{"id":"https://openalex.org/W2607353811","doi":"https://doi.org/10.1186/s12859-017-1611-2","title":"Comparison of different cell type correction methods for genome-scale epigenetics studies","display_name":"Comparison of different cell type correction methods for genome-scale epigenetics studies","publication_year":2017,"publication_date":"2017-04-14","ids":{"openalex":"https://openalex.org/W2607353811","doi":"https://doi.org/10.1186/s12859-017-1611-2","mag":"2607353811","pmid":"https://pubmed.ncbi.nlm.nih.gov/28410574"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-017-1611-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1611-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1611-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1611-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061211210","display_name":"Akhilesh Kaushal","orcid":null},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akhilesh Kaushal","raw_affiliation_strings":["Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA","institution_ids":["https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320787","display_name":"Hongmei Zhang","orcid":"https://orcid.org/0000-0003-3557-0364"},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongmei Zhang","raw_affiliation_strings":["Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA. hzhang6@memphis.edu","Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA"],"raw_orcid":"https://orcid.org/0000-0003-3557-0364","affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA. hzhang6@memphis.edu","institution_ids":["https://openalex.org/I94658018"]},{"raw_affiliation_string":"Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA","institution_ids":["https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007706022","display_name":"Wilfried Karmaus","orcid":"https://orcid.org/0000-0003-2684-1492"},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilfried J. J. Karmaus","raw_affiliation_strings":["Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA","institution_ids":["https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060703675","display_name":"Meredith Ray","orcid":"https://orcid.org/0000-0001-5312-3774"},"institutions":[{"id":"https://openalex.org/I94658018","display_name":"University of Memphis","ror":"https://ror.org/01cq23130","country_code":"US","type":"education","lineage":["https://openalex.org/I94658018"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith Ray","raw_affiliation_strings":["Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology, Biostatistics, and Environmental Health, University of Memphis, Memphis, 38152, TN, USA","institution_ids":["https://openalex.org/I94658018"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000734853","display_name":"Mylin A. Torres","orcid":"https://orcid.org/0000-0003-3582-5216"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2800556163","display_name":"Emory University Hospital","ror":"https://ror.org/05dm4ck87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I2800556163"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mylin A. Torres","raw_affiliation_strings":["Department of Radiation Oncology, Emory University School of Medicine, 1365 Clifton Rd. NE, Atlanta, 30322, GA, USA","Winship Cancer Institute, Emory University, 1365 Clifton Rd. NE, Atlanta, 30322, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Emory University School of Medicine, 1365 Clifton Rd. NE, Atlanta, 30322, GA, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2800556163"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, 1365 Clifton Rd. NE, Atlanta, 30322, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083615322","display_name":"Alicia K. Smith","orcid":"https://orcid.org/0000-0002-8537-5156"},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4210109911","display_name":"Woodruff Health Sciences Center","ror":"https://ror.org/01xm4tt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I150468666","https://openalex.org/I4210109911"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alicia K. Smith","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, 30322, GA, USA","Winship Cancer Institute, Emory University, 1365 Clifton Rd. NE, Atlanta, 30322, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, 30322, GA, USA","institution_ids":["https://openalex.org/I4210109911","https://openalex.org/I150468666"]},{"raw_affiliation_string":"Winship Cancer Institute, Emory University, 1365 Clifton Rd. NE, Atlanta, 30322, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101574809","display_name":"Shu\u2010Li Wang","orcid":"https://orcid.org/0000-0002-0686-4729"},"institutions":[{"id":"https://openalex.org/I165441096","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I165441096"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shu-Li Wang","raw_affiliation_strings":["National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. slwang@nhri.org.tw","National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. slwang@nhri.org.tw","institution_ids":["https://openalex.org/I165441096"]},{"raw_affiliation_string":"National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan","institution_ids":["https://openalex.org/I165441096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5101574809"],"corresponding_institution_ids":["https://openalex.org/I165441096"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":4.2625,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.95130448,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"18","issue":"1","first_page":"216","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6201490163803101},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6104708909988403},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.5877753496170044},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.49268442392349243},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.47748491168022156},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.44900426268577576},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39802229404449463},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3898323178291321},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3240770399570465},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12800434231758118},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11886361241340637},{"id":"https://openalex.org/keywords/geography","display_name":"Geography","score":0.08507511019706726},{"id":"https://openalex.org/keywords/cartography","display_name":"Cartography","score":0.06872451305389404}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6201490163803101},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6104708909988403},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5877753496170044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49268442392349243},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.47748491168022156},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.44900426268577576},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39802229404449463},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3898323178291321},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3240770399570465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12800434231758118},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11886361241340637},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.08507511019706726},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.06872451305389404}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001151","descriptor_name":"Arsenic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001151","descriptor_name":"Arsenic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001151","descriptor_name":"Arsenic","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001773","descriptor_name":"Blood Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001773","descriptor_name":"Blood Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001773","descriptor_name":"Blood Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018811","descriptor_name":"Maternal Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018811","descriptor_name":"Maternal Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018811","descriptor_name":"Maternal Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-017-1611-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1611-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1611-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28410574","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28410574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:82eadd35e3c449ccbe56af712749e4b6","is_oa":true,"landing_page_url":"https://doaj.org/article/82eadd35e3c449ccbe56af712749e4b6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, Vol 18, Iss 1, Pp 1-12 (2017)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5391562","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5391562","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-017-1611-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-017-1611-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-017-1611-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.46000000834465027,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G160336713","display_name":null,"funder_award_id":"MOST103-2314-B-400-006","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G4278036301","display_name":null,"funder_award_id":"R01AI091905","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8280148008","display_name":null,"funder_award_id":"104-2314-B-400-001","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G8768856677","display_name":null,"funder_award_id":"R01AI121226","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322845","display_name":"National Health Research Institutes","ror":"https://ror.org/02r6fpx29"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W133186721","https://openalex.org/W1545482900","https://openalex.org/W1963970354","https://openalex.org/W1972882006","https://openalex.org/W2003402014","https://openalex.org/W2011988545","https://openalex.org/W2015081876","https://openalex.org/W2019501651","https://openalex.org/W2019590128","https://openalex.org/W2021280825","https://openalex.org/W2033695374","https://openalex.org/W2040533846","https://openalex.org/W2043353293","https://openalex.org/W2061828443","https://openalex.org/W2070480173","https://openalex.org/W2073123191","https://openalex.org/W2079927753","https://openalex.org/W2083225704","https://openalex.org/W2086021638","https://openalex.org/W2097869179","https://openalex.org/W2099437253","https://openalex.org/W2101870168","https://openalex.org/W2103017472","https://openalex.org/W2107330391","https://openalex.org/W2116650193","https://openalex.org/W2117398145","https://openalex.org/W2120627772","https://openalex.org/W2123402141","https://openalex.org/W2130523009","https://openalex.org/W2131848047","https://openalex.org/W2133465414","https://openalex.org/W2137499573","https://openalex.org/W2145071027","https://openalex.org/W2157535100","https://openalex.org/W2158217645","https://openalex.org/W2159482845","https://openalex.org/W2160697532","https://openalex.org/W2169556367","https://openalex.org/W2170324063","https://openalex.org/W2170427580","https://openalex.org/W2170538199","https://openalex.org/W2172249877","https://openalex.org/W2197287738","https://openalex.org/W2309685155","https://openalex.org/W2324966680","https://openalex.org/W2347100089","https://openalex.org/W2408900562","https://openalex.org/W2493260742","https://openalex.org/W2951545629","https://openalex.org/W4240237951","https://openalex.org/W4294216483","https://openalex.org/W4302338619"],"related_works":["https://openalex.org/W4366603091","https://openalex.org/W2485141070","https://openalex.org/W2411374999","https://openalex.org/W2083798468","https://openalex.org/W2979314934","https://openalex.org/W2146527561","https://openalex.org/W2770084104","https://openalex.org/W3000356375","https://openalex.org/W4386476622","https://openalex.org/W4387875454"],"abstract_inverted_index":{"BACKGROUND:":[0],"Whole":[1],"blood":[2,178],"is":[3,55,284,305,310,330,344,353],"frequently":[4],"utilized":[5,171],"in":[6,14,46,80,99,162,271,326],"genome-wide":[7],"association":[8,119],"studies":[9,255],"of":[10,120,176,209,259,314],"DNA":[11,121,203],"methylation":[12,122,204],"patterns":[13],"relation":[15],"to":[16,34,244,279],"environmental":[17],"exposures":[18],"or":[19,36,340],"clinical":[20],"outcomes.":[21],"These":[22],"associations":[23],"can":[24],"be":[25,61,280],"confounded":[26],"by":[27,87,166,249],"cellular":[28],"heterogeneity.":[29],"Algorithms":[30],"have":[31,43],"been":[32,44],"developed":[33],"measure":[35],"adjust":[37],"for":[38,140,190,231],"this":[39],"heterogeneity,":[40],"and":[41,103,135,164,181,268,286,300],"some":[42,177],"compared":[45,72,150,182,243],"the":[47,58,78,81,85,91,97,118,127,159,185,218,223,245,289,308,312,323,327,342,350],"literature.":[48],"However,":[49,332],"with":[50,108,130,136,174,184,206,226],"new":[51],"methods":[52,76,98,160,191,229,257],"available,":[53,322],"it":[54],"unknown":[56],"whether":[57],"findings":[59],"will":[60],"consistent,":[62],"if":[63,333,341],"not":[64,192,345],"which":[65],"method(s)":[66],"perform":[67],"better.":[68],"RESULTS:":[69,215],"Methods:":[70],"We":[71,115,148],"eight":[73],"cell-type":[74,142],"correction":[75],"including":[77],"method":[79,86,220,248,324,352],"minfi":[82,163,236,328],"R":[83,105],"package,":[84],"Houseman":[88,167,250],"et":[89,168,251],"al.,":[90,169],"Removing":[92],"unwanted":[93],"variation":[94],"(RUV)":[95],"approach,":[96],"FaST-LMM-EWASher,":[100],"ReFACTor,":[101],"RefFreeEWAS,":[102],"RefFreeCellMix":[104,270],"programs,":[106],"along":[107],"one":[109],"approach":[110],"utilizing":[111],"surrogate":[112],"variables":[113,211],"(SVAs).":[114],"first":[116],"evaluated":[117,198],"at":[123],"each":[124],"CpG":[125],"across":[126],"whole":[128],"genome":[129],"prenatal":[131],"arsenic":[132],"exposure":[133],"levels":[134],"cancer":[137],"status,":[138],"adjusted":[139],"estimated":[141,186],"information":[143],"obtained":[144],"from":[145,155,217,297],"different":[146,156],"methods.":[147],"then":[149],"CpGs":[151],"showing":[152],"statistical":[153],"significance":[154],"approaches.":[157],"For":[158],"implemented":[161,325],"proposed":[165,247],"we":[170,197],"homogeneous":[172,234],"data":[173,205,261,299,320,337],"composition":[175],"cells":[179],"available":[180,339],"them":[183],"cell":[187,195,241,348],"compositions.":[188],"Finally,":[189],"explicitly":[193],"estimating":[194,347],"compositions,":[196],"their":[199],"performance":[200],"using":[201],"simulated":[202],"a":[207],"set":[208],"latent":[210],"representing":[212],"\"cell":[213],"types\".":[214],"Results":[216,296],"SVA-based":[219],"overall":[221],"showed":[222],"highest":[224,293],"agreement":[225],"all":[227],"other":[228],"except":[230],"FaST-LMM-EWASher.":[232],"Using":[233],"data,":[235],"provided":[237,265],"better":[238],"estimations":[239],"on":[240,256,311,346],"types":[242],"originally":[246],"al.":[252],"Further":[253],"simulation":[254],"free":[258],"reference":[260,319,336],"revealed":[262],"that":[263,303],"SVA":[264,304,351],"good":[266],"sensitivities":[267,275],"specificities,":[269],"general":[272],"produced":[273],"high":[274],"but":[276,292],"specificities":[277],"tended":[278],"low":[281],"when":[282,307],"confounding":[283],"present,":[285],"FaST-LMM-EWASher":[287],"gave":[288],"lowest":[290],"sensitivity":[291],"specificity.":[294],"CONCLUSIONS:":[295],"real":[298],"simulations":[301],"indicated":[302],"recommended":[306],"focus":[309,343],"identification":[313],"informative":[315],"CpGs.":[316],"When":[317],"appropriate":[318],"are":[321,338],"package":[329],"recommended.":[331],"no":[334],"such":[335],"proportions,":[349],"suggested.":[354]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2017-04-28T00:00:00"}
