{"id":"https://openalex.org/W2735057390","doi":"https://doi.org/10.1186/s12859-017-1746-1","title":"HLA-check: evaluating HLA data from SNP information","display_name":"HLA-check: evaluating HLA data from SNP information","publication_year":2017,"publication_date":"2017-07-11","ids":{"openalex":"https://openalex.org/W2735057390","doi":"https://doi.org/10.1186/s12859-017-1746-1","mag":"2735057390","pmid":"https://pubmed.ncbi.nlm.nih.gov/28697761"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-017-1746-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1746-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-017-1746-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-017-1746-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017269623","display_name":"Marc Jeanmougin","orcid":"https://orcid.org/0000-0002-0176-7129"},"institutions":[{"id":"https://openalex.org/I124158823","display_name":"Conservatoire National des Arts et M\u00e9tiers","ror":"https://ror.org/0175hh227","country_code":"FR","type":"education","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4210113863","display_name":"G\u00e9nomique Bioinformatique et Applications","ror":"https://ror.org/0264vhs54","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210113863","https://openalex.org/I4210134562"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Jeanmougin","raw_affiliation_strings":["Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France","institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4210113863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024518853","display_name":"Josselin Noirel","orcid":"https://orcid.org/0000-0001-6778-6966"},"institutions":[{"id":"https://openalex.org/I124158823","display_name":"Conservatoire National des Arts et M\u00e9tiers","ror":"https://ror.org/0175hh227","country_code":"FR","type":"education","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4210113863","display_name":"G\u00e9nomique Bioinformatique et Applications","ror":"https://ror.org/0264vhs54","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210113863","https://openalex.org/I4210134562"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Josselin Noirel","raw_affiliation_strings":["Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France","institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4210113863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110187898","display_name":"C\u00e9dric Coulonges","orcid":null},"institutions":[{"id":"https://openalex.org/I124158823","display_name":"Conservatoire National des Arts et M\u00e9tiers","ror":"https://ror.org/0175hh227","country_code":"FR","type":"education","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4210113863","display_name":"G\u00e9nomique Bioinformatique et Applications","ror":"https://ror.org/0264vhs54","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210113863","https://openalex.org/I4210134562"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9dric Coulonges","raw_affiliation_strings":["Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France","institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4210113863"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110526676","display_name":"Jean\u2010Fran\u00e7ois Zagury","orcid":null},"institutions":[{"id":"https://openalex.org/I124158823","display_name":"Conservatoire National des Arts et M\u00e9tiers","ror":"https://ror.org/0175hh227","country_code":"FR","type":"education","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210134562"]},{"id":"https://openalex.org/I4210113863","display_name":"G\u00e9nomique Bioinformatique et Applications","ror":"https://ror.org/0264vhs54","country_code":"FR","type":"facility","lineage":["https://openalex.org/I124158823","https://openalex.org/I4210113863","https://openalex.org/I4210134562"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Jean-Fran\u00e7ois Zagury","raw_affiliation_strings":["Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France. zagury@cnam.fr","Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France. zagury@cnam.fr","institution_ids":["https://openalex.org/I124158823"]},{"raw_affiliation_string":"Laboratoire G\u00e9nomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et M\u00e9tiers, 292 rue Saint-Martin, Paris, 75003, France","institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4210113863"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110526676"],"corresponding_institution_ids":["https://openalex.org/I124158823","https://openalex.org/I4210113863"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.3988,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.56931966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"18","issue":"1","first_page":"334","last_page":"334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4756999909877777,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.4756999909877777,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.4352000057697296,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-leukocyte-antigen","display_name":"Human leukocyte antigen","score":0.664989173412323},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.612700343132019},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.6119421720504761},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5058510303497314},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38466179370880127},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.38186001777648926},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.32893770933151245},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3224064111709595},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.2445104420185089},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.13316336274147034},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10788902640342712},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.10640081763267517},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.0807584822177887}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.664989173412323},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.612700343132019},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6119421720504761},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5058510303497314},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38466179370880127},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38186001777648926},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.32893770933151245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3224064111709595},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2445104420185089},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13316336274147034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10788902640342712},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.10640081763267517},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0807584822177887}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006650","descriptor_name":"Histocompatibility Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006650","descriptor_name":"Histocompatibility Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006650","descriptor_name":"Histocompatibility Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006650","descriptor_name":"Histocompatibility Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-017-1746-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1746-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-017-1746-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28697761","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28697761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a68993a7ca874837825a1ca7ce7f9d26","is_oa":false,"landing_page_url":"https://doaj.org/article/a68993a7ca874837825a1ca7ce7f9d26","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 18, Iss 1, Pp 1-8 (2017)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5504728","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5504728","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-017-1746-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1746-1","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-017-1746-1","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320322727","display_name":"Minist\u00e8re de l'Education Nationale, de l'Enseignement Superieur et de la Recherche","ror":"https://ror.org/03sjk9a61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2735057390.pdf","grobid_xml":"https://content.openalex.org/works/W2735057390.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W28108870","https://openalex.org/W1567333450","https://openalex.org/W1916657989","https://openalex.org/W1964713124","https://openalex.org/W1968789418","https://openalex.org/W2003652884","https://openalex.org/W2032330266","https://openalex.org/W2052655883","https://openalex.org/W2061539393","https://openalex.org/W2064956449","https://openalex.org/W2069587618","https://openalex.org/W2098951833","https://openalex.org/W2104549677","https://openalex.org/W2111307685","https://openalex.org/W2112752664","https://openalex.org/W2113395588","https://openalex.org/W2120738060","https://openalex.org/W2146293362","https://openalex.org/W2148568906","https://openalex.org/W2152269778","https://openalex.org/W2158262262","https://openalex.org/W2161098179","https://openalex.org/W2162495518","https://openalex.org/W2171984706","https://openalex.org/W2543066836","https://openalex.org/W2608242572","https://openalex.org/W4211174917","https://openalex.org/W4238803273","https://openalex.org/W4247403905"],"related_works":["https://openalex.org/W3026696341","https://openalex.org/W2774988270","https://openalex.org/W2258604039","https://openalex.org/W3110294858","https://openalex.org/W2978670733","https://openalex.org/W3207994248","https://openalex.org/W3045558373","https://openalex.org/W2415545834","https://openalex.org/W2069695727","https://openalex.org/W2966739945"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"major":[2,21],"histocompatibility":[3],"complex":[4],"(MHC)":[5],"region":[6,43],"of":[7,31,41,61,125,144,186],"the":[8,13,28,38,55,59,68,88,99,142,152,156,162],"human":[9,14,25],"genome,":[10],"and":[11,95,110,120,196],"specifically":[12],"leukocyte":[15],"antigen":[16],"(HLA)":[17],"genes,":[18],"play":[19],"a":[20,122,128,135,183,194],"role":[22],"in":[23,67,98,155,193],"numerous":[24],"diseases.":[26],"With":[27],"recent":[29],"progress":[30],"sequencing":[32],"methods":[33],"(eg,":[34],"Next-Generation":[35],"Sequencing,":[36],"NGS),":[37],"accurate":[39],"genotyping":[40],"this":[42,104,159],"has":[44],"become":[45],"possible":[46],"but":[47],"remains":[48],"relatively":[49],"costly.":[50],"In":[51,103],"order":[52],"to":[53,112,118,151,161,181],"obtain":[54],"HLA":[56,85,93,146,163,172,188,210],"information":[57,86],"for":[58,141,171,209],"millions":[60],"samples":[62,198],"already":[63],"genotyped":[64],"by":[65,207],"chips":[66],"past":[69],"ten":[70],"years,":[71],"efficient":[72],"bioinformatics":[73],"tools,":[74],"such":[75],"as":[76],"SNP2HLA":[77,119],"or":[78,204],"HIBAG,":[79],"have":[80],"been":[81],"developed":[82,134],"that":[83,139],"infer":[84],"from":[87],"linkage":[89],"disequilibrium":[90],"existing":[91],"between":[92],"alleles":[94],"SNP":[96,153],"markers":[97],"MHC":[100],"region.":[101,157],"RESULTS:":[102],"study,":[105],"we":[106,133],"first":[107],"used":[108],"ShapeIT":[109],"Impute2":[111],"implement":[113],"an":[114],"imputation":[115,126,164],"method":[116],"akin":[117],"found":[121],"comparable":[123],"quality":[124],"on":[127],"European":[129],"dataset.":[130],"More":[131],"importantly,":[132],"new":[136],"tool,":[137],"HLA-check,":[138],"allows":[140],"detection":[143],"aberrant":[145],"allele":[147],"calling":[148],"with":[149],"regard":[150],"genotypes":[154],"Adding":[158],"tool":[160],"software":[165],"increases":[166],"dramatically":[167],"their":[168],"accuracy,":[169],"especially":[170],"class":[173],"I":[174],"genes.":[175],"CONCLUSION:":[176],"Overall,":[177],"HLA-check":[178],"was":[179],"able":[180],"identify":[182],"limited":[184],"number":[185],"implausible":[187],"typings":[189],"(less":[190],"than":[191],"10%)":[192],"population,":[195],"these":[197],"can":[199],"then":[200],"either":[201],"be":[202,205],"removed":[203],"retyped":[206],"NGS":[208],"association":[211],"analysis.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}