{"id":"https://openalex.org/W2565904822","doi":"https://doi.org/10.1186/s12859-016-1310-4","title":"DegreeCox \u2013 a network-based regularization method for survival analysis","display_name":"DegreeCox \u2013 a network-based regularization method for survival analysis","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2565904822","doi":"https://doi.org/10.1186/s12859-016-1310-4","mag":"2565904822","pmid":"https://pubmed.ncbi.nlm.nih.gov/28105908"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-1310-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1310-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1310-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1310-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053180327","display_name":"Andr\u00e9 Ver\u00edssimo","orcid":"https://orcid.org/0000-0002-2212-339X"},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I203847022","display_name":"Instituto Polit\u00e9cnico de Lisboa","ror":"https://ror.org/04ea70f07","country_code":"PT","type":"education","lineage":["https://openalex.org/I203847022"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Andr\u00e9 Ver\u00edssimo","raw_affiliation_strings":["IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisboa, 1049-001, Portugal","Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, 1049-001, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisboa, 1049-001, Portugal","institution_ids":["https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, 1049-001, Portugal","institution_ids":["https://openalex.org/I203847022","https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001327675","display_name":"Arlindo L. Oliveira","orcid":"https://orcid.org/0000-0001-8638-5594"},"institutions":[{"id":"https://openalex.org/I121345201","display_name":"Instituto de Engenharia de Sistemas e Computadores Investiga\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/04mqy3p58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I121345201","https://openalex.org/I4210125590"]},{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I203847022","display_name":"Instituto Polit\u00e9cnico de Lisboa","ror":"https://ror.org/04ea70f07","country_code":"PT","type":"education","lineage":["https://openalex.org/I203847022"]},{"id":"https://openalex.org/I4210125590","display_name":"Institute for Systems Engineering and Computers","ror":"https://ror.org/033wn8m60","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210125590"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Arlindo Limede Oliveira","raw_affiliation_strings":["Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, 1049-001, Portugal","Instituto de Engenharia de Sistemas e Computadores: Investiga\u00e7\u00e3o e Desenvolvimento (INESC-ID), Lisbon, 1000-029, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisbon, 1049-001, Portugal","institution_ids":["https://openalex.org/I203847022","https://openalex.org/I141596103"]},{"raw_affiliation_string":"Instituto de Engenharia de Sistemas e Computadores: Investiga\u00e7\u00e3o e Desenvolvimento (INESC-ID), Lisbon, 1000-029, Portugal","institution_ids":["https://openalex.org/I4210125590","https://openalex.org/I121345201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044540605","display_name":"Marie\u2010France Sagot","orcid":null},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en informatique et en automatique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-France Sagot","raw_affiliation_strings":["ERABLE, Inria, Villeurbanne, France","Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, Universit\u00e9 de Lyon, CNRS UMR 5558, F-69622, Villeurbanne, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ERABLE, Inria, Villeurbanne, France","institution_ids":["https://openalex.org/I1326498283"]},{"raw_affiliation_string":"Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, Universit\u00e9 de Lyon, CNRS UMR 5558, F-69622, Villeurbanne, France","institution_ids":["https://openalex.org/I4210135640","https://openalex.org/I100532134","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005271169","display_name":"Susana Vinga","orcid":"https://orcid.org/0000-0002-1954-5487"},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana Vinga","raw_affiliation_strings":["IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisboa, 1049-001, Portugal. susanavinga@tecnico.ulisboa.pt","IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisboa, 1049-001, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisboa, 1049-001, Portugal. susanavinga@tecnico.ulisboa.pt","institution_ids":[]},{"raw_affiliation_string":"IDMEC, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Lisboa, 1049-001, Portugal","institution_ids":["https://openalex.org/I141596103"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5053180327"],"corresponding_institution_ids":["https://openalex.org/I141596103","https://openalex.org/I203847022"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":2.0889,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.8761516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"17","issue":"S16","first_page":"449","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8950999975204468,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8950999975204468,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6501742601394653},{"id":"https://openalex.org/keywords/betweenness-centrality","display_name":"Betweenness centrality","score":0.6256760358810425},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6149744987487793},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.6134527921676636},{"id":"https://openalex.org/keywords/regularization","display_name":"Regularization (linguistics)","score":0.4763236939907074},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.4714661240577698},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.4385473132133484},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3997196555137634},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3899790942668915},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.21541845798492432},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1971263587474823}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6501742601394653},{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.6256760358810425},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6149744987487793},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.6134527921676636},{"id":"https://openalex.org/C2776135515","wikidata":"https://www.wikidata.org/wiki/Q17143721","display_name":"Regularization (linguistics)","level":2,"score":0.4763236939907074},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.4714661240577698},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.4385473132133484},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3997196555137634},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3899790942668915},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.21541845798492432},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1971263587474823}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-016-1310-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1310-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1310-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:28105908","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28105908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:HAL:hal-01415968v1","is_oa":true,"landing_page_url":"https://inria.hal.science/hal-01415968","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 2016, 17 (Suppl 16), pp.109-121. ⟨10.1186/s12859-016-1310-4⟩","raw_type":"Journal articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:5249012","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5249012","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-1310-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1310-4","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1310-4","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.49000000953674316,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1355505928","display_name":null,"funder_award_id":"IF/00653/2012","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G290693955","display_name":null,"funder_award_id":"PTDC/EMS-SIS/0642/2014","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5723335707","display_name":"Statistical multi-Omics UNDerstanding of Patient Samples","funder_award_id":"633974","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5892973716","display_name":null,"funder_award_id":"IF/00653/2012","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7226342881","display_name":null,"funder_award_id":"UID/EMS/ 50022/2013","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G7842005466","display_name":null,"funder_award_id":"Horizon 2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8354620924","display_name":null,"funder_award_id":"SFRH/BD/97415/2013","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2565904822.pdf","grobid_xml":"https://content.openalex.org/works/W2565904822.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W282373936","https://openalex.org/W1497745584","https://openalex.org/W1570622790","https://openalex.org/W1580788756","https://openalex.org/W1977402675","https://openalex.org/W1979300931","https://openalex.org/W1981178452","https://openalex.org/W1983345514","https://openalex.org/W2025183726","https://openalex.org/W2025844353","https://openalex.org/W2047028564","https://openalex.org/W2056944867","https://openalex.org/W2060705109","https://openalex.org/W2074703669","https://openalex.org/W2079849392","https://openalex.org/W2082302018","https://openalex.org/W2095956310","https://openalex.org/W2104765303","https://openalex.org/W2112840798","https://openalex.org/W2120010395","https://openalex.org/W2122825543","https://openalex.org/W2123696077","https://openalex.org/W2131593373","https://openalex.org/W2132549764","https://openalex.org/W2135046866","https://openalex.org/W2138265962","https://openalex.org/W2139984188","https://openalex.org/W2140514146","https://openalex.org/W2148002238","https://openalex.org/W2149055390","https://openalex.org/W2152032358","https://openalex.org/W2155307989","https://openalex.org/W2157076315","https://openalex.org/W2160571019","https://openalex.org/W2164786997","https://openalex.org/W2401080882","https://openalex.org/W3147894994","https://openalex.org/W4234173777","https://openalex.org/W4249450547","https://openalex.org/W4293241248","https://openalex.org/W4299551643"],"related_works":["https://openalex.org/W1973509935","https://openalex.org/W4389076551","https://openalex.org/W2107855069","https://openalex.org/W2611574733","https://openalex.org/W2241641394","https://openalex.org/W2514739320","https://openalex.org/W2097992793","https://openalex.org/W2140653560","https://openalex.org/W2348831795","https://openalex.org/W4312461432"],"abstract_inverted_index":{"BACKGROUND:":[0],"Modeling":[1],"survival":[2],"oncological":[3],"data":[4],"has":[5],"become":[6],"a":[7,98,164,198,237,246],"major":[8],"challenge":[9],"as":[10,156],"the":[11,14,23,29,43,49,82,85,111,116,132,189,232,252],"increase":[12],"in":[13,48,134,188,197,236],"amount":[15],"of":[16,25,31,45,136,146,191,204,219,231,268],"molecular":[17],"information":[18,167,206],"nowadays":[19],"available":[20],"means":[21],"that":[22,100,212,226],"number":[24,30],"features":[26,112],"greatly":[27],"exceeds":[28],"observations.":[32],"One":[33],"possible":[34],"solution":[35],"to":[36,70,104,125,130,143,229,249,263],"cope":[37],"with":[38,64,180,200,210,251],"this":[39,68],"dimensionality":[40,253],"problem":[41],"is":[42,118,207],"use":[44,126,203],"additional":[46],"constraints":[47],"cost":[50],"function":[51],"optimization.":[52],"LASSO":[53],"and":[54,115,150,160,174,182,193,221],"other":[55,265],"sparsity":[56],"methods":[57,75],"have":[58],"thus":[59],"already":[60],"been":[61],"successfully":[62],"applied":[63,141],"such":[65,155],"idea.":[66],"Although":[67],"leads":[69],"more":[71],"interpretable":[72],"models,":[73,109],"these":[74,89],"still":[76],"do":[77],"not":[78,214],"fully":[79],"profit":[80],"from":[81,170],"relations":[83],"between":[84],"features,":[86],"specially":[87],"when":[88,110],"can":[90,259],"be":[91,260],"represented":[92],"through":[93],"graphs.":[94],"We":[95,140],"propose":[96,124],"DEGREECOX,":[97],"method":[99],"applies":[101],"network-based":[102],"regularizers":[103],"infer":[105],"Cox":[106],"proportional":[107],"hazard":[108],"are":[113,213,227],"genes":[114],"outcome":[117],"patient":[119],"survival.":[120],"In":[121,217],"particular,":[122],"we":[123],"network":[127,166,205],"centrality":[128,153,256],"measures":[129,154],"constrain":[131],"model":[133],"terms":[135,218],"significant":[137],"genes.":[138],"RESULTS:":[139],"DEGREECOX":[142,184,223],"three":[144],"datasets":[145,211],"ovarian":[147],"cancer":[148],"carcinoma":[149],"tested":[151],"several":[152],"weighted":[157],"degree,":[158],"betweenness":[159],"closeness":[161],"centrality.":[162],"The":[163,202,255],"priori":[165],"was":[168],"retrieved":[169],"Gene":[171,175],"Co-Expression":[172],"Networks":[173],"Functional":[176],"Maps.":[177],"When":[178],"compared":[179],"RIDGE":[181],"LASSO,":[183],"shows":[185],"an":[186],"improvement":[187],"classification":[190],"high":[192],"low":[194],"risk":[195],"patients":[196],"par":[199],"NET-COX.":[201],"especially":[208],"relevant":[209],"easily":[215,261],"separated.":[216],"RMSE":[220],"C-index,":[222],"gives":[224],"results":[225],"similar":[228],"those":[230],"best":[233],"performing":[234],"methods,":[235],"few":[238],"cases":[239],"slightly":[240],"better.":[241],"CONCLUSIONS:":[242],"Network-based":[243],"regularization":[244],"seems":[245],"promising":[247],"framework":[248],"deal":[250],"problem.":[254],"metrics":[257],"proposed":[258],"expanded":[262],"accommodate":[264],"topological":[266],"properties":[267],"different":[269],"biological":[270],"networks.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}