","https://openalex.org/W2104472920","https://openalex.org/W2108933868","https://openalex.org/W2118521406","https://openalex.org/W2119821739","https://openalex.org/W2122189635","https://openalex.org/W2123696077","https://openalex.org/W2134452881","https://openalex.org/W2154164391","https://openalex.org/W2157963336","https://openalex.org/W2168029744","https://openalex.org/W2176657689","https://openalex.org/W2214074259","https://openalex.org/W2623902889","https://openalex.org/W2735812438","https://openalex.org/W2748623813","https://openalex.org/W2783880833","https://openalex.org/W2796153844","https://openalex.org/W2900523370","https://openalex.org/W3101749733","https://openalex.org/W4238425072","https://openalex.org/W6680104628"],"related_works":["https://openalex.org/W2900715739","https://openalex.org/W2289496068","https://openalex.org/W2043864454","https://openalex.org/W2547116720","https://openalex.org/W2188831877","https://openalex.org/W3125885229","https://openalex.org/W4291669689","https://openalex.org/W2153379791","https://openalex.org/W2001173190","https://openalex.org/W2295320501"],"abstract_inverted_index":{"BACKGROUND:":[0],"Advances":[1],"in":[2,66,120,186],"medical":[3],"technology":[4],"have":[5],"allowed":[6],"for":[7,27,52,144,162,177,202],"customized":[8],"prognosis,":[9],"diagnosis,":[10],"and":[11,55,180],"treatment":[12],"regimens":[13],"that":[14,77,107,113],"utilize":[15],"multiple":[16,31],"heterogeneous":[17],"data":[18,34,74,95,131],"sources.":[19,35],"Multiple":[20,149],"kernel":[21,150,178],"learning":[22,151,160],"(MKL)":[23],"is":[24,199],"well":[25,138],"suited":[26],"the":[28,47,121,145,187],"integration":[29],"of":[30,49,64,96,124],"high":[32],"throughput":[33],"MKL":[36,65,78,86,108,171],"remains":[37],"to":[38,46,72,75,87,116],"be":[39],"under-utilized":[40],"by":[41],"genomic":[42,57,169],"researchers":[43],"partly":[44],"due":[45],"lack":[48],"unified":[50],"guidelines":[51],"its":[53],"use,":[54],"benchmark":[56],"datasets.":[58],"RESULTS:":[59],"We":[60,83],"provide":[61],"three":[62],"implementations":[63],"R.":[67],"These":[68],"methods":[69,184],"are":[70,114,189],"applied":[71],"simulated":[73],"illustrate":[76],"can":[79,109],"select":[80],"appropriate":[81],"models.":[82],"also":[84,172],"apply":[85],"combine":[88],"clinical":[89],"information":[90],"with":[91,153],"miRNA":[92],"gene":[93,111,129,142],"expression":[94,130],"ovarian":[97],"cancer":[98,126],"study":[99],"into":[100],"a":[101,118,158],"single":[102],"analysis.":[103],"Lastly,":[104],"we":[105],"show":[106],"identify":[110,140],"sets":[112,143],"known":[115],"play":[117],"role":[119],"prognostic":[122],"prediction":[123],"15":[125],"types":[127],"using":[128],"from":[132],"The":[133,183],"Cancer":[134],"Genome":[135],"Atlas,":[136],"as":[137,191],"as,":[139],"new":[141],"future":[146],"research.":[147],"CONCLUSION:":[148],"coupled":[152],"modern":[154],"optimization":[155],"techniques":[156],"provides":[157,173],"promising":[159],"tool":[161],"building":[163],"predictive":[164],"models":[165],"based":[166],"on":[167],"multi-source":[168],"data.":[170],"an":[174,192],"automated":[175],"scheme":[176],"prioritization":[179],"parameter":[181],"tuning.":[182],"used":[185],"paper":[188],"implemented":[190],"R":[193],"package":[194],"called":[195],"RMKL":[196],"package,":[197],"which":[198],"freely":[200],"available":[201],"download":[203],"through":[204],"CRAN":[205],"at":[206],"https://CRAN.R-project.org/package=RMKL":[207],".":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}