{"id":"https://openalex.org/W2794447976","doi":"https://doi.org/10.1186/s12859-018-2055-z","title":"Microvessel prediction in H&amp;E Stained Pathology Images using fully convolutional neural networks","display_name":"Microvessel prediction in H&amp;E Stained Pathology Images using fully convolutional neural networks","publication_year":2018,"publication_date":"2018-02-26","ids":{"openalex":"https://openalex.org/W2794447976","doi":"https://doi.org/10.1186/s12859-018-2055-z","mag":"2794447976","pmid":"https://pubmed.ncbi.nlm.nih.gov/29482496"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-018-2055-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2055-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-018-2055-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-018-2055-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062999747","display_name":"Faliu Yi","orcid":"https://orcid.org/0000-0002-1569-1436"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Faliu Yi","raw_affiliation_strings":["Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007704456","display_name":"Lin Yang","orcid":"https://orcid.org/0000-0002-7594-3770"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Lin Yang","raw_affiliation_strings":["Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100023, P. R. China","Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100023, P. R. China","institution_ids":["https://openalex.org/I200296433"]},{"raw_affiliation_string":"Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029148706","display_name":"Shidan Wang","orcid":"https://orcid.org/0000-0002-0001-3261"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shidan Wang","raw_affiliation_strings":["Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344274","display_name":"Lei Guo","orcid":"https://orcid.org/0000-0001-5944-4106"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Guo","raw_affiliation_strings":["Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100023, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100023, P. R. China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035798854","display_name":"Chenglong Huang","orcid":"https://orcid.org/0000-0001-6241-9745"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenglong Huang","raw_affiliation_strings":["Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100661771","display_name":"Yang Xie","orcid":"https://orcid.org/0000-0001-9456-1762"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Xie","raw_affiliation_strings":["Department of Bioinformatics, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009964025","display_name":"Guanghua Xiao","orcid":"https://orcid.org/0000-0001-9387-9883"},"institutions":[{"id":"https://openalex.org/I4210096815","display_name":"Southwestern Medical Center","ror":"https://ror.org/00t9vx427","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096815"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guanghua Xiao","raw_affiliation_strings":["Department of Bioinformatics, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA. guanghua.xiao@utsouthwestern.edu","Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA. guanghua.xiao@utsouthwestern.edu","Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA. guanghua.xiao@utsouthwestern.edu","Department of Bioinformatics, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA"],"raw_orcid":"https://orcid.org/0000-0001-9387-9883","affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA. guanghua.xiao@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210096815"]},{"raw_affiliation_string":"Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA. guanghua.xiao@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210096815"]},{"raw_affiliation_string":"Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA. guanghua.xiao@utsouthwestern.edu","institution_ids":["https://openalex.org/I867280407","https://openalex.org/I4210096815"]},{"raw_affiliation_string":"Department of Bioinformatics, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Quantitative Biomedical Research Center, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5325 Harry Hines Blvd, Dallas, TX, 75390, USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009964025"],"corresponding_institution_ids":["https://openalex.org/I4210096815","https://openalex.org/I867280407"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.9472,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.92833726,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"19","issue":"1","first_page":"64","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.5206000208854675,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.5206000208854675,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.10620000213384628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.08630000054836273,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.7856495380401611},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.7284832000732422},{"id":"https://openalex.org/keywords/h-e-stain","display_name":"H&E stain","score":0.6748285889625549},{"id":"https://openalex.org/keywords/cd34","display_name":"CD34","score":0.6084604859352112},{"id":"https://openalex.org/keywords/microvessel","display_name":"Microvessel","score":0.6083046197891235},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.5420149564743042},{"id":"https://openalex.org/keywords/immunostaining","display_name":"Immunostaining","score":0.5375418663024902},{"id":"https://openalex.org/keywords/surgical-pathology","display_name":"Surgical pathology","score":0.4858062267303467},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.47738116979599},{"id":"https://openalex.org/keywords/anatomical-pathology","display_name":"Anatomical pathology","score":0.474739134311676},{"id":"https://openalex.org/keywords/digital-pathology","display_name":"Digital pathology","score":0.4554452896118164},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.44836753606796265},{"id":"https://openalex.org/keywords/neovascularization","display_name":"Neovascularization","score":0.43162044882774353},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.4206874370574951},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3953956663608551},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.26807063817977905},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21480143070220947},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.09621220827102661},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.06633606553077698}],"concepts":[{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.7856495380401611},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7284832000732422},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.6748285889625549},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.6084604859352112},{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.6083046197891235},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5420149564743042},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5375418663024902},{"id":"https://openalex.org/C194495517","wikidata":"https://www.wikidata.org/wiki/Q7646222","display_name":"Surgical pathology","level":2,"score":0.4858062267303467},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.47738116979599},{"id":"https://openalex.org/C549673821","wikidata":"https://www.wikidata.org/wiki/Q683455","display_name":"Anatomical pathology","level":3,"score":0.474739134311676},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.4554452896118164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44836753606796265},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.43162044882774353},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.4206874370574951},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3953956663608551},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26807063817977905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21480143070220947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09621220827102661},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.06633606553077698},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-018-2055-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2055-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-018-2055-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29482496","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29482496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:fb6ed434c72f4b08883399d37789c63e","is_oa":false,"landing_page_url":"https://doaj.org/article/fb6ed434c72f4b08883399d37789c63e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 19, Iss 1, Pp 1-9 (2018)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5828328","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5828328","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-018-2055-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-018-2055-z","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-018-2055-z","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/8","display_name":"Decent work and economic growth"}],"awards":[{"id":"https://openalex.org/G2890630432","display_name":null,"funder_award_id":"R01 CA172211","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G395486044","display_name":null,"funder_award_id":"1R01CA172211","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4034800830","display_name":null,"funder_award_id":"R01 GM115473","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4754138834","display_name":null,"funder_award_id":"5P50CA070907","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G655703046","display_name":null,"funder_award_id":"1R01GM115473","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7419161810","display_name":null,"funder_award_id":"RP120732","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G798110305","display_name":null,"funder_award_id":"1R01GM115473","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8358240809","display_name":null,"funder_award_id":"5P50CA070907","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8598737324","display_name":null,"funder_award_id":"P50 CA070907","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8920426436","display_name":null,"funder_award_id":"1R01CA172211","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2794447976.pdf","grobid_xml":"https://content.openalex.org/works/W2794447976.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W596171880","https://openalex.org/W639708223","https://openalex.org/W1488979933","https://openalex.org/W1533861849","https://openalex.org/W1536680647","https://openalex.org/W1546771929","https://openalex.org/W1584635482","https://openalex.org/W1594358512","https://openalex.org/W1686810756","https://openalex.org/W1757796397","https://openalex.org/W1825077972","https://openalex.org/W1843965782","https://openalex.org/W1901129140","https://openalex.org/W1903029394","https://openalex.org/W1993272177","https://openalex.org/W2055242813","https://openalex.org/W2059634682","https://openalex.org/W2067191022","https://openalex.org/W2076063813","https://openalex.org/W2084783417","https://openalex.org/W2092323746","https://openalex.org/W2103243046","https://openalex.org/W2110243528","https://openalex.org/W2110327625","https://openalex.org/W2110599422","https://openalex.org/W2112038785","https://openalex.org/W2116044718","https://openalex.org/W2119754704","https://openalex.org/W2120615054","https://openalex.org/W2150461375","https://openalex.org/W2151608510","https://openalex.org/W2154043981","https://openalex.org/W2155893237","https://openalex.org/W2163605009","https://openalex.org/W2168117308","https://openalex.org/W2184188583","https://openalex.org/W2211629196","https://openalex.org/W2285838348","https://openalex.org/W2314755674","https://openalex.org/W2337438617","https://openalex.org/W2347064614","https://openalex.org/W2395611524","https://openalex.org/W2413042584","https://openalex.org/W2476585853","https://openalex.org/W2504220184","https://openalex.org/W2514628397","https://openalex.org/W2526009326","https://openalex.org/W2548615865","https://openalex.org/W2557283755","https://openalex.org/W2559597482","https://openalex.org/W2559655401","https://openalex.org/W2559737178","https://openalex.org/W2562844176","https://openalex.org/W2567662614","https://openalex.org/W2601414401","https://openalex.org/W2604272474","https://openalex.org/W2613718673","https://openalex.org/W2906033277","https://openalex.org/W2919115771","https://openalex.org/W2963881378","https://openalex.org/W4244003036","https://openalex.org/W4299828299","https://openalex.org/W6601604083","https://openalex.org/W6686207219","https://openalex.org/W6730267373","https://openalex.org/W7027716524"],"related_works":["https://openalex.org/W2724746526","https://openalex.org/W1976539995","https://openalex.org/W2520600158","https://openalex.org/W2416896828","https://openalex.org/W2413197985","https://openalex.org/W4298167497","https://openalex.org/W400724479","https://openalex.org/W1756481994","https://openalex.org/W4283168403","https://openalex.org/W2138335410"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pathological":[1],"angiogenesis":[2],"has":[3,72],"been":[4,74],"identified":[5,151],"in":[6,68,110,176],"many":[7],"malignancies":[8],"as":[9],"a":[10,90,125],"potential":[11],"prognostic":[12],"factor":[13],"and":[14,49,81,98],"target":[15],"for":[16,54,87,93,115,172],"therapy.":[17],"In":[18,120],"most":[19,40],"cases,":[20],"angiogenic":[21],"analysis":[22],"is":[23,44,56,89,103,140,164],"based":[24],"on":[25,145],"the":[26,60,150,158,165],"measurement":[27],"of":[28,35,47,66,136],"microvessel":[29,126,152,174],"density":[30],"(MVD)":[31],"detected":[32],"by":[33],"immunostaining":[34],"CD31":[36],"or":[37],"CD34.":[38],"However,":[39],"retrievable":[41],"public":[42],"data":[43],"generally":[45],"composed":[46],"Hematoxylin":[48],"Eosin":[50],"(H&E)-stained":[51],"pathology":[52,113,179],"images,":[53],"which":[55],"difficult":[57],"to":[58,78,105,168],"get":[59],"corresponding":[61],"immunohistochemistry":[62],"images.":[63,148,180],"The":[64,134],"role":[65],"microvessels":[67,85],"H&E":[69,111,146,177],"stained":[70,112,147,178],"images":[71,114],"not":[73],"widely":[75],"studied":[76],"due":[77],"their":[79],"complexity":[80],"heterogeneity.":[82],"Furthermore,":[83,149],"identifying":[84],"manually":[86],"study":[88,167],"labor-intensive":[91],"task":[92],"pathologists,":[94],"with":[95,157],"high":[96],"inter-":[97],"intra-observer":[99],"variation.":[100],"Therefore,":[101],"it":[102],"important":[104],"develop":[106,169],"automated":[107,173],"microvessel-detection":[108],"algorithms":[109],"clinical":[116,160],"association":[117],"analysis.":[118],"RESULTS:":[119],"this":[121],"paper,":[122],"we":[123],"propose":[124],"prediction":[127],"method":[128],"using":[129],"fully":[130],"convolutional":[131],"neural":[132],"networks.":[133],"feasibility":[135],"our":[137],"proposed":[138],"algorithm":[139,171],"demonstrated":[141],"through":[142],"experimental":[143],"results":[144],"features":[153],"were":[154],"significantly":[155],"associated":[156],"patient":[159],"outcomes.":[161],"CONCLUSIONS:":[162],"This":[163],"first":[166],"an":[170],"detection":[175]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2}],"updated_date":"2026-07-05T07:55:05.734416","created_date":"2018-04-06T00:00:00"}
