{"id":"https://openalex.org/W2953906682","doi":"https://doi.org/10.1186/s12859-019-2923-1","title":"DDGun: an untrained method for the prediction of protein stability changes upon single and multiple point variations","display_name":"DDGun: an untrained method for the prediction of protein stability changes upon single and multiple point variations","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W2953906682","doi":"https://doi.org/10.1186/s12859-019-2923-1","mag":"2953906682","pmid":"https://pubmed.ncbi.nlm.nih.gov/31266447"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2923-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2923-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2923-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2923-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078591821","display_name":"Ludovica Montanucci","orcid":"https://orcid.org/0000-0003-2375-7359"},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ludovica Montanucci","raw_affiliation_strings":["Department of Comparative Biomedicine and Food Science (BCA), University of Padova, Viale dell'Universit\u00e0 16, 35020, Legnaro, Italy","Department of Comparative Biomedicine and Food Science (BCA), University of Padova, Viale dell\u2019Universit\u00e0 16, 35020, Legnaro, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Comparative Biomedicine and Food Science (BCA), University of Padova, Viale dell'Universit\u00e0 16, 35020, Legnaro, Italy","institution_ids":["https://openalex.org/I138689650"]},{"raw_affiliation_string":"Department of Comparative Biomedicine and Food Science (BCA), University of Padova, Viale dell\u2019Universit\u00e0 16, 35020, Legnaro, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029911656","display_name":"Emidio Capriotti","orcid":"https://orcid.org/0000-0002-2323-0963"},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Emidio Capriotti","raw_affiliation_strings":["BioFolD Unit, Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Selmi 3, 40126, Bologna, Italy. emidio.capriotti@unibo.it","BioFolD Unit, Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Selmi 3, 40126, Bologna, Italy"],"affiliations":[{"raw_affiliation_string":"BioFolD Unit, Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Selmi 3, 40126, Bologna, Italy. emidio.capriotti@unibo.it","institution_ids":[]},{"raw_affiliation_string":"BioFolD Unit, Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Selmi 3, 40126, Bologna, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017939163","display_name":"Yotam Frank","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yotam Frank","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037671858","display_name":"Nir Ben\u2010Tal","orcid":"https://orcid.org/0000-0001-6901-832X"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nir Ben-Tal","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, 69978, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060232841","display_name":"Piero Fariselli","orcid":"https://orcid.org/0000-0003-1811-4762"},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Piero Fariselli","raw_affiliation_strings":["Department of Comparative Biomedicine and Food Science (BCA), University of Padova, Viale dell'Universit\u00e0 16, 35020, Legnaro, Italy. piero.fariselli@unito.it","Now at the Department of Medical Sciences, University of Torino, via Santena 19, 10126, Torino, Italy. piero.fariselli@unito.it","Now at the Department of Medical Sciences, University of Torino, via Santena 19, 10126, Torino, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Comparative Biomedicine and Food Science (BCA), University of Padova, Viale dell'Universit\u00e0 16, 35020, Legnaro, Italy. piero.fariselli@unito.it","institution_ids":[]},{"raw_affiliation_string":"Now at the Department of Medical Sciences, University of Torino, via Santena 19, 10126, Torino, Italy. piero.fariselli@unito.it","institution_ids":[]},{"raw_affiliation_string":"Now at the Department of Medical Sciences, University of Torino, via Santena 19, 10126, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5029911656","https://openalex.org/A5060232841"],"corresponding_institution_ids":["https://openalex.org/I55143463","https://openalex.org/I9360294"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.6822,"has_fulltext":true,"cited_by_count":166,"citation_normalized_percentile":{"value":0.94135518,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"20","issue":"S14","first_page":"335","last_page":"335"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.6083934307098389},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.49042579531669617},{"id":"https://openalex.org/keywords/single-point","display_name":"Single point","score":0.453016072511673},{"id":"https://openalex.org/keywords/protein-stability","display_name":"Protein stability","score":0.43918049335479736},{"id":"https://openalex.org/keywords/point","display_name":"Point (geometry)","score":0.43230023980140686},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4220530390739441},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3935803174972534},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35245707631111145},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32066091895103455},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23723652958869934},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2166001796722412},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20295459032058716},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19180533289909363},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12055036425590515},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10368329286575317},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.08819580078125}],"concepts":[{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.6083934307098389},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.49042579531669617},{"id":"https://openalex.org/C2992444157","wikidata":"https://www.wikidata.org/wiki/Q775079","display_name":"Single point","level":3,"score":0.453016072511673},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.43918049335479736},{"id":"https://openalex.org/C28719098","wikidata":"https://www.wikidata.org/wiki/Q44946","display_name":"Point (geometry)","level":2,"score":0.43230023980140686},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4220530390739441},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3935803174972534},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35245707631111145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32066091895103455},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23723652958869934},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2166001796722412},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20295459032058716},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19180533289909363},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12055036425590515},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10368329286575317},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08819580078125},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C2778800418","wikidata":"https://www.wikidata.org/wiki/Q631910","display_name":"TRIZ","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12859-019-2923-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2923-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2923-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31266447","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31266447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:cris.unibo.it:11585/738203","is_oa":true,"landing_page_url":"http://hdl.handle.net/11585/738203","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:034989d72abe4bc9a9797911b04d7791","is_oa":true,"landing_page_url":"https://doaj.org/article/034989d72abe4bc9a9797911b04d7791","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss S14, Pp 1-10 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5588225","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6606456","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:iris.unito.it:2318/1706443","is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1706443","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2923-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2923-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2923-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2953906682.pdf","grobid_xml":"https://content.openalex.org/works/W2953906682.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W579166296","https://openalex.org/W1974116969","https://openalex.org/W1975304761","https://openalex.org/W1985006546","https://openalex.org/W2003810144","https://openalex.org/W2008708467","https://openalex.org/W2031553026","https://openalex.org/W2041476324","https://openalex.org/W2064488723","https://openalex.org/W2083771969","https://openalex.org/W2092387745","https://openalex.org/W2093847279","https://openalex.org/W2099672241","https://openalex.org/W2103459989","https://openalex.org/W2104418738","https://openalex.org/W2113710405","https://openalex.org/W2114520383","https://openalex.org/W2120819598","https://openalex.org/W2120949690","https://openalex.org/W2121519777","https://openalex.org/W2125677968","https://openalex.org/W2126103104","https://openalex.org/W2132540199","https://openalex.org/W2134488721","https://openalex.org/W2135503340","https://openalex.org/W2136513422","https://openalex.org/W2143210482","https://openalex.org/W2149580316","https://openalex.org/W2152279845","https://openalex.org/W2157773221","https://openalex.org/W2160529747","https://openalex.org/W2165271176","https://openalex.org/W2171901881","https://openalex.org/W2262896633","https://openalex.org/W2428593791","https://openalex.org/W2734861826","https://openalex.org/W2774178591","https://openalex.org/W2794503008","https://openalex.org/W2794541436","https://openalex.org/W2799513065","https://openalex.org/W2893067056","https://openalex.org/W2902559445","https://openalex.org/W4255594044"],"related_works":["https://openalex.org/W2415545834","https://openalex.org/W2069695727","https://openalex.org/W1802639773","https://openalex.org/W2118505788","https://openalex.org/W4254166511","https://openalex.org/W2150084125","https://openalex.org/W1542823905","https://openalex.org/W1490878237","https://openalex.org/W4387581414","https://openalex.org/W4313339887"],"abstract_inverted_index":{"Evolutionary":[0],"information":[1],"alone":[2],"combined":[3],"in":[4,13],"an":[5],"untrained":[6],"method":[7],"can":[8],"achieve":[9],"remarkably":[10],"high":[11],"performances":[12],"the":[14,32,36,42],"prediction":[15],"of":[16,35,45],"\u2206\u2206G":[17],"upon":[18],"protein":[19],"mutation.":[20],"Non-trained":[21],"approaches":[22],"like":[23],"DDGun":[24],"represent":[25],"a":[26],"valid":[27],"benchmark":[28],"both":[29],"for":[30,40],"scoring":[31],"predictive":[33],"power":[34],"individual":[37],"features":[38],"and":[39],"assessing":[41],"learning":[43],"capability":[44],"supervised":[46],"methods.":[47]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":40},{"year":2024,"cited_by_count":44},{"year":2023,"cited_by_count":35},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}