{"id":"https://openalex.org/W2780281853","doi":"https://doi.org/10.1186/s12859-018-2204-4","title":"polyClustR: defining communities of reconciled cancer subtypes with biological and prognostic significance","display_name":"polyClustR: defining communities of reconciled cancer subtypes with biological and prognostic significance","publication_year":2018,"publication_date":"2018-05-25","ids":{"openalex":"https://openalex.org/W2780281853","doi":"https://doi.org/10.1186/s12859-018-2204-4","mag":"2780281853","pmid":"https://pubmed.ncbi.nlm.nih.gov/29801433"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-018-2204-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2204-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-018-2204-4.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12859-018-2204-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027308593","display_name":"Katherine Eason","orcid":"https://orcid.org/0000-0001-6903-9067"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Katherine Eason","raw_affiliation_strings":["Division of Molecular Pathology, The Institute of Cancer Research (ICR), London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Pathology, The Institute of Cancer Research (ICR), London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062518209","display_name":"Gift Nyamundanda","orcid":null},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Gift Nyamundanda","raw_affiliation_strings":["Centre for Molecular Pathology, Royal Marsden Hospital (RMH), London, UK","Division of Molecular Pathology, The Institute of Cancer Research (ICR), London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Molecular Pathology, Royal Marsden Hospital (RMH), London, UK","institution_ids":["https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Division of Molecular Pathology, The Institute of Cancer Research (ICR), London, UK","institution_ids":["https://openalex.org/I142947616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053519097","display_name":"Anguraj Sadanandam","orcid":"https://orcid.org/0000-0001-8485-5150"},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]},{"id":"https://openalex.org/I4210121186","display_name":"Royal Marsden Hospital","ror":"https://ror.org/034vb5t35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1325846038","https://openalex.org/I4210121186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Anguraj Sadanandam","raw_affiliation_strings":["Centre for Molecular Pathology, Royal Marsden Hospital (RMH), London, UK. Anguraj.Sadanandam@icr.ac.uk","Division of Molecular Pathology, The Institute of Cancer Research (ICR), London, UK. Anguraj.Sadanandam@icr.ac.uk","Division of Molecular Pathology, The Institute of Cancer Research (ICR), London, UK"],"raw_orcid":"https://orcid.org/0000-0001-8485-5150","affiliations":[{"raw_affiliation_string":"Centre for Molecular Pathology, Royal Marsden Hospital (RMH), London, UK. Anguraj.Sadanandam@icr.ac.uk","institution_ids":["https://openalex.org/I4210121186"]},{"raw_affiliation_string":"Division of Molecular Pathology, The Institute of Cancer Research (ICR), London, UK. Anguraj.Sadanandam@icr.ac.uk","institution_ids":["https://openalex.org/I142947616"]},{"raw_affiliation_string":"Division of Molecular Pathology, The Institute of Cancer Research (ICR), London, UK","institution_ids":["https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027308593","https://openalex.org/A5053519097","https://openalex.org/A5062518209"],"corresponding_institution_ids":["https://openalex.org/I142947616","https://openalex.org/I4210121186"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00367439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"19","issue":"1","first_page":"182","last_page":"182"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.8485000133514404,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.8485000133514404,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.03310000151395798,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.5963801145553589},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.5496533513069153},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5292823910713196},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.515510082244873},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.47419196367263794},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.44375720620155334},{"id":"https://openalex.org/keywords/hypergeometric-distribution","display_name":"Hypergeometric distribution","score":0.43833738565444946},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.4283123314380646},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3769805431365967},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2994207739830017},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2744041681289673},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20308992266654968},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14064475893974304},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13654136657714844},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.13454389572143555}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.5963801145553589},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.5496533513069153},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5292823910713196},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.515510082244873},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.47419196367263794},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44375720620155334},{"id":"https://openalex.org/C176671685","wikidata":"https://www.wikidata.org/wiki/Q730600","display_name":"Hypergeometric distribution","level":2,"score":0.43833738565444946},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4283123314380646},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3769805431365967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2994207739830017},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2744041681289673},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20308992266654968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14064475893974304},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13654136657714844},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.13454389572143555},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000098943","descriptor_name":"Uveal Melanoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098943","descriptor_name":"Uveal Melanoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014604","descriptor_name":"Uveal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-018-2204-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2204-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-018-2204-4.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29801433","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29801433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:4925804","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5970540","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5970540","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5970540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1ea9fe38c2ce4e8a9e5bf34ef86ff9e6","is_oa":true,"landing_page_url":"https://doaj.org/article/1ea9fe38c2ce4e8a9e5bf34ef86ff9e6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 19, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-018-2204-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2204-4","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-018-2204-4.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5699999928474426}],"awards":[{"id":"https://openalex.org/G7844657053","display_name":"DTA - Institute of Cancer Research","funder_award_id":"EP/J500240/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320313309","display_name":"Royal Marsden NHS Foundation Trust","ror":"https://ror.org/0008wzh48"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2780281853.pdf","grobid_xml":"https://content.openalex.org/works/W2780281853.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W229097380","https://openalex.org/W1481972425","https://openalex.org/W1497915798","https://openalex.org/W1902027874","https://openalex.org/W1924058902","https://openalex.org/W1934094702","https://openalex.org/W1987971958","https://openalex.org/W2000572045","https://openalex.org/W2033777710","https://openalex.org/W2038143310","https://openalex.org/W2042883111","https://openalex.org/W2044702943","https://openalex.org/W2055063781","https://openalex.org/W2060003036","https://openalex.org/W2076356585","https://openalex.org/W2096235123","https://openalex.org/W2097255042","https://openalex.org/W2107946060","https://openalex.org/W2108516575","https://openalex.org/W2115462905","https://openalex.org/W2127218421","https://openalex.org/W2130256950","https://openalex.org/W2130410032","https://openalex.org/W2132202037","https://openalex.org/W2133105825","https://openalex.org/W2138550913","https://openalex.org/W2149031002","https://openalex.org/W2154790710","https://openalex.org/W2154941270","https://openalex.org/W2157840751","https://openalex.org/W2160360616","https://openalex.org/W2162946128","https://openalex.org/W2164465994","https://openalex.org/W2169503644","https://openalex.org/W2172541985","https://openalex.org/W2186428165","https://openalex.org/W2259802687","https://openalex.org/W2290463785","https://openalex.org/W2299467264","https://openalex.org/W2417402543","https://openalex.org/W2495352863","https://openalex.org/W3100110286"],"related_works":["https://openalex.org/W3037187668","https://openalex.org/W2804364458","https://openalex.org/W4298130764","https://openalex.org/W2132641928","https://openalex.org/W2090259340","https://openalex.org/W4310225030","https://openalex.org/W2083665254","https://openalex.org/W2393816671","https://openalex.org/W1534720161","https://openalex.org/W2804957450"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"ensure":[2],"cancer":[3,91,161],"patients":[4],"are":[5,10,97,165],"stratified":[6],"towards":[7],"treatments":[8],"that":[9,58],"optimally":[11],"beneficial,":[12],"it":[13,44],"is":[14,45,179],"a":[15,56,69,73,89],"priority":[16],"to":[17,26,47,93,102,116],"define":[18],"robust":[19],"molecular":[20],"subtypes":[21],"using":[22,68,88],"clustering":[23,147],"methods":[24,34,64],"applied":[25],"high-dimensional":[27],"biological":[28],"data.":[29],"If":[30],"each":[31],"of":[32,38,75,78,105,139,143,159,170,176],"these":[33,171],"produces":[35],"different":[36,63],"numbers":[37],"clusters":[39,60],"for":[40],"the":[41,103,137,140,152,177],"same":[42],"data,":[43],"difficult":[46],"achieve":[48],"an":[49],"optimal":[50],"solution.":[51],"Here,":[52],"we":[53],"introduce":[54],"\"polyClustR\",":[55],"tool":[57],"reconciles":[59],"identified":[61],"by":[62],"into":[65],"subtype":[66,121,157],"\"communities\"":[67],"hypergeometric":[70],"test":[71],"or":[72],"measure":[74],"relative":[76],"proportion":[77],"common":[79],"samples.":[80],"RESULTS:":[81],"The":[82],"polyClustR":[83,141],"pipeline":[84,178],"was":[85],"initially":[86],"tested":[87],"breast":[90],"dataset":[92],"demonstrate":[94,136],"how":[95],"results":[96,153],"compatible":[98,166],"with":[99,123,130,167],"and":[100,118,128,149],"add":[101],"understanding":[104,169],"this":[106],"well-characterised":[107],"cancer.":[108],"Two":[109],"uveal":[110],"melanoma":[111],"datasets":[112],"were":[113],"then":[114],"utilised":[115],"identify":[117],"validate":[119],"novel":[120,156],"communities":[122,158],"significant":[124],"metastasis-free":[125],"prognostic":[126],"differences":[127],"associations":[129],"known":[131],"chromosomal":[132],"aberrations.":[133],"CONCLUSION:":[134],"We":[135],"value":[138],"approach":[142],"applying":[144],"multiple":[145],"consensus":[146],"algorithms":[148],"systematically":[150],"reconciling":[151],"in":[154],"identifying":[155],"two":[160],"types,":[162],"which":[163],"nevertheless":[164],"established":[168],"diseases.":[172],"An":[173],"R":[174],"implementation":[175],"available":[180],"at:":[181],"https://github.com/syspremed/polyClustR.":[182]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}