{"id":"https://openalex.org/W2947980028","doi":"https://doi.org/10.1186/s12859-019-2892-4","title":"MHCSeqNet: a deep neural network model for universal MHC binding prediction","display_name":"MHCSeqNet: a deep neural network model for universal MHC binding prediction","publication_year":2019,"publication_date":"2019-05-28","ids":{"openalex":"https://openalex.org/W2947980028","doi":"https://doi.org/10.1186/s12859-019-2892-4","mag":"2947980028","pmid":"https://pubmed.ncbi.nlm.nih.gov/31138107"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2892-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2892-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2892-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2892-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078643562","display_name":"Poomarin Phloyphisut","orcid":null},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Poomarin Phloyphisut","raw_affiliation_strings":["Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064401818","display_name":"Natapol Pornputtapong","orcid":"https://orcid.org/0000-0002-3833-0537"},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Natapol Pornputtapong","raw_affiliation_strings":["Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand. natapol.p@chula.ac.th","Vaccine and Therapeutic Protein, the Special Task Force for Activating Research, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. natapol.p@chula.ac.th","Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand. natapol.p@chula.ac.th","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Vaccine and Therapeutic Protein, the Special Task Force for Activating Research, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. natapol.p@chula.ac.th","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011451938","display_name":"Sira Sriswasdi","orcid":"https://orcid.org/0000-0002-4117-3632"},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sira Sriswasdi","raw_affiliation_strings":["Computational Molecular Biology Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. sira.sr@chula.ac.th","Research Affairs, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Road, Pathum Wan, Bangkok, 10330, Thailand. sira.sr@chula.ac.th","Computational Molecular Biology Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"],"raw_orcid":"https://orcid.org/0000-0002-4117-3632","affiliations":[{"raw_affiliation_string":"Computational Molecular Biology Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. sira.sr@chula.ac.th","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Research Affairs, Faculty of Medicine, Chulalongkorn University, 1873 Rama IV Road, Pathum Wan, Bangkok, 10330, Thailand. sira.sr@chula.ac.th","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Computational Molecular Biology Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030009288","display_name":"Ekapol Chuangsuwanich","orcid":"https://orcid.org/0000-0001-6104-4857"},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I4210153049","display_name":"Vidyasirimedhi Institute of Science and Technology","ror":"https://ror.org/053jehz60","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210153049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Ekapol Chuangsuwanich","raw_affiliation_strings":["Computational Molecular Biology Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. ekapol.c@chula.ac.th","Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand. ekapol.c@chula.ac.th","The School of Information Science and Technology, Vidyasirimedhi Institute of Science and Technology, Wangchan Valley 555 Moo 1 Payupnai, Wangchan, Rayong, 21210, Thailand. ekapol.c@chula.ac.th","Computational Molecular Biology Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Molecular Biology Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. ekapol.c@chula.ac.th","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok, 10330, Thailand. ekapol.c@chula.ac.th","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"The School of Information Science and Technology, Vidyasirimedhi Institute of Science and Technology, Wangchan Valley 555 Moo 1 Payupnai, Wangchan, Rayong, 21210, Thailand. ekapol.c@chula.ac.th","institution_ids":["https://openalex.org/I4210153049"]},{"raw_affiliation_string":"Computational Molecular Biology Group, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand","institution_ids":["https://openalex.org/I158708052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064401818"],"corresponding_institution_ids":["https://openalex.org/I158708052"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.06,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.94994855,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"270","last_page":"270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"Major histocompatibility complex","score":0.7372878193855286},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6800427436828613},{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.5752604007720947},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5572394728660583},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"Immunogenicity","score":0.5461089611053467},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.5449073314666748},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.4241606295108795},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4012531042098999},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.3557204604148865},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3413667678833008},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.317147821187973},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16543084383010864}],"concepts":[{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.7372878193855286},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6800427436828613},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5752604007720947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5572394728660583},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5461089611053467},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.5449073314666748},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4241606295108795},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4012531042098999},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3557204604148865},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3413667678833008},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.317147821187973},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16543084383010864}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-019-2892-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2892-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2892-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31138107","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31138107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:caff2f01614744a6b10c0e24de992f17","is_oa":true,"landing_page_url":"https://doaj.org/article/caff2f01614744a6b10c0e24de992f17","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss 1, Pp 1-10 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5524109","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6540523","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2892-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2892-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2892-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.44999998807907104,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G46722034","display_name":null,"funder_award_id":"MRG6080087","funder_id":"https://openalex.org/F4320322614","funder_display_name":"Thailand Research Fund"}],"funders":[{"id":"https://openalex.org/F4320313904","display_name":"Vidyasirimedhi Institute of Science and Technology","ror":"https://ror.org/053jehz60"},{"id":"https://openalex.org/F4320321557","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58"},{"id":"https://openalex.org/F4320322614","display_name":"Thailand Research Fund","ror":"https://ror.org/03gd1bh37"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2947980028.pdf","grobid_xml":"https://content.openalex.org/works/W2947980028.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1501531009","https://openalex.org/W1502957213","https://openalex.org/W1677098616","https://openalex.org/W1924770834","https://openalex.org/W2011458181","https://openalex.org/W2033048068","https://openalex.org/W2038810952","https://openalex.org/W2053707749","https://openalex.org/W2084492053","https://openalex.org/W2108706633","https://openalex.org/W2132926880","https://openalex.org/W2143612262","https://openalex.org/W2153579005","https://openalex.org/W2154139219","https://openalex.org/W2155786171","https://openalex.org/W2158899491","https://openalex.org/W2181393016","https://openalex.org/W2336509392","https://openalex.org/W2524611247","https://openalex.org/W2555228033","https://openalex.org/W2586154810","https://openalex.org/W2589139221","https://openalex.org/W2607303097","https://openalex.org/W2743893844","https://openalex.org/W2756048586","https://openalex.org/W2781173963","https://openalex.org/W2791512052","https://openalex.org/W2953065444","https://openalex.org/W2964121744","https://openalex.org/W2964199361","https://openalex.org/W2964308564","https://openalex.org/W3106003309","https://openalex.org/W4210702584"],"related_works":["https://openalex.org/W2019183242","https://openalex.org/W1840653008","https://openalex.org/W2977793531","https://openalex.org/W2023967363","https://openalex.org/W1939527068","https://openalex.org/W2126139339","https://openalex.org/W2168688111","https://openalex.org/W2070684866","https://openalex.org/W4281625971","https://openalex.org/W2094567316"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immunotherapy":[1],"is":[2,77],"an":[3,103],"emerging":[4],"approach":[5,73],"in":[6,28,39,67,201],"cancer":[7,17,68,202],"treatment":[8],"that":[9,82],"activates":[10],"the":[11,29,80,88,186],"host":[12],"immune":[13,56],"system":[14],"to":[15,129,145,169],"destroy":[16],"cells":[18],"expressing":[19],"unique":[20],"peptide":[21,33,156],"signatures":[22],"(neoepitopes).":[23],"Administrations":[24],"of":[25,31,51,59,151,178],"cancer-specific":[26,52],"neoepitopes":[27,53,62,200],"form":[30],"synthetic":[32],"vaccine":[34,69,203],"have":[35],"been":[36],"proven":[37],"effective":[38,83,199],"both":[40,115],"mouse":[41],"models":[42],"and":[43,119,154,185],"human":[44],"patients.":[45],"Because":[46],"only":[47,110],"a":[48,64,194],"tiny":[49],"fraction":[50],"actually":[54],"elicits":[55],"response,":[57],"selection":[58],"potent,":[60],"immunogenic":[61],"remains":[63],"challenging":[65],"step":[66],"development.":[70,204],"A":[71],"basic":[72],"for":[74,141,197],"immunogenicity":[75],"prediction":[76],"based":[78],"on":[79,114],"premise":[81],"neoepitope":[84],"should":[85,191],"bind":[86],"with":[87,93,159],"Major":[89],"Histocompatibility":[90],"Complex":[91],"(MHC)":[92],"high":[94],"affinity.":[95],"RESULTS:":[96],"In":[97],"this":[98],"study,":[99],"we":[100],"developed":[101,140],"MHCSeqNet,":[102],"open-source":[104],"deep":[105],"learning":[106],"model,":[107],"which":[108],"not":[109],"outperforms":[111],"state-of-the-art":[112],"predictors":[113],"MHC":[116,120,131,152,172],"binding":[117],"affinity":[118],"ligand":[121],"peptidome":[122],"datasets":[123],"but":[124],"also":[125],"exhibits":[126],"promising":[127],"generalization":[128],"unseen":[130],"class":[132],"I":[133],"alleles.":[134],"MHCSeqNet":[135,168,190],"employed":[136],"neural":[137],"network":[138],"architectures":[139],"natural":[142],"language":[143],"processing":[144],"model":[146],"amino":[147,160],"acid":[148],"sequence":[149],"representations":[150],"allele":[153],"epitope":[155],"as":[157,162,174,176],"sentences":[158],"acids":[161],"individual":[163],"words.":[164],"This":[165],"consideration":[166],"allows":[167],"accept":[170],"new":[171],"alleles":[173],"well":[175],"peptides":[177],"any":[179],"length.":[180],"CONCLUSIONS:":[181],"The":[182],"improved":[183],"performance":[184],"flexibility":[187],"offered":[188],"by":[189],"make":[192],"it":[193],"valuable":[195],"tool":[196],"screening":[198]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}