{"id":"https://openalex.org/W2460857593","doi":"https://doi.org/10.1186/s12859-016-1235-y","title":"BTR: training asynchronous Boolean models using single-cell expression data","display_name":"BTR: training asynchronous Boolean models using single-cell expression data","publication_year":2016,"publication_date":"2016-09-06","ids":{"openalex":"https://openalex.org/W2460857593","doi":"https://doi.org/10.1186/s12859-016-1235-y","mag":"2460857593","pmid":"https://pubmed.ncbi.nlm.nih.gov/27600248"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-1235-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1235-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1235-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1235-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006928989","display_name":"Chee Lim","orcid":null},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chee Yee Lim","raw_affiliation_strings":["Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK","Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002212068","display_name":"Huange Wang","orcid":"https://orcid.org/0000-0002-9216-2749"},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Huange Wang","raw_affiliation_strings":["Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK","Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056852977","display_name":"Steven Woodhouse","orcid":"https://orcid.org/0000-0002-8605-2762"},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven Woodhouse","raw_affiliation_strings":["Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK","Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045161607","display_name":"Nir Piterman","orcid":"https://orcid.org/0000-0002-8242-5357"},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nir Piterman","raw_affiliation_strings":["Department of Computer Science, University of Leicester, Leicester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Leicester, Leicester, UK","institution_ids":["https://openalex.org/I153648349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064848972","display_name":"Lorenz Wernisch","orcid":"https://orcid.org/0000-0003-3113-7942"},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lorenz Wernisch","raw_affiliation_strings":["Biostatistics Unit, Medical Research Council, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Unit, Medical Research Council, Cambridge, UK","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066189305","display_name":"Jasmin Fisher","orcid":"https://orcid.org/0000-0003-4477-9047"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210164937","display_name":"Microsoft Research (United Kingdom)","ror":"https://ror.org/05k87vq12","country_code":"GB","type":"company","lineage":["https://openalex.org/I1290206253","https://openalex.org/I4210164937"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jasmin Fisher","raw_affiliation_strings":["Department of Biochemistry, University of Cambridge, Cambridge, UK","Microsoft Research Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Microsoft Research Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210164937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017318024","display_name":"Berthold G\u00f6ttgens","orcid":"https://orcid.org/0000-0001-6302-5705"},"institutions":[{"id":"https://openalex.org/I21196054","display_name":"Wellcome/MRC Cambridge Stem Cell Institute","ror":"https://ror.org/05nz0zp31","country_code":"GB","type":"facility","lineage":["https://openalex.org/I21196054","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I87048295","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Berthold G\u00f6ttgens","raw_affiliation_strings":["Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK. bg200@cam.ac.uk","Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK. bg200@cam.ac.uk","institution_ids":["https://openalex.org/I21196054"]},{"raw_affiliation_string":"Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5017318024"],"corresponding_institution_ids":["https://openalex.org/I21196054","https://openalex.org/I241749"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":843,"currency":"EUR","value_usd":909},"fwci":4.0045,"has_fulltext":true,"cited_by_count":90,"citation_normalized_percentile":{"value":0.94174796,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"355","last_page":"355"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.07530000060796738,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6526325941085815},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6257362961769104},{"id":"https://openalex.org/keywords/asynchronous-communication","display_name":"Asynchronous communication","score":0.5909746885299683},{"id":"https://openalex.org/keywords/boolean-expression","display_name":"Boolean expression","score":0.5773406028747559},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.4831123352050781},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4783979654312134},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.35532891750335693},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.26129963994026184},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2606470286846161},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.21512362360954285},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16651570796966553},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.1398814618587494},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13125309348106384},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.1310611069202423},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.10182580351829529}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6526325941085815},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6257362961769104},{"id":"https://openalex.org/C151319957","wikidata":"https://www.wikidata.org/wiki/Q752739","display_name":"Asynchronous communication","level":2,"score":0.5909746885299683},{"id":"https://openalex.org/C158465420","wikidata":"https://www.wikidata.org/wiki/Q1979515","display_name":"Boolean expression","level":3,"score":0.5773406028747559},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.4831123352050781},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4783979654312134},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35532891750335693},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26129963994026184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2606470286846161},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.21512362360954285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16651570796966553},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.1398814618587494},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13125309348106384},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.1310611069202423},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.10182580351829529}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1186/s12859-016-1235-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1235-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1235-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5012073","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5012073","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmid:27600248","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27600248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:figshare.com:article/10121387","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/BTR_training_asynchronous_Boolean_models_using_single-cell_expression_data_/10121387","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:lra.le.ac.uk:2381/38718","is_oa":true,"landing_page_url":"http://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-016-1235-y","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/31926","is_oa":true,"landing_page_url":"http://qmro.qmul.ac.uk/xmlui/handle/123456789/31926","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/260949","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/260949","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.6035","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.6035","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-1235-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1235-y","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1235-y","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.6700000166893005}],"awards":[{"id":"https://openalex.org/G2074623370","display_name":null,"funder_award_id":"MR/M008975/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2084223052","display_name":null,"funder_award_id":"2012-023","funder_id":"https://openalex.org/F4320308943","funder_display_name":"Microsoft Research"},{"id":"https://openalex.org/G2537149883","display_name":null,"funder_award_id":"MC_PC_12009","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3189174212","display_name":null,"funder_award_id":"BB/I00050X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3577816368","display_name":null,"funder_award_id":"12029","funder_id":"https://openalex.org/F4320324760","funder_display_name":"Bloodwise"},{"id":"https://openalex.org/G5041423612","display_name":null,"funder_award_id":"100140/Z/12/Z; 097922/Z/11/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6395817484","display_name":"Establishment of the haemopoietic transcriptional programme: From systems approaches to molecular mechanisms","funder_award_id":"BB/I00050X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6541211795","display_name":"Wellcome Trust PhD Programme in Mathematical Genomics and Medicine.","funder_award_id":"102273/Z/13/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6609318545","display_name":null,"funder_award_id":"RP-PG-0310-1002","funder_id":"https://openalex.org/F4320334635","funder_display_name":"Cambridge Institute for Medical Research, University of Cambridge"},{"id":"https://openalex.org/G724990545","display_name":null,"funder_award_id":"12765","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G7368943397","display_name":"Cellular Medicine at the Cambridge Institute for Medical Research.","funder_award_id":"100140/Z/12/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7802786893","display_name":"Cambridge Stem Cell Institute.","funder_award_id":"097922/Z/11/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G7924050367","display_name":null,"funder_award_id":"12029","funder_id":"https://openalex.org/F4320329013","funder_display_name":"Blood Cancer UK"}],"funders":[{"id":"https://openalex.org/F4320308943","display_name":"Microsoft Research","ror":"https://ror.org/00d0nc645"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320324760","display_name":"Bloodwise","ror":"https://ror.org/0055acf80"},{"id":"https://openalex.org/F4320329013","display_name":"Blood Cancer UK","ror":null},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334635","display_name":"Cambridge Institute for Medical Research, University of Cambridge","ror":null},{"id":"https://openalex.org/F4320336709","display_name":"NIHR Cambridge Biomedical Research Centre","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2460857593.pdf","grobid_xml":"https://content.openalex.org/works/W2460857593.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W172260869","https://openalex.org/W1563425389","https://openalex.org/W1587026990","https://openalex.org/W1600339875","https://openalex.org/W1963895735","https://openalex.org/W1967327758","https://openalex.org/W1986397618","https://openalex.org/W1994892791","https://openalex.org/W2003571703","https://openalex.org/W2007439698","https://openalex.org/W2007771322","https://openalex.org/W2010653277","https://openalex.org/W2031285837","https://openalex.org/W2033072655","https://openalex.org/W2035824523","https://openalex.org/W2036363967","https://openalex.org/W2039053938","https://openalex.org/W2039542842","https://openalex.org/W2044525257","https://openalex.org/W2050559302","https://openalex.org/W2053961182","https://openalex.org/W2058221907","https://openalex.org/W2063957967","https://openalex.org/W2073586815","https://openalex.org/W2076513103","https://openalex.org/W2103454055","https://openalex.org/W2107680358","https://openalex.org/W2109384743","https://openalex.org/W2114402708","https://openalex.org/W2121146753","https://openalex.org/W2122902176","https://openalex.org/W2128088446","https://openalex.org/W2129905934","https://openalex.org/W2131025189","https://openalex.org/W2132935366","https://openalex.org/W2136453810","https://openalex.org/W2139997707","https://openalex.org/W2146009166","https://openalex.org/W2147615881","https://openalex.org/W2149573463","https://openalex.org/W2152641162","https://openalex.org/W2157523980","https://openalex.org/W2159675211","https://openalex.org/W2162544653","https://openalex.org/W2162652393","https://openalex.org/W2163296115","https://openalex.org/W2552577366","https://openalex.org/W2595840341","https://openalex.org/W2787027754","https://openalex.org/W3099289621","https://openalex.org/W4230096730","https://openalex.org/W4285719527","https://openalex.org/W4399649500"],"related_works":["https://openalex.org/W2116677773","https://openalex.org/W2155261584","https://openalex.org/W2584231425","https://openalex.org/W2150611273","https://openalex.org/W4207086172","https://openalex.org/W2042919702","https://openalex.org/W4225981436","https://openalex.org/W2156185805","https://openalex.org/W2770353918","https://openalex.org/W2122502560"],"abstract_inverted_index":{"BACKGROUND:":[0],"Rapid":[1],"technological":[2],"innovation":[3],"for":[4,16,113,167,235,268],"the":[5,24,42,45,61,87,101,145,156,163,247,260,281,287,297],"generation":[6],"of":[7,26,36,44,48,50,63,81,133,249,283,290,306],"single-cell":[8,37,93,119,186,227,239,291],"genomics":[9,292],"data":[10,95,121,240],"presents":[11],"new":[12,27,140,211],"challenges":[13],"and":[14,138,150,185,286],"opportunities":[15],"bioinformatics":[17],"analysis.":[18],"One":[19],"such":[20,66],"area":[21],"lies":[22],"in":[23,92,182,196,206,259],"development":[25],"ways":[28],"to":[29,60,73,85,201,208,220,246,299],"train":[30],"gene":[31,76,271],"regulatory":[32,77,272],"networks.":[33,169],"The":[34],"use":[35,199],"expression":[38,46,54,89,94,120,151,188,228,261],"profiling":[39,43],"technique":[40],"allows":[41],"states":[47,55,90,262],"hundreds":[49],"cells,":[51,264],"but":[52],"these":[53],"are":[56,83],"typically":[57],"noisier":[58],"due":[59],"presence":[62],"technical":[64,103],"artefacts":[65],"as":[67,275,278],"drop-outs.":[68,250],"While":[69],"many":[70,177,304],"algorithms":[71,181],"exist":[72],"infer":[74],"a":[75,123,217,270],"network,":[78],"very":[79],"few":[80,276],"them":[82],"able":[84],"harness":[86],"extra":[88],"present":[91],"without":[96],"getting":[97],"adversely":[98],"affected":[99],"by":[100,143,293],"substantial":[102],"noise":[104],"present.":[105],"RESULTS:":[106],"Here":[107],"we":[108,172,191,198],"introduce":[109,192],"BTR,":[110],"an":[111,301],"algorithm":[112],"training":[114],"asynchronous":[115],"Boolean":[116,125,136,141,157,204,224,230,284],"models":[117,137,142,205,225,285],"with":[118,274],"using":[122,226,238],"novel":[124,218],"state":[126],"space":[127],"scoring":[128,158,165],"function.":[129],"BTR":[130,175,200,215,253,295],"is":[131,232,243,266],"capable":[132],"refining":[134],"existing":[135],"reconstructing":[139,269],"improving":[144],"match":[146],"between":[147],"model":[148,231],"prediction":[149],"data.":[152,189,229],"We":[153],"demonstrate":[154],"that":[155,174],"function":[159,166],"performed":[160],"favourably":[161],"against":[162],"BIC":[164],"Bayesian":[168],"In":[170,251],"addition,":[171,252],"show":[173],"outperforms":[176],"other":[178],"network":[179,236,273],"inference":[180],"both":[183],"bulk":[184],"synthetic":[187],"Lastly,":[190],"two":[193],"case":[194],"studies,":[195],"which":[197],"improve":[202],"published":[203],"order":[207],"generate":[209],"potentially":[210],"biological":[212],"insights.":[213],"CONCLUSIONS:":[214],"provides":[216],"way":[219],"refine":[221],"or":[222],"reconstruct":[223],"particularly":[233],"useful":[234,267],"reconstruction":[237],"because":[241],"it":[242,265],"more":[244],"robust":[245],"effect":[248],"does":[254],"not":[255],"assume":[256],"any":[257],"relationship":[258],"among":[263],"assumptions":[277],"possible.":[279],"Given":[280],"simplicity":[282],"rapid":[288],"adoption":[289],"biologists,":[294],"has":[296],"potential":[298],"make":[300],"impact":[302],"across":[303],"fields":[305],"biomedical":[307],"research.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}