{"id":"https://openalex.org/W2565115450","doi":"https://doi.org/10.1186/s12859-016-1371-4","title":"SCMBYK: prediction and characterization of bacterial tyrosine-kinases based on propensity scores of dipeptides","display_name":"SCMBYK: prediction and characterization of bacterial tyrosine-kinases based on propensity scores of dipeptides","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2565115450","doi":"https://doi.org/10.1186/s12859-016-1371-4","mag":"2565115450","pmid":"https://pubmed.ncbi.nlm.nih.gov/28155663"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-1371-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1371-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1371-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1371-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038905794","display_name":"Tamara Vasylenko","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tamara Vasylenko","raw_affiliation_strings":["Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113470213","display_name":"Yi-Fan Liou","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Fan Liou","raw_affiliation_strings":["Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058944043","display_name":"Po-Chin Chiou","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Po-Chin Chiou","raw_affiliation_strings":["Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041140492","display_name":"Hsiao-Wei Chu","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsiao-Wei Chu","raw_affiliation_strings":["Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068726321","display_name":"Yung-Sung Lai","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yung-Sung Lai","raw_affiliation_strings":["Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044629350","display_name":"Yu-Ling Chou","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Ling Chou","raw_affiliation_strings":["Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112007823","display_name":"Hui-Ling Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hui-Ling Huang","raw_affiliation_strings":["Center for Bioinformatics Research, National Chiao Tung University, Hsinchu, Taiwan. hlhuang.nctu@gmail.com","College of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan. hlhuang.nctu@gmail.com","Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan. hlhuang.nctu@gmail.com","College of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics Research, National Chiao Tung University, Hsinchu, Taiwan. hlhuang.nctu@gmail.com","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"College of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan. hlhuang.nctu@gmail.com","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan. hlhuang.nctu@gmail.com","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"College of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070924732","display_name":"Shinn\u2010Ying Ho","orcid":"https://orcid.org/0000-0002-1901-8353"},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Shinn-Ying Ho","raw_affiliation_strings":["Center for Bioinformatics Research, National Chiao Tung University, Hsinchu, Taiwan. syho@mail.nctu.edu.tw","College of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan. syho@mail.nctu.edu.tw","Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan. syho@mail.nctu.edu.tw","College of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics Research, National Chiao Tung University, Hsinchu, Taiwan. syho@mail.nctu.edu.tw","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"College of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan. syho@mail.nctu.edu.tw","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, 300, Taiwan. syho@mail.nctu.edu.tw","institution_ids":["https://openalex.org/I148366613"]},{"raw_affiliation_string":"College of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5070924732","https://openalex.org/A5112007823"],"corresponding_institution_ids":["https://openalex.org/I148366613"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.1741,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.66104747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"17","issue":"S19","first_page":"514","last_page":"514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9449999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9449999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.8594011068344116},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5837408304214478},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5647926926612854},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5563282370567322},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4881508946418762},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"Mitogen-activated protein kinase","score":0.47007113695144653},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.4516720473766327},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"Tyrosine kinase","score":0.449025958776474},{"id":"https://openalex.org/keywords/protein-serine-threonine-kinases","display_name":"Protein-Serine-Threonine Kinases","score":0.4397851824760437},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.32565543055534363},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.21092703938484192},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.19160419702529907},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18211936950683594}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.8594011068344116},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5837408304214478},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5647926926612854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5563282370567322},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4881508946418762},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.47007113695144653},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4516720473766327},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.449025958776474},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.4397851824760437},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32565543055534363},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21092703938484192},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.19160419702529907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18211936950683594}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057216","descriptor_name":"Propensity Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057216","descriptor_name":"Propensity Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057216","descriptor_name":"Propensity Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12859-016-1371-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1371-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1371-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28155663","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28155663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5260027","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5260027","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-1371-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1371-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1371-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[{"id":"https://openalex.org/G5247883035","display_name":null,"funder_award_id":"MOST-105-2627-M-009-008","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"},{"id":"https://openalex.org/G7089230189","display_name":null,"funder_award_id":"MOST-105-2221-E-009-138-MY2","funder_id":"https://openalex.org/F4320321040","funder_display_name":"National Science Council"}],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320321528","display_name":"Shanghai Educational Development Foundation","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320323443","display_name":"National Chiao Tung University","ror":"https://ror.org/00se2k293"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2565115450.pdf","grobid_xml":"https://content.openalex.org/works/W2565115450.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1573617318","https://openalex.org/W1889312334","https://openalex.org/W1968249643","https://openalex.org/W1970968348","https://openalex.org/W1976030780","https://openalex.org/W1990060072","https://openalex.org/W1998661009","https://openalex.org/W2001484619","https://openalex.org/W2004156590","https://openalex.org/W2005750609","https://openalex.org/W2014731953","https://openalex.org/W2015205329","https://openalex.org/W2020194549","https://openalex.org/W2022012484","https://openalex.org/W2023551634","https://openalex.org/W2028751775","https://openalex.org/W2041301976","https://openalex.org/W2058292715","https://openalex.org/W2060210606","https://openalex.org/W2062849515","https://openalex.org/W2070034694","https://openalex.org/W2076847722","https://openalex.org/W2077128644","https://openalex.org/W2103824638","https://openalex.org/W2104628742","https://openalex.org/W2112946624","https://openalex.org/W2118817344","https://openalex.org/W2128077684","https://openalex.org/W2135893370","https://openalex.org/W2141062474","https://openalex.org/W2149851123","https://openalex.org/W2153635508","https://openalex.org/W2155653793","https://openalex.org/W2158266834","https://openalex.org/W2163095542","https://openalex.org/W2167485812","https://openalex.org/W2234991979","https://openalex.org/W2303117993","https://openalex.org/W4213345021"],"related_works":["https://openalex.org/W2051108283","https://openalex.org/W1964515703","https://openalex.org/W2085362455","https://openalex.org/W2027159465","https://openalex.org/W1995212344","https://openalex.org/W2091587849","https://openalex.org/W1968921410","https://openalex.org/W2000390423","https://openalex.org/W2083839424","https://openalex.org/W2316548913"],"abstract_inverted_index":{"BACKGROUND:":[0],"Bacterial":[1],"tyrosine-kinases":[2],"(BY-kinases),":[3],"which":[4,107,223],"play":[5,189],"an":[6,201],"important":[7],"role":[8],"in":[9,31,47,192],"numerous":[10],"cellular":[11],"processes,":[12,50],"are":[13,45,52],"characterized":[14],"as":[15,174,214,252],"a":[16,64,81,215,218,253],"separate":[17],"class":[18],"of":[19,94,113,130,145,155,161,164,206,217,245],"enzymes":[20,44],"and":[21,51,66,87,97,110,115,178,227,248],"share":[22],"no":[23],"structural":[24],"similarity":[25],"with":[26],"their":[27],"eukaryotic":[28],"counterparts.":[29],"However,":[30],"silico":[32],"methods":[33],"for":[34,55,85,204,256],"predicting":[35,86],"BY-kinases":[36,96,146,150,165,181,226],"have":[37],"not":[38],"been":[39],"developed":[40],"yet.":[41],"Since":[42],"these":[43],"involved":[46],"key":[48],"regulatory":[49],"promising":[53],"targets":[54],"anti-bacterial":[56],"drug":[57,220],"design,":[58],"it":[59,210],"is":[60,166,200],"desirable":[61],"to":[62,70,102,124,152,168,230],"develop":[63],"simple":[65],"easily":[67],"interpretable":[68],"predictor":[69,199],"gain":[71],"new":[72],"insights":[73],"into":[74],"bacterial":[75,127],"tyrosine":[76],"phosphorylation.":[77],"This":[78],"study":[79],"proposes":[80],"novel":[82,219],"SCMBYK":[83,105,198],"method":[84,121,203],"characterizing":[88],"BY-kinases.":[89,208],"RESULTS:":[90],"A":[91],"dataset":[92],"consisting":[93],"797":[95],"783":[98],"non-BY-kinases":[99],"was":[100,122],"established":[101],"design":[103],"the":[104,119,158,243],"predictor,":[106],"achieved":[108],"training":[109],"test":[111,136],"accuracies":[112],"97.55":[114],"96.73%,":[116],"respectively.":[117],"Furthermore,":[118,209],"leave-one-phylum-out":[120],"used":[123,213],"predict":[125],"specific":[126],"phyla":[128],"hosts":[129],"target":[131],"sequences,":[132],"gaining":[133],"97.39%":[134],"average":[135],"accuracy.":[137],"After":[138],"analyzing":[139],"SCMBYK-derived":[140],"propensity":[141],"scores,":[142],"four":[143],"characteristics":[144],"were":[147],"determined:":[148],"1)":[149],"tend":[151],"be":[153,169,212,250],"composed":[154],"\u03b1-helices;":[156],"2)":[157],"amino-acid":[159],"content":[160],"extracellular":[162],"regions":[163],"expected":[167],"dominated":[170],"by":[171],"residues":[172],"such":[173],"Val,":[175],"Ile,":[176],"Phe":[177],"Tyr;":[179],"3)":[180],"structurally":[182],"resemble":[183],"nuclear":[184],"proteins;":[185],"4)":[186],"different":[187,190],"domains":[188],"roles":[191],"triggering":[193],"BY-kinase":[194],"activity.":[195],"CONCLUSIONS:":[196],"The":[197],"effective":[202],"identification":[205],"possible":[207],"can":[211],"part":[216],"repurposing":[221],"method,":[222],"recognizes":[224],"putative":[225],"matches":[228],"them":[229],"approved":[231],"drugs.":[232],"Among":[233],"other":[234],"results,":[235],"our":[236],"analysis":[237],"revealed":[238],"that":[239],"azathioprine":[240],"could":[241],"suppress":[242],"virulence":[244],"M.":[246],"tuberculosis,":[247],"thus":[249],"considered":[251],"potential":[254],"antibiotic":[255],"tuberculosis":[257],"treatment.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}
