{"id":"https://openalex.org/W2897254825","doi":"https://doi.org/10.1186/s12859-018-2331-y","title":"Analysis of drug resistance in HIV protease","display_name":"Analysis of drug resistance in HIV protease","publication_year":2018,"publication_date":"2018-10-01","ids":{"openalex":"https://openalex.org/W2897254825","doi":"https://doi.org/10.1186/s12859-018-2331-y","mag":"2897254825","pmid":"https://pubmed.ncbi.nlm.nih.gov/30343664"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-018-2331-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2331-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2331-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2331-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shrikant D. Pawar","orcid":null},"institutions":[{"id":"https://openalex.org/I2801405887","display_name":"Piedmont Atlanta Hospital","ror":"https://ror.org/0008s4w86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801405887","https://openalex.org/I4210153954"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shrikant D. Pawar","raw_affiliation_strings":["Department of Biology, 100 Piedmont Ave., Atlanta, GA 30303, USA","Department of Computer Science, 25 Park Place, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, 100 Piedmont Ave., Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I2801405887"]},{"raw_affiliation_string":"Department of Computer Science, 25 Park Place, Atlanta, GA 30303, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022855139","display_name":"Christopher B. Freas","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Freas","raw_affiliation_strings":["Department of Computer Science, 25 Park Place, Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, 25 Park Place, Atlanta, GA 30303, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077368913","display_name":"Irene T. Weber","orcid":"https://orcid.org/0000-0003-4876-7393"},"institutions":[{"id":"https://openalex.org/I2801405887","display_name":"Piedmont Atlanta Hospital","ror":"https://ror.org/0008s4w86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801405887","https://openalex.org/I4210153954"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene T. Weber","raw_affiliation_strings":["Department of Biology, 100 Piedmont Ave., Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, 100 Piedmont Ave., Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I2801405887"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007378854","display_name":"Robert W. Harrison","orcid":"https://orcid.org/0000-0003-2449-1214"},"institutions":[{"id":"https://openalex.org/I181565077","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18","country_code":"US","type":"education","lineage":["https://openalex.org/I181565077"]},{"id":"https://openalex.org/I2801405887","display_name":"Piedmont Atlanta Hospital","ror":"https://ror.org/0008s4w86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801405887","https://openalex.org/I4210153954"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert W. Harrison","raw_affiliation_strings":["Department of Biology, 100 Piedmont Ave., Atlanta, GA 30303, USA. rwh@gsu.edu","Department of Computer Science, 25 Park Place, Atlanta, GA 30303, USA. rwh@gsu.edu","Department of Biology, 100 Piedmont Ave., Atlanta, GA 30303, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, 100 Piedmont Ave., Atlanta, GA 30303, USA. rwh@gsu.edu","institution_ids":["https://openalex.org/I2801405887"]},{"raw_affiliation_string":"Department of Computer Science, 25 Park Place, Atlanta, GA 30303, USA. rwh@gsu.edu","institution_ids":["https://openalex.org/I181565077"]},{"raw_affiliation_string":"Department of Biology, 100 Piedmont Ave., Atlanta, GA 30303, USA","institution_ids":["https://openalex.org/I2801405887"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007378854"],"corresponding_institution_ids":["https://openalex.org/I181565077","https://openalex.org/I2801405887"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.4994,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.81830384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"19","issue":"S11","first_page":"362","last_page":"362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8549000024795532,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8549000024795532,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.02810000069439411,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protease","display_name":"Protease","score":0.7301263809204102},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.664050281047821},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5961431860923767},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.5478935837745667},{"id":"https://openalex.org/keywords/protease-inhibitor","display_name":"Protease inhibitor (pharmacology)","score":0.5233365893363953},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5098823308944702},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.46921196579933167},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4629787802696228},{"id":"https://openalex.org/keywords/hiv-drug-resistance","display_name":"HIV drug resistance","score":0.4363102912902832},{"id":"https://openalex.org/keywords/limiting","display_name":"Limiting","score":0.43239104747772217},{"id":"https://openalex.org/keywords/hiv-1-protease","display_name":"HIV-1 protease","score":0.42595988512039185},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3965792655944824},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3589016795158386},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.35148781538009644},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"Antiretroviral therapy","score":0.22221022844314575},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.21052828431129456},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.2004660964012146},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.15261390805244446},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.11485445499420166},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.11397847533226013},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11389118432998657}],"concepts":[{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.7301263809204102},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.664050281047821},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5961431860923767},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5478935837745667},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.5233365893363953},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5098823308944702},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.46921196579933167},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4629787802696228},{"id":"https://openalex.org/C2778451633","wikidata":"https://www.wikidata.org/wiki/Q5629934","display_name":"HIV drug resistance","level":5,"score":0.4363102912902832},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.43239104747772217},{"id":"https://openalex.org/C2777583353","wikidata":"https://www.wikidata.org/wiki/Q410261","display_name":"HIV-1 protease","level":4,"score":0.42595988512039185},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3965792655944824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3589016795158386},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.35148781538009644},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.22221022844314575},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21052828431129456},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2004660964012146},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15261390805244446},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.11485445499420166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11397847533226013},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11389118432998657},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016333","descriptor_name":"HIV Protease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-018-2331-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2331-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2331-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30343664","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30343664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:28cced70cf8a4cd2b8a5fb13c8a735cb","is_oa":false,"landing_page_url":"https://doaj.org/article/28cced70cf8a4cd2b8a5fb13c8a735cb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 19, Iss S11, Pp 1-6 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5150522","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6196403","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-018-2331-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2331-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2331-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2340758747","display_name":null,"funder_award_id":"GM062920","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3327903668","display_name":null,"funder_award_id":"U01 GM062920","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4794298069","display_name":null,"funder_award_id":"R01 GM062920","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310607","display_name":"Georgia State University","ror":"https://ror.org/03qt6ba18"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2897254825.pdf","grobid_xml":"https://content.openalex.org/works/W2897254825.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1977109152","https://openalex.org/W1982044779","https://openalex.org/W2009378244","https://openalex.org/W2014619388","https://openalex.org/W2032735163","https://openalex.org/W2035095394","https://openalex.org/W2063691120","https://openalex.org/W2069313265","https://openalex.org/W2098164870","https://openalex.org/W2099866409","https://openalex.org/W2101234009","https://openalex.org/W2101885498","https://openalex.org/W2130479394","https://openalex.org/W2150215096","https://openalex.org/W2159769151","https://openalex.org/W2181616869","https://openalex.org/W2190790144","https://openalex.org/W2195725860","https://openalex.org/W2342329147","https://openalex.org/W2491572170","https://openalex.org/W2507538451","https://openalex.org/W2560674852","https://openalex.org/W2564554996","https://openalex.org/W2747271593","https://openalex.org/W2758355038","https://openalex.org/W2758744379","https://openalex.org/W2759892999","https://openalex.org/W4248694486","https://openalex.org/W4297914773","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W2049250591","https://openalex.org/W2126525653","https://openalex.org/W1516237426","https://openalex.org/W4245621070","https://openalex.org/W1973441633","https://openalex.org/W2256372280","https://openalex.org/W2801493643","https://openalex.org/W2075748968","https://openalex.org/W2128025541","https://openalex.org/W1986563007"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drug":[1],"resistance":[2,18,44,91,135],"in":[3,48],"HIV":[4,65],"is":[5],"the":[6,25,49,73,101,106],"major":[7],"problem":[8],"limiting":[9],"effective":[10,117],"antiviral":[11],"therapy.":[12,29],"Computational":[13],"techniques":[14,31],"for":[15,40,121],"predicting":[16],"drug":[17],"profiles":[19,136],"from":[20,92],"genomic":[21,124],"data":[22,69],"can":[23,32,129],"accelerate":[24],"appropriate":[26],"choice":[27],"of":[28,43,51,64,98,123,137],"These":[30],"also":[33,130],"be":[34,131],"used":[35,132],"to":[36,72,133],"select":[37],"protease":[38,66,139],"mutants":[39],"experimental":[41],"studies":[42],"and":[45,61,76,125],"thereby":[46],"assist":[47],"development":[50],"next-generation":[52],"therapies.":[53],"RESULTS:":[54],"The":[55],"machine":[56,82,118],"learning":[57,83,119],"produced":[58],"highly":[59],"accurate":[60],"robust":[62],"classification":[63,122],"resistance.":[67],"Genotype":[68],"were":[70,108],"mapped":[71],"enzyme":[74],"structure":[75],"encoded":[77],"using":[78],"Delaunay":[79],"triangulation.":[80],"Generative":[81],"models":[84],"trained":[85],"on":[86],"one":[87],"inhibitor":[88],"could":[89],"classify":[90],"other":[93],"inhibitors":[94,107],"with":[95],"varying":[96],"levels":[97],"accuracy.":[99],"Generally,":[100],"accuracy":[102],"was":[103],"best":[104],"when":[105],"chemically":[109],"similar.":[110],"CONCLUSIONS:":[111],"Restricted":[112],"Boltzmann":[113],"Machines":[114],"are":[115],"an":[116],"tool":[120],"structural":[126],"data.":[127],"They":[128],"compare":[134],"different":[138],"inhibitors.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}