{"id":"https://openalex.org/W2949245097","doi":"https://doi.org/10.1186/s12859-019-2862-x","title":"DDmap: a MATLAB package for the double digest problem using multiple genetic operators","display_name":"DDmap: a MATLAB package for the double digest problem using multiple genetic operators","publication_year":2019,"publication_date":"2019-06-18","ids":{"openalex":"https://openalex.org/W2949245097","doi":"https://doi.org/10.1186/s12859-019-2862-x","mag":"2949245097","pmid":"https://pubmed.ncbi.nlm.nih.gov/31215408"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2862-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2862-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2862-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2862-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100736219","display_name":"Licheng Wang","orcid":"https://orcid.org/0000-0001-8418-1897"},"institutions":[{"id":"https://openalex.org/I139759216","display_name":"Beijing University of Posts and Telecommunications","ror":"https://ror.org/04w9fbh59","country_code":"CN","type":"education","lineage":["https://openalex.org/I139759216"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Licheng Wang","raw_affiliation_strings":["State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, 10 West Tucheng Road, Haidian District, Beijing, 100876, China"],"raw_orcid":"https://orcid.org/0000-0001-8418-1897","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, 10 West Tucheng Road, Haidian District, Beijing, 100876, China","institution_ids":["https://openalex.org/I139759216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021939800","display_name":"Jingwen Suo","orcid":null},"institutions":[{"id":"https://openalex.org/I139759216","display_name":"Beijing University of Posts and Telecommunications","ror":"https://ror.org/04w9fbh59","country_code":"CN","type":"education","lineage":["https://openalex.org/I139759216"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwen Suo","raw_affiliation_strings":["State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, 10 West Tucheng Road, Haidian District, Beijing, 100876, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, 10 West Tucheng Road, Haidian District, Beijing, 100876, China","institution_ids":["https://openalex.org/I139759216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028207505","display_name":"Yun Pan","orcid":"https://orcid.org/0000-0002-0626-5478"},"institutions":[{"id":"https://openalex.org/I75689368","display_name":"Communication University of China","ror":"https://ror.org/04facbs33","country_code":"CN","type":"education","lineage":["https://openalex.org/I75689368"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Pan","raw_affiliation_strings":["School of Computer Science, Communication University of China, 1 East of Dingfuzhuang Street, Chaoyang District, Beijing, 100024, China. pany@cuc.edu.cn","School of Computer Science, Communication University of China, 1 East of Dingfuzhuang Street, Chaoyang District, Beijing, 100024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Communication University of China, 1 East of Dingfuzhuang Street, Chaoyang District, Beijing, 100024, China. pany@cuc.edu.cn","institution_ids":["https://openalex.org/I75689368"]},{"raw_affiliation_string":"School of Computer Science, Communication University of China, 1 East of Dingfuzhuang Street, Chaoyang District, Beijing, 100024, China","institution_ids":["https://openalex.org/I75689368"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100734103","display_name":"Lixiang Li","orcid":"https://orcid.org/0000-0001-9949-8731"},"institutions":[{"id":"https://openalex.org/I139759216","display_name":"Beijing University of Posts and Telecommunications","ror":"https://ror.org/04w9fbh59","country_code":"CN","type":"education","lineage":["https://openalex.org/I139759216"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixiang Li","raw_affiliation_strings":["State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, 10 West Tucheng Road, Haidian District, Beijing, 100876, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, 10 West Tucheng Road, Haidian District, Beijing, 100876, China","institution_ids":["https://openalex.org/I139759216"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028207505"],"corresponding_institution_ids":["https://openalex.org/I75689368"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.171,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.52244985,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"20","issue":"1","first_page":"348","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.34139999747276306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.34139999747276306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.1981000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.14880000054836273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7298243045806885},{"id":"https://openalex.org/keywords/matlab","display_name":"MATLAB","score":0.6546679735183716},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.5680819153785706},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.534558892250061},{"id":"https://openalex.org/keywords/rounding","display_name":"Rounding","score":0.5113048553466797},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.5055255889892578},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4868544936180115},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.4582888185977936},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.4346975088119507},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.4296046495437622},{"id":"https://openalex.org/keywords/computational-science","display_name":"Computational science","score":0.3489258885383606},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.22220826148986816},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.16487380862236023},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.06956541538238525}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7298243045806885},{"id":"https://openalex.org/C2780365114","wikidata":"https://www.wikidata.org/wiki/Q169478","display_name":"MATLAB","level":2,"score":0.6546679735183716},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.5680819153785706},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.534558892250061},{"id":"https://openalex.org/C136625980","wikidata":"https://www.wikidata.org/wiki/Q663208","display_name":"Rounding","level":2,"score":0.5113048553466797},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.5055255889892578},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4868544936180115},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.4582888185977936},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.4346975088119507},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.4296046495437622},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.3489258885383606},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.22220826148986816},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.16487380862236023},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.06956541538238525},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009875","descriptor_name":"Operator Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009875","descriptor_name":"Operator Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009875","descriptor_name":"Operator Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020161","descriptor_name":"Physical Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020161","descriptor_name":"Physical Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020161","descriptor_name":"Physical Chromosome Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-019-2862-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2862-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2862-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31215408","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31215408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:538662229fc346e6b3b95e83e82b0395","is_oa":true,"landing_page_url":"https://doaj.org/article/538662229fc346e6b3b95e83e82b0395","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss 1, Pp 1-12 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6582610","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6582610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2862-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2862-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2862-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3051456368","display_name":null,"funder_award_id":"2016YFB0800602","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2949245097.pdf","grobid_xml":"https://content.openalex.org/works/W2949245097.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W313567648","https://openalex.org/W1506010125","https://openalex.org/W1595601604","https://openalex.org/W2005381060","https://openalex.org/W2007888399","https://openalex.org/W2021134019","https://openalex.org/W2048074870","https://openalex.org/W2053468479","https://openalex.org/W2054590722","https://openalex.org/W2059127308","https://openalex.org/W2070626789","https://openalex.org/W2093843227","https://openalex.org/W2158787071","https://openalex.org/W2162614295","https://openalex.org/W2395492357","https://openalex.org/W4237922239","https://openalex.org/W6635735662"],"related_works":["https://openalex.org/W4220780102","https://openalex.org/W2410881844","https://openalex.org/W3196334750","https://openalex.org/W1502401885","https://openalex.org/W2004257129","https://openalex.org/W2116281088","https://openalex.org/W2357551824","https://openalex.org/W2016668641","https://openalex.org/W2019368960","https://openalex.org/W2349094459"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,94,158],"computational":[2],"biology,":[3],"the":[4,16,30,50,71,140,144,155],"physical":[5],"mapping":[6],"of":[7,73,143],"DNA":[8],"is":[9,21,34,172],"a":[10,54,77,108,160],"key":[11],"problem.":[12,157],"We":[13,41,69],"know":[14],"that":[15,59,139],"double":[17],"digest":[18],"problem":[19],"(DDP)":[20],"NP-complete.":[22],"Many":[23],"algorithms":[24,152],"have":[25],"been":[26],"proposed":[27],"for":[28,48,66,101,153,164],"solving":[29,49,102,154],"DDP,":[31,51],"although":[32],"it":[33],"still":[35],"far":[36],"from":[37],"being":[38],"resolved.":[39],"RESULTS:":[40],"present":[42],"DDmap,":[43,136],"an":[44,91,98],"open-source":[45],"MATLAB":[46],"package":[47],"based":[52],"on":[53,126,129],"newly":[55],"designed":[56],"genetic":[57,62,151],"algorithm":[58],"combines":[60],"six":[61],"operators":[63],"in":[64,90],"searching":[65],"optimal":[67],"solutions.":[68],"test":[70,115],"performance":[72],"DDmap":[74,117],"by":[75,134],"using":[76,135],"typical":[78,113],"DDP":[79,88,105,114,132,156,166],"dataset,":[80],"and":[81],"we":[82,96,137],"depict":[83],"exact":[84,119],"solutions":[85,120,167],"to":[86],"these":[87],"instances":[89,133],"explicit":[92],"manner.":[93],"addition,":[95,159],"propose":[97],"approximate":[99],"method":[100],"some":[103],"hard":[104],"scenarios":[106],"via":[107],"scaling-rounding-adjusting":[109],"process.":[110],"CONCLUSIONS:":[111],"For":[112],"instances,":[116],"finds":[118],"within":[121],"approximately":[122],"1":[123],"s.":[124],"Based":[125],"our":[127],"simulations":[128],"1000":[130],"random":[131],"find":[138],"maximum":[141],"length":[142],"combining":[145],"fragments":[146],"has":[147],"observable":[148],"effects":[149],"towards":[150],"Maple":[161],"source":[162],"code":[163],"illustrating":[165],"as":[168],"nested":[169],"pie":[170],"charts":[171],"also":[173],"included.":[174]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}