{"id":"https://openalex.org/W2950625953","doi":"https://doi.org/10.1186/s12859-019-2871-9","title":"Filtering procedures for untargeted LC-MS metabolomics data","display_name":"Filtering procedures for untargeted LC-MS metabolomics data","publication_year":2019,"publication_date":"2019-06-14","ids":{"openalex":"https://openalex.org/W2950625953","doi":"https://doi.org/10.1186/s12859-019-2871-9","mag":"2950625953","pmid":"https://pubmed.ncbi.nlm.nih.gov/31200644"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2871-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2871-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2871-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2871-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081025016","display_name":"Courtney Schiffman","orcid":"https://orcid.org/0000-0003-4126-9033"},"institutions":[{"id":"https://openalex.org/I134446601","display_name":"Berkeley College","ror":"https://ror.org/02xewxa75","country_code":"US","type":"education","lineage":["https://openalex.org/I134446601"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Courtney Schiffman","raw_affiliation_strings":["Division of Biostatistics, UC Berkeley, Berkeley, 94720, USA. courtneys@berkeley.edu","Division of Biostatistics, UC Berkeley, Berkeley, 94720, USA"],"raw_orcid":"https://orcid.org/0000-0003-4126-9033","affiliations":[{"raw_affiliation_string":"Division of Biostatistics, UC Berkeley, Berkeley, 94720, USA. courtneys@berkeley.edu","institution_ids":["https://openalex.org/I95457486","https://openalex.org/I134446601"]},{"raw_affiliation_string":"Division of Biostatistics, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017989983","display_name":"Lauren Petrick","orcid":"https://orcid.org/0000-0003-3493-7419"},"institutions":[{"id":"https://openalex.org/I134446601","display_name":"Berkeley College","ror":"https://ror.org/02xewxa75","country_code":"US","type":"education","lineage":["https://openalex.org/I134446601"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Petrick","raw_affiliation_strings":["Center for Integrative Research on Childhood Leukemia and the Environment, UC Berkeley, Berkeley, 94720, USA","The Senator Frank R. Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Research on Childhood Leukemia and the Environment, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I134446601"]},{"raw_affiliation_string":"The Senator Frank R. Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031172740","display_name":"Kelsi Perttula","orcid":"https://orcid.org/0000-0002-5520-7792"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelsi Perttula","raw_affiliation_strings":["Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006937523","display_name":"Yukiko Yano","orcid":"https://orcid.org/0000-0001-9816-0384"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yukiko Yano","raw_affiliation_strings":["Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100731933","display_name":"Henrik Carlsson","orcid":"https://orcid.org/0000-0002-6748-6119"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henrik Carlsson","raw_affiliation_strings":["Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023345692","display_name":"Todd P. Whitehead","orcid":null},"institutions":[{"id":"https://openalex.org/I134446601","display_name":"Berkeley College","ror":"https://ror.org/02xewxa75","country_code":"US","type":"education","lineage":["https://openalex.org/I134446601"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Whitehead","raw_affiliation_strings":["Center for Integrative Research on Childhood Leukemia and the Environment, UC Berkeley, Berkeley, 94720, USA","Division of Epidemiology, UC Berkeley, Berkeley, 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Research on Childhood Leukemia and the Environment, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I134446601"]},{"raw_affiliation_string":"Division of Epidemiology, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059955772","display_name":"Catherine Metayer","orcid":"https://orcid.org/0000-0003-3467-4145"},"institutions":[{"id":"https://openalex.org/I134446601","display_name":"Berkeley College","ror":"https://ror.org/02xewxa75","country_code":"US","type":"education","lineage":["https://openalex.org/I134446601"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Metayer","raw_affiliation_strings":["Center for Integrative Research on Childhood Leukemia and the Environment, UC Berkeley, Berkeley, 94720, USA","Division of Epidemiology, UC Berkeley, Berkeley, 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Research on Childhood Leukemia and the Environment, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I134446601"]},{"raw_affiliation_string":"Division of Epidemiology, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088393052","display_name":"Josie Hayes","orcid":"https://orcid.org/0000-0001-6402-6320"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josie Hayes","raw_affiliation_strings":["Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075251834","display_name":"Stephen M. Rappaport","orcid":"https://orcid.org/0000-0002-3806-0848"},"institutions":[{"id":"https://openalex.org/I134446601","display_name":"Berkeley College","ror":"https://ror.org/02xewxa75","country_code":"US","type":"education","lineage":["https://openalex.org/I134446601"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Rappaport","raw_affiliation_strings":["Center for Integrative Research on Childhood Leukemia and the Environment, UC Berkeley, Berkeley, 94720, USA","Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Research on Childhood Leukemia and the Environment, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I134446601"]},{"raw_affiliation_string":"Division of Environmental Health Sciences, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018207168","display_name":"Sandrine Dudoit","orcid":"https://orcid.org/0000-0002-6069-8629"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandrine Dudoit","raw_affiliation_strings":["Department of Statistics, UC Berkeley, Berkeley, 94720, USA","Division of Biostatistics, UC Berkeley, Berkeley, 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Division of Biostatistics, UC Berkeley, Berkeley, 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5081025016"],"corresponding_institution_ids":["https://openalex.org/I134446601","https://openalex.org/I95457486"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":5.2146,"has_fulltext":true,"cited_by_count":123,"citation_normalized_percentile":{"value":0.96564094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"334","last_page":"334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7291811108589172},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.709000825881958},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.7012761235237122},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5467842221260071},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.21834009885787964},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12390187382698059}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7291811108589172},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.709000825881958},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.7012761235237122},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5467842221260071},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21834009885787964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12390187382698059},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12859-019-2871-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2871-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2871-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31200644","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31200644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt95d363zt","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/95d363zt","pdf_url":"https://escholarship.org/uc/item/95d363zt","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, vol 20, iss 1","raw_type":"article"},{"id":"pmh:ark:/13030/qt95d363zt","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:518c34e1fd2646dab48aca2af57114c0","is_oa":true,"landing_page_url":"https://doaj.org/article/518c34e1fd2646dab48aca2af57114c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss 1, Pp 1-10 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6570933","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6570933","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2871-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2871-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2871-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1084989740","display_name":null,"funder_award_id":"P50ES018172","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G2767973019","display_name":null,"funder_award_id":"R01ES009137 and P42ES004705 and P42ES004705","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3388104181","display_name":null,"funder_award_id":"P01ES018172","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5861272137","display_name":null,"funder_award_id":"RD83451101 and RD83615901","funder_id":"https://openalex.org/F4320320835","funder_display_name":"Environmental Protection Agency"}],"funders":[{"id":"https://openalex.org/F4320320835","display_name":"Environmental Protection Agency","ror":"https://ror.org/05qbqeh37"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2950625953.pdf","grobid_xml":"https://content.openalex.org/works/W2950625953.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1589724644","https://openalex.org/W1964010911","https://openalex.org/W1992085043","https://openalex.org/W2019497601","https://openalex.org/W2025944550","https://openalex.org/W2039077785","https://openalex.org/W2073939393","https://openalex.org/W2086500586","https://openalex.org/W2104057864","https://openalex.org/W2149309843","https://openalex.org/W2341820027","https://openalex.org/W2410662908","https://openalex.org/W2529012673","https://openalex.org/W2567523041","https://openalex.org/W2603590667","https://openalex.org/W2614303923","https://openalex.org/W2725788675","https://openalex.org/W2743576058","https://openalex.org/W2754517160","https://openalex.org/W2763572134","https://openalex.org/W2766131086","https://openalex.org/W2777966573","https://openalex.org/W2803664483","https://openalex.org/W2897716935","https://openalex.org/W2923506657"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W4283390424","https://openalex.org/W2137270828","https://openalex.org/W1976072307","https://openalex.org/W4205440119","https://openalex.org/W1561393703","https://openalex.org/W4292104203","https://openalex.org/W2040768604"],"abstract_inverted_index":{"BACKGROUND:":[0],"Untargeted":[1],"metabolomics":[2,52,87,170],"datasets":[3,88],"contain":[4],"large":[5],"proportions":[6,76],"of":[7,77,97,130,178],"uninformative":[8,166],"features":[9,71,133,167],"that":[10,54,89,116],"can":[11],"impede":[12],"subsequent":[13],"statistical":[14],"analysis":[15],"such":[16],"as":[17,100,102],"biomarker":[18],"discovery":[19],"and":[20,31,80,134,163],"metabolic":[21],"pathway":[22],"analysis.":[23],"Thus,":[24],"there":[25],"is":[26,150,161,173],"a":[27,47],"need":[28],"for":[29,34,50,69,144,176],"versatile":[30],"data-adaptive":[32,48,64,110,123,147,158],"methods":[33,68,115],"filtering":[35,51,70,111,148,159],"data":[36,53,182],"prior":[37],"to":[38],"investigating":[39],"the":[40,146],"underlying":[41],"biological":[42,179],"phenomena.":[43],"Here,":[44],"we":[45,107],"propose":[46],"pipeline":[49,65,160],"are":[55],"generated":[56,91],"by":[57],"liquid":[58],"chromatography-mass":[59],"spectrometry":[60],"(LC-MS)":[61],"platforms.":[62],"Our":[63,156],"includes":[66],"novel":[67],"based":[72],"on":[73,118],"blank":[74],"samples,":[75],"missing":[78],"values,":[79],"estimated":[81],"intra-class":[82],"correlation":[83],"coefficients.":[84],"RESULTS:":[85],"Using":[86],"were":[90],"in":[92,128,181],"our":[93,109],"laboratory":[94],"from":[95,168,184],"samples":[96],"human":[98],"blood,":[99],"well":[101],"two":[103],"public":[104],"LC-MS":[105],"datasets,":[106],"compared":[108],"method":[112,149],"with":[113,188],"traditional":[114,126],"rely":[117],"non-method":[119],"specific":[120],"thresholds.":[121],"The":[122,141],"approach":[124],"outperformed":[125],"approaches":[127],"terms":[129],"removing":[131],"noisy":[132],"retaining":[135],"high":[136],"quality,":[137],"biologically":[138],"informative":[139],"ones.":[140],"R":[142],"code":[143],"running":[145],"provided":[151],"at":[152],"https://github.com/courtneyschiffman/Metabolomics-Filtering":[153],".":[154],"CONCLUSIONS:":[155],"proposed":[157],"intuitive":[162],"effectively":[164],"removes":[165],"untargeted":[169],"datasets.":[171],"It":[172],"particularly":[174],"relevant":[175],"interrogation":[177],"phenomena":[180],"derived":[183],"complex":[185],"matrices":[186],"associated":[187],"biospecimens.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}
