{"id":"https://openalex.org/W2566050472","doi":"https://doi.org/10.1186/s12859-016-1339-4","title":"Homology modeling and molecular dynamics provide structural insights into tospovirus nucleoprotein","display_name":"Homology modeling and molecular dynamics provide structural insights into tospovirus nucleoprotein","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2566050472","doi":"https://doi.org/10.1186/s12859-016-1339-4","mag":"2566050472","pmid":"https://pubmed.ncbi.nlm.nih.gov/28105914"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-1339-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1339-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1339-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1339-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090998925","display_name":"Rayane Nunes Lima","orcid":"https://orcid.org/0000-0003-2669-885X"},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rayane Nunes Lima","raw_affiliation_strings":["Laborat\u00f3rio de Virologia Vegetal, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Virologia Vegetal, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100784090","display_name":"Muhammad Faheem","orcid":"https://orcid.org/0000-0002-3635-1246"},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]},{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Muhammad Faheem","raw_affiliation_strings":["Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, DF, Brazil","Laborat\u00f3rio de Biof\u00edsica, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I24871856"]},{"raw_affiliation_string":"Laborat\u00f3rio de Biof\u00edsica, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052734051","display_name":"J.A.R.G. Barbosa","orcid":"https://orcid.org/0000-0002-0534-481X"},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]},{"id":"https://openalex.org/I24871856","display_name":"Universidade Cat\u00f3lica de Bras\u00edlia","ror":"https://ror.org/0058wy590","country_code":"BR","type":"education","lineage":["https://openalex.org/I24871856"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Alexandre Ribeiro Gon\u00e7alves Barbosa","raw_affiliation_strings":["Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, DF, Brazil","Laborat\u00f3rio de Biof\u00edsica, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ci\u00eancias Gen\u00f4micas e Biotecnologia, Universidade Cat\u00f3lica de Bras\u00edlia, Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I24871856"]},{"raw_affiliation_string":"Laborat\u00f3rio de Biof\u00edsica, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017891381","display_name":"Marcelo D. Pol\u00eato","orcid":"https://orcid.org/0000-0001-9210-690X"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Dep\u00f3lo Pol\u00eato","raw_affiliation_strings":["Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086599258","display_name":"Hugo Verli","orcid":"https://orcid.org/0000-0002-4796-8620"},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Hugo Verli","raw_affiliation_strings":["Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028711141","display_name":"Fernando L. Melo","orcid":"https://orcid.org/0000-0002-9591-0239"},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Lucas Melo","raw_affiliation_strings":["Laborat\u00f3rio de Virologia Vegetal, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Virologia Vegetal, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051286713","display_name":"Renato O. Resende","orcid":"https://orcid.org/0000-0003-3852-1576"},"institutions":[{"id":"https://openalex.org/I150729083","display_name":"Universidade de Bras\u00edlia","ror":"https://ror.org/02xfp8v59","country_code":"BR","type":"education","lineage":["https://openalex.org/I150729083"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Renato Oliveira Resende","raw_affiliation_strings":["Laborat\u00f3rio de Virologia Vegetal, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil. rresende@unb.br","Laborat\u00f3rio de Virologia Vegetal, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Virologia Vegetal, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil. rresende@unb.br","institution_ids":["https://openalex.org/I150729083"]},{"raw_affiliation_string":"Laborat\u00f3rio de Virologia Vegetal, Departamento de Biologia Celular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade de Bras\u00edlia, Bras\u00edlia, DF, Brazil","institution_ids":["https://openalex.org/I150729083"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051286713"],"corresponding_institution_ids":["https://openalex.org/I150729083"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.9228,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.90099547,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"17","issue":"S18","first_page":"489","last_page":"489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10494","display_name":"Plant Virus Research Studies","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10494","display_name":"Plant Virus Research Studies","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.21379999816417694,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orthobunyavirus","display_name":"Orthobunyavirus","score":0.8186187148094177},{"id":"https://openalex.org/keywords/tospovirus","display_name":"Tospovirus","score":0.7952522039413452},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7809499502182007},{"id":"https://openalex.org/keywords/bunyaviridae","display_name":"Bunyaviridae","score":0.7450700998306274},{"id":"https://openalex.org/keywords/nucleoprotein","display_name":"Nucleoprotein","score":0.7065298557281494},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.5169622302055359},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4879278838634491},{"id":"https://openalex.org/keywords/druggability","display_name":"Druggability","score":0.4441889524459839},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.42994213104248047},{"id":"https://openalex.org/keywords/plant-virus","display_name":"Plant virus","score":0.41308358311653137},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.28934603929519653},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10714879631996155}],"concepts":[{"id":"https://openalex.org/C2778706330","wikidata":"https://www.wikidata.org/wiki/Q2580182","display_name":"Orthobunyavirus","level":3,"score":0.8186187148094177},{"id":"https://openalex.org/C2779553184","wikidata":"https://www.wikidata.org/wiki/Q2716408","display_name":"Tospovirus","level":5,"score":0.7952522039413452},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7809499502182007},{"id":"https://openalex.org/C2779271554","wikidata":"https://www.wikidata.org/wiki/Q29000551","display_name":"Bunyaviridae","level":3,"score":0.7450700998306274},{"id":"https://openalex.org/C60325843","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Nucleoprotein","level":3,"score":0.7065298557281494},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5169622302055359},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4879278838634491},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.4441889524459839},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42994213104248047},{"id":"https://openalex.org/C109110057","wikidata":"https://www.wikidata.org/wiki/Q1495434","display_name":"Plant virus","level":3,"score":0.41308358311653137},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.28934603929519653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10714879631996155},{"id":"https://openalex.org/C2910476756","wikidata":"https://www.wikidata.org/wiki/Q1706774","display_name":"Tomato spotted wilt virus","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017865","descriptor_name":"Tospovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017865","descriptor_name":"Tospovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017865","descriptor_name":"Tospovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017865","descriptor_name":"Tospovirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017865","descriptor_name":"Tospovirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017865","descriptor_name":"Tospovirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12859-016-1339-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1339-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1339-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28105914","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28105914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5249003","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5249003","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-1339-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1339-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1339-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.5299999713897705}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323350","display_name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","ror":"https://ror.org/04djvx395"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2566050472.pdf","grobid_xml":"https://content.openalex.org/works/W2566050472.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W88999550","https://openalex.org/W255996521","https://openalex.org/W1031578623","https://openalex.org/W1483247593","https://openalex.org/W1966384699","https://openalex.org/W1978085341","https://openalex.org/W1978092700","https://openalex.org/W1979503818","https://openalex.org/W1981627789","https://openalex.org/W1988298217","https://openalex.org/W1990833931","https://openalex.org/W1994273846","https://openalex.org/W2002447403","https://openalex.org/W2004008940","https://openalex.org/W2012399976","https://openalex.org/W2013754612","https://openalex.org/W2014004435","https://openalex.org/W2016100061","https://openalex.org/W2016187752","https://openalex.org/W2020775656","https://openalex.org/W2029367671","https://openalex.org/W2035503835","https://openalex.org/W2035687084","https://openalex.org/W2040155197","https://openalex.org/W2044002382","https://openalex.org/W2065283382","https://openalex.org/W2068475096","https://openalex.org/W2069154986","https://openalex.org/W2085178658","https://openalex.org/W2102109596","https://openalex.org/W2102993309","https://openalex.org/W2106431378","https://openalex.org/W2108627006","https://openalex.org/W2112491247","https://openalex.org/W2116375742","https://openalex.org/W2120034417","https://openalex.org/W2123432782","https://openalex.org/W2124026197","https://openalex.org/W2128572087","https://openalex.org/W2134855545","https://openalex.org/W2142189905","https://openalex.org/W2144362290","https://openalex.org/W2146387859","https://openalex.org/W2149525061","https://openalex.org/W2153097182","https://openalex.org/W2154714625","https://openalex.org/W2161605421","https://openalex.org/W2162962921","https://openalex.org/W2168092433"],"related_works":["https://openalex.org/W2752071758","https://openalex.org/W2114918273","https://openalex.org/W2566050472","https://openalex.org/W1986526676","https://openalex.org/W2090114456","https://openalex.org/W2479718659","https://openalex.org/W2591349738","https://openalex.org/W1978648029","https://openalex.org/W1990527376","https://openalex.org/W2793213746"],"abstract_inverted_index":{"BACKGROUND:":[0],"Tospovirus":[1,28],"is":[2,119,142,186],"a":[3,120,124,131,135],"plant-infecting":[4],"genus":[5],"within":[6],"the":[7,25,62,70,74,89,103,108,149,178,190,223,230,238],"family":[8],"Bunyaviridae,":[9],"which":[10,140],"also":[11],"includes":[12],"four":[13],"animal-infecting":[14],"genera:":[15],"Hantavirus,":[16],"Nairovirus,":[17],"Phlebovirus":[18],"and":[19,49,59,73,97,105,127,130,158,210,214,235],"Orthobunyavirus.":[20],"Compared":[21],"to":[22,39,101,165],"these":[23,83,169],"members,":[24],"structures":[26],"of":[27,76,92,107,217,232,240],"proteins":[29],"still":[30],"are":[31,171],"poorly":[32],"understood.":[33],"Despite":[34],"multiple":[35],"studies":[36,194,216],"have":[37],"attempted":[38],"identify":[40],"candidate":[41,150],"N":[42,185,219],"protein":[43,50],"regions":[44],"involved":[45,154,167],"in":[46,139,155,168],"RNA":[47,141,156],"binding":[48],"multimerization":[51],"for":[52,183,248],"tospovirus":[53,63,111,218,249],"using":[54],"yeast":[55],"two-hybrid":[56],"systems":[57],"(Y2HS)":[58],"site-directed":[60],"mutagenesis,":[61],"ribonucleocapsids":[64],"(RNPs)":[65],"remains":[66],"largely":[67],"uncharacterized":[68],"at":[69],"molecular":[71,98],"level":[72],"lack":[75],"structural":[77],"information":[78],"prevents":[79],"detailed":[80],"insight":[81],"into":[82],"interactions.":[84],"RESULTS:":[85],"Here":[86],"we":[87],"used":[88],"nucleoprotein":[90,109],"structure":[91,104],"LACV":[93],"(La":[94],"Crosse":[95],"virus-Orthobunyavirus)":[96],"dynamics":[99,106],"simulations":[100],"access":[102],"from":[110],"GRSV":[112,184],"(Groundnut":[113],"ringspot":[114],"virus).":[115],"The":[116],"resulting":[117],"model":[118,146,180,225],"monomer":[121],"composed":[122],"by":[123,189],"flexible":[125],"N-terminal":[126],"C-terminal":[128],"arms":[129],"globular":[132],"domain":[133],"with":[134],"positively":[136],"charged":[137],"groove":[138],"deeply":[143],"encompassed.":[144],"This":[145],"allowed":[147],"identifying":[148],"amino":[151,242],"acids":[152],"residues":[153,163,244],"interaction":[157,179],"N-N":[159],"multimerization.":[160],"Moreover,":[161],"most":[162],"predicted":[164],"be":[166],"interactions":[170],"highly":[172],"conserved":[173],"among":[174],"tospoviruses.":[175],"CONCLUSIONS:":[176],"Crucially,":[177],"proposed":[181,224],"here":[182],"further":[187,209],"corroborated":[188],"all":[191],"available":[192],"mutational":[193,213],"on":[195,229],"TSWV":[196],"(Tomato":[197],"spotted":[198],"wilt":[199],"virus)":[200],"N,":[201],"so":[202],"far.":[203],"Our":[204],"data":[205],"will":[206],"help":[207],"designing":[208],"more":[211],"accurate":[212],"functional":[215],"proteins.":[220],"In":[221],"addition,":[222],"may":[226],"shed":[227],"light":[228],"mechanisms":[231],"RNP":[233],"shaping":[234],"could":[236],"allow":[237],"identification":[239],"essential":[241],"acid":[243],"as":[245],"potential":[246],"targets":[247],"control":[250],"strategies.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}