{"id":"https://openalex.org/W2906092989","doi":"https://doi.org/10.1186/s12859-018-2509-3","title":"Predicting tumor cell line response to drug pairs with deep learning","display_name":"Predicting tumor cell line response to drug pairs with deep learning","publication_year":2018,"publication_date":"2018-12-01","ids":{"openalex":"https://openalex.org/W2906092989","doi":"https://doi.org/10.1186/s12859-018-2509-3","mag":"2906092989","pmid":"https://pubmed.ncbi.nlm.nih.gov/30577754"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-018-2509-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2509-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2509-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2509-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049471852","display_name":"Fangfang Xia","orcid":"https://orcid.org/0000-0001-6567-0564"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fangfang Xia","raw_affiliation_strings":["Computation Institute, The University of Chicago, Chicago, IL, USA. fangfang@anl.gov","Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA. fangfang@anl.gov","Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computation Institute, The University of Chicago, Chicago, IL, USA. fangfang@anl.gov","institution_ids":[]},{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA. fangfang@anl.gov","institution_ids":[]},{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040025864","display_name":"Maulik Shukla","orcid":"https://orcid.org/0009-0002-3396-5725"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maulik Shukla","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046675967","display_name":"Thomas Brettin","orcid":"https://orcid.org/0000-0001-9301-9760"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Brettin","raw_affiliation_strings":["Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086975677","display_name":"Cristina Garc\u00eda\u2013Cardona","orcid":"https://orcid.org/0000-0002-5641-3491"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Garcia-Cardona","raw_affiliation_strings":["Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM, USA","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065877660","display_name":"Judith D. Cohn","orcid":"https://orcid.org/0000-0002-1333-3395"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith Cohn","raw_affiliation_strings":["Computer Science, Los Alamos National Laboratory, Los Alamos, NM, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computer Science, Los Alamos National Laboratory, Los Alamos, NM, USA","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035849909","display_name":"Jonathan Allen","orcid":"https://orcid.org/0000-0002-4359-8263"},"institutions":[{"id":"https://openalex.org/I1282311441","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282311441","https://openalex.org/I1330989302","https://openalex.org/I198811213","https://openalex.org/I4210138311"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan E. Allen","raw_affiliation_strings":["Computation Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computation Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA","institution_ids":["https://openalex.org/I1282311441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017591427","display_name":"Sergei Maslov","orcid":"https://orcid.org/0000-0002-3701-492X"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergei Maslov","raw_affiliation_strings":["Department of Bioengineering and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049975653","display_name":"Susan L. Holbeck","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan L. Holbeck","raw_affiliation_strings":["Developmental Therapeutics Branch, National Cancer Institute, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Branch, National Cancer Institute, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041200743","display_name":"James H. Doroshow","orcid":"https://orcid.org/0000-0002-4463-1790"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James H. Doroshow","raw_affiliation_strings":["Developmental Therapeutics Branch, National Cancer Institute, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Branch, National Cancer Institute, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044153234","display_name":"Yvonne A. Evrard","orcid":"https://orcid.org/0000-0002-3475-4850"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yvonne A. Evrard","raw_affiliation_strings":["Developmental Therapeutics Branch, National Cancer Institute, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Therapeutics Branch, National Cancer Institute, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023060808","display_name":"Eric Stahlberg","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric A. Stahlberg","raw_affiliation_strings":["Data Science and Information Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data Science and Information Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053682943","display_name":"Rick Stevens","orcid":"https://orcid.org/0000-0002-4268-4020"},"institutions":[{"id":"https://openalex.org/I1282105669","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1282105669","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I40347166"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rick L. Stevens","raw_affiliation_strings":["Computation Institute, The University of Chicago, Chicago, IL, USA","Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computation Institute, The University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Computing, Environment and Life Sciences, Argonne National Laboratory, Lemont, IL, USA","institution_ids":["https://openalex.org/I1282105669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5049471852"],"corresponding_institution_ids":["https://openalex.org/I1282105669"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":5.7533,"has_fulltext":true,"cited_by_count":130,"citation_normalized_percentile":{"value":0.97100104,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"19","issue":"S18","first_page":"486","last_page":"486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.6204000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.6204000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.043299999088048935,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-response","display_name":"Drug response","score":0.6735937595367432},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5291082262992859},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.523868978023529},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5232654809951782},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.516922652721405},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4943366050720215},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4612409770488739},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4284886419773102},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.40799203515052795},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3253706693649292},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.268154114484787},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.10544329881668091}],"concepts":[{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.6735937595367432},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5291082262992859},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.523868978023529},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5232654809951782},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.516922652721405},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4943366050720215},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4612409770488739},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4284886419773102},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.40799203515052795},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3253706693649292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.268154114484787},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.10544329881668091},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054547","descriptor_name":"National Cancer Institute (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054547","descriptor_name":"National Cancer Institute (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054547","descriptor_name":"National Cancer Institute (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054547","descriptor_name":"National Cancer Institute (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054547","descriptor_name":"National Cancer Institute (U.S.)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12859-018-2509-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2509-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2509-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30577754","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30577754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:osti.gov:1507790","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1507790","pdf_url":"https://www.osti.gov/servlets/purl/1507790","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:1860769","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1860769","pdf_url":"https://www.osti.gov/servlets/purl/1860769","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:fd72bada8c0f46febf9520c3cdac029a","is_oa":true,"landing_page_url":"https://doaj.org/article/fd72bada8c0f46febf9520c3cdac029a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 19, Iss S18, Pp 71-79 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5287151","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6302446","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6302446","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6302446","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-018-2509-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2509-3","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2509-3","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5699999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1313983767","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G1716777315","display_name":null,"funder_award_id":"DE-AC52-07NA27344","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1899543020","display_name":null,"funder_award_id":"DE-AC5206NA25396","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G2569679037","display_name":null,"funder_award_id":"JDACS4C","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3005847338","display_name":null,"funder_award_id":"JDACS4C","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G314071323","display_name":null,"funder_award_id":"JDACS4C","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4519693722","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5359441962","display_name":null,"funder_award_id":"DE-AC5206NA25396","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G5522089832","display_name":null,"funder_award_id":"DE-AC52-07NA27344","funder_id":"https://openalex.org/F4320338286","funder_display_name":"Lawrence Livermore National Laboratory"},{"id":"https://openalex.org/G5783643890","display_name":null,"funder_award_id":"DE-AC02-06-CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6032214852","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G632693473","display_name":null,"funder_award_id":"DE-AC52-07NA27344","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6474786868","display_name":null,"funder_award_id":"DE-AC5206NA25396","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6558272803","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G7989027471","display_name":null,"funder_award_id":"DE-AC52-07NA27344","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G8374966015","display_name":null,"funder_award_id":"AC52-07NA27344","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G8595310706","display_name":null,"funder_award_id":"DE-AC02-06-CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G8666256197","display_name":null,"funder_award_id":"DE-AC52-07NA27344","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G991281326","display_name":null,"funder_award_id":"AC52-07NA27344","funder_id":"https://openalex.org/F4320338286","funder_display_name":"Lawrence Livermore National Laboratory"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"},{"id":"https://openalex.org/F4320338286","display_name":"Lawrence Livermore National Laboratory","ror":"https://ror.org/041nk4h53"},{"id":"https://openalex.org/F4320338304","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2906092989.pdf","grobid_xml":"https://content.openalex.org/works/W2906092989.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1974254202","https://openalex.org/W1992014004","https://openalex.org/W1996880875","https://openalex.org/W1999798000","https://openalex.org/W2034235577","https://openalex.org/W2036291018","https://openalex.org/W2087312216","https://openalex.org/W2089856956","https://openalex.org/W2101234009","https://openalex.org/W2103196126","https://openalex.org/W2108933868","https://openalex.org/W2117692612","https://openalex.org/W2120204563","https://openalex.org/W2121404287","https://openalex.org/W2125789330","https://openalex.org/W2129860849","https://openalex.org/W2130240391","https://openalex.org/W2139602588","https://openalex.org/W2177689130","https://openalex.org/W2194775991","https://openalex.org/W2290847742","https://openalex.org/W2326790354","https://openalex.org/W2502949459","https://openalex.org/W2562523657","https://openalex.org/W2582187633","https://openalex.org/W2594183968","https://openalex.org/W2604306554","https://openalex.org/W2608863179","https://openalex.org/W3100157108","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W4375867731","https://openalex.org/W2611989081","https://openalex.org/W2480711475","https://openalex.org/W4230611425","https://openalex.org/W2731899572","https://openalex.org/W4294635752","https://openalex.org/W4304166257","https://openalex.org/W4383066092","https://openalex.org/W3215138031","https://openalex.org/W2804383999"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"National":[2],"Cancer":[3],"Institute":[4],"drug":[5,24,41,97,110,144],"pair":[6],"screening":[7,150],"effort":[8],"against":[9],"60":[10],"well-characterized":[11],"human":[12],"tumor":[13,59],"cell":[14,34,114,154],"lines":[15,155],"(NCI-60)":[16],"presents":[17],"an":[18],"unprecedented":[19],"resource":[20],"for":[21,32,52,112,158],"modeling":[22],"combinational":[23,143],"activity.":[25,131],"RESULTS:":[26],"We":[27,133],"present":[28,134],"a":[29,38,76],"computational":[30],"model":[31,62,118],"predicting":[33,58,142],"line":[35,115],"response":[36,67],"to":[37,141,161],"subset":[39],"of":[40,65,78,91,125,165],"pairs":[42,111,128],"in":[43,103,137],"the":[44,66,92,109,126,159],"NCI-ALMANAC":[45],"database.":[46],"Based":[47],"on":[48,117],"residual":[49],"neural":[50],"networks":[51],"encoding":[53],"features":[54],"as":[55,57],"well":[56],"growth,":[60],"our":[61,70],"explains":[63],"94%":[64],"variance.":[68],"While":[69],"best":[71],"result":[72],"is":[73],"achieved":[74],"with":[75,129],"combination":[77,120],"molecular":[79,166],"feature":[80,147],"types":[81],"(gene":[82],"expression,":[83],"microRNA":[84],"and":[85,122],"proteome),":[86],"we":[87,107],"show":[88],"that":[89],"most":[90],"predictive":[93],"power":[94],"comes":[95],"from":[96],"descriptors.":[98],"To":[99],"further":[100],"demonstrate":[101],"value":[102],"detecting":[104],"anticancer":[105],"therapy,":[106],"rank":[108],"each":[113],"based":[116],"predicted":[119],"effect":[121],"recover":[123],"80%":[124],"top":[127],"enhanced":[130],"CONCLUSIONS:":[132],"promising":[135],"results":[136],"applying":[138],"deep":[139],"learning":[140],"response.":[145],"Our":[146],"analysis":[148],"indicates":[149],"data":[151],"involving":[152],"more":[153],"are":[156],"needed":[157],"models":[160],"make":[162],"better":[163],"use":[164],"features.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":21},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":13}],"updated_date":"2026-05-14T08:36:36.166977","created_date":"2025-10-10T00:00:00"}