{"id":"https://openalex.org/W2794500076","doi":"https://doi.org/10.1186/s12859-018-2075-8","title":"Variance component analysis to assess protein quantification in biomarker validation: application to selected reaction monitoring-mass spectrometry","display_name":"Variance component analysis to assess protein quantification in biomarker validation: application to selected reaction monitoring-mass spectrometry","publication_year":2018,"publication_date":"2018-02-28","ids":{"openalex":"https://openalex.org/W2794500076","doi":"https://doi.org/10.1186/s12859-018-2075-8","mag":"2794500076","pmid":"https://pubmed.ncbi.nlm.nih.gov/29490628"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-018-2075-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2075-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2075-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2075-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024583988","display_name":"Amna Klich","orcid":"https://orcid.org/0000-0002-3052-7335"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I178906410","display_name":"Lyon College","ror":"https://ror.org/03c4kec23","country_code":"US","type":"education","lineage":["https://openalex.org/I178906410"]},{"id":"https://openalex.org/I4210096512","display_name":"Communaut\u00e9 urbaine de Lyon","ror":"https://ror.org/00pbrnp49","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210096512"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]},{"id":"https://openalex.org/I4210145913","display_name":"Laboratoire Amp\u00e8re","ror":"https://ror.org/04xbczw40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I112936343","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I203339264","https://openalex.org/I4210145913","https://openalex.org/I48430043"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"Amna Klich","raw_affiliation_strings":["CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France. amna.klich@chu-lyon.fr","PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France. amna.klich@chu-lyon.fr","Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, 162, avenue Lacassagne, F-69003, Lyon, France. amna.klich@chu-lyon.fr","Universit\u00e9 de Lyon, Lyon, France. amna.klich@chu-lyon.fr","CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France","PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France","Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France","Universit\u00e9 de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France. amna.klich@chu-lyon.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210135640","https://openalex.org/I4210145913"]},{"raw_affiliation_string":"PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France. amna.klich@chu-lyon.fr","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210096512","https://openalex.org/I4210145913"]},{"raw_affiliation_string":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, 162, avenue Lacassagne, F-69003, Lyon, France. amna.klich@chu-lyon.fr","institution_ids":["https://openalex.org/I4210100596"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France. amna.klich@chu-lyon.fr","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I178906410"]},{"raw_affiliation_string":"CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210135640"]},{"raw_affiliation_string":"PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France","institution_ids":["https://openalex.org/I4210100596"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101924101","display_name":"Catherine Mercier","orcid":"https://orcid.org/0000-0003-4906-6855"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Mercier","raw_affiliation_strings":["CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France","PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France","Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, 162, avenue Lacassagne, F-69003, Lyon, France","Universit\u00e9 de Lyon, Lyon, France","Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210135640"]},{"raw_affiliation_string":"PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, 162, avenue Lacassagne, F-69003, Lyon, France","institution_ids":["https://openalex.org/I4210100596"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France","institution_ids":["https://openalex.org/I4210100596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059353502","display_name":"Laurent Gerfault","orcid":null},"institutions":[{"id":"https://openalex.org/I106785703","display_name":"Institut polytechnique de Grenoble","ror":"https://ror.org/05sbt2524","country_code":"FR","type":"education","lineage":["https://openalex.org/I106785703","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Gerfault","raw_affiliation_strings":["Commissariat \u00e0 l'\u00c9nergie Atomique, Laboratoire d'\u00c9lectronique et de Technologie de l'Information, MINATEC Campus, D\u00e9partement Micro-technologies pour la Biologie et la Sant\u00e9, F-38054, Grenoble, France","Universit\u00e9 Grenoble-Alpes, F-38000, Grenoble, France","Commissariat \u00e0 l\u2019\u00c9nergie Atomique, Laboratoire d\u2019\u00c9lectronique et de Technologie de l\u2019Information, MINATEC Campus, D\u00e9partement Micro-technologies pour la Biologie et la Sant\u00e9, Grenoble, France","Universit\u00e9 Grenoble-Alpes, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Commissariat \u00e0 l'\u00c9nergie Atomique, Laboratoire d'\u00c9lectronique et de Technologie de l'Information, MINATEC Campus, D\u00e9partement Micro-technologies pour la Biologie et la Sant\u00e9, F-38054, Grenoble, France","institution_ids":["https://openalex.org/I106785703","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble-Alpes, F-38000, Grenoble, France","institution_ids":["https://openalex.org/I899635006"]},{"raw_affiliation_string":"Commissariat \u00e0 l\u2019\u00c9nergie Atomique, Laboratoire d\u2019\u00c9lectronique et de Technologie de l\u2019Information, MINATEC Campus, D\u00e9partement Micro-technologies pour la Biologie et la Sant\u00e9, Grenoble, France","institution_ids":["https://openalex.org/I106785703","https://openalex.org/I2738703131","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble-Alpes, Grenoble, France","institution_ids":["https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090446807","display_name":"Pierre Grangeat","orcid":"https://orcid.org/0000-0003-4414-3604"},"institutions":[{"id":"https://openalex.org/I106785703","display_name":"Institut polytechnique de Grenoble","ror":"https://ror.org/05sbt2524","country_code":"FR","type":"education","lineage":["https://openalex.org/I106785703","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Grangeat","raw_affiliation_strings":["Commissariat \u00e0 l'\u00c9nergie Atomique, Laboratoire d'\u00c9lectronique et de Technologie de l'Information, MINATEC Campus, D\u00e9partement Micro-technologies pour la Biologie et la Sant\u00e9, F-38054, Grenoble, France","Universit\u00e9 Grenoble-Alpes, F-38000, Grenoble, France","Commissariat \u00e0 l\u2019\u00c9nergie Atomique, Laboratoire d\u2019\u00c9lectronique et de Technologie de l\u2019Information, MINATEC Campus, D\u00e9partement Micro-technologies pour la Biologie et la Sant\u00e9, Grenoble, France","Universit\u00e9 Grenoble-Alpes, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Commissariat \u00e0 l'\u00c9nergie Atomique, Laboratoire d'\u00c9lectronique et de Technologie de l'Information, MINATEC Campus, D\u00e9partement Micro-technologies pour la Biologie et la Sant\u00e9, F-38054, Grenoble, France","institution_ids":["https://openalex.org/I106785703","https://openalex.org/I2738703131"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble-Alpes, F-38000, Grenoble, France","institution_ids":["https://openalex.org/I899635006"]},{"raw_affiliation_string":"Commissariat \u00e0 l\u2019\u00c9nergie Atomique, Laboratoire d\u2019\u00c9lectronique et de Technologie de l\u2019Information, MINATEC Campus, D\u00e9partement Micro-technologies pour la Biologie et la Sant\u00e9, Grenoble, France","institution_ids":["https://openalex.org/I106785703","https://openalex.org/I2738703131","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Universit\u00e9 Grenoble-Alpes, Grenoble, France","institution_ids":["https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060466602","display_name":"Corinne Beaulieu","orcid":null},"institutions":[{"id":"https://openalex.org/I1284886586","display_name":"Institut M\u00e9rieux (France)","ror":"https://ror.org/008s67533","country_code":"FR","type":"company","lineage":["https://openalex.org/I1284886586"]},{"id":"https://openalex.org/I4210139047","display_name":"bioM\u00e9rieux (France)","ror":"https://ror.org/03hf69k85","country_code":"FR","type":"company","lineage":["https://openalex.org/I1284886586","https://openalex.org/I4210139047"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Corinne Beaulieu","raw_affiliation_strings":["Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-69280, Marcy l'\u00c9toile, France","Innovation Unit, Technology Research Department, bioM\u00e9rieux, Marcy l\u2019\u00c9toile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-69280, Marcy l'\u00c9toile, France","institution_ids":["https://openalex.org/I1284886586"]},{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, Marcy l\u2019\u00c9toile, France","institution_ids":["https://openalex.org/I4210139047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058999038","display_name":"Elodie Degout-Charmette","orcid":null},"institutions":[{"id":"https://openalex.org/I1284886586","display_name":"Institut M\u00e9rieux (France)","ror":"https://ror.org/008s67533","country_code":"FR","type":"company","lineage":["https://openalex.org/I1284886586"]},{"id":"https://openalex.org/I4210139047","display_name":"bioM\u00e9rieux (France)","ror":"https://ror.org/03hf69k85","country_code":"FR","type":"company","lineage":["https://openalex.org/I1284886586","https://openalex.org/I4210139047"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Elodie Degout-Charmette","raw_affiliation_strings":["Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-69280, Marcy l'\u00c9toile, France","Innovation Unit, Technology Research Department, bioM\u00e9rieux, Marcy l\u2019\u00c9toile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-69280, Marcy l'\u00c9toile, France","institution_ids":["https://openalex.org/I1284886586"]},{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, Marcy l\u2019\u00c9toile, France","institution_ids":["https://openalex.org/I4210139047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047251298","display_name":"Tanguy Fortin","orcid":null},"institutions":[{"id":"https://openalex.org/I1284886586","display_name":"Institut M\u00e9rieux (France)","ror":"https://ror.org/008s67533","country_code":"FR","type":"company","lineage":["https://openalex.org/I1284886586"]},{"id":"https://openalex.org/I4210089901","display_name":"D\u00e9l\u00e9gation Rh\u00f4ne Auvergne","ror":"https://ror.org/00bjjqs38","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210089901","https://openalex.org/I4210139971"]},{"id":"https://openalex.org/I4210139047","display_name":"bioM\u00e9rieux (France)","ror":"https://ror.org/03hf69k85","country_code":"FR","type":"company","lineage":["https://openalex.org/I1284886586","https://openalex.org/I4210139047"]},{"id":"https://openalex.org/I4210152383","display_name":"Forum R\u00e9fugi\u00e9s - Cosi","ror":"https://ror.org/04r3a4v95","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210152383"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Tanguy Fortin","raw_affiliation_strings":[", Present Address: Villeurbanne, France","Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-69280, Marcy l'\u00c9toile, France","Innovation Unit, Technology Research Department, bioM\u00e9rieux, Marcy l\u2019\u00c9toile, France","Present Address: Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Present Address: Villeurbanne, France","institution_ids":["https://openalex.org/I4210089901"]},{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-69280, Marcy l'\u00c9toile, France","institution_ids":["https://openalex.org/I1284886586"]},{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, Marcy l\u2019\u00c9toile, France","institution_ids":["https://openalex.org/I4210139047"]},{"raw_affiliation_string":"Present Address: Villeurbanne, France","institution_ids":["https://openalex.org/I4210152383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015231461","display_name":"Pierre Mah\u00e9","orcid":"https://orcid.org/0000-0002-3173-6614"},"institutions":[{"id":"https://openalex.org/I4210139047","display_name":"bioM\u00e9rieux (France)","ror":"https://ror.org/03hf69k85","country_code":"FR","type":"company","lineage":["https://openalex.org/I1284886586","https://openalex.org/I4210139047"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Mah\u00e9","raw_affiliation_strings":["Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-38000, Grenoble, France","Innovation Unit, Technology Research Department, bioM\u00e9rieux, Grenoble, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-38000, Grenoble, France","institution_ids":["https://openalex.org/I4210139047"]},{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, Grenoble, France","institution_ids":["https://openalex.org/I4210139047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091811958","display_name":"Jean\u2010Fran\u00e7ois Giovannelli","orcid":"https://orcid.org/0000-0002-0372-9329"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210157089","display_name":"Laboratoire de l'Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me","ror":"https://ror.org/04nabhy78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210091158","https://openalex.org/I4210095849","https://openalex.org/I4210157089","https://openalex.org/I4210160189"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Fran\u00e7ois Giovannelli","raw_affiliation_strings":["Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me (Universit\u00e9 de Bordeaux, CNRS, Bordeaux Aquitaine INP), F-33400, Talence, France","Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me (Universit\u00e9 de Bordeaux, CNRS, Bordeaux Aquitaine INP), Talence, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me (Universit\u00e9 de Bordeaux, CNRS, Bordeaux Aquitaine INP), F-33400, Talence, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210157089"]},{"raw_affiliation_string":"Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me (Universit\u00e9 de Bordeaux, CNRS, Bordeaux Aquitaine INP), Talence, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210157089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047063090","display_name":"Jean\u2010Philippe Charrier","orcid":"https://orcid.org/0000-0001-5769-1189"},"institutions":[{"id":"https://openalex.org/I1284886586","display_name":"Institut M\u00e9rieux (France)","ror":"https://ror.org/008s67533","country_code":"FR","type":"company","lineage":["https://openalex.org/I1284886586"]},{"id":"https://openalex.org/I4210139047","display_name":"bioM\u00e9rieux (France)","ror":"https://ror.org/03hf69k85","country_code":"FR","type":"company","lineage":["https://openalex.org/I1284886586","https://openalex.org/I4210139047"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Charrier","raw_affiliation_strings":["Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-69280, Marcy l'\u00c9toile, France","Innovation Unit, Technology Research Department, bioM\u00e9rieux, Marcy l\u2019\u00c9toile, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, F-69280, Marcy l'\u00c9toile, France","institution_ids":["https://openalex.org/I1284886586"]},{"raw_affiliation_string":"Innovation Unit, Technology Research Department, bioM\u00e9rieux, Marcy l\u2019\u00c9toile, France","institution_ids":["https://openalex.org/I4210139047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028019403","display_name":"Audrey Giremus","orcid":"https://orcid.org/0000-0003-0585-4243"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4210157089","display_name":"Laboratoire de l'Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me","ror":"https://ror.org/04nabhy78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210091158","https://openalex.org/I4210095849","https://openalex.org/I4210157089","https://openalex.org/I4210160189"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Audrey Giremus","raw_affiliation_strings":["Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me (Universit\u00e9 de Bordeaux, CNRS, Bordeaux Aquitaine INP), F-33400, Talence, France","Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me (Universit\u00e9 de Bordeaux, CNRS, Bordeaux Aquitaine INP), Talence, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me (Universit\u00e9 de Bordeaux, CNRS, Bordeaux Aquitaine INP), F-33400, Talence, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210157089"]},{"raw_affiliation_string":"Int\u00e9gration du Mat\u00e9riau au Syst\u00e8me (Universit\u00e9 de Bordeaux, CNRS, Bordeaux Aquitaine INP), Talence, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I15057530","https://openalex.org/I4210157089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068622087","display_name":"Delphine Maucort\u2010Boulch","orcid":"https://orcid.org/0000-0003-0042-7787"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Delphine Maucort-Boulch","raw_affiliation_strings":["CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France","PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France","Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, 162, avenue Lacassagne, F-69003, Lyon, France","Universit\u00e9 de Lyon, Lyon, France","Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210135640"]},{"raw_affiliation_string":"PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, 162, avenue Lacassagne, F-69003, Lyon, France","institution_ids":["https://openalex.org/I4210100596"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France","institution_ids":["https://openalex.org/I4210100596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054799901","display_name":"Pascal Roy","orcid":"https://orcid.org/0000-0003-3837-3198"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Roy","raw_affiliation_strings":["CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France","PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France","Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, 162, avenue Lacassagne, F-69003, Lyon, France","Universit\u00e9 de Lyon, Lyon, France","Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 5558, LBBE, \u00c9quipe Biostatistique Sant\u00e9, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210135640"]},{"raw_affiliation_string":"PRABI, Universit\u00e9 Lyon 1, Villeurbanne, France","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, 162, avenue Lacassagne, F-69003, Lyon, France","institution_ids":["https://openalex.org/I4210100596"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Service de Biostatistique-Bioinformatique, Hospices Civils de Lyon, Lyon, France","institution_ids":["https://openalex.org/I4210100596"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5024583988"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I178906410","https://openalex.org/I4210096512","https://openalex.org/I4210100596","https://openalex.org/I4210135640","https://openalex.org/I4210145913"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.02245982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"19","issue":"1","first_page":"73","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.6924999952316284,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.6924999952316284,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.13510000705718994,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.07940000295639038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/variance","display_name":"Variance (accounting)","score":0.7144278287887573},{"id":"https://openalex.org/keywords/component","display_name":"Component (thermodynamics)","score":0.5756581425666809},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.49307629466056824},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45897597074508667},{"id":"https://openalex.org/keywords/component-analysis","display_name":"Component analysis","score":0.4181404113769531},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.38416123390197754},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3346998691558838},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3250504732131958}],"concepts":[{"id":"https://openalex.org/C196083921","wikidata":"https://www.wikidata.org/wiki/Q7915758","display_name":"Variance (accounting)","level":2,"score":0.7144278287887573},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.5756581425666809},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.49307629466056824},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45897597074508667},{"id":"https://openalex.org/C2780692498","wikidata":"https://www.wikidata.org/wiki/Q16950721","display_name":"Component analysis","level":2,"score":0.4181404113769531},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.38416123390197754},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3346998691558838},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3250504732131958},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C121955636","wikidata":"https://www.wikidata.org/wiki/Q4116214","display_name":"Accounting","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12859-018-2075-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2075-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2075-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29490628","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29490628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:HAL:hal-02531646v1","is_oa":true,"landing_page_url":"https://hal.science/hal-02531646","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-018-2075-8","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-04152516v1","is_oa":false,"landing_page_url":"https://hal.science/hal-04152516","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1471-2105","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-04384518v1","is_oa":false,"landing_page_url":"https://hal.science/hal-04384518","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 2018, 19 (1), pp.73. ⟨10.1186/s12859-018-2075-8⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:2b146fcfe14548f3946e848d139c47b9","is_oa":true,"landing_page_url":"https://doaj.org/article/2b146fcfe14548f3946e848d139c47b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 19, Iss 1, Pp 1-12 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4746413","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5831836","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-018-2075-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2075-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-018-2075-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G463169127","display_name":null,"funder_award_id":"BLAN 0313","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6398227198","display_name":"Bayesian hierarchical inversion for mass spectrometry. Application to discovery and validation of new protein biomarkers.","funder_award_id":"ANR-10-BLAN-0313","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320323878","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2794500076.pdf","grobid_xml":"https://content.openalex.org/works/W2794500076.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W14911914","https://openalex.org/W1576246901","https://openalex.org/W1592039881","https://openalex.org/W1965087659","https://openalex.org/W1990596163","https://openalex.org/W1996601807","https://openalex.org/W2001472155","https://openalex.org/W2001713637","https://openalex.org/W2024424774","https://openalex.org/W2034001550","https://openalex.org/W2087832083","https://openalex.org/W2093162919","https://openalex.org/W2094229819","https://openalex.org/W2107710616","https://openalex.org/W2111713797","https://openalex.org/W2130652959","https://openalex.org/W2138001499","https://openalex.org/W2140335518","https://openalex.org/W2170791918","https://openalex.org/W2170989872","https://openalex.org/W2470118614","https://openalex.org/W2492294785","https://openalex.org/W2741569870","https://openalex.org/W4241595597","https://openalex.org/W4253410337"],"related_works":["https://openalex.org/W2357256365","https://openalex.org/W2348502264","https://openalex.org/W2365486383","https://openalex.org/W1563551083","https://openalex.org/W2350806976","https://openalex.org/W2901443725","https://openalex.org/W2084935737","https://openalex.org/W1974936441","https://openalex.org/W2910914527","https://openalex.org/W2004583609"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,18],"the":[2,11,27,54,60,77,83,87,135,139,142,166,180,198,208,217],"field":[3],"of":[4,29,38,43,48,63,68,76,86,95,207,220,226],"biomarker":[5],"validation":[6],"with":[7,151,186],"mass":[8],"spectrometry,":[9],"controlling":[10],"technical":[12,143,177],"variability":[13],"is":[14],"a":[15,106,123,126,170,175],"critical":[16],"issue.":[17],"selected":[19],"reaction":[20],"monitoring":[21],"(SRM)":[22],"measurements,":[23],"this":[24],"issue":[25],"provides":[26],"opportunity":[28],"using":[30],"variance":[31,78,173,178,209,218],"component":[32,79,92,210],"analysis":[33,80,211],"to":[34,81,109,214],"distinguish":[35],"various":[36,61,84],"sources":[37,62],"variability.":[39],"However,":[40],"in":[41,50,66,93,148,183,224],"case":[42,94,225],"unbalanced":[44,96,227],"data":[45],"(unequal":[46],"number":[47],"observations":[49],"all":[51,202],"factor":[52],"combinations),":[53],"classical":[55,124,181],"methods":[56],"cannot":[57],"correctly":[58,216],"estimate":[59,82,215],"variability,":[64],"particularly":[65],"presence":[67],"interaction.":[69],"The":[70,130,205],"present":[71],"paper":[72],"proposes":[73],"an":[74,90,101,149],"extension":[75,206],"components":[85,219],"variance,":[88],"including":[89],"interaction":[91],"data.":[97],"RESULTS:":[98],"We":[99],"applied":[100],"experimental":[102],"design":[103],"that":[104],"uses":[105],"serial":[107],"dilution":[108,140,172],"generate":[110],"known":[111],"relative":[112],"protein":[113,221],"concentrations":[114,118],"and":[115,125,141,163,174,190],"estimated":[116],"these":[117],"by":[119,138,145],"two":[120,184,199],"processing":[121],"algorithms,":[122],"more":[127],"recent":[128,167],"one.":[129],"extended":[131],"method":[132],"allowed":[133],"estimating":[134],"variances":[136],"explained":[137],"process":[144],"each":[146],"algorithm":[147,168],"experiment":[150],"9":[152],"proteins:":[153],"L-FABP,":[154],"14.3.3":[155],"sigma,":[156],"Calgi,":[157],"Def.A6,":[158],"Villin,":[159],"Calmo,":[160],"I-FABP,":[161],"Peroxi-5,":[162],"S100A14.":[164],"Whereas,":[165],"gave":[169],"higher":[171],"lower":[176],"than":[179],"one":[182],"proteins":[185],"three":[187],"peptides":[188],"(L-FABP":[189],"Villin),":[191],"there":[192],"were":[193],"no":[194],"significant":[195],"difference":[196],"between":[197],"algorithms":[200],"on":[201],"proteins.":[203],"CONCLUSIONS:":[204],"was":[212],"able":[213],"concentration":[222],"measurement":[223],"design.":[228]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}