{"id":"https://openalex.org/W2617393191","doi":"https://doi.org/10.1186/s12859-017-1642-8","title":"Contextualization of drug-mediator relations using evidence networks","display_name":"Contextualization of drug-mediator relations using evidence networks","publication_year":2017,"publication_date":"2017-05-01","ids":{"openalex":"https://openalex.org/W2617393191","doi":"https://doi.org/10.1186/s12859-017-1642-8","mag":"2617393191","pmid":"https://pubmed.ncbi.nlm.nih.gov/28617226"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-017-1642-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1642-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1642-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1642-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084277038","display_name":"Hai Joey Tran","orcid":null},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hai Joey Tran","raw_affiliation_strings":["Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, 85004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, 85004, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040257305","display_name":"Gil Speyer","orcid":"https://orcid.org/0000-0001-5888-5209"},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gil Speyer","raw_affiliation_strings":["Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, 85004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, 85004, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064611417","display_name":"Jeffrey Kiefer","orcid":"https://orcid.org/0000-0002-1238-3120"},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Kiefer","raw_affiliation_strings":["Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, 85004, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, 85004, USA","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100723831","display_name":"Seungchan Kim","orcid":"https://orcid.org/0000-0003-4183-4338"},"institutions":[{"id":"https://openalex.org/I250520410","display_name":"Prairie View A&M University","ror":"https://ror.org/0449kf092","country_code":"US","type":"education","lineage":["https://openalex.org/I250520410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Seungchan Kim","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Roy G. Perry College of Engineering, Prairie View A&M University, Prairie View, TX, 77446, USA. sekim@pvamu.edu","Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, 85004, USA. sekim@pvamu.edu","Department of Electrical and Computer Engineering, Roy G. Perry College of Engineering, Prairie View A&M University, Prairie View, TX, 77446, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Roy G. Perry College of Engineering, Prairie View A&M University, Prairie View, TX, 77446, USA. sekim@pvamu.edu","institution_ids":[]},{"raw_affiliation_string":"Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, AZ, 85004, USA. sekim@pvamu.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Roy G. Perry College of Engineering, Prairie View A&M University, Prairie View, TX, 77446, USA","institution_ids":["https://openalex.org/I250520410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100723831"],"corresponding_institution_ids":["https://openalex.org/I250520410"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.1122,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.50008762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"S7","first_page":"252","last_page":"252"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.6859999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.20100000500679016,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/contextualization","display_name":"Contextualization","score":0.9304801225662231},{"id":"https://openalex.org/keywords/mediator","display_name":"Mediator","score":0.8155249357223511},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5204846262931824},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.49713805317878723},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46691372990608215},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4205501079559326},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.3229910731315613},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3183375895023346},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.25301599502563477},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17786526679992676},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.13443797826766968},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.09439870715141296},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.08953076601028442},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08178490400314331}],"concepts":[{"id":"https://openalex.org/C2780712339","wikidata":"https://www.wikidata.org/wiki/Q5165204","display_name":"Contextualization","level":3,"score":0.9304801225662231},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.8155249357223511},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5204846262931824},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.49713805317878723},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46691372990608215},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4205501079559326},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3229910731315613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3183375895023346},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25301599502563477},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17786526679992676},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13443797826766968},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09439870715141296},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.08953076601028442},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08178490400314331},{"id":"https://openalex.org/C527412718","wikidata":"https://www.wikidata.org/wiki/Q855395","display_name":"Interpretation (philosophy)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056748","descriptor_name":"Cyclin H","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056748","descriptor_name":"Cyclin H","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056748","descriptor_name":"Cyclin H","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056748","descriptor_name":"Cyclin H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056748","descriptor_name":"Cyclin H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056748","descriptor_name":"Cyclin H","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056748","descriptor_name":"Cyclin H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056748","descriptor_name":"Cyclin H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056748","descriptor_name":"Cyclin H","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12859-017-1642-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1642-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1642-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28617226","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28617226","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:f7ea340a18814c79ab2405085d08e169","is_oa":false,"landing_page_url":"https://doaj.org/article/f7ea340a18814c79ab2405085d08e169","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 18, Iss S7, Pp 69-78 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4323875","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC5471944","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5471944","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5471944","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-017-1642-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1642-8","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1642-8","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6299999952316284}],"awards":[{"id":"https://openalex.org/G7877974583","display_name":null,"funder_award_id":"U01CA168397","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320317673","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21"},{"id":"https://openalex.org/F4320319357","display_name":"Helios Education Foundation","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2617393191.pdf","grobid_xml":"https://content.openalex.org/works/W2617393191.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1976643073","https://openalex.org/W1978370150","https://openalex.org/W1989277387","https://openalex.org/W2011282943","https://openalex.org/W2043398720","https://openalex.org/W2084224084","https://openalex.org/W2096173332","https://openalex.org/W2131058166","https://openalex.org/W2136444502","https://openalex.org/W2150723605","https://openalex.org/W2152883907","https://openalex.org/W2152931274","https://openalex.org/W2155875510","https://openalex.org/W2163485494","https://openalex.org/W2164298117","https://openalex.org/W2169528473","https://openalex.org/W2175970000","https://openalex.org/W2179127114","https://openalex.org/W2283903563","https://openalex.org/W2551883086"],"related_works":["https://openalex.org/W1687432146","https://openalex.org/W1591874556","https://openalex.org/W3216994056","https://openalex.org/W2185608106","https://openalex.org/W3046258185","https://openalex.org/W1548083239","https://openalex.org/W2268232908","https://openalex.org/W205610463","https://openalex.org/W2893240344","https://openalex.org/W4385272430"],"abstract_inverted_index":{"BACKGROUND:":[0],"Genomic":[1],"analysis":[2,238],"of":[3,28,43,48,98,150,157,245,284,320],"drug":[4,20,130,133,178,223,300,324],"response":[5],"can":[6,13],"provide":[7],"unique":[8],"insights":[9,32,322],"into":[10],"therapies":[11],"that":[12,62,118,193,307,326],"be":[14],"used":[15,74],"to":[16,21,54,66,108,213,217,232,264,280,323,329],"match":[17],"the":[18,22,26,78,102,138,148,181,219,257,266,282,285,290,299,302,318],"\"right":[19],"right":[23],"patient.\"":[24],"However,":[25,147],"process":[27],"discovering":[29],"such":[30],"therapeutic":[31],"using":[33],"genomic":[34,64],"data":[35,65,97],"is":[36,59],"not":[37,252],"straightforward":[38],"and":[39,95,132,137,177,183,188,196,200,224,239,272,292,301,316],"represents":[40],"an":[41],"area":[42],"active":[44],"investigation.":[45],"EDDY":[46,71],"(Evaluation":[47],"Differential":[49],"DependencY),":[50],"a":[51,84,143,211,222,225],"statistical":[52,57,124],"test":[53],"detect":[55],"differential":[56,68],"dependencies,":[58],"one":[60],"method":[61,212],"leverages":[63],"identify":[67],"genetic":[69,123],"dependencies.":[70],"has":[72],"been":[73],"in":[75,101,122,236],"conjunction":[76],"with":[77,86,175,269,294,297],"Cancer":[79,103],"Therapeutics":[80],"Response":[81],"Portal":[82],"(CTRP),":[83],"dataset":[85],"drug-response":[87],"measurements":[88],"for":[89,243,256],"more":[90],"than":[91],"400":[92],"small":[93],"molecules,":[94],"RNAseq":[96],"cell":[99,135],"lines":[100],"Cell":[104],"Line":[105],"Encyclopedia":[106],"(CCLE)":[107],"find":[109],"potential":[110],"drug-mediator":[111,151,233,246,267],"pairs.":[112],"Mediators":[113],"were":[114,251,278],"identified":[115,240],"as":[116,142],"genes":[117,295],"showed":[119],"significant":[120],"change":[121],"dependencies":[125],"within":[126],"annotated":[127],"pathways":[128],"between":[129,221],"sensitive":[131],"non-sensitive":[134],"lines,":[136],"results":[139,287,315],"are":[140,190],"presented":[141],"public":[144],"web-portal":[145],"(EDDY-CTRP).":[146],"interpretability":[149,283],"pairs":[152,247],"currently":[153],"hinders":[154],"further":[155],"exploration":[156],"these":[158,205,308],"potentially":[159],"valuable":[160],"results.":[161],"METHODS:":[162],"In":[163],"this":[164,168,230],"study,":[165],"we":[166,208,277],"address":[167],"challenge":[169],"by":[170,288],"constructing":[171],"evidence":[172,215,241,260,275,309],"networks":[173,216,242,261,310],"built":[174],"protein":[176],"interactions":[179,199],"from":[180],"STITCH":[182,187],"STRING":[184,189],"interaction":[185],"databases.":[186],"sister":[191],"databases":[192],"catalog":[194],"known":[195,253],"predicted":[197],"drug-protein":[198],"protein-protein":[201],"interactions,":[202],"respectively.":[203],"Using":[204,274],"two":[206],"databases,":[207],"have":[209],"developed":[210],"construct":[214],"\"explain\"":[218],"relation":[220],"mediator.":[226,303],"RESULTS:":[227],"We":[228,305],"applied":[229],"approach":[231],"relations":[234],"discovered":[235],"EDDY-CTRP":[237,286,314],"~70%":[244],"where":[248],"most":[249],"mediators":[250,293],"direct":[254],"targets":[255],"drug.":[258],"Constructed":[259],"enable":[262],"researchers":[263],"contextualize":[265],"pair":[268],"current":[270],"research":[271],"knowledge.":[273],"networks,":[276],"able":[279],"improve":[281],"linking":[289],"drugs":[291],"associated":[296],"both":[298],"CONCLUSION:":[304],"anticipate":[306],"will":[311,327],"help":[312],"inform":[313],"enhance":[317],"generation":[319],"important":[321],"sensitivity":[325],"lead":[328],"improved":[330],"precision":[331],"medicine":[332],"applications.":[333]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
