{"id":"https://openalex.org/W2294333053","doi":"https://doi.org/10.1186/s12859-016-0972-2","title":"PeTTSy: a computational tool for perturbation analysis of complex systems biology models","display_name":"PeTTSy: a computational tool for perturbation analysis of complex systems biology models","publication_year":2016,"publication_date":"2016-03-10","ids":{"openalex":"https://openalex.org/W2294333053","doi":"https://doi.org/10.1186/s12859-016-0972-2","mag":"2294333053","pmid":"https://pubmed.ncbi.nlm.nih.gov/26964749"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-0972-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0972-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0972-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0972-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018935321","display_name":"Mirela Domijan","orcid":"https://orcid.org/0000-0003-3853-9119"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I2800011936","display_name":"Sainsbury Laboratory","ror":"https://ror.org/02tdtzx53","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2800011936"]},{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Mirela Domijan","raw_affiliation_strings":["Current address: The Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK. mirela.domijan@slcu.cam.ac.uk","Warwick Systems Biology Centre, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. mirela.domijan@slcu.cam.ac.uk","Current address: The Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: The Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK. mirela.domijan@slcu.cam.ac.uk","institution_ids":["https://openalex.org/I2800011936"]},{"raw_affiliation_string":"Warwick Systems Biology Centre, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. mirela.domijan@slcu.cam.ac.uk","institution_ids":["https://openalex.org/I39555362"]},{"raw_affiliation_string":"Current address: The Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK","institution_ids":["https://openalex.org/I2800011936","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068740868","display_name":"Paul E. Brown","orcid":"https://orcid.org/0000-0002-8764-4583"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul E. Brown","raw_affiliation_strings":["Warwick Systems Biology Centre, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Systems Biology Centre, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002224327","display_name":"\u0411. \u0412. \u0428\u0443\u043b\u044c\u0433\u0438\u043d","orcid":"https://orcid.org/0000-0003-2117-3499"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Boris V. Shulgin","raw_affiliation_strings":["M&S Decisions LLC, Black Swan villa, Naryshkinskaya al., Moscow, 125167, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M&S Decisions LLC, Black Swan villa, Naryshkinskaya al., Moscow, 125167, Russia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012032003","display_name":"D.A.J. Rand","orcid":"https://orcid.org/0000-0002-2217-3274"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David A. Rand","raw_affiliation_strings":["Warwick Systems Biology Centre, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Systems Biology Centre, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018935321"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I2800011936","https://openalex.org/I39555362"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.6964,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.7347557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"17","issue":"1","first_page":"124","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9754999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9754999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10928","display_name":"Probabilistic and Robust Engineering Design","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ode","display_name":"Ode","score":0.6609489917755127},{"id":"https://openalex.org/keywords/ordinary-differential-equation","display_name":"Ordinary differential equation","score":0.6444034576416016},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6376416087150574},{"id":"https://openalex.org/keywords/toolbox","display_name":"Toolbox","score":0.6217356324195862},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.5429404377937317},{"id":"https://openalex.org/keywords/matlab","display_name":"MATLAB","score":0.5348272323608398},{"id":"https://openalex.org/keywords/complex-system","display_name":"Complex system","score":0.4731277823448181},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.4550924301147461},{"id":"https://openalex.org/keywords/observable","display_name":"Observable","score":0.45308271050453186},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4512998163700104},{"id":"https://openalex.org/keywords/differential-equation","display_name":"Differential equation","score":0.3213023543357849},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.20485061407089233},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.193575918674469},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.16285431385040283},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1362898349761963},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1218002438545227},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09669625759124756},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08170244097709656}],"concepts":[{"id":"https://openalex.org/C34862557","wikidata":"https://www.wikidata.org/wiki/Q178985","display_name":"Ode","level":2,"score":0.6609489917755127},{"id":"https://openalex.org/C51544822","wikidata":"https://www.wikidata.org/wiki/Q465274","display_name":"Ordinary differential equation","level":3,"score":0.6444034576416016},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6376416087150574},{"id":"https://openalex.org/C2777655017","wikidata":"https://www.wikidata.org/wiki/Q1501161","display_name":"Toolbox","level":2,"score":0.6217356324195862},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.5429404377937317},{"id":"https://openalex.org/C2780365114","wikidata":"https://www.wikidata.org/wiki/Q169478","display_name":"MATLAB","level":2,"score":0.5348272323608398},{"id":"https://openalex.org/C47822265","wikidata":"https://www.wikidata.org/wiki/Q854457","display_name":"Complex system","level":2,"score":0.4731277823448181},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.4550924301147461},{"id":"https://openalex.org/C32848918","wikidata":"https://www.wikidata.org/wiki/Q845789","display_name":"Observable","level":2,"score":0.45308271050453186},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4512998163700104},{"id":"https://openalex.org/C78045399","wikidata":"https://www.wikidata.org/wiki/Q11214","display_name":"Differential equation","level":2,"score":0.3213023543357849},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.20485061407089233},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.193575918674469},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.16285431385040283},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1362898349761963},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1218002438545227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09669625759124756},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08170244097709656},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12859-016-0972-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0972-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0972-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26964749","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26964749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:wrap.warwick.ac.uk:77654","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/260465","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/260465","pdf_url":"https://www.repository.cam.ac.uk/handle/1810/260465","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:europepmc.org:3759107","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4785672","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"doi:10.17863/cam.4699","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.4699","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-0972-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0972-2","pdf_url":"https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-016-0972-2","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","score":0.49000000953674316,"id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1059042294","display_name":null,"funder_award_id":"BB/K003097/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G1314499027","display_name":"Dynamics and function of the NF-kappaB signalling system","funder_award_id":"BB/F005938/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G1657959758","display_name":null,"funder_award_id":"BBF0059381","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2244883995","display_name":"Regulation of Biological Signalling by Temperature (ROBUST)","funder_award_id":"BB/F005261/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2298205076","display_name":null,"funder_award_id":"BB/F005938/2","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2456592724","display_name":null,"funder_award_id":"BBF0058141 BB","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G347666902","display_name":null,"funder_award_id":"EP/C544587/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3643414835","display_name":null,"funder_award_id":"BBF0059381/BBF0058141","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3911968438","display_name":"Dynamics and Function of the NF-kB Signalling System","funder_award_id":"BB/F005814/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4817460009","display_name":"Systems medicine of chronic inflammatory bowel disease","funder_award_id":"305564","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5184873459","display_name":null,"funder_award_id":"C544587/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6386835508","display_name":null,"funder_award_id":"BB/F005938/2","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6601167538","display_name":"Systems Biology analysis of biological timers and inflammation","funder_award_id":"BB/K003097/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6627234182","display_name":"Mathematics of Biological Systems: Modelling, Data & Analysis","funder_award_id":"EP/C544587/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7035532266","display_name":null,"funder_award_id":"BB/F005261/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8152561102","display_name":null,"funder_award_id":"BB/F005938/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8561459807","display_name":null,"funder_award_id":"BB/F005814/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8796945004","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2294333053.pdf","grobid_xml":"https://content.openalex.org/works/W2294333053.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1821846400","https://openalex.org/W1988507461","https://openalex.org/W1998463022","https://openalex.org/W2031144848","https://openalex.org/W2089068724","https://openalex.org/W2089876099","https://openalex.org/W2105379381","https://openalex.org/W2112080061","https://openalex.org/W2115343689","https://openalex.org/W2120260648","https://openalex.org/W2130618526","https://openalex.org/W2136120517","https://openalex.org/W2154387393","https://openalex.org/W2156444576","https://openalex.org/W2156730317","https://openalex.org/W2166071821","https://openalex.org/W2166751342","https://openalex.org/W2167566709","https://openalex.org/W2179083909","https://openalex.org/W2327627360","https://openalex.org/W2742470390","https://openalex.org/W3115050390","https://openalex.org/W3141151088","https://openalex.org/W4235527302","https://openalex.org/W4236623370"],"related_works":["https://openalex.org/W3082668976","https://openalex.org/W2517973022","https://openalex.org/W1543121148","https://openalex.org/W1580703421","https://openalex.org/W2996841952","https://openalex.org/W2618518959","https://openalex.org/W2231364979","https://openalex.org/W4295745414","https://openalex.org/W4382202915","https://openalex.org/W2489516236"],"abstract_inverted_index":{"BACKGROUND:":[0],"Over":[1],"the":[2,27,64,100,142,149,161,172,191,193,197,200,241,267,277,340,358],"last":[3],"decade":[4],"sensitivity":[5,104,139,344],"analysis":[6,105,133,140,278,311,345],"techniques":[7,98],"have":[8,31,54],"been":[9,36],"shown":[10],"to":[11,15,144,179,195,249,265,339,357],"be":[12,67,158,165,219,353],"very":[13],"useful":[14,275],"analyse":[16],"complex":[17,109,282,299,325],"and":[18,103,108,129,154,184,214,230,233,281,287,298,303,310,320,363],"high":[19],"dimensional":[20],"Systems":[21],"Biology":[22],"models.":[23,115],"However,":[24],"many":[25,177,204,285],"of":[26,42,45,49,97,106,126,134,141,146,199,207,212,225,253,269,279,301,312,317,324,332,343,354],"currently":[28],"available":[29],"toolboxes":[30],"either":[32],"used":[33],"parameter":[34,61,201],"sampling,":[35],"focused":[37],"on":[38,203,221],"a":[39,50,88,94,118,124,168,222,254,257,292,315,336],"restricted":[40],"set":[41,331],"model":[43,60,215,255,258],"observables":[44],"interest,":[46],"studied":[47],"optimisation":[48,239,323],"objective":[51],"function,":[52],"or":[53,69],"not":[55],"dealt":[56],"with":[57,259],"multiple":[58,251,260],"simultaneous":[59],"changes":[62,65],"where":[63,148],"can":[66,157,164,174,218],"permanent":[68],"temporary.":[70],"RESULTS:":[71],"Here":[72],"we":[73],"introduce":[74],"our":[75],"new,":[76],"freely":[77],"downloadable":[78],"toolbox,":[79],"PeTTSy":[80,86,116,188,217,290],"(Perturbation":[81],"Theory":[82],"Toolbox":[83],"for":[84,90,99,185,295,308,321],"Systems).":[85],"is":[87,117,273,291],"package":[89],"MATLAB":[91],"which":[92],"implements":[93],"wide":[95,223],"array":[96],"perturbation":[101,150],"theory":[102],"large":[107,280,297],"ordinary":[110],"differential":[111],"equation":[112],"(ODE)":[113],"based":[114],"comprehensive":[119,293],"modelling":[120,364],"framework":[121],"that":[122,130,349],"introduces":[123],"number":[125],"new":[127,270],"approaches":[128],"fully":[131],"addresses":[132],"oscillatory":[135],"systems.":[136,235,305],"It":[137,272,306],"examines":[138],"models":[143,227,283,300,313],"perturbations":[145,202],"parameters,":[147],"timing,":[151],"strength,":[152],"length":[153],"overall":[155],"shape":[156],"controlled":[159],"by":[160,181],"user.":[162],"This":[163],"done":[166],"in":[167,263,276],"system-global":[169],"setting,":[170],"namely,":[171],"user":[173,192],"determine":[175,266],"how":[176,182,186],"parameters":[178],"perturb,":[180],"much":[183],"long.":[187],"also":[189],"offers":[190],"ability":[194],"explore":[196],"effect":[198],"different":[205],"types":[206],"outputs:":[208],"period,":[209],"phase":[210],"(timing":[211],"peak)":[213],"solutions.":[216],"employed":[220],"range":[224],"mathematical":[226],"including":[228],"free-running":[229],"forced":[231],"oscillators":[232],"signalling":[234,304],"To":[236],"enable":[237],"experimental":[238,261,322],"using":[240],"Fisher":[242],"Information":[243],"Matrix":[244],"it":[245,334],"efficiently":[246],"allows":[247,307],"one":[248],"combine":[250],"variants":[252],"(i.e.":[256],"conditions)":[262],"order":[264],"value":[268],"experiments.":[271,327],"especially":[274],"involving":[284],"variables":[286],"parameters.":[288],"CONCLUSIONS:":[289],"tool":[294],"analysing":[296],"regulatory":[302],"simulation":[309],"under":[314],"variety":[316],"environmental":[318],"conditions":[319],"combined":[326],"With":[328],"its":[329],"unique":[330],"tools":[333],"makes":[335],"valuable":[337],"addition":[338],"current":[341],"library":[342],"toolboxes.":[346],"We":[347],"believe":[348],"this":[350],"software":[351],"will":[352],"great":[355],"use":[356],"wider":[359],"biological,":[360],"systems":[361],"biology":[362],"communities.":[365]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}