{"id":"https://openalex.org/W2794943250","doi":"https://doi.org/10.1186/s12859-018-2081-x","title":"Control procedures and estimators of the false discovery rate and their application in low-dimensional settings: an empirical investigation","display_name":"Control procedures and estimators of the false discovery rate and their application in low-dimensional settings: an empirical investigation","publication_year":2018,"publication_date":"2018-03-02","ids":{"openalex":"https://openalex.org/W2794943250","doi":"https://doi.org/10.1186/s12859-018-2081-x","mag":"2794943250","pmid":"https://pubmed.ncbi.nlm.nih.gov/29499647"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-018-2081-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2081-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2081-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2081-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023939877","display_name":"Regina Brinster","orcid":"https://orcid.org/0000-0001-5731-173X"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I169724904","display_name":"Zimmer Biomet (Netherlands)","ror":"https://ror.org/034k8cv93","country_code":"NL","type":"company","lineage":["https://openalex.org/I169724904","https://openalex.org/I4210115238"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]},{"id":"https://openalex.org/I4210099379","display_name":"Zimmer Biomet (Germany)","ror":"https://ror.org/016731f38","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099379","https://openalex.org/I4210115238"]}],"countries":["DE","NL"],"is_corresponding":true,"raw_author_name":"Regina Brinster","raw_affiliation_strings":["Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany. brinster@imbi.uni-heidelberg.de","Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 130.3, 69120, Heidelberg, Germany. brinster@imbi.uni-heidelberg.de","Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany","Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5731-173X","affiliations":[{"raw_affiliation_string":"Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany. brinster@imbi.uni-heidelberg.de","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073","https://openalex.org/I169724904"]},{"raw_affiliation_string":"Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 130.3, 69120, Heidelberg, Germany. brinster@imbi.uni-heidelberg.de","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I169724904"]},{"raw_affiliation_string":"Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210099379"]},{"raw_affiliation_string":"Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071554578","display_name":"Anna K\u00f6ttgen","orcid":"https://orcid.org/0000-0002-4671-3714"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna K\u00f6ttgen","raw_affiliation_strings":["Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Hugstetter Str. 49, 79106, Freiburg, Germany","Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Hugstetter Str. 49, 79106, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073","https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075367863","display_name":"Bamidele O. Tayo","orcid":"https://orcid.org/0000-0002-2277-3958"},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bamidele O. Tayo","raw_affiliation_strings":["Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA","Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083132916","display_name":"Martin Schumacher","orcid":"https://orcid.org/0000-0002-5037-0099"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Schumacher","raw_affiliation_strings":["Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany","Institute for Medical Biometry and Statistics Faculty of Medicine and Medical Center, University of Freiburg Freiburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Institute for Medical Biometry and Statistics Faculty of Medicine and Medical Center, University of Freiburg Freiburg Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081187562","display_name":"Peggy Sekula","orcid":"https://orcid.org/0000-0003-2263-447X"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peggy Sekula","raw_affiliation_strings":["Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Hugstetter Str. 49, 79106, Freiburg, Germany","Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Hugstetter Str. 49, 79106, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073","https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5023939877"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I169724904","https://openalex.org/I223822909","https://openalex.org/I2801240073","https://openalex.org/I4210099379"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1661,"currency":"EUR","value_usd":1791},"fwci":2.0697,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.87570743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"78","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5945000052452087,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5945000052452087,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.12639999389648438,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.8679860830307007},{"id":"https://openalex.org/keywords/multiple-comparisons-problem","display_name":"Multiple comparisons problem","score":0.7839692234992981},{"id":"https://openalex.org/keywords/replication","display_name":"Replication (statistics)","score":0.7312790155410767},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.6925345659255981},{"id":"https://openalex.org/keywords/null-hypothesis","display_name":"Null hypothesis","score":0.6583774089813232},{"id":"https://openalex.org/keywords/null","display_name":"Null (SQL)","score":0.5740723013877869},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5580562949180603},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.5540477633476257},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.55076003074646},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5053053498268127},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.5004978179931641},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.46052441000938416},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38826847076416016},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2846999168395996},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18737897276878357},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10589948296546936}],"concepts":[{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.8679860830307007},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.7839692234992981},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.7312790155410767},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.6925345659255981},{"id":"https://openalex.org/C191988596","wikidata":"https://www.wikidata.org/wiki/Q628374","display_name":"Null hypothesis","level":2,"score":0.6583774089813232},{"id":"https://openalex.org/C203763787","wikidata":"https://www.wikidata.org/wiki/Q371029","display_name":"Null (SQL)","level":2,"score":0.5740723013877869},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5580562949180603},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.5540477633476257},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.55076003074646},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5053053498268127},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.5004978179931641},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.46052441000938416},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38826847076416016},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2846999168395996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18737897276878357},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10589948296546936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036262","descriptor_name":"Empirical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036262","descriptor_name":"Empirical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D036262","descriptor_name":"Empirical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-018-2081-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2081-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2081-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29499647","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29499647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:archiv.ub.uni-heidelberg.de:24264","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402333","display_name":"heiDOK (Heidelberg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I223822909","host_organization_name":"Heidelberg University","host_organization_lineage":["https://openalex.org/I223822909"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d9e2fd38273e47d49b61372aea204593","is_oa":true,"landing_page_url":"https://doaj.org/article/d9e2fd38273e47d49b61372aea204593","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 19, Iss 1, Pp 1-10 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4746741","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5833079","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-018-2081-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2081-x","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2081-x","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5199999809265137,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, Justice and strong institutions"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320881","display_name":"Universit\u00e4t Heidelberg","ror":"https://ror.org/038t36y30"},{"id":"https://openalex.org/F4320321421","display_name":"Albert-Ludwigs-Universit\u00e4t Freiburg","ror":"https://ror.org/0245cg223"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2794943250.pdf","grobid_xml":"https://content.openalex.org/works/W2794943250.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1596515083","https://openalex.org/W1847429134","https://openalex.org/W1869362176","https://openalex.org/W1964895626","https://openalex.org/W1980361506","https://openalex.org/W2036714085","https://openalex.org/W2049131636","https://openalex.org/W2074089196","https://openalex.org/W2099657218","https://openalex.org/W2104549677","https://openalex.org/W2105381419","https://openalex.org/W2107755054","https://openalex.org/W2110065044","https://openalex.org/W2115012618","https://openalex.org/W2120824812","https://openalex.org/W2121044470","https://openalex.org/W2161633633","https://openalex.org/W2163184920","https://openalex.org/W2169294950","https://openalex.org/W2411709723","https://openalex.org/W2599261982","https://openalex.org/W2763873366","https://openalex.org/W2949830473","https://openalex.org/W7039612861"],"related_works":["https://openalex.org/W2046875666","https://openalex.org/W3003558595","https://openalex.org/W2088387197","https://openalex.org/W2113330311","https://openalex.org/W1976797354","https://openalex.org/W200550325","https://openalex.org/W1995992573","https://openalex.org/W3174861742","https://openalex.org/W154531455","https://openalex.org/W2067995684"],"abstract_inverted_index":{"BACKGROUND:":[0],"When":[1],"many":[2],"(up":[3],"to":[4,34,84,97,129,155,247],"millions)":[5],"of":[6,38,50,59,62,88,93,137,152,166,176,179,191,200,203,227,231],"statistical":[7],"tests":[8],"are":[9,32,69],"conducted":[10],"in":[11,47,72,101,217,235],"discovery":[12,29],"set":[13,78,195],"analyses":[14,79],"such":[15,75,233],"as":[16,76,234],"genome-wide":[17],"association":[18],"studies":[19],"(GWAS),":[20],"approaches":[21,68,100,124],"controlling":[22],"family-wise":[23],"error":[24],"rate":[25,30],"(FWER)":[26],"or":[27,141],"false":[28,39],"(FDR)":[31],"required":[33],"reduce":[35],"the":[36,48,57,60,109,146,150,164,177,189,201,222],"number":[37,87,136,165,230],"positive":[40],"decisions.":[41],"Some":[42],"methods":[43,208,239,243],"were":[44,125,139],"specifically":[45],"developed":[46],"context":[49],"high-dimensional":[51,218],"settings":[52,74,103],"and":[53,112,121],"partially":[54],"rely":[55],"on":[56,210,225],"estimation":[58,175,199,212],"proportion":[61,178,202],"true":[63,157,180,204],"null":[64,158,181,205],"hypotheses.":[65,90,206],"However,":[66,149],"these":[67],"also":[70],"applied":[71,216],"low-dimensional":[73,102,173],"replication":[77,236],"that":[80],"might":[81],"be":[82,215,245],"restricted":[83],"a":[85,114,134,192,197,228],"small":[86,229],"specific":[89],"The":[91,186],"aim":[92],"this":[94,153,172,211],"study":[95],"was":[96,145,160,169,183],"compare":[98],"different":[99],"using":[104],"(a)":[105],"real":[106],"data":[107,194],"from":[108],"CKDGen":[110],"Consortium":[111],"(b)":[113],"simulation":[115,122],"study.":[116],"RESULTS:":[117],"In":[118,171],"both":[119],"application":[120],"FWER":[123,238],"less":[126],"powerful":[127,144],"compared":[128],"FDR":[130,242],"control":[131],"methods,":[132],"whether":[133],"larger":[135],"hypotheses":[138,159,168,182,232],"tested":[140,167],"not.":[142],"Most":[143],"q-value":[147],"method.":[148],"specificity":[151],"method":[154],"maintain":[156,248],"especially":[161],"decreased":[162],"when":[163],"small.":[170],"situation,":[174],"biased.":[184],"CONCLUSIONS:":[185],"results":[187],"highlight":[188],"importance":[190],"sizeable":[193],"for":[196],"reliable":[198],"Consequently,":[207],"relying":[209],"should":[213,244],"only":[214],"settings.":[219],"Furthermore,":[220],"if":[221],"focus":[223],"lies":[224],"testing":[226],"settings,":[237],"rather":[240],"than":[241],"preferred":[246],"high":[249],"specificity.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
