{"id":"https://openalex.org/W2764035603","doi":"https://doi.org/10.1186/s12859-017-1851-1","title":"Block-based characterization of protease specificity from substrate sequence profile","display_name":"Block-based characterization of protease specificity from substrate sequence profile","publication_year":2017,"publication_date":"2017-10-03","ids":{"openalex":"https://openalex.org/W2764035603","doi":"https://doi.org/10.1186/s12859-017-1851-1","mag":"2764035603","pmid":"https://pubmed.ncbi.nlm.nih.gov/28974219"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-017-1851-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1851-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-017-1851-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-017-1851-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049997520","display_name":"Enfeng Qi","orcid":null},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Enfeng Qi","raw_affiliation_strings":["School of Mathematics, Shandong University, Jinan, 250100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics, Shandong University, Jinan, 250100, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100764282","display_name":"Dongyu Wang","orcid":"https://orcid.org/0000-0002-7499-6846"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4391767886","display_name":"State Key Laboratory of Microbial Technology","ror":"https://ror.org/03x08qn04","country_code":null,"type":"facility","lineage":["https://openalex.org/I154099455","https://openalex.org/I4391767886"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongyu Wang","raw_affiliation_strings":["The State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4391767886"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004012174","display_name":"Bo Gao","orcid":"https://orcid.org/0000-0002-8750-0547"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Gao","raw_affiliation_strings":["School of Mathematics, Shandong University, Jinan, 250100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics, Shandong University, Jinan, 250100, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421627","display_name":"Yang Li","orcid":"https://orcid.org/0000-0002-7677-9028"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Li","raw_affiliation_strings":["School of Mathematics, Shandong University, Jinan, 250100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics, Shandong University, Jinan, 250100, China","institution_ids":["https://openalex.org/I154099455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100696687","display_name":"Guojun Li","orcid":"https://orcid.org/0000-0003-1581-5897"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guojun Li","raw_affiliation_strings":["School of Mathematics, Shandong University, Jinan, 250100, China. guojunsdu@gmail.com","School of Mathematics, Shandong University, Jinan, 250100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics, Shandong University, Jinan, 250100, China. guojunsdu@gmail.com","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"School of Mathematics, Shandong University, Jinan, 250100, China","institution_ids":["https://openalex.org/I154099455"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100696687"],"corresponding_institution_ids":["https://openalex.org/I154099455"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.5332,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.65481201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"18","issue":"1","first_page":"438","last_page":"438"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.15109999477863312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.15109999477863312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.11389999836683273,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.08330000191926956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteases","display_name":"Proteases","score":0.8944970369338989},{"id":"https://openalex.org/keywords/cleavage","display_name":"Cleavage (geology)","score":0.699124813079834},{"id":"https://openalex.org/keywords/protease","display_name":"Protease","score":0.6876920461654663},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.6352542638778687},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"Substrate specificity","score":0.4925020635128021},{"id":"https://openalex.org/keywords/peptide-bond","display_name":"Peptide bond","score":0.45833614468574524},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.4365312457084656},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3802061676979065},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.35835000872612},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.34697574377059937},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3202173113822937},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31213632225990295},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.23040276765823364},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09069159626960754}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.8944970369338989},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.699124813079834},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.6876920461654663},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6352542638778687},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.4925020635128021},{"id":"https://openalex.org/C31684184","wikidata":"https://www.wikidata.org/wiki/Q33293","display_name":"Peptide bond","level":3,"score":0.45833614468574524},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4365312457084656},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3802061676979065},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35835000872612},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34697574377059937},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3202173113822937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31213632225990295},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23040276765823364},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09069159626960754},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019277","descriptor_name":"Entropy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-017-1851-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1851-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-017-1851-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28974219","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28974219","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4557942","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5627433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:46e181167d02497d8b8346e7de18a6a0","is_oa":false,"landing_page_url":"https://doaj.org/article/46e181167d02497d8b8346e7de18a6a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 18, Iss 1, Pp 1-9 (2017)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-017-1851-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1851-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-017-1851-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2940576611","display_name":"\u4ec5\u57fa\u4e8eRNA-Seq\u6570\u636e\u62fc\u88c5\u53ef\u53d8\u526a\u63a5\u8f6c\u5f55\u7ec4\u7684\u8ba1\u7b97\u65b9\u6cd5\u7814\u7a76","funder_award_id":"61272016","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3040862546","display_name":"\u57fa\u4e8e\u9ad8\u901a\u91cfRNA-seq\u6570\u636e\u8f6c\u5f55\u7ec4\u62fc\u63a5\u7684\u5173\u952e\u6280\u672f\u4e0e\u7b97\u6cd5\u7814\u7a76","funder_award_id":"61432010","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3877602480","display_name":"III: EAGER: Novel algorithms for de novo transcriptome assembly using RNA-seq data and for metagenome assembly","funder_award_id":"1553680","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2764035603.pdf","grobid_xml":"https://content.openalex.org/works/W2764035603.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1499093538","https://openalex.org/W1555862556","https://openalex.org/W1817715517","https://openalex.org/W1923386801","https://openalex.org/W1953569147","https://openalex.org/W1965152120","https://openalex.org/W1965871233","https://openalex.org/W1966581230","https://openalex.org/W1968178167","https://openalex.org/W1985469117","https://openalex.org/W1995875735","https://openalex.org/W1996278518","https://openalex.org/W2001349696","https://openalex.org/W2010912389","https://openalex.org/W2015830307","https://openalex.org/W2028768078","https://openalex.org/W2030060549","https://openalex.org/W2040385059","https://openalex.org/W2041686750","https://openalex.org/W2041877620","https://openalex.org/W2049387903","https://openalex.org/W2051420589","https://openalex.org/W2055666215","https://openalex.org/W2058647425","https://openalex.org/W2065518020","https://openalex.org/W2069508712","https://openalex.org/W2073681519","https://openalex.org/W2074912245","https://openalex.org/W2075503331","https://openalex.org/W2084468336","https://openalex.org/W2089199521","https://openalex.org/W2091273971","https://openalex.org/W2094079380","https://openalex.org/W2103700658","https://openalex.org/W2116876798","https://openalex.org/W2119294728","https://openalex.org/W2126843316","https://openalex.org/W2139750801","https://openalex.org/W2150087300","https://openalex.org/W2158266834","https://openalex.org/W2159694071","https://openalex.org/W2165824222","https://openalex.org/W2268048347","https://openalex.org/W2290195878","https://openalex.org/W2306646692","https://openalex.org/W2322640036","https://openalex.org/W4256291926"],"related_works":["https://openalex.org/W1985041519","https://openalex.org/W2018012534","https://openalex.org/W2973344506","https://openalex.org/W1977790220","https://openalex.org/W2045012663","https://openalex.org/W2570942072","https://openalex.org/W2041130219","https://openalex.org/W2800333284","https://openalex.org/W2069508712","https://openalex.org/W2056783698"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"mechanism":[2],"of":[3,5,34,53,61,66,93,97,100,113,125],"action":[4,60],"proteases":[6,81,133],"has":[7,17],"been":[8,18],"widely":[9],"studied":[10],"based":[11],"on":[12,20,32],"substrate":[13,115,127,136,139],"specificity.":[14],"Prior":[15],"research":[16],"focused":[19],"the":[21,38,50,59,64,110,114,123],"amino":[22,27,35,54,102],"acids":[23,36,55,103],"at":[24,70],"a":[25,44,71,76,91,105],"single":[26],"acid":[28],"site,":[29],"but":[30],"rarely":[31],"combinations":[33,52],"around":[37],"cleavage":[39,72,106,135],"bond.":[40],"RESULTS:":[41],"We":[42],"propose":[43],"novel":[45],"block-based":[46],"approach":[47,119],"to":[48,82],"reveal":[49],"potential":[51],"which":[56,98,129],"may":[57,130],"regulate":[58],"proteases.":[62],"Using":[63],"entropies":[65],"eight":[67],"blocks":[68],"centered":[69],"bond,":[73,107],"we":[74,89],"created":[75],"distance":[77],"matrix":[78],"for":[79],"61":[80],"compare":[83],"their":[84],"specificities.":[85],"After":[86],"quantitative":[87],"analysis,":[88],"discovered":[90],"number":[92],"prominent":[94],"blocks,":[95],"each":[96],"consists":[99],"successive":[101],"near":[104],"intuitively":[108],"characterizing":[109],"site":[111],"cooperation":[112],"sequences.":[116],"CONCLUSION:":[117],"This":[118],"will":[120],"help":[121],"in":[122],"discovery":[124],"specific":[126],"sequences":[128],"bridge":[131],"between":[132],"and":[134],"as":[137],"more":[138],"information":[140],"becomes":[141],"available.":[142]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-08-25T07:29:55.448023","created_date":"2025-10-10T00:00:00"}