{"id":"https://openalex.org/W2942514872","doi":"https://doi.org/10.1186/s12859-019-2734-4","title":"Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data","display_name":"Investigation of lipid metabolism dysregulation and the effects on immune microenvironments in pan-cancer using multiple omics data","publication_year":2019,"publication_date":"2019-05-01","ids":{"openalex":"https://openalex.org/W2942514872","doi":"https://doi.org/10.1186/s12859-019-2734-4","mag":"2942514872","pmid":"https://pubmed.ncbi.nlm.nih.gov/31074374"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-019-2734-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2734-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-019-2734-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-019-2734-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yang Hao","orcid":null},"institutions":[{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]},{"id":"https://openalex.org/I4210120203","display_name":"Shanghai Academy of Science & Technology","ror":"https://ror.org/02mg3as63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120203"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Hao","raw_affiliation_strings":["School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","institution_ids":["https://openalex.org/I148128674"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I4210120203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010248726","display_name":"Daixi Li","orcid":"https://orcid.org/0000-0002-7112-2801"},"institutions":[{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Daixi Li","raw_affiliation_strings":["School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China. dxli75@126.com","School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China. dxli75@126.com","institution_ids":["https://openalex.org/I148128674"]},{"raw_affiliation_string":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","institution_ids":["https://openalex.org/I148128674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010154803","display_name":"Yong Xu","orcid":"https://orcid.org/0000-0001-5889-1094"},"institutions":[{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]},{"id":"https://openalex.org/I4210120203","display_name":"Shanghai Academy of Science & Technology","ror":"https://ror.org/02mg3as63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120203"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Xu","raw_affiliation_strings":["School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","institution_ids":["https://openalex.org/I148128674"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I4210120203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101796254","display_name":"Jian Ouyang","orcid":"https://orcid.org/0000-0002-7851-7064"},"institutions":[{"id":"https://openalex.org/I4210120203","display_name":"Shanghai Academy of Science & Technology","ror":"https://ror.org/02mg3as63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120203"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Ouyang","raw_affiliation_strings":["Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I4210120203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101883503","display_name":"Yongkun Wang","orcid":"https://orcid.org/0000-0001-5705-8674"},"institutions":[{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]},{"id":"https://openalex.org/I4210120203","display_name":"Shanghai Academy of Science & Technology","ror":"https://ror.org/02mg3as63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120203"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongkun Wang","raw_affiliation_strings":["School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","institution_ids":["https://openalex.org/I148128674"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I4210120203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100340321","display_name":"Yuqi Zhang","orcid":"https://orcid.org/0009-0006-3903-6352"},"institutions":[{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]},{"id":"https://openalex.org/I4210120203","display_name":"Shanghai Academy of Science & Technology","ror":"https://ror.org/02mg3as63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120203"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Zhang","raw_affiliation_strings":["School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","institution_ids":["https://openalex.org/I148128674"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I4210120203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100758248","display_name":"Baoguo Li","orcid":"https://orcid.org/0000-0002-5466-705X"},"institutions":[{"id":"https://openalex.org/I148128674","display_name":"University of Shanghai for Science and Technology","ror":"https://ror.org/00ay9v204","country_code":"CN","type":"education","lineage":["https://openalex.org/I148128674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baoguo Li","raw_affiliation_strings":["School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China","institution_ids":["https://openalex.org/I148128674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033203853","display_name":"Lu Xie","orcid":"https://orcid.org/0000-0001-7541-2243"},"institutions":[{"id":"https://openalex.org/I4210120203","display_name":"Shanghai Academy of Science & Technology","ror":"https://ror.org/02mg3as63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120203"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lu Xie","raw_affiliation_strings":["Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China. luxiex2017@outlook.com","Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China. luxiex2017@outlook.com","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I4210120203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039544050","display_name":"Guangrong Qin","orcid":"https://orcid.org/0000-0001-8836-1246"},"institutions":[{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]},{"id":"https://openalex.org/I4210120203","display_name":"Shanghai Academy of Science & Technology","ror":"https://ror.org/02mg3as63","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120203"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Guangrong Qin","raw_affiliation_strings":["Institute for Systems Biology, Seattle, WA, 98109, USA. guangrong.qin@systemsbiology.org","Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China. guangrong.qin@systemsbiology.org","Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Systems Biology, Seattle, WA, 98109, USA. guangrong.qin@systemsbiology.org","institution_ids":["https://openalex.org/I3148997608"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China. guangrong.qin@systemsbiology.org","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"Shanghai Center for Bioinformation Technology, Shanghai Academy of Science and Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648","https://openalex.org/I4210120203"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010248726","https://openalex.org/A5033203853","https://openalex.org/A5039544050"],"corresponding_institution_ids":["https://openalex.org/I148128674","https://openalex.org/I3148997608","https://openalex.org/I4210120203","https://openalex.org/I4210162648"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":3.9419,"has_fulltext":true,"cited_by_count":137,"citation_normalized_percentile":{"value":0.95762142,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"20","issue":"S7","first_page":"195","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9574000239372253,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9574000239372253,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6710450053215027},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"Lipid metabolism","score":0.6267432570457458},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"Immune dysregulation","score":0.6032178401947021},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.5393251180648804},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5180390477180481},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.5152766704559326},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5040034651756287},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48388776183128357},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4762685000896454},{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.4170185327529907},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3711722493171692},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.26613783836364746},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.18703216314315796},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1848951280117035},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1789473593235016},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15090736746788025}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6710450053215027},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.6267432570457458},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.6032178401947021},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5393251180648804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5180390477180481},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5152766704559326},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5040034651756287},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48388776183128357},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4762685000896454},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.4170185327529907},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3711722493171692},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26613783836364746},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18703216314315796},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1848951280117035},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1789473593235016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15090736746788025}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-019-2734-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2734-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-019-2734-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31074374","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31074374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:d8693b3cb1754f8a93a899a8afe61b8e","is_oa":true,"landing_page_url":"https://doaj.org/article/d8693b3cb1754f8a93a899a8afe61b8e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 20, Iss S7, Pp 29-39 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5527948","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6509864","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-019-2734-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-019-2734-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-019-2734-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2029770524","display_name":null,"funder_award_id":"17ZR1420300","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G2491103884","display_name":null,"funder_award_id":"2016YFC0904101","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5220503569","display_name":null,"funder_award_id":"16CXXF001","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5227407644","display_name":null,"funder_award_id":"2014DFB30020","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8639900445","display_name":null,"funder_award_id":"2014DFB30030","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2942514872.pdf","grobid_xml":"https://content.openalex.org/works/W2942514872.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1980568044","https://openalex.org/W1985987855","https://openalex.org/W1986705681","https://openalex.org/W1988393300","https://openalex.org/W2016661249","https://openalex.org/W2037320975","https://openalex.org/W2055515174","https://openalex.org/W2061869088","https://openalex.org/W2086993468","https://openalex.org/W2093172432","https://openalex.org/W2101870168","https://openalex.org/W2114104545","https://openalex.org/W2117692326","https://openalex.org/W2129873144","https://openalex.org/W2150629192","https://openalex.org/W2160368262","https://openalex.org/W2165191737","https://openalex.org/W2191029587","https://openalex.org/W2507880739","https://openalex.org/W2594575075","https://openalex.org/W2734141593","https://openalex.org/W2735511041","https://openalex.org/W2752053733","https://openalex.org/W2773709091","https://openalex.org/W2783371025","https://openalex.org/W2788142646","https://openalex.org/W2795395475"],"related_works":["https://openalex.org/W3127131116","https://openalex.org/W177137871","https://openalex.org/W4292302930","https://openalex.org/W4386960635","https://openalex.org/W4213236275","https://openalex.org/W4307869277","https://openalex.org/W4388793972","https://openalex.org/W2924366642","https://openalex.org/W2594649246","https://openalex.org/W4388460489"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lipid":[1],"metabolism":[2,22,59,98,110,120,130,134,143,191,210,225,233,269,277,289,294,312],"reprogramming":[3],"is":[4,25],"a":[5],"hallmark":[6],"for":[7,188,254,305],"tumor":[8,36,52,147,203,255,296],"which":[9,250],"contributes":[10],"to":[11,47,231],"tumorigenesis":[12,77,280],"and":[13,18,41,78,111,131,157,170,180,205,226,234,248,281,290],"progression,":[14],"but":[15],"the":[16,33,51,74,85,94,126,166,173,184,189,196,202,206,220,273,283],"commonality":[17],"difference":[19],"of":[20,43,57,76,84,117,152,172,183,195,198,208,267,275,286,292,310],"lipid":[21,58,97,142,174,190,209,216,224,232,268,288,293,311],"among":[23],"pan-cancer":[24,101],"not":[26],"fully":[27],"investigated.":[28],"Increasing":[29],"evidences":[30],"suggest":[31],"that":[32,93,161,237],"alterations":[34],"in":[35,50,60,100,128,145,201,270,279,313],"metabolism,":[37,105,108],"including":[38,165,245],"metabolite":[39],"abundance":[40],"accumulation":[42],"metabolic":[44,217],"products,":[45],"lead":[46],"local":[48],"immunosuppression":[49],"microenvironment.":[53,298],"An":[54,149],"integrated":[55,150,265],"analysis":[56,83,151,194,266],"cancers":[61],"from":[62,89],"different":[63,146],"tissues":[64],"using":[65],"multiple":[66,86],"omics":[67,87],"data":[68,88],"may":[69,251],"provide":[70,252],"novel":[71],"insight":[72],"into":[73],"understanding":[75],"progression.":[79],"RESULTS:":[80],"Through":[81],"systematic":[82],"TCGA,":[90],"we":[91],"found":[92],"most-widely":[95],"altered":[96],"pathways":[99],"are":[102,238],"fatty":[103,118],"acid":[104,107,119,133],"arachidonic":[106,132],"cholesterol":[109,129],"PPAR":[112],"signaling.":[113],"Gene":[114],"expression":[115,182,207],"profiles":[116],"show":[121],"commonalities":[122],"across":[123],"pan-cancer,":[124,271],"while":[125],"alteration":[127],"differ":[135],"with":[136,240],"tissue":[137,140],"origin,":[138],"suggesting":[139],"specific":[141],"features":[144],"types.":[148],"gene":[153,163],"expression,":[154,164],"DNA":[155],"methylation":[156],"mutations":[158,171],"revealed":[159,212],"factors":[160,187],"regulate":[162],"differentially":[167,214],"methylated":[168],"sites":[169],"genes,":[175,218],"as":[176,178],"well":[177],"mutation":[179],"differential":[181],"up-stream":[185],"transcription":[186],"pathways.":[192],"Correlation":[193],"proportion":[197],"immune":[199,227,235,297],"cells":[200],"microenvironment":[204],"genes":[211],"immune-related":[213],"expressed":[215],"indicating":[219],"potential":[221],"crosstalk":[222],"between":[223],"response.":[228],"Genes":[229],"related":[230],"response":[236],"associated":[239],"poor":[241],"prognosis":[242],"were":[243],"discovered":[244],"HMGCS2,":[246],"GPX2":[247],"CD36,":[249],"clues":[253,304],"biomarkers":[256,306],"or":[257,307],"therapeutic":[258,308],"targets.":[259],"CONCLUSIONS:":[260],"Our":[261],"study":[262,300],"provides":[263,302],"an":[264],"highlights":[272],"perturbation":[274],"key":[276],"processes":[278],"clarificates":[282],"regulation":[284],"mechanism":[285],"abnormal":[287],"effects":[291],"on":[295],"This":[299],"also":[301],"new":[303],"targets":[309],"tumors.":[314]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":33},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":3}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2025-10-10T00:00:00"}
