{"id":"https://openalex.org/W2883544453","doi":"https://doi.org/10.1186/s12859-018-2263-6","title":"Alternative empirical Bayes models for adjusting for batch effects in genomic studies","display_name":"Alternative empirical Bayes models for adjusting for batch effects in genomic studies","publication_year":2018,"publication_date":"2018-07-13","ids":{"openalex":"https://openalex.org/W2883544453","doi":"https://doi.org/10.1186/s12859-018-2263-6","mag":"2883544453","pmid":"https://pubmed.ncbi.nlm.nih.gov/30001694"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-018-2263-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2263-6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2263-6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2263-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015051319","display_name":"Yuqing Zhang","orcid":"https://orcid.org/0000-0001-7954-1149"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuqing Zhang","raw_affiliation_strings":["Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA","Graduate Program in Bioinformatics, Boston University, 24 Cummington Mall, Boston, 02215, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Graduate Program in Bioinformatics, Boston University, 24 Cummington Mall, Boston, 02215, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080596276","display_name":"David F. Jenkins","orcid":"https://orcid.org/0000-0002-7451-4288"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David F. Jenkins","raw_affiliation_strings":["Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA","Graduate Program in Bioinformatics, Boston University, 24 Cummington Mall, Boston, 02215, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Graduate Program in Bioinformatics, Boston University, 24 Cummington Mall, Boston, 02215, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025271649","display_name":"Solaiappan Manimaran","orcid":"https://orcid.org/0000-0001-8485-780X"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Solaiappan Manimaran","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, 02118, MA, USA","Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021633597","display_name":"W. Evan Johnson","orcid":"https://orcid.org/0000-0002-6247-6595"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Evan Johnson","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, 02118, MA, USA. wej@bu.edu","Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA. wej@bu.edu","Graduate Program in Bioinformatics, Boston University, 24 Cummington Mall, Boston, 02215, MA, USA. wej@bu.edu","Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6247-6595","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, 02118, MA, USA. wej@bu.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA. wej@bu.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Graduate Program in Bioinformatics, Boston University, 24 Cummington Mall, Boston, 02215, MA, USA. wej@bu.edu","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, 02118, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015051319"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.1213,"has_fulltext":true,"cited_by_count":122,"citation_normalized_percentile":{"value":0.94362742,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"262","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6963000297546387,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.1444000005722046,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7185172438621521},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.6644843816757202},{"id":"https://openalex.org/keywords/bayes-theorem","display_name":"Bayes' theorem","score":0.6503798365592957},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.6440749168395996},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.5887545347213745},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5732508301734924},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.45703402161598206},{"id":"https://openalex.org/keywords/batch-processing","display_name":"Batch processing","score":0.4109984338283539},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.29053229093551636},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.24387437105178833},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.22980403900146484},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1969987154006958},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1328325867652893}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7185172438621521},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.6644843816757202},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.6503798365592957},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.6440749168395996},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.5887545347213745},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5732508301734924},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.45703402161598206},{"id":"https://openalex.org/C172658912","wikidata":"https://www.wikidata.org/wiki/Q661613","display_name":"Batch processing","level":2,"score":0.4109984338283539},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.29053229093551636},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.24387437105178833},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.22980403900146484},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1969987154006958},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1328325867652893},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-018-2263-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2263-6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2263-6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:30001694","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30001694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:11c13fcbc012456e85f49cae87e51a9f","is_oa":true,"landing_page_url":"https://doaj.org/article/11c13fcbc012456e85f49cae87e51a9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 19, Iss 1, Pp 1-15 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4997406","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6044013","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-018-2263-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2263-6","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2263-6","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6245873399","display_name":null,"funder_award_id":"NIH R01ES025002","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8822980388","display_name":null,"funder_award_id":"U01CA164720","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2883544453.pdf","grobid_xml":"https://content.openalex.org/works/W2883544453.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1577822803","https://openalex.org/W1781241866","https://openalex.org/W1991208598","https://openalex.org/W2012382065","https://openalex.org/W2015538730","https://openalex.org/W2020541351","https://openalex.org/W2044702943","https://openalex.org/W2047218894","https://openalex.org/W2049446938","https://openalex.org/W2060002238","https://openalex.org/W2074014788","https://openalex.org/W2084821192","https://openalex.org/W2096192437","https://openalex.org/W2096283457","https://openalex.org/W2100922775","https://openalex.org/W2105805010","https://openalex.org/W2107665951","https://openalex.org/W2108568006","https://openalex.org/W2109373478","https://openalex.org/W2116650193","https://openalex.org/W2120865735","https://openalex.org/W2127711365","https://openalex.org/W2138418129","https://openalex.org/W2139345901","https://openalex.org/W2140593657","https://openalex.org/W2147013674","https://openalex.org/W2148541040","https://openalex.org/W2151886124","https://openalex.org/W2155683393","https://openalex.org/W2168113705","https://openalex.org/W2169353806","https://openalex.org/W2329659234","https://openalex.org/W2512452276","https://openalex.org/W2560367415","https://openalex.org/W2608769745"],"related_works":["https://openalex.org/W3113091479","https://openalex.org/W2162899405","https://openalex.org/W941090075","https://openalex.org/W2044987316","https://openalex.org/W3134374554","https://openalex.org/W2237480245","https://openalex.org/W2075065631","https://openalex.org/W2519167559","https://openalex.org/W4311248832","https://openalex.org/W4386113923"],"abstract_inverted_index":{"BACKGROUND:":[0],"Combining":[1],"genomic":[2,104],"data":[3,40,121,176],"sets":[4],"from":[5,44,122],"multiple":[6,37,73,110,123],"studies":[7,15],"is":[8,33,88,141],"advantageous":[9],"to":[10,79,188],"increase":[11],"statistical":[12],"power":[13,69],"in":[14,64,82,102,161,171,192],"where":[16,134,147],"logistical":[17],"considerations":[18],"restrict":[19],"sample":[20],"size":[21],"or":[22,47,52],"require":[23],"the":[24,65,68,135,138,158,181,193],"sequential":[25],"generation":[26],"of":[27,39,71,120,137,183],"data.":[28],"However,":[29],"significant":[30,89],"technical":[31],"heterogeneity":[32],"commonly":[34],"observed":[35],"across":[36],"batches":[38],"that":[41,97],"are":[42],"generated":[43],"different":[45],"processing":[46],"reagent":[48],"batches,":[49,74],"experimenters,":[50],"protocols,":[51],"profiling":[53],"platforms.":[54],"These":[55],"so-called":[56],"batch":[57,100,129,139,150,195],"effects":[58,101,140],"often":[59],"confound":[60],"true":[61],"biological":[62],"relationships":[63],"data,":[66],"reducing":[67],"benefits":[70],"combining":[72],"and":[75,94,112,118,144,169,174],"may":[76],"even":[77],"lead":[78],"spurious":[80],"results":[81],"some":[83],"combined":[84],"studies.":[85,105],"Therefore":[86],"there":[87],"need":[90],"for":[91,99,115,132,145],"effective":[92],"methods":[93,111],"software":[95,113,170],"tools":[96,114],"account":[98],"high-throughput":[103],"RESULTS:":[106],"Here":[107],"we":[108,127],"contribute":[109],"improved":[116],"combination":[117],"analysis":[119],"batches.":[124],"In":[125],"particular,":[126],"provide":[128],"effect":[130],"solutions":[131],"cases":[133,146],"severity":[136],"not":[142],"extreme,":[143],"one":[148],"high-quality":[149],"can":[151],"serve":[152],"as":[153,157],"a":[154,162],"reference,":[155],"such":[156],"training":[159],"set":[160],"biomarker":[163],"study.":[164],"We":[165,179],"illustrate":[166],"our":[167],"approaches":[168,191],"both":[172],"simulated":[173],"real":[175],"scenarios.":[177],"CONCLUSIONS:":[178],"demonstrate":[180],"value":[182],"these":[184],"new":[185],"contributions":[186],"compared":[187],"currently":[189],"established":[190],"specified":[194],"correction":[196],"situations.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":43},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-05-29T09:21:14.243279","created_date":"2025-10-10T00:00:00"}