{"id":"https://openalex.org/W2899127703","doi":"https://doi.org/10.1186/s12859-018-2437-2","title":"Adaptively capturing the heterogeneity of expression for cancer biomarker identification","display_name":"Adaptively capturing the heterogeneity of expression for cancer biomarker identification","publication_year":2018,"publication_date":"2018-11-03","ids":{"openalex":"https://openalex.org/W2899127703","doi":"https://doi.org/10.1186/s12859-018-2437-2","mag":"2899127703","pmid":"https://pubmed.ncbi.nlm.nih.gov/30390627"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-018-2437-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2437-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2437-2.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2437-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113133440","display_name":"Xin-Ping Xie","orcid":null},"institutions":[{"id":"https://openalex.org/I118987531","display_name":"Anhui Jianzhu University","ror":"https://ror.org/0108wjw08","country_code":"CN","type":"education","lineage":["https://openalex.org/I118987531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin-Ping Xie","raw_affiliation_strings":["School of Mathematics and Physics, Anhui Jianzhu University, Hefei, 230022, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Physics, Anhui Jianzhu University, Hefei, 230022, Anhui, China","institution_ids":["https://openalex.org/I118987531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100704299","display_name":"Yufeng Xie","orcid":"https://orcid.org/0000-0002-9458-7003"},"institutions":[{"id":"https://openalex.org/I118987531","display_name":"Anhui Jianzhu University","ror":"https://ror.org/0108wjw08","country_code":"CN","type":"education","lineage":["https://openalex.org/I118987531"]},{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]},{"id":"https://openalex.org/I2802624667","display_name":"Hefei Institutes of Physical Science","ror":"https://ror.org/046n57345","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667"]},{"id":"https://openalex.org/I4210099079","display_name":"Institute of Intelligent Machines","ror":"https://ror.org/00w0qep84","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667","https://openalex.org/I4210099079"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Feng Xie","raw_affiliation_strings":["Institute of Intelligent Machines, Hefei Institutes of Physical Science, CAS, 350 Shushanhu Road, P.O.Box 1130, Hefei, 230031, Anhui, China","Present Address: School of Electronics and Information, Northwestern Polytechnical University, Xi'an, 710100, China","School of Mathematics and Physics, Anhui Jianzhu University, Hefei, 230022, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Intelligent Machines, Hefei Institutes of Physical Science, CAS, 350 Shushanhu Road, P.O.Box 1130, Hefei, 230031, Anhui, China","institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I4210099079"]},{"raw_affiliation_string":"Present Address: School of Electronics and Information, Northwestern Polytechnical University, Xi'an, 710100, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Mathematics and Physics, Anhui Jianzhu University, Hefei, 230022, Anhui, China","institution_ids":["https://openalex.org/I118987531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100779101","display_name":"Yitong Liu","orcid":"https://orcid.org/0000-0003-0728-3018"},"institutions":[{"id":"https://openalex.org/I118987531","display_name":"Anhui Jianzhu University","ror":"https://ror.org/0108wjw08","country_code":"CN","type":"education","lineage":["https://openalex.org/I118987531"]},{"id":"https://openalex.org/I2802624667","display_name":"Hefei Institutes of Physical Science","ror":"https://ror.org/046n57345","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667"]},{"id":"https://openalex.org/I4210099079","display_name":"Institute of Intelligent Machines","ror":"https://ror.org/00w0qep84","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667","https://openalex.org/I4210099079"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Tong Liu","raw_affiliation_strings":["Institute of Intelligent Machines, Hefei Institutes of Physical Science, CAS, 350 Shushanhu Road, P.O.Box 1130, Hefei, 230031, Anhui, China","School of Mathematics and Physics, Anhui Jianzhu University, Hefei, 230022, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Intelligent Machines, Hefei Institutes of Physical Science, CAS, 350 Shushanhu Road, P.O.Box 1130, Hefei, 230031, Anhui, China","institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I4210099079"]},{"raw_affiliation_string":"School of Mathematics and Physics, Anhui Jianzhu University, Hefei, 230022, Anhui, China","institution_ids":["https://openalex.org/I118987531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100757646","display_name":"Hongqiang Wang","orcid":"https://orcid.org/0000-0003-1885-7611"},"institutions":[{"id":"https://openalex.org/I2802624667","display_name":"Hefei Institutes of Physical Science","ror":"https://ror.org/046n57345","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667"]},{"id":"https://openalex.org/I4210099079","display_name":"Institute of Intelligent Machines","ror":"https://ror.org/00w0qep84","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667","https://openalex.org/I4210099079"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong-Qiang Wang","raw_affiliation_strings":["Institute of Intelligent Machines, Hefei Institutes of Physical Science, CAS, 350 Shushanhu Road, P.O.Box 1130, Hefei, 230031, Anhui, China. hqwang126@126.com","Institute of Intelligent Machines, Hefei Institutes of Physical Science, CAS, 350 Shushanhu Road, P.O.Box 1130, Hefei, 230031, Anhui, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Intelligent Machines, Hefei Institutes of Physical Science, CAS, 350 Shushanhu Road, P.O.Box 1130, Hefei, 230031, Anhui, China. hqwang126@126.com","institution_ids":["https://openalex.org/I4210099079"]},{"raw_affiliation_string":"Institute of Intelligent Machines, Hefei Institutes of Physical Science, CAS, 350 Shushanhu Road, P.O.Box 1130, Hefei, 230031, Anhui, China","institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I4210099079"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100757646"],"corresponding_institution_ids":["https://openalex.org/I2802624667","https://openalex.org/I4210099079"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.10386429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"19","issue":"1","first_page":"401","last_page":"401"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8571000099182129,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.8571000099182129,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.04479999840259552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6309942603111267},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5578535199165344},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4883236587047577},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.46595296263694763},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4596428871154785},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4548490643501282},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.43541407585144043},{"id":"https://openalex.org/keywords/tumour-heterogeneity","display_name":"Tumour heterogeneity","score":0.4282296597957611},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41650527715682983},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.4114590883255005},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37629586458206177},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.35962021350860596},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.34166401624679565},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18056440353393555},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.129216730594635},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10056152939796448}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6309942603111267},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5578535199165344},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4883236587047577},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.46595296263694763},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4596428871154785},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4548490643501282},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.43541407585144043},{"id":"https://openalex.org/C2777306565","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumour heterogeneity","level":3,"score":0.4282296597957611},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41650527715682983},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.4114590883255005},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37629586458206177},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35962021350860596},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34166401624679565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18056440353393555},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.129216730594635},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10056152939796448},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-018-2437-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2437-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2437-2.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30390627","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30390627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:ce6025eb750a45349a2d00e63a4aaea6","is_oa":true,"landing_page_url":"https://doaj.org/article/ce6025eb750a45349a2d00e63a4aaea6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 19, Iss 1, Pp 1-12 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5169597","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6215657","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6215657","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6215657","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-018-2437-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2437-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2437-2.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4180045683","display_name":null,"funder_award_id":"1408085MF133","funder_id":"https://openalex.org/F4320334897","funder_display_name":"Natural Science Foundation of Anhui Province"},{"id":"https://openalex.org/G6560139808","display_name":"\u57fa\u4e8e\u7a00\u758f\u8868\u793a\u7684\u764c\u53d8\u57fa\u56e0\u7f51\u7edc\u5efa\u6a21\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61374181","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G922714588","display_name":null,"funder_award_id":"61402010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326664","display_name":"Anhui Provincial Department of Education","ror":null},{"id":"https://openalex.org/F4320327721","display_name":"K. C. Wong Education Foundation","ror":null},{"id":"https://openalex.org/F4320334897","display_name":"Natural Science Foundation of Anhui Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2899127703.pdf","grobid_xml":"https://content.openalex.org/works/W2899127703.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1546952499","https://openalex.org/W1763139064","https://openalex.org/W1837170756","https://openalex.org/W1982861440","https://openalex.org/W2006547416","https://openalex.org/W2015840454","https://openalex.org/W2023898364","https://openalex.org/W2031870285","https://openalex.org/W2034564381","https://openalex.org/W2039729161","https://openalex.org/W2041993682","https://openalex.org/W2042209114","https://openalex.org/W2045568334","https://openalex.org/W2056753605","https://openalex.org/W2057929153","https://openalex.org/W2059848727","https://openalex.org/W2065817349","https://openalex.org/W2079781075","https://openalex.org/W2100305481","https://openalex.org/W2114104545","https://openalex.org/W2119034410","https://openalex.org/W2126282808","https://openalex.org/W2140141449","https://openalex.org/W2142384696","https://openalex.org/W2143754687","https://openalex.org/W2148139839","https://openalex.org/W2150778145","https://openalex.org/W2152239989","https://openalex.org/W2157795344","https://openalex.org/W2161828876","https://openalex.org/W2167784579","https://openalex.org/W2172215633","https://openalex.org/W2172358623","https://openalex.org/W2179438025","https://openalex.org/W2197589217","https://openalex.org/W2252918338","https://openalex.org/W2283341904","https://openalex.org/W2288735625","https://openalex.org/W2289109591","https://openalex.org/W2361629187","https://openalex.org/W2395922439","https://openalex.org/W2412882418","https://openalex.org/W2475073020","https://openalex.org/W2515462796","https://openalex.org/W2526070630","https://openalex.org/W2569105763","https://openalex.org/W2573268273","https://openalex.org/W2582016570","https://openalex.org/W2588585220","https://openalex.org/W2619486396","https://openalex.org/W2765770547","https://openalex.org/W2767931201","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2069695727","https://openalex.org/W1996185163","https://openalex.org/W2084813257","https://openalex.org/W2045929470","https://openalex.org/W2081127504","https://openalex.org/W2122223946","https://openalex.org/W4233500668","https://openalex.org/W1974145978","https://openalex.org/W1977867163","https://openalex.org/W2393426762"],"abstract_inverted_index":{"BACKGROUND:":[0],"Identifying":[1],"cancer":[2,11,26,47,209],"biomarkers":[3,27],"from":[4,212,258],"transcriptomics":[5,14,213],"data":[6,15,165,168],"is":[7,112,145],"of":[8,25,43,60,70,98,110,122,180,188,196,208,237,253],"importance":[9],"to":[10,55,141,149,234],"research.":[12],"However,":[13],"are":[16,216],"often":[17],"complex":[18],"and":[19,86,102,117,147,166,169,243],"heterogeneous,":[20],"which":[21],"complicates":[22],"the":[23,31,58,120,134,159,177,181,186,206,222,240,244],"identification":[24,211],"in":[28,46,64,71,184,199,246],"practice.":[29],"Currently,":[30],"heterogeneity":[32,59,121,187,203,242],"still":[33],"remains":[34],"a":[35,65,72,230],"challenge":[36],"for":[37,94,133,151,190],"detecting":[38],"subtle":[39,192],"but":[40,193],"consistent":[41,194],"changes":[42],"gene":[44,66,73,79,83,89,123,197],"expression":[45,61,74,80,97,189,198,223],"cells.":[48],"RESULTS:":[49],"In":[50],"this":[51],"paper,":[52],"we":[53,77],"propose":[54],"adaptively":[56,118,238],"capture":[57,119],"across":[62],"samples":[63],"regulation":[67,84,90],"space":[68],"instead":[69],"space.":[75],"Specifically,":[76],"transform":[78],"profiles":[81,85],"into":[82],"mathematically":[87],"formulate":[88],"probabilities":[91],"(GRPs)-based":[92],"statistics":[93],"characterizing":[95],"differential":[96],"genes":[99],"between":[100],"tumor":[101],"normal":[103],"tissues.":[104],"Finally,":[105],"an":[106,128],"unbiased":[107],"estimator":[108],"(aGRP)":[109],"GRPs":[111],"devised":[113],"that":[114,218],"can":[115,228,255],"interrogate":[116],"expression.":[124],"We":[125,157],"also":[126],"derived":[127],"asymptotical":[129],"significance":[130],"analysis":[131],"procedure":[132],"new":[135],"statistic.":[136],"Since":[137],"no":[138],"parameter":[139],"needs":[140],"be":[142,229,256],"preset,":[143],"aGRP":[144,254],"easy":[146],"friendly":[148],"use":[150],"researchers":[152],"without":[153],"computer":[154],"programming":[155],"background.":[156],"evaluated":[158],"proposed":[160,182,226],"method":[161,183,227],"on":[162],"both":[163],"simulated":[164],"real-world":[167],"compared":[170],"with":[171,221],"previous":[172],"methods.":[173],"Experimental":[174],"results":[175],"demonstrated":[176],"superior":[178],"performance":[179,207],"exploring":[185],"capturing":[191,239],"alterations":[195],"cancer.":[200],"CONCLUSIONS:":[201],"Expression":[202],"largely":[204],"influences":[205],"biomarker":[210],"data.":[214],"Models":[215],"needed":[217],"efficiently":[219],"deal":[220],"heterogeneity.":[224],"The":[225,250],"standalone":[231],"tool":[232],"due":[233],"its":[235],"capacity":[236],"sample":[241],"simplicity":[245],"use.":[247],"SOFTWARE":[248],"AVAILABILITY:":[249],"source":[251],"code":[252],"downloaded":[257],"https://github.com/hqwang126/aGRP":[259],".":[260]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}