{"id":"https://openalex.org/W2346333604","doi":"https://doi.org/10.1186/s12859-016-1053-2","title":"Hierarchical classification strategy for Phenotype extraction from epidermal growth factor receptor endocytosis screening","display_name":"Hierarchical classification strategy for Phenotype extraction from epidermal growth factor receptor endocytosis screening","publication_year":2016,"publication_date":"2016-05-03","ids":{"openalex":"https://openalex.org/W2346333604","doi":"https://doi.org/10.1186/s12859-016-1053-2","mag":"2346333604","pmid":"https://pubmed.ncbi.nlm.nih.gov/27142862"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-1053-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1053-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-016-1053-2.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12859-016-1053-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100393055","display_name":"Lu Cao","orcid":"https://orcid.org/0000-0002-1847-068X"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I4210117844","display_name":"Department of Embryology","ror":"https://ror.org/03bvtqh46","country_code":"US","type":"facility","lineage":["https://openalex.org/I196817621","https://openalex.org/I4210117844"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Lu Cao","raw_affiliation_strings":["Imaging and Bio-informatics group, LIACS, Leiden University, Niels Bohrweg 1, Leiden, 2333, CA, The Netherlands","The Department of Anatomy and Embryology, LUMC, Einthovenweg 20, Leiden, 2333, ZC, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging and Bio-informatics group, LIACS, Leiden University, Niels Bohrweg 1, Leiden, 2333, CA, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"The Department of Anatomy and Embryology, LUMC, Einthovenweg 20, Leiden, 2333, ZC, The Netherlands","institution_ids":["https://openalex.org/I4210117844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040422403","display_name":"Marjo de Graauw","orcid":null},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marjo de Graauw","raw_affiliation_strings":["Division of Toxicology, LACDR, Leiden University, Einsteinweg 55, Leiden, 2333, CC, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Toxicology, LACDR, Leiden University, Einsteinweg 55, Leiden, 2333, CC, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088282459","display_name":"Kuan Yan","orcid":"https://orcid.org/0000-0003-4143-3569"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kuan Yan","raw_affiliation_strings":["Imaging and Bio-informatics group, LIACS, Leiden University, Niels Bohrweg 1, Leiden, 2333, CA, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging and Bio-informatics group, LIACS, Leiden University, Niels Bohrweg 1, Leiden, 2333, CA, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008062776","display_name":"Leah C.J. Winkel","orcid":null},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]},{"id":"https://openalex.org/I913958620","display_name":"Erasmus University Rotterdam","ror":"https://ror.org/057w15z03","country_code":"NL","type":"education","lineage":["https://openalex.org/I913958620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leah Winkel","raw_affiliation_strings":["Biomechanics Laboratory, Erasmus MC, Wytemaweg 80, Rotterdam, 3015, CN, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomechanics Laboratory, Erasmus MC, Wytemaweg 80, Rotterdam, 3015, CN, The Netherlands","institution_ids":["https://openalex.org/I913958620","https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022631255","display_name":"Fons J. Verbeek","orcid":"https://orcid.org/0000-0003-2445-8158"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Fons J. Verbeek","raw_affiliation_strings":["Imaging and Bio-informatics group, LIACS, Leiden University, Niels Bohrweg 1, Leiden, 2333, CA, The Netherlands. f.j.verbeek@liacs.leidenuniv.nl","Imaging and Bio-informatics group, LIACS, Leiden University, Niels Bohrweg 1, Leiden, 2333, CA, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging and Bio-informatics group, LIACS, Leiden University, Niels Bohrweg 1, Leiden, 2333, CA, The Netherlands. f.j.verbeek@liacs.leidenuniv.nl","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Imaging and Bio-informatics group, LIACS, Leiden University, Niels Bohrweg 1, Leiden, 2333, CA, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022631255"],"corresponding_institution_ids":["https://openalex.org/I121797337"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.01958645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":"1","first_page":"196","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8288000226020813,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8288000226020813,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocytosis","display_name":"Endocytosis","score":0.584640622138977},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"Epidermal growth factor receptor","score":0.5320609211921692},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.478115975856781},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.47586768865585327},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4620484709739685},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.43455106019973755},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4339449405670166},{"id":"https://openalex.org/keywords/wavelet","display_name":"Wavelet","score":0.41535431146621704},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4146479368209839},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"Epidermal growth factor","score":0.41205090284347534},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35088932514190674},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.15588364005088806},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1308848261833191}],"concepts":[{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.584640622138977},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.5320609211921692},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.478115975856781},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.47586768865585327},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4620484709739685},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.43455106019973755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4339449405670166},{"id":"https://openalex.org/C47432892","wikidata":"https://www.wikidata.org/wiki/Q831390","display_name":"Wavelet","level":2,"score":0.41535431146621704},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4146479368209839},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.41205090284347534},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35088932514190674},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15588364005088806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1308848261833191},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057166","descriptor_name":"High-Throughput Screening Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1186/s12859-016-1053-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1053-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-016-1053-2.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:27142862","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27142862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:eur:oai:pure.eur.nl:publications/0e9a1fee-a797-49c2-8a86-f77685a98696","is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/0e9a1fee-a797-49c2-8a86-f77685a98696","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics, 17:196. BioMed Central Ltd.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:85986","is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/85986","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics, 17(1)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/46971","is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/46971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"17","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pubmedcentral.nih.gov:4855371","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4855371","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:pure.eur.nl:publications/0e9a1fee-a797-49c2-8a86-f77685a98696","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:repub.eur.nl:85986","is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/85986","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Bioinformatics vol. 17 no. 1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2887833","is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/46971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC bioinformatics","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:zenodo.org:58827","is_oa":true,"landing_page_url":"https://zenodo.org/record/58827","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics 17(1) 196 (2016)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-1053-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-1053-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12859-016-1053-2.pdf","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7300000190734863,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2383734359","display_name":null,"funder_award_id":"911-02-022","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G2682050640","display_name":null,"funder_award_id":"UL 2006-3538","funder_id":"https://openalex.org/F4320322777","funder_display_name":"KWF Kankerbestrijding"},{"id":"https://openalex.org/G7288368035","display_name":null,"funder_award_id":"UL 2007-3860","funder_id":"https://openalex.org/F4320322777","funder_display_name":"KWF Kankerbestrijding"},{"id":"https://openalex.org/G8131683532","display_name":null,"funder_award_id":"2006-3538","funder_id":"https://openalex.org/F4320322777","funder_display_name":"KWF Kankerbestrijding"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320322706","display_name":"Top Institute Pharma","ror":"https://ror.org/01qmxzb47"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2346333604.pdf","grobid_xml":"https://content.openalex.org/works/W2346333604.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W20983250","https://openalex.org/W23149702","https://openalex.org/W783341876","https://openalex.org/W1518936718","https://openalex.org/W1540596182","https://openalex.org/W1563088657","https://openalex.org/W1564947197","https://openalex.org/W1592919350","https://openalex.org/W1831561245","https://openalex.org/W1916834241","https://openalex.org/W1952355053","https://openalex.org/W1986201595","https://openalex.org/W2012514949","https://openalex.org/W2031669208","https://openalex.org/W2032141751","https://openalex.org/W2032240256","https://openalex.org/W2035679275","https://openalex.org/W2053334540","https://openalex.org/W2056881172","https://openalex.org/W2064760916","https://openalex.org/W2070619727","https://openalex.org/W2071122929","https://openalex.org/W2091364465","https://openalex.org/W2102858230","https://openalex.org/W2105428289","https://openalex.org/W2109943925","https://openalex.org/W2115044652","https://openalex.org/W2115755118","https://openalex.org/W2119821739","https://openalex.org/W2121847038","https://openalex.org/W2125251546","https://openalex.org/W2133218851","https://openalex.org/W2138641998","https://openalex.org/W2144438046","https://openalex.org/W2150766729","https://openalex.org/W2154688191","https://openalex.org/W2165456024","https://openalex.org/W2166481425","https://openalex.org/W2172246201","https://openalex.org/W2503135644","https://openalex.org/W2538359960","https://openalex.org/W3146003712","https://openalex.org/W4235541692","https://openalex.org/W4240374930","https://openalex.org/W4255375128","https://openalex.org/W4302067267"],"related_works":["https://openalex.org/W1989945146","https://openalex.org/W2058869315","https://openalex.org/W2046128749","https://openalex.org/W2758732886","https://openalex.org/W2105691706","https://openalex.org/W3142747831","https://openalex.org/W2397178007","https://openalex.org/W2621222105","https://openalex.org/W3121949222","https://openalex.org/W146556653"],"abstract_inverted_index":{"BACKGROUND:":[0],"Endocytosis":[1],"is":[2,21,31,56,74,148,229,285],"regarded":[3],"as":[4],"a":[5,34,66,89,102,133,166,170,214,267,273],"mechanism":[6],"of":[7,17,92,128,139,157,203,217,235,238,255,270,280,290],"attenuating":[8],"the":[9,60,80,99,106,116,126,129,137,140,143,177,218,222,233,277,288,291],"epidermal":[10],"growth":[11],"factor":[12],"receptor":[13,18],"(EGFR)":[14],"signaling":[15],"and":[16,70,76,83,183,248],"degradation.":[19],"There":[20],"increasing":[22],"evidence":[23],"becoming":[24],"available":[25],"showing":[26],"that":[27,260,287],"breast":[28],"cancer":[29],"progression":[30],"associated":[32],"with":[33,53,266],"defect":[35],"in":[36,48,118,180,221,276],"EGFR":[37,62,130,198,223,239,281,310],"endocytosis.":[38,241,282],"In":[39,142,188],"order":[40],"to":[41,58,78,124,150,175,212,231,296,304,307],"find":[42],"related":[43],"Ribonucleic":[44],"acid":[45],"(RNA)":[46],"regulators":[47],"this":[49,189,297],"process,":[50],"high-throughput":[51,96],"imaging":[52],"fluorescent":[54],"markers":[55],"used":[57,149,211],"visualize":[59],"complex":[61],"endocytosis":[63,311],"process.":[64],"Subsequently":[65],"dedicated":[67],"automatic":[68],"image":[69,100,108,163,182,201],"data":[71,145,184],"analysis":[72,185,195,202,279],"system":[73],"developed":[75],"applied":[77,303],"extract":[79],"phenotype":[81,103],"measurement":[82,104],"distinguish":[84],"different":[85],"developmental":[86],"episodes":[87,237],"from":[88,162],"huge":[90],"amount":[91],"images":[93],"acquired":[94],"through":[95,200],"imaging.":[97],"For":[98],"analysis,":[101,146],"quantifies":[105],"important":[107],"information":[109],"into":[110],"distinct":[111],"features":[112,271,294],"or":[113],"measurements.":[114],"Therefore,":[115,165],"manner":[117],"which":[119],"prominent":[120,159],"measurements":[121,160,209],"are":[122,210,250],"chosen":[123],"represent":[125],"dynamics":[127],"process":[131],"becomes":[132],"crucial":[134],"step":[135],"for":[136,169,197,244],"identification":[138],"phenotype.":[141],"subsequent":[144],"classification":[147,171,227,249,263],"categorize":[151],"each":[152],"observation":[153],"by":[154],"making":[155],"use":[156],"all":[158],"obtained":[161],"analysis.":[164],"better":[167],"construction":[168],"strategy":[172,228],"will":[173],"support":[174],"raise":[176],"performance":[178,256],"level":[179],"our":[181,261],"system.":[186],"RESULTS:":[187],"paper,":[190],"we":[191],"illustrate":[192],"an":[193],"integrated":[194],"method":[196],"signalling":[199],"microscopy":[204],"images.":[205],"Sophisticated":[206],"wavelet-based":[207,292],"texture":[208,293],"obtain":[213],"good":[215],"description":[216],"characteristic":[219],"stages":[220],"signalling.":[224],"A":[225],"hierarchical":[226,262],"designed":[230],"improve":[232],"recognition":[234],"phenotypic":[236],"during":[240],"Different":[242],"strategies":[243],"normalization,":[245],"feature":[246],"selection":[247],"evaluated.":[251],"CONCLUSIONS:":[252],"The":[253],"results":[254],"assessment":[257],"clearly":[258],"demonstrate":[259],"scheme":[264],"combined":[265],"selected":[268],"set":[269],"provides":[272],"notable":[274],"improvement":[275],"temporal":[278],"Moreover,":[283],"it":[284],"shown":[286],"addition":[289],"contributes":[295],"improvement.":[298],"Our":[299],"workflow":[300],"can":[301],"be":[302],"drug":[305],"discovery":[306],"analyze":[308],"defected":[309],"processes.":[312]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
