{"id":"https://openalex.org/W2951104827","doi":"https://doi.org/10.1186/s12859-019-2838-x","title":"Characterizing building blocks of resource constrained biological networks","display_name":"Characterizing building blocks of resource constrained biological networks","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2951104827","doi":"https://doi.org/10.1186/s12859-019-2838-x","mag":"2951104827","pmid":"https://pubmed.ncbi.nlm.nih.gov/31216986"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2838-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2838-x","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12859-019-2838-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073900873","display_name":"Yuanfang Ren","orcid":"https://orcid.org/0000-0002-4716-2408"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanfang Ren","raw_affiliation_strings":["Computer and Information Science and Engineering, University of Florida, Gainesville, 32611, FL, USA","Computer and Information Science and Engineering, University of Florida, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer and Information Science and Engineering, University of Florida, Gainesville, 32611, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Computer and Information Science and Engineering, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033580922","display_name":"Ahmet Ay","orcid":"https://orcid.org/0000-0002-0726-5461"},"institutions":[{"id":"https://openalex.org/I39660569","display_name":"Colgate University","ror":"https://ror.org/05d23ve83","country_code":"US","type":"education","lineage":["https://openalex.org/I39660569"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmet Ay","raw_affiliation_strings":["Departments of Biology and Mathematics, Colgate University, Hamilton, 13346, NY, USA","Departments of Biology and Mathematics, Colgate University, Hamilton, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biology and Mathematics, Colgate University, Hamilton, 13346, NY, USA","institution_ids":["https://openalex.org/I39660569"]},{"raw_affiliation_string":"Departments of Biology and Mathematics, Colgate University, Hamilton, USA","institution_ids":["https://openalex.org/I39660569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008335723","display_name":"Alin Dobra","orcid":"https://orcid.org/0000-0003-2033-9952"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alin Dobra","raw_affiliation_strings":["Computer and Information Science and Engineering, University of Florida, Gainesville, 32611, FL, USA","Computer and Information Science and Engineering, University of Florida, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer and Information Science and Engineering, University of Florida, Gainesville, 32611, FL, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Computer and Information Science and Engineering, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091769289","display_name":"Tamer Kahveci","orcid":"https://orcid.org/0000-0002-4403-8612"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tamer Kahveci","raw_affiliation_strings":["Computer and Information Science and Engineering, University of Florida, Gainesville, 32611, FL, USA. tamer@cise.ufl.edu","Computer and Information Science and Engineering, University of Florida, Gainesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer and Information Science and Engineering, University of Florida, Gainesville, 32611, FL, USA. tamer@cise.ufl.edu","institution_ids":[]},{"raw_affiliation_string":"Computer and Information Science and Engineering, University of Florida, Gainesville, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5091769289"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0855,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.46824136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":95},"biblio":{"volume":"20","issue":"S12","first_page":"318","last_page":"318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.3472999930381775,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.13989999890327454,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/motif","display_name":"Motif (music)","score":0.8432636260986328},{"id":"https://openalex.org/keywords/network-motif","display_name":"Network motif","score":0.7657215595245361},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.7102887034416199},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5856881141662598},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4880012571811676},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.43368515372276306},{"id":"https://openalex.org/keywords/structural-motif","display_name":"Structural motif","score":0.4208073914051056},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.41516950726509094},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3464128375053406},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3200272023677826},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3037552237510681},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2028837502002716}],"concepts":[{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.8432636260986328},{"id":"https://openalex.org/C60723933","wikidata":"https://www.wikidata.org/wiki/Q7001080","display_name":"Network motif","level":3,"score":0.7657215595245361},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.7102887034416199},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5856881141662598},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4880012571811676},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.43368515372276306},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.4208073914051056},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.41516950726509094},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3464128375053406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3200272023677826},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3037552237510681},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2028837502002716},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-019-2838-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2838-x","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31216986","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31216986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:864cbc9af204431d9ae949acd89c03a7","is_oa":true,"landing_page_url":"https://doaj.org/article/864cbc9af204431d9ae949acd89c03a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss S12, Pp 1-14 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6584510","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6584510","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2838-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2838-x","pdf_url":null,"source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1507763859","https://openalex.org/W1508044906","https://openalex.org/W1592376869","https://openalex.org/W1671250342","https://openalex.org/W1969351946","https://openalex.org/W1977943300","https://openalex.org/W1987815409","https://openalex.org/W1988100928","https://openalex.org/W2007387912","https://openalex.org/W2008620264","https://openalex.org/W2010707723","https://openalex.org/W2019827052","https://openalex.org/W2023832559","https://openalex.org/W2025177571","https://openalex.org/W2036265926","https://openalex.org/W2043004358","https://openalex.org/W2051964904","https://openalex.org/W2056069438","https://openalex.org/W2058913657","https://openalex.org/W2060071214","https://openalex.org/W2061425021","https://openalex.org/W2064982479","https://openalex.org/W2071869259","https://openalex.org/W2074631079","https://openalex.org/W2080182143","https://openalex.org/W2080525033","https://openalex.org/W2093050872","https://openalex.org/W2102039892","https://openalex.org/W2105039688","https://openalex.org/W2106362845","https://openalex.org/W2107817133","https://openalex.org/W2110503722","https://openalex.org/W2110699703","https://openalex.org/W2112090702","https://openalex.org/W2118258530","https://openalex.org/W2122144032","https://openalex.org/W2125278887","https://openalex.org/W2136593687","https://openalex.org/W2145951763","https://openalex.org/W2150164025","https://openalex.org/W2153624566","https://openalex.org/W2160998060","https://openalex.org/W2161112329","https://openalex.org/W2163480486","https://openalex.org/W2307303546","https://openalex.org/W2528717069","https://openalex.org/W4312512934"],"related_works":["https://openalex.org/W3079957389","https://openalex.org/W2796517744","https://openalex.org/W15348386","https://openalex.org/W2807926763","https://openalex.org/W3113308218","https://openalex.org/W2142272337","https://openalex.org/W1498018581","https://openalex.org/W2123854512","https://openalex.org/W782572168","https://openalex.org/W2135602072"],"abstract_inverted_index":{"BACKGROUND:":[0],"Identification":[1],"of":[2,23,74,175,182,188,209,216,253],"motifs-recurrent":[3],"and":[4,18,95,131,150,207,245,250],"statistically":[5],"significant":[6],"patterns-in":[7],"biological":[8,24,39,98,156,255],"networks":[9,133,157,256],"is":[10,28,35,202],"the":[11,15,51,139,145,173,227,254],"key":[12],"to":[13,19,88,154,171,205,231,241,246],"understand":[14],"design":[16],"principles,":[17],"infer":[20],"governing":[21],"mechanisms":[22],"systems.":[25],"This,":[26],"however,":[27],"a":[29,46,57,71,106,189],"computationally":[30],"challenging":[31],"task.":[32],"This":[33,61,84],"task":[34],"further":[36],"complicated":[37],"as":[38],"interactions":[40,122],"depend":[41],"on":[42,129,179,226],"limited":[43,72],"resources,":[44],"i.e.,":[45],"reaction":[47],"takes":[48],"place":[49],"if":[50],"reactant":[52],"molecule":[53],"concentrations":[54],"are":[55],"above":[56],"certain":[58],"threshold":[59],"level.":[60],"biochemical":[62],"property":[63],"implies":[64],"that":[65,116,135,165,199,223,229],"network":[66,194,213],"edges":[67,228],"can":[68,238],"participate":[69],"in":[70,123,158,211,233],"number":[73],"motifs":[75,210],"simultaneously.":[76],"Existing":[77],"motif":[78,90,108,136,147,234],"counting":[79,109,124,148],"methods":[80],"ignore":[81],"this":[82,102,185,212],"problem.":[83],"simplification":[85],"often":[86],"leads":[87],"inaccurate":[89],"counts":[91],"(over-":[92],"or":[93],"under-estimates),":[94],"thus,":[96],"wrong":[97],"interpretations.":[99],"RESULTS:":[100],"In":[101,184],"paper,":[103],"we":[104],"develop":[105],"novel":[107],"algorithm,":[110],"Partially":[111],"Overlapping":[112],"MOtif":[113],"Counting":[114],"(POMOC),":[115],"considers":[117],"capacity":[118],"levels":[119],"for":[120],"all":[121],"motifs.":[125],"CONCLUSIONS:":[126],"Our":[127,161,219],"experiments":[128],"real":[130],"synthetic":[132],"demonstrate":[134],"count":[137],"using":[138,195],"POMOC":[140],"method":[141,152,167,197,237],"significantly":[142],"differs":[143],"from":[144],"existing":[146],"approaches,":[149],"our":[151,166,196,236],"extends":[153],"large-scale":[155],"practical":[159],"time.":[160],"results":[162],"also":[163,221],"show":[164],"makes":[168],"it":[169],"possible":[170],"characterize":[172],"impact":[174],"different":[176,258],"stress":[177,201],"factors":[178],"cell's":[180],"organization":[181,206],"network.":[183],"regard,":[186],"analysis":[187,220],"S.":[190],"cerevisiae":[191],"transcriptional":[192],"regulatory":[193],"shows":[198],"oxidative":[200],"more":[203],"disruptive":[204],"abundance":[208],"than":[214],"mutations":[215],"individual":[217],"genes.":[218],"suggests":[222],"by":[224],"focusing":[225],"lead":[230],"variation":[232],"counts,":[235],"be":[239],"used":[240],"find":[242],"important":[243],"genes,":[244],"reveal":[247],"subtle":[248],"topological":[249],"functional":[251],"differences":[252],"under":[257],"cell":[259],"states.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}