{"id":"https://openalex.org/W2942619232","doi":"https://doi.org/10.1186/s12859-019-2804-7","title":"pwrEWAS: a user-friendly tool for comprehensive power estimation for epigenome wide association studies (EWAS)","display_name":"pwrEWAS: a user-friendly tool for comprehensive power estimation for epigenome wide association studies (EWAS)","publication_year":2019,"publication_date":"2019-04-29","ids":{"openalex":"https://openalex.org/W2942619232","doi":"https://doi.org/10.1186/s12859-019-2804-7","mag":"2942619232","pmid":"https://pubmed.ncbi.nlm.nih.gov/31035919"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2804-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2804-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2804-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2804-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078983295","display_name":"Stefan Graw","orcid":"https://orcid.org/0000-0002-6386-8267"},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stefan Graw","raw_affiliation_strings":["Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA. sgraw@kumc.edu","Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA. sgraw@kumc.edu","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071062793","display_name":"Rosalyn Henn","orcid":null},"institutions":[{"id":"https://openalex.org/I4210097601","display_name":"The University of Kansas Cancer Center","ror":"https://ror.org/00cj35179","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210097601"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosalyn Henn","raw_affiliation_strings":["Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210097601","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043239621","display_name":"Jeffrey Thompson","orcid":"https://orcid.org/0000-0002-0876-2582"},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Thompson","raw_affiliation_strings":["Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046887908","display_name":"Devin C. Koestler","orcid":"https://orcid.org/0000-0002-0598-0146"},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devin C. Koestler","raw_affiliation_strings":["Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5078983295"],"corresponding_institution_ids":["https://openalex.org/I4210128618"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":3.0359,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.92607754,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"20","issue":"1","first_page":"218","last_page":"218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9757000207901001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9757000207901001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenome","display_name":"Epigenome","score":0.6675655841827393},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5467133522033691},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4875158965587616},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.4315093159675598},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34718018770217896},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3344745934009552},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16187646985054016},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.12623968720436096},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.05979400873184204}],"concepts":[{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.6675655841827393},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5467133522033691},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4875158965587616},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4315093159675598},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34718018770217896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3344745934009552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16187646985054016},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.12623968720436096},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.05979400873184204},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072137","descriptor_name":"Vaping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072137","descriptor_name":"Vaping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072137","descriptor_name":"Vaping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-019-2804-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2804-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2804-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31035919","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31035919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:bfe80e3521fb4ff6b7f0b1c0bcb9959a","is_oa":true,"landing_page_url":"https://doaj.org/article/bfe80e3521fb4ff6b7f0b1c0bcb9959a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6489300","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6489300","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2804-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2804-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-2804-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1562291867","display_name":null,"funder_award_id":"P20GM130423","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2122358390","display_name":null,"funder_award_id":"P20GM103428","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2947088261","display_name":null,"funder_award_id":"P20GM103418","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8876850027","display_name":null,"funder_award_id":"R01 GM103428","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320318255","display_name":"Kansas IDeA Network of Biomedical Research Excellence","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2942619232.pdf","grobid_xml":"https://content.openalex.org/works/W2942619232.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1505461723","https://openalex.org/W1831033366","https://openalex.org/W1903636186","https://openalex.org/W1973276909","https://openalex.org/W1988142188","https://openalex.org/W1998781826","https://openalex.org/W2004078197","https://openalex.org/W2006345816","https://openalex.org/W2013250198","https://openalex.org/W2013394396","https://openalex.org/W2017421607","https://openalex.org/W2028934624","https://openalex.org/W2029033394","https://openalex.org/W2056040742","https://openalex.org/W2085245717","https://openalex.org/W2098831884","https://openalex.org/W2110065044","https://openalex.org/W2115937056","https://openalex.org/W2120731353","https://openalex.org/W2125154191","https://openalex.org/W2127196115","https://openalex.org/W2131971406","https://openalex.org/W2140126911","https://openalex.org/W2146512944","https://openalex.org/W2153250619","https://openalex.org/W2157710407","https://openalex.org/W2159355317","https://openalex.org/W2163125553","https://openalex.org/W2265071267","https://openalex.org/W2330913826","https://openalex.org/W2409726837","https://openalex.org/W2417825602","https://openalex.org/W2462888294","https://openalex.org/W2475097768","https://openalex.org/W2523285199","https://openalex.org/W2529024004","https://openalex.org/W2559035279","https://openalex.org/W2559803947","https://openalex.org/W2604095865","https://openalex.org/W2606184024","https://openalex.org/W2745699865","https://openalex.org/W2759370647","https://openalex.org/W2767572999","https://openalex.org/W2784262524","https://openalex.org/W2788635059","https://openalex.org/W2803621926","https://openalex.org/W2806489581","https://openalex.org/W2808054557","https://openalex.org/W4210458536"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W3004038459","https://openalex.org/W2172945310","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W4388200994","https://openalex.org/W1993764875","https://openalex.org/W2787062849"],"abstract_inverted_index":{"When":[0],"designing":[1],"an":[2],"epigenome-wide":[3],"association":[4],"study":[5],"(EWAS)":[6],"to":[7,24,30,60,144,155,160,169,205,276,283],"investigate":[8],"the":[9,26,40,62,105,146,157,171,188,196,212,286,298],"relationship":[10],"between":[11],"DNA":[12],"methylation":[13,99,208],"(DNAm)":[14],"and":[15,42,59,131,187,194,222,256,262,282,288,308],"some":[16],"exposure(s)":[17],"or":[18],"phenotype(s),":[19],"it":[20],"is":[21,101,112,123,295,309,319],"critically":[22],"important":[23],"assess":[25],"sample":[27,172],"size":[28],"needed":[29],"detect":[31],"a":[32,66,115,238,249,267,273],"hypothesized":[33],"difference":[34],"with":[35],"adequate":[36],"statistical":[37,52,203,300],"power.":[38],"However,":[39],"complex":[41],"nuanced":[43],"nature":[44],"of":[45,51,80,88,136,175,190,198,251,266,290],"DNAm":[46,89,121,140,164],"data":[47,122,141,192],"makes":[48],"direct":[49],"assessment":[50,100],"power":[53,71,83],"challenging.":[54],"To":[55],"circumvent":[56,279],"these":[57,280],"challenges":[58],"address":[61],"outstanding":[63],"need":[64],"for":[65,69,85,163,317],"user-friendly":[67,274],"interface":[68,294],"EWAS":[70],"evaluation,":[72],"we":[73,228,243,271],"have":[74,195],"developed":[75],"pwrEWAS.":[76],"The":[77,292,314],"current":[78],"implementation":[79],"pwrEWAS":[81,210,231,318],"accommodates":[82],"estimation":[84],"two-group":[86],"comparisons":[87],"(e.g.":[90],"case":[91],"vs":[92,95],"control,":[93],"exposed":[94],"non-exposed,":[96],"etc.),":[97],"where":[98],"carried":[102],"out":[103],"using":[104,114,128,237,303],"Illumina":[106],"Human":[107],"Methylation":[108],"BeadChip":[109],"technology.":[110],"Power":[111],"calculated":[113],"semi-parametric":[116],"simulation-based":[117],"approach":[118],"in":[119,151,235,285,297],"which":[120],"randomly":[124],"generated":[125],"from":[126,134,200],"beta-distributions":[127],"CpG-specific":[129],"means":[130],"variances":[132],"estimated":[133],"one":[135],"several":[137,201],"different":[138,202],"existing":[139],"sets,":[142,193],"chosen":[143],"cover":[145],"most":[147],"common":[148],"tissue-types":[149],"used":[150,162],"EWAS.":[152,240,291],"In":[153,241],"addition":[154],"specifying":[156],"tissue":[158],"type":[159,216],"be":[161,233],"profiling,":[165],"users":[166],"are":[167],"required":[168],"specify":[170],"size,":[173],"number":[174,189],"differentially":[176],"methylated":[177],"CpGs,":[178],"effect":[179],"size(s)":[180],"(\u0394\u03b2),":[181],"target":[182],"false":[183,223],"discovery":[184,224],"rate":[185],"(FDR)":[186],"simulated":[191],"option":[197],"selecting":[199],"methods":[204],"perform":[206],"differential":[207],"analyses.":[209],"reports":[211],"marginal":[213,215,220],"power,":[214],"I":[217],"error":[218],"rate,":[219],"FDR,":[221],"cost":[225],"(FDC).":[226],"Here,":[227],"demonstrate":[229],"how":[230],"can":[232],"applied":[234],"practice":[236],"hypothetical":[239],"addition,":[242],"report":[244],"its":[245],"computational":[246],"efficiency":[247],"across":[248],"variety":[250],"user":[252],"settings.":[253],"Both":[254],"under-":[255],"overpowered":[257],"studies":[258],"unnecessarily":[259],"deplete":[260],"resources":[261],"even":[263],"risk":[264],"failure":[265],"study.":[268],"With":[269],"pwrEWAS,":[270],"provide":[272],"tool":[275],"help":[277],"researchers":[278],"risks":[281],"assist":[284],"design":[287],"planning":[289],"web":[293],"written":[296],"R":[299,315],"programming":[301],"language":[302],"Shiny":[304],"(RStudio":[305],"Inc.,":[306],"2016)":[307],"available":[310,321],"at":[311,322],"https://biostats-shinyr.kumc.edu/pwrEWAS/":[312],".":[313],"package":[316],"publicly":[320],"GitHub":[323],"(":[324],"https://github.com/stefangraw/pwrEWAS":[325],").":[326]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":2}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}