{"id":"https://openalex.org/W2952109320","doi":"https://doi.org/10.1186/s12859-019-2834-1","title":"Network-based prediction of polygenic disease genes involved in cell motility","display_name":"Network-based prediction of polygenic disease genes involved in cell motility","publication_year":2019,"publication_date":"2019-06-01","ids":{"openalex":"https://openalex.org/W2952109320","doi":"https://doi.org/10.1186/s12859-019-2834-1","mag":"2952109320"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2834-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2834-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-019-2834-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-019-2834-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004472290","display_name":"Miriam Bern","orcid":null},"institutions":[{"id":"https://openalex.org/I55486353","display_name":"Reed College","ror":"https://ror.org/00a6ram87","country_code":"US","type":"education","lineage":["https://openalex.org/I55486353"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Miriam Bern","raw_affiliation_strings":["Biology Department, Reed College, Portland, OR, USA"],"affiliations":[{"raw_affiliation_string":"Biology Department, Reed College, Portland, OR, USA","institution_ids":["https://openalex.org/I55486353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040724704","display_name":"Alexander King","orcid":null},"institutions":[{"id":"https://openalex.org/I55486353","display_name":"Reed College","ror":"https://ror.org/00a6ram87","country_code":"US","type":"education","lineage":["https://openalex.org/I55486353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander King","raw_affiliation_strings":["Biology Department, Reed College, Portland, OR, USA"],"affiliations":[{"raw_affiliation_string":"Biology Department, Reed College, Portland, OR, USA","institution_ids":["https://openalex.org/I55486353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048373307","display_name":"Derek A. Applewhite","orcid":"https://orcid.org/0000-0002-2431-0316"},"institutions":[{"id":"https://openalex.org/I55486353","display_name":"Reed College","ror":"https://ror.org/00a6ram87","country_code":"US","type":"education","lineage":["https://openalex.org/I55486353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek A. Applewhite","raw_affiliation_strings":["Biology Department, Reed College, Portland, OR, USA"],"affiliations":[{"raw_affiliation_string":"Biology Department, Reed College, Portland, OR, USA","institution_ids":["https://openalex.org/I55486353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087718701","display_name":"Anna Ritz","orcid":"https://orcid.org/0000-0002-7925-5369"},"institutions":[{"id":"https://openalex.org/I55486353","display_name":"Reed College","ror":"https://ror.org/00a6ram87","country_code":"US","type":"education","lineage":["https://openalex.org/I55486353"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Ritz","raw_affiliation_strings":["Biology Department, Reed College, Portland, OR, USA"],"affiliations":[{"raw_affiliation_string":"Biology Department, Reed College, Portland, OR, USA","institution_ids":["https://openalex.org/I55486353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004472290"],"corresponding_institution_ids":["https://openalex.org/I55486353"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.7173,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.7576953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"20","issue":"S12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.6988001465797424},{"id":"https://openalex.org/keywords/autism","display_name":"Autism","score":0.6708093881607056},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"Schizophrenia (object-oriented programming)","score":0.6607739329338074},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.6159849762916565},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5950964689254761},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.55572110414505},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.541293740272522},{"id":"https://openalex.org/keywords/motility","display_name":"Motility","score":0.5212724208831787},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4944484233856201},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.4648754894733429},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4424581825733185},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4060799479484558},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3909991681575775},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3295174837112427},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2057659924030304},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20351439714431763},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2022683322429657},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.16349905729293823},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1228884756565094},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.07342076301574707}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6988001465797424},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6708093881607056},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6607739329338074},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.6159849762916565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5950964689254761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.55572110414505},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.541293740272522},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5212724208831787},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4944484233856201},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.4648754894733429},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4424581825733185},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4060799479484558},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3909991681575775},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3295174837112427},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2057659924030304},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20351439714431763},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2022683322429657},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16349905729293823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1228884756565094},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07342076301574707},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s12859-019-2834-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2834-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-019-2834-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:96741b6a7b144d0ea10bfca65ce4a131","is_oa":true,"landing_page_url":"https://doaj.org/article/96741b6a7b144d0ea10bfca65ce4a131","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss S12, Pp 1-13 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6584515","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6584515","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2834-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2834-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-019-2834-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1267142038","display_name":null,"funder_award_id":"1750981","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3433177501","display_name":null,"funder_award_id":"1716964","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5921281487","display_name":null,"funder_award_id":"number","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2952109320.pdf","grobid_xml":"https://content.openalex.org/works/W2952109320.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W953912505","https://openalex.org/W1520083411","https://openalex.org/W1981409633","https://openalex.org/W1985213868","https://openalex.org/W2009405916","https://openalex.org/W2018035705","https://openalex.org/W2046683077","https://openalex.org/W2055043387","https://openalex.org/W2057381986","https://openalex.org/W2058539819","https://openalex.org/W2083796801","https://openalex.org/W2090247362","https://openalex.org/W2098597355","https://openalex.org/W2101357408","https://openalex.org/W2125118217","https://openalex.org/W2139823104","https://openalex.org/W2146980885","https://openalex.org/W2155535327","https://openalex.org/W2159482845","https://openalex.org/W2168950294","https://openalex.org/W2337092408","https://openalex.org/W2484866312","https://openalex.org/W2514549943","https://openalex.org/W2526546796","https://openalex.org/W2531144091","https://openalex.org/W2545753590","https://openalex.org/W2559588208","https://openalex.org/W2568716867","https://openalex.org/W2594056681","https://openalex.org/W2623056867","https://openalex.org/W2626562392","https://openalex.org/W2758446026","https://openalex.org/W2777388159","https://openalex.org/W2809129882","https://openalex.org/W4230455772","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W4280602684","https://openalex.org/W4310092953","https://openalex.org/W2227393071","https://openalex.org/W4402326599","https://openalex.org/W1995350144","https://openalex.org/W2082102603","https://openalex.org/W1557094818","https://openalex.org/W2166141227","https://openalex.org/W3133980636","https://openalex.org/W4378085486"],"abstract_inverted_index":{"Schizophrenia":[0],"and":[1,32,84,117,119],"autism":[2,85],"are":[3,18,128],"examples":[4],"of":[5,12,16,107],"polygenic":[6],"diseases":[7,24],"caused":[8],"by":[9,142],"a":[10,41,66,74,88,157],"multitude":[11],"genetic":[13],"variants,":[14],"many":[15],"which":[17,54],"still":[19],"poorly":[20],"understood.":[21],"Recently,":[22],"both":[23,115],"have":[25],"been":[26],"associated":[27,64,132],"with":[28,65,133],"disrupted":[29],"neuron":[30],"motility":[31,39,135,154],"migration":[33],"patterns,":[34],"suggesting":[35],"that":[36,61,127],"aberrant":[37],"cell":[38,70,134,153],"is":[40],"phenotype":[42,67],"for":[43,82,114,136,159,162],"these":[44,149],"neurological":[45],"diseases.":[46],"We":[47,72,110],"formulate":[48],"the":[49],"Polygenic":[50],"Disease":[51],"Phenotype":[52],"Problem":[53],"seeks":[55],"to":[56,78,130],"identify":[57,111],"candidate":[58],"disease":[59],"genes":[60,86,122,140],"may":[62],"be":[63,131],"such":[68],"as":[69,124],"motility.":[71],"present":[73],"machine":[75],"learning":[76,98],"approach":[77],"solve":[79],"this":[80],"problem":[81],"schizophrenia":[83,116,125],"within":[87],"brain-specific":[89],"functional":[90],"interaction":[91],"network.":[92],"Our":[93],"method":[94,144],"outperforms":[95],"peer":[96],"semi-supervised":[97],"approaches,":[99],"achieving":[100],"better":[101],"cross-validation":[102],"accuracy":[103],"across":[104],"different":[105],"sets":[106],"gold-standard":[108],"positives.":[109],"top":[112],"candidates":[113],"autism,":[118],"select":[120],"six":[121],"labeled":[123],"positives":[126],"predicted":[129,141],"follow-up":[137],"experiments.":[138],"Candidate":[139],"our":[143],"suggest":[145],"testable":[146],"hypotheses":[147],"about":[148],"genes&#x2019;":[150],"role":[151],"in":[152],"regulation,":[155],"offering":[156],"framework":[158],"generating":[160],"predictions":[161],"experimental":[163],"validation.":[164]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2019-06-27T00:00:00"}
