{"id":"https://openalex.org/W2971870835","doi":"https://doi.org/10.1186/s12859-019-2984-1","title":"Sibe: a computation tool to apply protein sequence statistics to predict folding and design in silico","display_name":"Sibe: a computation tool to apply protein sequence statistics to predict folding and design in silico","publication_year":2019,"publication_date":"2019-09-06","ids":{"openalex":"https://openalex.org/W2971870835","doi":"https://doi.org/10.1186/s12859-019-2984-1","mag":"2971870835","pmid":"https://pubmed.ncbi.nlm.nih.gov/31492097"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2984-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2984-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-019-2984-1.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12859-019-2984-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112741055","display_name":"Ngaam J. Cheung","orcid":null},"institutions":[{"id":"https://openalex.org/I193352282","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69","country_code":"KR","type":"education","lineage":["https://openalex.org/I193352282"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210096386","display_name":"Bridge University","ror":"https://ror.org/00cbm0437","country_code":"SS","type":"education","lineage":["https://openalex.org/I4210096386"]}],"countries":["GB","KR","SS"],"is_corresponding":false,"raw_author_name":"Ngaam J. Cheung","raw_affiliation_strings":["Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, CB3 0HA, UK","Department of Brain and Cognitive Science, DGIST, Daegu, 42988, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, CB3 0HA, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210096386"]},{"raw_affiliation_string":"Department of Brain and Cognitive Science, DGIST, Daegu, 42988, South Korea","institution_ids":["https://openalex.org/I193352282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047055322","display_name":"Wookyung Yu","orcid":"https://orcid.org/0000-0001-9835-930X"},"institutions":[{"id":"https://openalex.org/I193352282","display_name":"Daegu Gyeongbuk Institute of Science and Technology","ror":"https://ror.org/03frjya69","country_code":"KR","type":"education","lineage":["https://openalex.org/I193352282"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Wookyung Yu","raw_affiliation_strings":["Core Protein Resources Center, DGIST, Daegu, 42988, South Korea. wkyu@dgist.ac.kr","Department of Brain and Cognitive Science, DGIST, Daegu, 42988, South Korea. wkyu@dgist.ac.kr","Department of Brain and Cognitive Science, DGIST, Daegu, 42988, South Korea"],"raw_orcid":"https://orcid.org/0000-0001-9835-930X","affiliations":[{"raw_affiliation_string":"Core Protein Resources Center, DGIST, Daegu, 42988, South Korea. wkyu@dgist.ac.kr","institution_ids":["https://openalex.org/I193352282"]},{"raw_affiliation_string":"Department of Brain and Cognitive Science, DGIST, Daegu, 42988, South Korea. wkyu@dgist.ac.kr","institution_ids":["https://openalex.org/I193352282"]},{"raw_affiliation_string":"Department of Brain and Cognitive Science, DGIST, Daegu, 42988, South Korea","institution_ids":["https://openalex.org/I193352282"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047055322"],"corresponding_institution_ids":["https://openalex.org/I193352282"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.6839,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.6936343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"20","issue":"1","first_page":"455","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8348000049591064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8348000049591064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.020899999886751175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.6749656200408936},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6371908187866211},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6022900342941284},{"id":"https://openalex.org/keywords/protein-design","display_name":"Protein design","score":0.5514390468597412},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.522733747959137},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.5137702226638794},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4924953877925873},{"id":"https://openalex.org/keywords/rational-design","display_name":"Rational design","score":0.47800412774086},{"id":"https://openalex.org/keywords/structural-bioinformatics","display_name":"Structural bioinformatics","score":0.46422621607780457},{"id":"https://openalex.org/keywords/multiple-sequence-alignment","display_name":"Multiple sequence alignment","score":0.45666390657424927},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.4293330907821655},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.4290081262588501},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4253271222114563},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4237220883369446},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.4224906861782074},{"id":"https://openalex.org/keywords/sequence-space","display_name":"Sequence space","score":0.4179028272628784},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.3813122510910034},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3762430250644684},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.3052671551704407},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.20743650197982788},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19006574153900146},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18257775902748108},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.12382698059082031},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12210765480995178}],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.6749656200408936},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6371908187866211},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6022900342941284},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.5514390468597412},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.522733747959137},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5137702226638794},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4924953877925873},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.47800412774086},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.46422621607780457},{"id":"https://openalex.org/C88031987","wikidata":"https://www.wikidata.org/wiki/Q1377767","display_name":"Multiple sequence alignment","level":5,"score":0.45666390657424927},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.4293330907821655},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4290081262588501},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4253271222114563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4237220883369446},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4224906861782074},{"id":"https://openalex.org/C30711495","wikidata":"https://www.wikidata.org/wiki/Q289411","display_name":"Sequence space","level":3,"score":0.4179028272628784},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.3813122510910034},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3762430250644684},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3052671551704407},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.20743650197982788},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19006574153900146},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18257775902748108},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12382698059082031},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12210765480995178},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C132954091","wikidata":"https://www.wikidata.org/wiki/Q194397","display_name":"Banach space","level":2,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12859-019-2984-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2984-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-019-2984-1.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31492097","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31492097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:b0d61b9cb7a6434b87842a9621492028","is_oa":true,"landing_page_url":"https://doaj.org/article/b0d61b9cb7a6434b87842a9621492028","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6728967","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6728967","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/309954","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/309954","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.57055","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.57055","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2984-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2984-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-019-2984-1.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5799999833106995,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G7663912139","display_name":null,"funder_award_id":"N0001822","funder_id":"https://openalex.org/F4320321681","funder_display_name":"Ministry of Trade, Industry and Energy"}],"funders":[{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2971870835.pdf","grobid_xml":"https://content.openalex.org/works/W2971870835.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1538131130","https://openalex.org/W1965555277","https://openalex.org/W1969644422","https://openalex.org/W1972728295","https://openalex.org/W1974093948","https://openalex.org/W1974312616","https://openalex.org/W1976603396","https://openalex.org/W1978885914","https://openalex.org/W1979762151","https://openalex.org/W1982583124","https://openalex.org/W1987134040","https://openalex.org/W1989415425","https://openalex.org/W2008545402","https://openalex.org/W2029423438","https://openalex.org/W2043284163","https://openalex.org/W2048469982","https://openalex.org/W2053671774","https://openalex.org/W2055503200","https://openalex.org/W2061042699","https://openalex.org/W2065921821","https://openalex.org/W2092006899","https://openalex.org/W2099741732","https://openalex.org/W2102461176","https://openalex.org/W2104477830","https://openalex.org/W2121627241","https://openalex.org/W2131011986","https://openalex.org/W2131313323","https://openalex.org/W2135194391","https://openalex.org/W2137566700","https://openalex.org/W2138122982","https://openalex.org/W2151457629","https://openalex.org/W2166701319","https://openalex.org/W2199134476","https://openalex.org/W2209424705","https://openalex.org/W2226390547","https://openalex.org/W2245592118","https://openalex.org/W2345741266","https://openalex.org/W2519539312","https://openalex.org/W2574496196","https://openalex.org/W2588321446","https://openalex.org/W2601134342","https://openalex.org/W2735621019","https://openalex.org/W2742834898","https://openalex.org/W2792977793","https://openalex.org/W2883984694","https://openalex.org/W2888162369","https://openalex.org/W2918296775","https://openalex.org/W2951944072","https://openalex.org/W3102341076","https://openalex.org/W4211049762","https://openalex.org/W4248328359","https://openalex.org/W6727271100"],"related_works":["https://openalex.org/W2904811114","https://openalex.org/W2977684889","https://openalex.org/W2167707974","https://openalex.org/W1995100036","https://openalex.org/W2743276551","https://openalex.org/W4280560662","https://openalex.org/W2901595550","https://openalex.org/W4214858168","https://openalex.org/W1988730649","https://openalex.org/W1509269256"],"abstract_inverted_index":{"Evolutionary":[0],"information":[1,19],"contained":[2,20],"in":[3,21,61,70,84,96,210,274,284],"the":[4,11,22,46,143,148,183,198,265,280],"amino":[5,53,108,127],"acid":[6],"sequences":[7],"of":[8,27,49,98,222,240,307],"proteins":[9,241],"specifies":[10],"biological":[12,285],"function":[13],"and":[14,65,102,129,151,163,202,212,229,242,287,305],"fold,":[15],"but":[16,40,295],"exactly":[17],"what":[18],"protein":[23,79,82,99,132,161,208,244,258,292],"sequence":[24,293],"drives":[25],"both":[26,197],"these":[28],"processes?":[29],"Considerable":[30],"progress":[31],"has":[32,68],"been":[33],"made":[34],"to":[35,44,73,81,120,142,159,177,234,260,300,302],"answer":[36],"this":[37,115,135],"fundamental":[38],"question,":[39],"it":[41,288,296],"remains":[42],"challenging":[43],"explore":[45],"potential":[47],"space":[48],"cooperative":[50],"interactions":[51,64],"between":[52,107,125],"acids.":[54],"Statistical":[55],"analysis":[56,256],"plays":[57],"a":[58,89,111,237,251,269],"significant":[59],"role":[60],"studying":[62],"such":[63,226],"its":[66,261],"use":[67,95],"expanded":[69],"recent":[71],"years":[72],"studies":[74,97],"ranging":[75],"from":[76,147,257],"coevolution-guided":[77],"rational":[78,131,184],"design":[80,103,185,236],"folding":[83,162,193,209],"silico.":[85],"Here":[86],"we":[87],"describe":[88],"computational":[90,252],"tool":[91,253],"named":[92],"Sibe":[93,117,190,249],"for":[94,186,206,254,277],"sequence,":[100],"folding,":[101],"using":[104,264],"evolutionary":[105,224,266],"coupling":[106],"acids":[109,128],"as":[110,227,268],"driving":[112,160,270],"factor.":[113,271],"In":[114,134],"study,":[116],"is":[118,297],"used":[119,176,233],"identify":[121],"positionally":[122,199],"conserved":[123,200],"couplings":[124,138,201,267],"pairwise":[126,137],"aid":[130],"design.":[133,164],"process,":[136],"are":[139],"filtered":[140],"according":[141],"relative":[144],"entropy":[145],"computed":[146],"positional":[149],"conservations":[150,228],"grouped":[152],"into":[153],"several":[154],"\u2019blocks\u2019,":[155],"which":[156],"could":[157],"contribute":[158,182],"A":[165],"human":[166],"\u03b2":[167,172],"2":[168,173],"-adrenergic":[169],"receptor":[170],"(":[171],"AR)":[174],"was":[175],"demonstrate":[178],"that":[179,219],"those":[180],"\u2019blocks\u2019":[181],"specifying":[187],"functional":[188],"residues.":[189],"also":[191,298],"provides":[192,250],"modules":[194],"based":[195],"on":[196,291],"well-established":[203],"statistical":[204],"potentials":[205],"simulating":[207],"silico":[211],"predicting":[213],"tertiary":[214,262],"structure.":[215],"Our":[216],"results":[217],"show":[218],"statistically":[220],"inferences":[221],"basic":[223],"principles,":[225],"coupled-mutations,":[230],"can":[231],"be":[232],"rapidly":[235],"diverse":[238],"set":[239],"study":[243],"folding.":[245],"The":[246],"developed":[247],"software":[248],"systematical":[255],"primary":[259],"structure":[263],"Sibe,":[272],"written":[273],"C++,":[275],"accounts":[276],"compatibility":[278],"with":[279],"\u2019big":[281],"data\u2019":[282],"era":[283],"science,":[286],"primarily":[289],"focuses":[290],"analysis,":[294],"applicable":[299],"extend":[301],"other":[303],"modeling":[304],"predictions":[306],"experimental":[308],"measurements":[309]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2}],"updated_date":"2026-06-16T07:32:37.131356","created_date":"2025-10-10T00:00:00"}