{"id":"https://openalex.org/W2511479883","doi":"https://doi.org/10.1186/s12859-016-1210-7","title":"Tilting the lasso by knowledge-based post-processing","display_name":"Tilting the lasso by knowledge-based post-processing","publication_year":2016,"publication_date":"2016-09-02","ids":{"openalex":"https://openalex.org/W2511479883","doi":"https://doi.org/10.1186/s12859-016-1210-7","mag":"2511479883","pmid":"https://pubmed.ncbi.nlm.nih.gov/27590269"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-1210-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1210-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1210-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1210-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015771421","display_name":"Kukatharmini Tharmaratnam","orcid":"https://orcid.org/0000-0002-8255-9822"},"institutions":[{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kukatharmini Tharmaratnam","raw_affiliation_strings":["Department of Mathematics and Statistics, Lancaster University, Lancaster, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Lancaster University, Lancaster, UK","institution_ids":["https://openalex.org/I67415387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009872155","display_name":"Matthew Sperrin","orcid":"https://orcid.org/0000-0002-5351-9960"},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Matthew Sperrin","raw_affiliation_strings":["Institute of Population Health, The University of Manchester, Manchester, UK. matthew.sperrin@manchester.ac.uk","Institute of Population Health, The University of Manchester, Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0002-5351-9960","affiliations":[{"raw_affiliation_string":"Institute of Population Health, The University of Manchester, Manchester, UK. matthew.sperrin@manchester.ac.uk","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Institute of Population Health, The University of Manchester, Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053252382","display_name":"Thomas Jaki","orcid":"https://orcid.org/0000-0002-1096-188X"},"institutions":[{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas Jaki","raw_affiliation_strings":["Department of Mathematics and Statistics, Lancaster University, Lancaster, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, Lancaster University, Lancaster, UK","institution_ids":["https://openalex.org/I67415387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045872291","display_name":"Sjur Reppe","orcid":"https://orcid.org/0000-0002-4330-5379"},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4210141471","display_name":"Lovisenberg Diakonale Sykehus","ror":"https://ror.org/03ym7ve89","country_code":"NO","type":"funder","lineage":["https://openalex.org/I4210141471"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Sjur Reppe","raw_affiliation_strings":["Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway","Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway","Lovisenberg Diakonale Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175"]},{"raw_affiliation_string":"Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Lovisenberg Diakonale Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I4210141471"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025750693","display_name":"Arnoldo Frigessi","orcid":"https://orcid.org/0000-0001-7103-7589"},"institutions":[{"id":"https://openalex.org/I1281400175","display_name":"Oslo University Hospital","ror":"https://ror.org/00j9c2840","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I1281400175"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Arnoldo Frigessi","raw_affiliation_strings":["Oslo Centre for Biostatistics and Epidemiology, University of Oslo and Oslo University Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oslo Centre for Biostatistics and Epidemiology, University of Oslo and Oslo University Hospital, Oslo, Norway","institution_ids":["https://openalex.org/I1281400175","https://openalex.org/I184942183"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5009872155"],"corresponding_institution_ids":["https://openalex.org/I28407311"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1686,"currency":"EUR","value_usd":1818},"fwci":1.4494,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.83997473,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"17","issue":"1","first_page":"344","last_page":"344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.5026000142097473,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.5026000142097473,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.13410000503063202,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.9065216183662415},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.574891984462738},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.5745922327041626},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.5671728253364563},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5029091238975525},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.4432024359703064},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43444210290908813},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3776361644268036},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.25455114245414734},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.23195978999137878},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16101762652397156}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.9065216183662415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.574891984462738},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.5745922327041626},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.5671728253364563},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5029091238975525},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.4432024359703064},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43444210290908813},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3776361644268036},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25455114245414734},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23195978999137878},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16101762652397156},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019359","descriptor_name":"Knowledge","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019359","descriptor_name":"Knowledge","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019359","descriptor_name":"Knowledge","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019359","descriptor_name":"Knowledge","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12859-016-1210-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1210-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1210-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:27590269","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27590269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:eprints.lancs.ac.uk:81524","is_oa":true,"landing_page_url":null,"pdf_url":"https://eprints.lancs.ac.uk/id/eprint/81524/1/BMC_epublish_version.pdf","source":{"id":"https://openalex.org/S4306401916","display_name":"Lancaster EPrints (Lancaster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67415387","host_organization_name":"Lancaster University","host_organization_lineage":["https://openalex.org/I67415387"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:pubmedcentral.nih.gov:5010709","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5010709","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ab42366f-5618-4f15-8d40-9217c471844b","is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/ab42366f-5618-4f15-8d40-9217c471844b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tharmaratnam, K, Sperrin, M, Jaki, T, Reppe, S & Frigessi, A 2016, 'Tilting the Lasso by Knowledge-Based Post-Processing', B M C Bioinformatics. https://doi.org/10.1186/s12859-016-1210-7","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/ab42366f-5618-4f15-8d40-9217c471844b","is_oa":true,"landing_page_url":"https://www.research.manchester.ac.uk/portal/en/publications/tilting-the-lasso-by-knowledgebased-postprocessing(ab42366f-5618-4f15-8d40-9217c471844b).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tharmaratnam, K, Sperrin, M, Jaki, T, Reppe, S & Frigessi, A 2016, 'Tilting the Lasso by Knowledge-Based Post-Processing', B M C Bioinformatics. https://doi.org/10.1186/s12859-016-1210-7","raw_type":"article"},{"id":"pmh:oai:www.duo.uio.no:10852/51965","is_oa":true,"landing_page_url":"http://hdl.handle.net/10852/51965","pdf_url":null,"source":{"id":"https://openalex.org/S4306401716","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-1210-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1210-7","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-1210-7","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3572308733","display_name":"MICA: Health e-Research Centre","funder_award_id":"MR/K006665/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4457955224","display_name":null,"funder_award_id":"MR/K006665/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2511479883.pdf","grobid_xml":"https://content.openalex.org/works/W2511479883.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1578530776","https://openalex.org/W1982652137","https://openalex.org/W1995119847","https://openalex.org/W2020925091","https://openalex.org/W2045756756","https://openalex.org/W2047329948","https://openalex.org/W2084831115","https://openalex.org/W2087448554","https://openalex.org/W2097360283","https://openalex.org/W2122825543","https://openalex.org/W2125354326","https://openalex.org/W2129075946","https://openalex.org/W2135046866","https://openalex.org/W2150940164","https://openalex.org/W2562162676","https://openalex.org/W3101040439","https://openalex.org/W3103643510","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W1986582023","https://openalex.org/W2966829450"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1,18],"is":[2,34,77,117],"useful":[3],"to":[4,24,40,103,127,149],"incorporate":[5],"biological":[6,63,167],"knowledge":[7,168],"on":[8,80],"the":[9,30,48,84,88,111],"role":[10],"of":[11,32,47,53,62,72,87,166],"genetic":[12],"determinants":[13,33,56],"in":[14],"predicting":[15],"an":[16,38,75],"outcome.":[17],"is,":[19],"however,":[20],"not":[21],"always":[22],"feasible":[23,164],"fully":[25],"elicit":[26],"this":[27,42,68,81,100],"information":[28],"when":[29],"number":[31,71],"large.":[35],"We":[36,91,122],"present":[37],"approach":[39,101,126],"overcome":[41],"difficulty.":[43],"First,":[44],"using":[45,83],"half":[46,86],"available":[49],"data,":[50,131],"a":[51],"shortlist":[52,82],"potentially":[54],"interesting":[55],"are":[57,65],"generated.":[58],"Second,":[59],"binary":[60],"indications":[61],"importance":[64],"elicited":[66],"for":[67],"much":[69],"smaller":[70],"determinants.":[73],"Third,":[74],"analysis":[76],"carried":[78],"out":[79],"second":[85],"data.":[89],"RESULTS:":[90],"show":[92],"through":[93],"simulations":[94],"that,":[95],"compared":[96],"with":[97,157,163],"adaptive":[98],"lasso,":[99],"leads":[102,148],"models":[104,135,156],"containing":[105],"more":[106,137],"biologically":[107,138],"relevant":[108,139],"variables,":[109],"while":[110],"prediction":[112],"mean":[113],"squared":[114],"error":[115],"(PMSE)":[116],"comparable":[118,150],"or":[119,151],"even":[120],"reduced.":[121],"also":[123],"apply":[124],"our":[125],"bone":[128],"mineral":[129],"density":[130],"and":[132,141,155,161],"again":[133],"final":[134],"contain":[136],"variables":[140],"have":[142],"reduced":[143],"PMSEs.":[144],"CONCLUSION:":[145],"Our":[146],"method":[147],"improved":[152],"predictive":[153,170],"performance,":[154],"greater":[158],"face":[159],"validity":[160],"interpretability":[162],"incorporation":[165],"into":[169],"models.":[171]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}