{"id":"https://openalex.org/W2606817705","doi":"https://doi.org/10.1186/s12859-017-1619-7","title":"Meta-analysis approach as a gene selection method in class prediction: does it improve model performance? A case study in acute myeloid leukemia","display_name":"Meta-analysis approach as a gene selection method in class prediction: does it improve model performance? A case study in acute myeloid leukemia","publication_year":2017,"publication_date":"2017-04-11","ids":{"openalex":"https://openalex.org/W2606817705","doi":"https://doi.org/10.1186/s12859-017-1619-7","mag":"2606817705","pmid":"https://pubmed.ncbi.nlm.nih.gov/28399794"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-017-1619-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1619-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1619-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1619-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050906408","display_name":"Putri W. Novianti","orcid":"https://orcid.org/0000-0002-8130-027X"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Putri W. Novianti","raw_affiliation_strings":["Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands. p.novianti@vumc.nl","Department of Epidemiology and Biostatistics, VU University medical center, Amsterdam, The Netherlands. p.novianti@vumc.nl","Department of Pathology, VU University medical center, Amsterdam, The Netherlands. p.novianti@vumc.nl","Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands. p.novianti@vumc.nl","institution_ids":[]},{"raw_affiliation_string":"Department of Epidemiology and Biostatistics, VU University medical center, Amsterdam, The Netherlands. p.novianti@vumc.nl","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, VU University medical center, Amsterdam, The Netherlands. p.novianti@vumc.nl","institution_ids":[]},{"raw_affiliation_string":"Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005952579","display_name":"Victor L. Jong","orcid":null},"institutions":[{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]},{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Victor L. Jong","raw_affiliation_strings":["Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands","Viroscience Laboratory, Erasmus Medical Center Rotterdam, 3015, CE, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Viroscience Laboratory, Erasmus Medical Center Rotterdam, 3015, CE, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004890153","display_name":"Kit C. B. Roes","orcid":"https://orcid.org/0000-0002-6775-1963"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kit C. B. Roes","raw_affiliation_strings":["Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056077573","display_name":"Marinus J.C. Eijkemans","orcid":"https://orcid.org/0000-0001-9400-0615"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marinus J. C. Eijkemans","raw_affiliation_strings":["Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics & Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508, GA, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050906408"],"corresponding_institution_ids":["https://openalex.org/I3018483916"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.3279,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58366925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"18","issue":"1","first_page":"210","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.92330002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14065","display_name":"Biological Research and Disease Studies","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.7255473732948303},{"id":"https://openalex.org/keywords/predictive-modelling","display_name":"Predictive modelling","score":0.5467960238456726},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5427922606468201},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5191128253936768},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.46666187047958374},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.43140944838523865},{"id":"https://openalex.org/keywords/gene-selection","display_name":"Gene selection","score":0.42186346650123596},{"id":"https://openalex.org/keywords/model-selection","display_name":"Model selection","score":0.4216920733451843},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4187651574611664},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.41608351469039917},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.4138447046279907},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4098838269710541},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3927939236164093},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34975653886795044},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.32673364877700806},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.32186347246170044},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2536354660987854},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23989790678024292},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.2128000557422638},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17731571197509766},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1295735239982605}],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.7255473732948303},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.5467960238456726},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5427922606468201},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5191128253936768},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.46666187047958374},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.43140944838523865},{"id":"https://openalex.org/C2984324147","wikidata":"https://www.wikidata.org/wiki/Q3080021","display_name":"Gene selection","level":5,"score":0.42186346650123596},{"id":"https://openalex.org/C93959086","wikidata":"https://www.wikidata.org/wiki/Q6888345","display_name":"Model selection","level":2,"score":0.4216920733451843},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4187651574611664},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.41608351469039917},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4138447046279907},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4098838269710541},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3927939236164093},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34975653886795044},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32673364877700806},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32186347246170044},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2536354660987854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23989790678024292},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.2128000557422638},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17731571197509766},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1295735239982605},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052138","descriptor_name":"Genes, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":12,"locations":[{"id":"doi:10.1186/s12859-017-1619-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1619-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1619-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28399794","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28399794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5387259","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5387259","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:eur:oai:pure.eur.nl:publications/706636e0-399a-47d4-b07c-1298ec2a1227","is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/706636e0-399a-47d4-b07c-1298ec2a1227","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 18:210. BioMed Central Ltd.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:99380","is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/99380","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics, 18(1)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:99617","is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/99617","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics, 18(1)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3cae4b83d1144df3bf30ba0699124658","is_oa":true,"landing_page_url":"https://doaj.org/article/3cae4b83d1144df3bf30ba0699124658","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 18, Iss 1, Pp 1-11 (2017)","raw_type":"article"},{"id":"pmh:oai:pure.eur.nl:publications/706636e0-399a-47d4-b07c-1298ec2a1227","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:repub.eur.nl:99380","is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/99380","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics vol. 18 no. 1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repub.eur.nl:99617","is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/99617","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics vol. 18 no. 1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/349631","is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/349631","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 18(1). BioMed Central","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/349631","is_oa":true,"landing_page_url":"http://dspace.library.uu.nl/handle/1874/349631","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 18(1)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12859-017-1619-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1619-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1619-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322140","display_name":"Universitair Medisch Centrum Utrecht","ror":"https://ror.org/0575yy874"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606817705.pdf","grobid_xml":"https://content.openalex.org/works/W2606817705.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1506806321","https://openalex.org/W1507205421","https://openalex.org/W1510850304","https://openalex.org/W1523843467","https://openalex.org/W1546952499","https://openalex.org/W1566270348","https://openalex.org/W1572443983","https://openalex.org/W1587026990","https://openalex.org/W1678356000","https://openalex.org/W1770196752","https://openalex.org/W1943245961","https://openalex.org/W1951724000","https://openalex.org/W1966626540","https://openalex.org/W1982730485","https://openalex.org/W1982932084","https://openalex.org/W1996354288","https://openalex.org/W2020242768","https://openalex.org/W2022829943","https://openalex.org/W2033993681","https://openalex.org/W2037815828","https://openalex.org/W2055350603","https://openalex.org/W2058414075","https://openalex.org/W2065784891","https://openalex.org/W2068576035","https://openalex.org/W2072245877","https://openalex.org/W2081098333","https://openalex.org/W2087347434","https://openalex.org/W2091336075","https://openalex.org/W2092290577","https://openalex.org/W2097554668","https://openalex.org/W2100744492","https://openalex.org/W2103365735","https://openalex.org/W2107598685","https://openalex.org/W2108750263","https://openalex.org/W2109103446","https://openalex.org/W2110065044","https://openalex.org/W2113778023","https://openalex.org/W2116634113","https://openalex.org/W2117812871","https://openalex.org/W2120517678","https://openalex.org/W2122825543","https://openalex.org/W2124201592","https://openalex.org/W2127019337","https://openalex.org/W2128640268","https://openalex.org/W2145245891","https://openalex.org/W2146712834","https://openalex.org/W2152155643","https://openalex.org/W2154981570","https://openalex.org/W2157132621","https://openalex.org/W2160697532","https://openalex.org/W2163091639","https://openalex.org/W2215458745","https://openalex.org/W2338675851","https://openalex.org/W2787894218","https://openalex.org/W2911964244","https://openalex.org/W3022387011","https://openalex.org/W4230096730"],"related_works":["https://openalex.org/W2487162673","https://openalex.org/W2793211469","https://openalex.org/W2949152769","https://openalex.org/W4372354731","https://openalex.org/W2807634898","https://openalex.org/W1692008701","https://openalex.org/W2942366970","https://openalex.org/W2597588799","https://openalex.org/W4360593462","https://openalex.org/W2562400057"],"abstract_inverted_index":{"BACKGROUND:":[0],"Aggregating":[1],"gene":[2,44,52,61,96,114,124,155,235,284],"expression":[3,53,62,97,115,285],"data":[4,98,251],"across":[5],"experiments":[6,63,101],"via":[7,237],"meta-analysis":[8,40,129,158,238,268],"is":[9],"expected":[10],"to":[11,20,25,48,76,80,118,162,168,225],"increase":[12,21],"the":[13,16,22,34,90,111,120,139,143,149,208,226,231,261,275],"precision":[14],"of":[15,37,194,250,277],"effect":[17,193],"estimates":[18],"and":[19,69,107,133,146,199,212,220,256],"statistical":[23],"power":[24],"detect":[26],"a":[27,39,43,173,248,278,282],"certain":[28],"fold":[29,197,218,254],"change.":[30],"This":[31],"study":[32],"evaluates":[33],"potential":[35],"benefit":[36],"using":[38,102,247],"approach":[41,239],"as":[42,83,119,166],"selection":[45,106,125,156,236,266],"method":[46],"prior":[47],"predictive":[49,134,169,279],"modeling":[50,170],"in":[51,64,228],"data.":[54,286],"RESULTS:":[55],"Six":[56],"raw":[57],"datasets":[58,116,185],"from":[59,99,188],"different":[60,71],"acute":[65],"myeloid":[66],"leukemia":[67],"(AML)":[68],"11":[70],"classification":[72,78,91,160],"methods":[73],"were":[74,93,136,186],"used":[75],"build":[77],"models":[79,92,135,161],"classify":[81],"samples":[82],"either":[84],"AML":[85],"or":[86],"healthy":[87],"control.":[88],"First,":[89],"trained":[94,137],"on":[95,130,142,148,172,207,260,269,281],"single":[100,174],"conventional":[103],"supervised":[104],"variable":[105],"externally":[108],"validated":[109,147],"with":[110,138,252],"other":[112],"five":[113],"(referred":[117],"individual-classification":[121,213],"approach).":[122],"Next,":[123],"was":[126,180,215,240,245],"performed":[127],"through":[128,157,267],"four":[131],"datasets,":[132,154],"selected":[140],"genes":[141,206],"fifth":[144],"dataset":[145],"sixth":[150],"dataset.":[151],"For":[152],"some":[153],"helped":[159],"achieve":[163],"higher":[164],"performance":[165,229,276],"compared":[167],"based":[171],"dataset;":[175],"but":[176],"for":[177],"others,":[178],"there":[179],"no":[181],"major":[182],"improvement.":[183],"Synthetic":[184],"generated":[187],"nine":[189],"simulation":[190],"scenarios.":[191],"The":[192,217,234],"sample":[195],"size,":[196],"change":[198,219,255],"pairwise":[200,221,258],"correlation":[201,222,259],"between":[202,210,230],"differentially":[203],"expressed":[204],"(DE)":[205],"difference":[209,227],"MA-":[211],"model":[214,280],"evaluated.":[216],"significantly":[223],"contributed":[224],"two":[232],"methods.":[233],"more":[241],"effective":[242],"when":[243],"it":[244],"conducted":[246],"set":[249],"low":[253],"high":[257],"DE":[262],"genes.":[263],"CONCLUSION:":[264],"Gene":[265],"previously":[270],"published":[271],"studies":[272],"potentially":[273],"improves":[274],"given":[283]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}