{"id":"https://openalex.org/W2283470404","doi":"https://doi.org/10.1186/s12859-016-0941-9","title":"Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology","display_name":"Drug repurposing to target Ebola virus replication and virulence using structural systems pharmacology","publication_year":2016,"publication_date":"2016-02-18","ids":{"openalex":"https://openalex.org/W2283470404","doi":"https://doi.org/10.1186/s12859-016-0941-9","mag":"2283470404","pmid":"https://pubmed.ncbi.nlm.nih.gov/26887654"},"language":"en","primary_location":{"id":"doi:10.1186/s12859-016-0941-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0941-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-016-0941-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-016-0941-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000273221","display_name":"Zheng Zhao","orcid":"https://orcid.org/0000-0003-1453-3230"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210102600","display_name":"High Magnetic Field Laboratory","ror":"https://ror.org/01gh88804","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667","https://openalex.org/I4210102600"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zheng Zhao","raw_affiliation_strings":["High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, P. R. China","National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, P. R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210102600"]},{"raw_affiliation_string":"National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086248364","display_name":"Che Martin","orcid":"https://orcid.org/0000-0002-7582-3103"},"institutions":[{"id":"https://openalex.org/I121847817","display_name":"The Graduate Center, CUNY","ror":"https://ror.org/00awd9g61","country_code":"US","type":"education","lineage":["https://openalex.org/I121847817"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Che Martin","raw_affiliation_strings":["The Graduate Center, The City University of New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Graduate Center, The City University of New York, New York, USA","institution_ids":["https://openalex.org/I121847817","https://openalex.org/I174216632"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067496537","display_name":"Raymond Fan","orcid":null},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I39694355","display_name":"Hunter College","ror":"https://ror.org/00g2xk477","country_code":"US","type":"education","lineage":["https://openalex.org/I39694355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond Fan","raw_affiliation_strings":["Department of Chemistry, Hunter College, The City University of New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Hunter College, The City University of New York, New York, USA","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I39694355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075833022","display_name":"Philip E. Bourne","orcid":"https://orcid.org/0000-0002-7618-7292"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210091794","display_name":"Office of the Director","ror":"https://ror.org/00fj8a872","country_code":"US","type":"other","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210091794"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip E. Bourne","raw_affiliation_strings":["Office of the Director, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Office of the Director, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210091794"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066245750","display_name":"Lei Xie","orcid":"https://orcid.org/0000-0001-9051-2111"},"institutions":[{"id":"https://openalex.org/I121847817","display_name":"The Graduate Center, CUNY","ror":"https://ror.org/00awd9g61","country_code":"US","type":"education","lineage":["https://openalex.org/I121847817"]},{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I39694355","display_name":"Hunter College","ror":"https://ror.org/00g2xk477","country_code":"US","type":"education","lineage":["https://openalex.org/I39694355"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lei Xie","raw_affiliation_strings":["Department of Computer Science, Hunter College, The City University of New York, New York, USA. lxie@iscb.org","The Graduate Center, The City University of New York, New York, USA. lxie@iscb.org","The Graduate Center, The City University of New York, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Hunter College, The City University of New York, New York, USA. lxie@iscb.org","institution_ids":["https://openalex.org/I39694355"]},{"raw_affiliation_string":"The Graduate Center, The City University of New York, New York, USA. lxie@iscb.org","institution_ids":["https://openalex.org/I121847817","https://openalex.org/I174216632"]},{"raw_affiliation_string":"The Graduate Center, The City University of New York, New York, USA","institution_ids":["https://openalex.org/I121847817","https://openalex.org/I174216632"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5066245750"],"corresponding_institution_ids":["https://openalex.org/I121847817","https://openalex.org/I174216632","https://openalex.org/I39694355"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":6.8679,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.9749958,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"90","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebola-virus","display_name":"Ebola virus","score":0.7661519050598145},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.7084805369377136},{"id":"https://openalex.org/keywords/maraviroc","display_name":"Maraviroc","score":0.6527017951011658},{"id":"https://openalex.org/keywords/ebolavirus","display_name":"Ebolavirus","score":0.6218515634536743},{"id":"https://openalex.org/keywords/indinavir","display_name":"Indinavir","score":0.6024873852729797},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.5924066305160522},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5047694444656372},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.42977991700172424},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.42590391635894775},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4127139151096344},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.40786880254745483},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.33827927708625793},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.22687748074531555},{"id":"https://openalex.org/keywords/outbreak","display_name":"Outbreak","score":0.20768731832504272},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.16927698254585266},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.15537256002426147}],"concepts":[{"id":"https://openalex.org/C2777469322","wikidata":"https://www.wikidata.org/wiki/Q8064876","display_name":"Ebola virus","level":3,"score":0.7661519050598145},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.7084805369377136},{"id":"https://openalex.org/C2778899366","wikidata":"https://www.wikidata.org/wiki/Q421369","display_name":"Maraviroc","level":3,"score":0.6527017951011658},{"id":"https://openalex.org/C2909623084","wikidata":"https://www.wikidata.org/wiki/Q5331908","display_name":"Ebolavirus","level":4,"score":0.6218515634536743},{"id":"https://openalex.org/C2777210460","wikidata":"https://www.wikidata.org/wiki/Q425490","display_name":"Indinavir","level":5,"score":0.6024873852729797},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.5924066305160522},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5047694444656372},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42977991700172424},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.42590391635894775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4127139151096344},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40786880254745483},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33827927708625793},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.22687748074531555},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.20768731832504272},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.16927698254585266},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.15537256002426147},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D029043","descriptor_name":"Ebolavirus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D029043","descriptor_name":"Ebolavirus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D029043","descriptor_name":"Ebolavirus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12859-016-0941-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0941-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-016-0941-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26887654","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26887654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4757998","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4757998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Bioinformatics","raw_type":"Text"},{"id":"pmh:oai:academicworks.cuny.edu:hc_pubs-1443","is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/hc_pubs/417","pdf_url":null,"source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publications and Research","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12859-016-0941-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12859-016-0941-9","pdf_url":"https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/s12859-016-0941-9","source":{"id":"https://openalex.org/S19032547","display_name":"BMC Bioinformatics","issn_l":"1471-2105","issn":["1471-2105"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1406212572","display_name":"II-EN: CUNY Computing Research Infrastructure","funder_award_id":"0958379","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2650954463","display_name":null,"funder_award_id":"R01 LM011986","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G2970038619","display_name":null,"funder_award_id":"CNS-0958379","funder_id":"https://openalex.org/F4320309102","funder_display_name":"City University of New York"},{"id":"https://openalex.org/G3608562717","display_name":"Drug discovery by integrating chemical genomics and structural systems biology","funder_award_id":"5r01lm011986-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6871019987","display_name":null,"funder_award_id":"CNS\u20100855217","funder_id":"https://openalex.org/F4320309102","funder_display_name":"City University of New York"},{"id":"https://openalex.org/G8724749099","display_name":"II-EN: City University of New York - Computing Research Infrastructure","funder_award_id":"0855217","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309102","display_name":"City University of New York","ror":"https://ror.org/00453a208"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2283470404.pdf","grobid_xml":"https://content.openalex.org/works/W2283470404.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W179329265","https://openalex.org/W1525289848","https://openalex.org/W1705116382","https://openalex.org/W1722748669","https://openalex.org/W1971172451","https://openalex.org/W1971412145","https://openalex.org/W1971592397","https://openalex.org/W1985570405","https://openalex.org/W1986191025","https://openalex.org/W1988437166","https://openalex.org/W1988527797","https://openalex.org/W1990495809","https://openalex.org/W1993310312","https://openalex.org/W1994790204","https://openalex.org/W2004427090","https://openalex.org/W2006667691","https://openalex.org/W2007233756","https://openalex.org/W2009313526","https://openalex.org/W2009682500","https://openalex.org/W2011495938","https://openalex.org/W2014397762","https://openalex.org/W2015147525","https://openalex.org/W2019974881","https://openalex.org/W2020329769","https://openalex.org/W2022659284","https://openalex.org/W2023096091","https://openalex.org/W2023170820","https://openalex.org/W2041046009","https://openalex.org/W2041881307","https://openalex.org/W2043830764","https://openalex.org/W2051783184","https://openalex.org/W2052350794","https://openalex.org/W2059118814","https://openalex.org/W2061799302","https://openalex.org/W2064489317","https://openalex.org/W2065283382","https://openalex.org/W2065484767","https://openalex.org/W2068095506","https://openalex.org/W2071486470","https://openalex.org/W2071717945","https://openalex.org/W2072180710","https://openalex.org/W2074192927","https://openalex.org/W2074473216","https://openalex.org/W2076764146","https://openalex.org/W2078645984","https://openalex.org/W2082586732","https://openalex.org/W2084266282","https://openalex.org/W2092723276","https://openalex.org/W2095207285","https://openalex.org/W2102230160","https://openalex.org/W2103945336","https://openalex.org/W2105668062","https://openalex.org/W2108768863","https://openalex.org/W2115318272","https://openalex.org/W2116373967","https://openalex.org/W2117940625","https://openalex.org/W2121895929","https://openalex.org/W2125102767","https://openalex.org/W2128054164","https://openalex.org/W2131017257","https://openalex.org/W2133035849","https://openalex.org/W2133114049","https://openalex.org/W2134967712","https://openalex.org/W2137632714","https://openalex.org/W2139942857","https://openalex.org/W2145268834","https://openalex.org/W2145665475","https://openalex.org/W2156244640","https://openalex.org/W2161605421","https://openalex.org/W2166744107","https://openalex.org/W2169815691","https://openalex.org/W2170354954","https://openalex.org/W2417630304","https://openalex.org/W2418156800","https://openalex.org/W2432328780","https://openalex.org/W2469908587","https://openalex.org/W2599425772","https://openalex.org/W4246356731"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W4320009247","https://openalex.org/W4206422705","https://openalex.org/W3186872001","https://openalex.org/W3174741986","https://openalex.org/W4386502171","https://openalex.org/W2959798450","https://openalex.org/W4287114073"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"recent":[2],"outbreak":[3],"of":[4,39,100,118,134,163,175,187,195,210],"Ebola":[5,26,45,152,189],"has":[6,114],"been":[7],"cited":[8],"as":[9],"the":[10,37,92,96,105,132,158,173,185,188,207],"largest":[11],"in":[12,42,130,199,202],"history.":[13],"Despite":[14],"this":[15],"global":[16,190],"health":[17],"crisis,":[18],"few":[19],"drugs":[20,81,85,143,212],"are":[21],"available":[22],"to":[23,35,44,88,94,103,181,205],"efficiently":[24],"treat":[25],"infections.":[27],"Drug":[28],"repurposing":[29],"provides":[30],"a":[31,116,168],"potentially":[32],"efficient":[33],"solution":[34],"accelerating":[36],"development":[38],"therapeutic":[40,179],"approaches":[41,180],"response":[43],"outbreak.":[46],"To":[47],"identify":[48,89],"such":[49],"candidates,":[50],"we":[51],"use":[52],"an":[53,123,137],"integrated":[54],"structural":[55],"systems":[56],"pharmacology":[57],"pipeline":[58],"which":[59],"combines":[60],"proteome-scale":[61],"ligand":[62],"binding":[63,106],"site":[64],"comparison,":[65],"protein-ligand":[66],"docking,":[67],"and":[68,78,82,98,102,140,148,177,183,192,201],"Molecular":[69],"Dynamics":[70],"(MD)":[71],"simulation.":[72],"RESULTS:":[73],"One":[74],"thousand":[75],"seven":[76],"hundred":[77],"sixty-six":[79],"FDA-approved":[80],"259":[83],"experimental":[84],"were":[86],"screened":[87],"those":[90],"with":[91,108],"potential":[93],"inhibit":[95,151],"replication":[97],"virulence":[99,133],"Ebola,":[101],"determine":[104],"modes":[107],"their":[109],"respective":[110],"targets.":[111],"Initial":[112],"screening":[113],"identified":[115],"number":[117],"promising":[119],"hits.":[120],"Notably,":[121],"Indinavir;":[122],"HIV":[124],"protease":[125],"inhibitor,":[126],"may":[127,150],"be":[128],"effective":[129,178],"reducing":[131],"Ebola.":[135],"Additionally,":[136],"antifungal":[138],"(Sinefungin)":[139],"several":[141],"anti-viral":[142],"(e.g.":[144],"Maraviroc,":[145],"Abacavir,":[146],"Telbivudine,":[147],"Cidofovir)":[149],"RNA-directed":[153],"RNA":[154],"polymerase":[155],"through":[156],"targeting":[157],"MTase":[159],"domain.":[160],"CONCLUSIONS:":[161],"Identification":[162],"safe":[164],"drug":[165],"candidates":[166],"is":[167,213],"crucial":[169],"first":[170],"step":[171],"toward":[172],"determination":[174],"timely":[176],"address":[182],"mitigate":[184],"impact":[186],"crisis":[191],"future":[193],"outbreaks":[194],"pathogenic":[196],"diseases.":[197],"Further":[198],"vitro":[200],"vivo":[203],"testing":[204],"evaluate":[206],"anti-Ebola":[208],"activity":[209],"these":[211],"warranted.":[214]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":4}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
